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Items: 25

1.

Egr-1 identifies neointimal remodeling and relates to progression in human pulmonary arterial hypertension.

van der Feen DE, Dickinson MG, Bartelds B, Borgdorff MA, Sietsma H, Lévy M, Berger RM.

J Heart Lung Transplant. 2016 Apr;35(4):481-90. doi: 10.1016/j.healun.2015.12.004. Epub 2015 Dec 17.

PMID:
26774383
2.

A critical role for Egr-1 during vascular remodelling in pulmonary arterial hypertension.

Dickinson MG, Kowalski PS, Bartelds B, Borgdorff MA, van der Feen D, Sietsma H, Molema G, Kamps JA, Berger RM.

Cardiovasc Res. 2014 Sep 1;103(4):573-84. doi: 10.1093/cvr/cvu169. Epub 2014 Jul 14.

PMID:
25028387
3.

Correlation of immunohistochemical staining p63 and TTF-1 with EGFR and K-ras mutational spectrum and diagnostic reproducibility in non small cell lung carcinoma.

Thunnissen E, Boers E, Heideman DA, Grünberg K, Kuik DJ, Noorduin A, van Oosterhout M, Pronk D, Seldenrijk C, Sietsma H, Smit EF, van Suylen R, von der Thusen J, Vrugt B, Wiersma A, Witte BI, den Bakker M.

Virchows Arch. 2012 Dec;461(6):629-38. doi: 10.1007/s00428-012-1324-x. Epub 2012 Oct 12.

PMID:
23064619
4.

Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer.

Peifer M, Fernández-Cuesta L, Sos ML, George J, Seidel D, Kasper LH, Plenker D, Leenders F, Sun R, Zander T, Menon R, Koker M, Dahmen I, Müller C, Di Cerbo V, Schildhaus HU, Altmüller J, Baessmann I, Becker C, de Wilde B, Vandesompele J, Böhm D, Ansén S, Gabler F, Wilkening I, Heynck S, Heuckmann JM, Lu X, Carter SL, Cibulskis K, Banerji S, Getz G, Park KS, Rauh D, Grütter C, Fischer M, Pasqualucci L, Wright G, Wainer Z, Russell P, Petersen I, Chen Y, Stoelben E, Ludwig C, Schnabel P, Hoffmann H, Muley T, Brockmann M, Engel-Riedel W, Muscarella LA, Fazio VM, Groen H, Timens W, Sietsma H, Thunnissen E, Smit E, Heideman DA, Snijders PJ, Cappuzzo F, Ligorio C, Damiani S, Field J, Solberg S, Brustugun OT, Lund-Iversen M, Sänger J, Clement JH, Soltermann A, Moch H, Weder W, Solomon B, Soria JC, Validire P, Besse B, Brambilla E, Brambilla C, Lantuejoul S, Lorimier P, Schneider PM, Hallek M, Pao W, Meyerson M, Sage J, Shendure J, Schneider R, Büttner R, Wolf J, Nürnberg P, Perner S, Heukamp LC, Brindle PK, Haas S, Thomas RK.

Nat Genet. 2012 Oct;44(10):1104-10. doi: 10.1038/ng.2396. Epub 2012 Sep 2.

5.

Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer.

Hammerman PS, Sos ML, Ramos AH, Xu C, Dutt A, Zhou W, Brace LE, Woods BA, Lin W, Zhang J, Deng X, Lim SM, Heynck S, Peifer M, Simard JR, Lawrence MS, Onofrio RC, Salvesen HB, Seidel D, Zander T, Heuckmann JM, Soltermann A, Moch H, Koker M, Leenders F, Gabler F, Querings S, Ansén S, Brambilla E, Brambilla C, Lorimier P, Brustugun OT, Helland A, Petersen I, Clement JH, Groen H, Timens W, Sietsma H, Stoelben E, Wolf J, Beer DG, Tsao MS, Hanna M, Hatton C, Eck MJ, Janne PA, Johnson BE, Winckler W, Greulich H, Bass AJ, Cho J, Rauh D, Gray NS, Wong KK, Haura EB, Thomas RK, Meyerson M.

Cancer Discov. 2011 Jun;1(1):78-89. doi: 10.1158/2159-8274.CD-11-0005.

6.

Randomized, placebo-controlled phase III study of docetaxel plus carboplatin with celecoxib and cyclooxygenase-2 expression as a biomarker for patients with advanced non-small-cell lung cancer: the NVALT-4 study.

Groen HJ, Sietsma H, Vincent A, Hochstenbag MM, van Putten JW, van den Berg A, Dalesio O, Biesma B, Smit HJ, Termeer A, Hiltermann TJ, van den Borne BE, Schramel FM.

J Clin Oncol. 2011 Nov 10;29(32):4320-6. doi: 10.1200/JCO.2011.35.5214. Epub 2011 Oct 11.

PMID:
21990410
7.

Egr-1 expression during neointimal development in flow-associated pulmonary hypertension.

Dickinson MG, Bartelds B, Molema G, Borgdorff MA, Boersma B, Takens J, Weij M, Wichers P, Sietsma H, Berger RM.

Am J Pathol. 2011 Nov;179(5):2199-209. doi: 10.1016/j.ajpath.2011.07.030. Epub 2011 Sep 13.

8.

Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer.

Weiss J, Sos ML, Seidel D, Peifer M, Zander T, Heuckmann JM, Ullrich RT, Menon R, Maier S, Soltermann A, Moch H, Wagener P, Fischer F, Heynck S, Koker M, Schöttle J, Leenders F, Gabler F, Dabow I, Querings S, Heukamp LC, Balke-Want H, Ansén S, Rauh D, Baessmann I, Altmüller J, Wainer Z, Conron M, Wright G, Russell P, Solomon B, Brambilla E, Brambilla C, Lorimier P, Sollberg S, Brustugun OT, Engel-Riedel W, Ludwig C, Petersen I, Sänger J, Clement J, Groen H, Timens W, Sietsma H, Thunnissen E, Smit E, Heideman D, Cappuzzo F, Ligorio C, Damiani S, Hallek M, Beroukhim R, Pao W, Klebl B, Baumann M, Buettner R, Ernestus K, Stoelben E, Wolf J, Nürnberg P, Perner S, Thomas RK.

Sci Transl Med. 2010 Dec 15;2(62):62ra93. doi: 10.1126/scitranslmed.3001451. Erratum in: Sci Transl Med. 2011 Jan 19;3(66):66er2. Sci Transl Med. 2012 Apr 18;4(130):130er2.

9.

A chronic obstructive pulmonary disease related signature in squamous cell lung cancer.

Boelens MC, Gustafson AM, Postma DS, Kok K, van der Vries G, van der Vlies P, Spira A, Lenburg ME, Geerlings M, Sietsma H, Timens W, van den Berg A, Groen HJ.

Lung Cancer. 2011 May;72(2):177-83. doi: 10.1016/j.lungcan.2010.08.014. Epub 2010 Sep 15.

PMID:
20832896
10.

Current smoking-specific gene expression signature in normal bronchial epithelium is enhanced in squamous cell lung cancer.

Boelens MC, van den Berg A, Fehrmann RS, Geerlings M, de Jong WK, te Meerman GJ, Sietsma H, Timens W, Postma DS, Groen HJ.

J Pathol. 2009 Jun;218(2):182-91. doi: 10.1002/path.2520.

PMID:
19334046
11.

Genomic aberrations in squamous cell lung carcinoma related to lymph node or distant metastasis.

Boelens MC, Kok K, van der Vlies P, van der Vries G, Sietsma H, Timens W, Postma DS, Groen HJ, van den Berg A.

Lung Cancer. 2009 Dec;66(3):372-8. doi: 10.1016/j.lungcan.2009.02.017. Epub 2009 Mar 25.

PMID:
19324446
12.

Gangliosides do not affect ABC transporter function in human neuroblastoma cells.

Dijkhuis AJ, Klappe K, Kamps W, Sietsma H, Kok JW.

J Lipid Res. 2006 Jun;47(6):1187-95. Epub 2006 Mar 18.

13.

PDMP sensitizes neuroblastoma to paclitaxel by inducing aberrant cell cycle progression leading to hyperploidy.

Dijkhuis AJ, Klappe K, Jacobs S, Kroesen BJ, Kamps W, Sietsma H, Kok JW.

Mol Cancer Ther. 2006 Mar;5(3):593-601.

14.

Sphingolipid metabolism enzymes as targets for anticancer therapy.

Kok JW, Sietsma H.

Curr Drug Targets. 2004 May;5(4):375-82. Review.

PMID:
15134220
15.
16.
17.

BcR-induced apoptosis involves differential regulation of C16 and C24-ceramide formation and sphingolipid-dependent activation of the proteasome.

Kroesen BJ, Jacobs S, Pettus BJ, Sietsma H, Kok JW, Hannun YA, de Leij LF.

J Biol Chem. 2003 Apr 25;278(17):14723-31. Epub 2003 Feb 10.

18.

Sphingolipids in neuroblastoma: their role in drug resistance mechanisms.

Sietsma H, Dijkhuis AJ, Kamps W, Kok JW.

Neurochem Res. 2002 Aug;27(7-8):665-74. Review.

PMID:
12374201
19.

Altered sphingolipid metabolism in multidrug-resistant ovarian cancer cells is due to uncoupling of glycolipid biosynthesis in the Golgi apparatus.

Veldman RJ, Klappe K, Hinrichs J, Hummel I, van der Schaaf G, Sietsma H, Kok JW.

FASEB J. 2002 Jul;16(9):1111-3. Epub 2002 May 8.

PMID:
12039850
20.

The involvement of sphingolipids in multidrug resistance.

Sietsma H, Veldman RJ, Kok JW.

J Membr Biol. 2001 Jun 1;181(3):153-62. Review.

PMID:
11420602
21.

Induction of apoptosis through B-cell receptor cross-linking occurs via de novo generated C16-ceramide and involves mitochondria.

Kroesen BJ, Pettus B, Luberto C, Busman M, Sietsma H, de Leij L, Hannun YA.

J Biol Chem. 2001 Apr 27;276(17):13606-14. Epub 2001 Jan 17.

22.

1-phenyl-2-decanoylamino-3-morpholino-1-propanol chemosensitizes neuroblastoma cells for taxol and vincristine.

Sietsma H, Veldman RJ, Kolk D, Ausema B, Nijhof W, Kamps W, Vellenga E, Kok JW.

Clin Cancer Res. 2000 Mar;6(3):942-8.

23.

Inhibition of P-glycoprotein activity and chemosensitization of multidrug-resistant ovarian carcinoma 2780AD cells by hexanoylglucosylceramide.

Veldman RJ, Sietsma H, Klappe K, Hoekstra D, Kok JW.

Biochem Biophys Res Commun. 1999 Dec 20;266(2):492-6.

PMID:
10600530
24.

Leukemia-induced bone marrow depression: effects of gangliosides on erythroid cell production.

Sietsma H, Kamps WA, Dontje B, Hendriks D, Kok JW, Vellenga E, Nijhof W.

Int J Cancer. 1999 Jul 2;82(1):92-7.

25.

Inhibition of hemopoiesis in vitro by neuroblastoma-derived gangliosides.

Sietsma H, Nijhof W, Dontje B, Vellenga E, Kamps WA, Kok JW.

Cancer Res. 1998 Nov 1;58(21):4840-4.

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