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Items: 9

1.

Glycosylation of KEAP1 links nutrient sensing to redox stress signaling.

Chen PH, Smith TJ, Wu J, Siesser PF, Bisnett BJ, Khan F, Hogue M, Soderblom E, Tang F, Marks JR, Major MB, Swarts BM, Boyce M, Chi JT.

EMBO J. 2017 Aug 1;36(15):2233-2250. doi: 10.15252/embj.201696113. Epub 2017 Jun 29.

2.

Identification and Characterization of MCM3 as a Kelch-like ECH-associated Protein 1 (KEAP1) Substrate.

Mulvaney KM, Matson JP, Siesser PF, Tamir TY, Goldfarb D, Jacobs TM, Cloer EW, Harrison JS, Vaziri C, Cook JG, Major MB.

J Biol Chem. 2016 Nov 4;291(45):23719-23733. Epub 2016 Sep 12.

3.

Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase.

Kim TY, Siesser PF, Rossman KL, Goldfarb D, Mackinnon K, Yan F, Yi X, MacCoss MJ, Moon RT, Der CJ, Major MB.

Mol Cell Biol. 2015 Jan;35(1):167-81. doi: 10.1128/MCB.00857-14. Epub 2014 Oct 20.

4.

Cancer-derived mutations in KEAP1 impair NRF2 degradation but not ubiquitination.

Hast BE, Cloer EW, Goldfarb D, Li H, Siesser PF, Yan F, Walter V, Zheng N, Hayes DN, Major MB.

Cancer Res. 2014 Feb 1;74(3):808-17. doi: 10.1158/0008-5472.CAN-13-1655. Epub 2013 Dec 9.

5.

Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination.

Hast BE, Goldfarb D, Mulvaney KM, Hast MA, Siesser PF, Yan F, Hayes DN, Major MB.

Cancer Res. 2013 Apr 1;73(7):2199-210. doi: 10.1158/0008-5472.CAN-12-4400. Epub 2013 Feb 4.

6.

FAM123A binds to microtubules and inhibits the guanine nucleotide exchange factor ARHGEF2 to decrease actomyosin contractility.

Siesser PF, Motolese M, Walker MP, Goldfarb D, Gewain K, Yan F, Kulikauskas RM, Chien AJ, Wordeman L, Major MB.

Sci Signal. 2012 Sep 4;5(240):ra64. doi: 10.1126/scisignal.2002871.

7.

L1 and CHL1 Cooperate in Thalamocortical Axon Targeting.

Demyanenko GP, Siesser PF, Wright AG, Brennaman LH, Bartsch U, Schachner M, Maness PF.

Cereb Cortex. 2011 Feb;21(2):401-12. doi: 10.1093/cercor/bhq115. Epub 2010 Jun 24.

8.

L1 cell adhesion molecules as regulators of tumor cell invasiveness.

Siesser PF, Maness PF.

Cell Adh Migr. 2009 Jul-Sep;3(3):275-7. Epub 2009 Jul 7. Review. Erratum in: Cell Adh Migr. 2010 Oct-Dec;4(4):635.

9.

Crk-associated substrate tyrosine phosphorylation sites are critical for invasion and metastasis of SRC-transformed cells.

Brábek J, Constancio SS, Siesser PF, Shin NY, Pozzi A, Hanks SK.

Mol Cancer Res. 2005 Jun;3(6):307-15.

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