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Items: 1 to 50 of 146

1.

Btk Inhibitors as First Oral Atherothrombosis-Selective Antiplatelet Drugs?

Busygina K, Denzinger V, Bernlochner I, Weber C, Lorenz R, Siess W.

Thromb Haemost. 2019 Aug;119(8):1212-1221. doi: 10.1055/s-0039-1687877. Epub 2019 May 14.

PMID:
31087308
2.

Optimizing Platelet GPVI Inhibition versus Haemostatic Impairment by the Btk Inhibitors Ibrutinib, Acalabrutinib, ONO/GS-4059, BGB-3111 and Evobrutinib.

Denzinger V, Busygina K, Jamasbi J, Pekrul I, Spannagl M, Weber C, Lorenz R, Siess W.

Thromb Haemost. 2019 Mar;119(3):397-406. doi: 10.1055/s-0039-1677744. Epub 2019 Jan 27.

PMID:
30685871
3.

Oral Bruton tyrosine kinase inhibitors selectively block atherosclerotic plaque-triggered thrombus formation in humans.

Busygina K, Jamasbi J, Seiler T, Deckmyn H, Weber C, Brandl R, Lorenz R, Siess W.

Blood. 2018 Jun 14;131(24):2605-2616. doi: 10.1182/blood-2017-09-808808. Epub 2018 Mar 20.

PMID:
29559479
4.

Dimeric Glycoprotein VI Binds to Collagen but Not to Fibrin.

Ebrahim M, Jamasbi J, Adler K, Megens RTA, M'Bengue Y, Blanchet X, Uhland K, Ungerer M, Brandl R, Weber C, Elia N, Lorenz R, Münch G, Siess W.

Thromb Haemost. 2018 Feb;118(2):351-361. doi: 10.1160/TH17-04-0302. Epub 2018 Jan 29.

PMID:
29378359
5.

ADPase CD39 Fused to Glycoprotein VI-Fc Boosts Local Antithrombotic Effects at Vascular Lesions.

Degen H, Borst O, Ziegler M, Mojica Munoz AK, Jamasbi J, Walker B, Göbel S, Fassbender J, Adler K, Brandl R, Münch G, Lorenz R, Siess W, Gawaz M, Ungerer M.

J Am Heart Assoc. 2017 Jul 27;6(8). pii: e005991. doi: 10.1161/JAHA.117.005991.

6.

Platelet receptors as therapeutic targets: Past, present and future.

Jamasbi J, Ayabe K, Goto S, Nieswandt B, Peter K, Siess W.

Thromb Haemost. 2017 Jun 28;117(7):1249-1257. doi: 10.1160/TH16-12-0911. Epub 2017 Jun 9. Review.

PMID:
28597906
7.

Recombinant GPVI-Fc added to single or dual antiplatelet therapy in vitro prevents plaque-induced platelet thrombus formation.

Mojica Muñoz AK, Jamasbi J, Uhland K, Degen H, Münch G, Ungerer M, Brandl R, Megens R, Weber C, Lorenz R, Siess W.

Thromb Haemost. 2017 Aug 1;117(8):1651-1659. doi: 10.1160/TH16-11-0856. Epub 2017 Jun 1.

PMID:
28569920
8.

Oral thrombin inhibitor aggravates platelet adhesion and aggregation during arterial thrombosis.

Petzold T, Thienel M, Konrad I, Schubert I, Regenauer R, Hoppe B, Lorenz M, Eckart A, Chandraratne S, Lennerz C, Kolb C, Braun D, Jamasbi J, Brandl R, Braun S, Siess W, Schulz C, Massberg S.

Sci Transl Med. 2016 Nov 30;8(367):367ra168.

PMID:
27903864
9.

Cross-Linking GPVI-Fc by Anti-Fc Antibodies Potentiates Its Inhibition of Atherosclerotic Plaque- and Collagen-Induced Platelet Activation.

Jamasbi J, Megens RT, Bianchini M, Uhland K, Münch G, Ungerer M, Sherman S, Faussner A, Brandl R, John C, Buchner J, Weber C, Lorenz R, Elia N, Siess W.

JACC Basic Transl Sci. 2016 Apr 25;1(3):131-142.. eCollection 2016 Apr. Review.

10.

Cathepsin G Controls Arterial But Not Venular Myeloid Cell Recruitment.

Ortega-Gomez A, Salvermoser M, Rossaint J, Pick R, Brauner J, Lemnitzer P, Tilgner J, de Jong RJ, Megens RT, Jamasbi J, Döring Y, Pham CT, Scheiermann C, Siess W, Drechsler M, Weber C, Grommes J, Zarbock A, Walzog B, Soehnlein O.

Circulation. 2016 Oct 18;134(16):1176-1188. Epub 2016 Sep 22.

11.

Impact of immature platelets on platelet response to ticagrelor and prasugrel in patients with acute coronary syndrome.

Bernlochner I, Goedel A, Plischke C, Schüpke S, Haller B, Schulz C, Mayer K, Morath T, Braun S, Schunkert H, Siess W, Kastrati A, Laugwitz KL.

Eur Heart J. 2015 Dec 1;36(45):3202-10. doi: 10.1093/eurheartj/ehv326. Epub 2015 Jul 27.

PMID:
26216931
12.

Differential Inhibition of Human Atherosclerotic Plaque-Induced Platelet Activation by Dimeric GPVI-Fc and Anti-GPVI Antibodies: Functional and Imaging Studies.

Jamasbi J, Megens RT, Bianchini M, Münch G, Ungerer M, Faussner A, Sherman S, Walker A, Goyal P, Jung S, Brandl R, Weber C, Lorenz R, Farndale R, Elia N, Siess W.

J Am Coll Cardiol. 2015 Jun 9;65(22):2404-15. doi: 10.1016/j.jacc.2015.03.573.

13.

Inflammatory role and prognostic value of platelet chemokines in acute coronary syndrome.

Blanchet X, Cesarek K, Brandt J, Herwald H, Teupser D, Küchenhoff H, Karshovska E, Mause SF, Siess W, Wasmuth H, Soehnlein O, Koenen RR, Weber C, von Hundelshausen P.

Thromb Haemost. 2014 Dec;112(6):1277-87. doi: 10.1160/TH14-02-0139. Epub 2014 Aug 28.

PMID:
25183015
14.

Activation of platelets by the endocannabinoids 2-arachidonoylglycerol and virodhamine is mediated by their conversion to arachidonic acid and thromboxane A2, not by activation of cannabinoid receptors.

Brantl SA, Khandoga AL, Siess W.

Platelets. 2014;25(6):465-6. doi: 10.3109/09537104.2013.835040. Epub 2013 Oct 8. Review. No abstract available.

PMID:
24102401
15.

β1 integrin-mediated signals are required for platelet granule secretion and hemostasis in mouse.

Petzold T, Ruppert R, Pandey D, Barocke V, Meyer H, Lorenz M, Zhang L, Siess W, Massberg S, Moser M.

Blood. 2013 Oct 10;122(15):2723-31. doi: 10.1182/blood-2013-06-508721. Epub 2013 Sep 4.

PMID:
24004668
16.

Cofilin oligomer formation occurs in vivo and is regulated by cofilin phosphorylation.

Goyal P, Pandey D, Brünnert D, Hammer E, Zygmunt M, Siess W.

PLoS One. 2013 Aug 8;8(8):e71769. doi: 10.1371/journal.pone.0071769. eCollection 2013.

17.

Mechanism of platelet activation induced by endocannabinoids in blood and plasma.

Brantl SA, Khandoga AL, Siess W.

Platelets. 2014;25(3):151-61. doi: 10.3109/09537104.2013.803530. Epub 2013 Jun 21.

PMID:
23789792
18.

Stereo specific platelet inhibition by the natural LXR agonist 22(R)-OH-cholesterol and its fluorescence labelling with preserved bioactivity and chiral handling in macrophages.

Schaffer S, Tandon R, Zipse H, Siess W, Schmidt A, Jamasbi J, Karshovska E, Steglich W, Lorenz R.

Biochem Pharmacol. 2013 Jul 15;86(2):279-85. doi: 10.1016/j.bcp.2013.04.024. Epub 2013 May 9.

PMID:
23665353
19.

Why and how to eliminate spontaneous platelet aggregation in blood measured by multiple electrode aggregometry.

Bampalis VG, Brantl SA, Siess W.

J Thromb Haemost. 2012 Aug;10(8):1710-4. doi: 10.1111/j.1538-7836.2012.04819.x. No abstract available.

20.

Lysophosphatidic acid in atherosclerotic diseases.

Schober A, Siess W.

Br J Pharmacol. 2012 Oct;167(3):465-82. doi: 10.1111/j.1476-5381.2012.02021.x. Review.

21.

Recombinant GPI-anchored TIMP-1 stimulates growth and migration of peritoneal mesothelial cells.

Djafarzadeh R, Sauter M, Notohamiprodjo S, Noessner E, Goyal P, Siess W, Wörnle M, Ribeiro A, Himmelein S, Sitter T, Nelson PJ.

PLoS One. 2012;7(4):e33963. doi: 10.1371/journal.pone.0033963. Epub 2012 Apr 27.

22.

Effect of 5-HT2A receptor antagonists on human platelet activation in blood exposed to physiologic stimuli and atherosclerotic plaque.

Bampalis VG, Dwivedi S, Shai E, Brandl R, Varon D, Siess W.

J Thromb Haemost. 2011 Oct;9(10):2112-5. doi: 10.1111/j.1538-7836.2011.04476.x. No abstract available.

23.

The role of PGE(2) in human atherosclerotic plaque on platelet EP(3) and EP(4) receptor activation and platelet function in whole blood.

Schober LJ, Khandoga AL, Dwivedi S, Penz SM, Maruyama T, Brandl R, Siess W.

J Thromb Thrombolysis. 2011 Aug;32(2):158-66. doi: 10.1007/s11239-011-0577-6.

PMID:
21424266
24.

STK35L1 associates with nuclear actin and regulates cell cycle and migration of endothelial cells.

Goyal P, Behring A, Kumar A, Siess W.

PLoS One. 2011 Jan 20;6(1):e16249. doi: 10.1371/journal.pone.0016249.

25.

Rac1-mediated signaling plays a central role in secretion-dependent platelet aggregation in human blood stimulated by atherosclerotic plaque.

Dwivedi S, Pandey D, Khandoga AL, Brandl R, Siess W.

J Transl Med. 2010 Dec 6;8:128. doi: 10.1186/1479-5876-8-128.

26.

GPR92/LPA₅ lysophosphatidate receptor mediates megakaryocytic cell shape change induced by human atherosclerotic plaques.

Khandoga AL, Pandey D, Welsch U, Brandl R, Siess W.

Cardiovasc Res. 2011 Apr 1;90(1):157-64. doi: 10.1093/cvr/cvq369. Epub 2010 Nov 23.

27.

Fluoxetine inhibition of 5-HT-potentiated platelet aggregation in whole blood.

Bampalis VG, Khandoga AL, Siess W.

Thromb Haemost. 2010 Dec;104(6):1272-4. doi: 10.1160/TH10-05-0313. Epub 2010 Aug 30. No abstract available.

PMID:
20806122
28.

Selective and rapid monitoring of dual platelet inhibition by aspirin and P2Y12 antagonists by using multiple electrode aggregometry.

Penz SM, Bernlochner I, Tóth O, Lorenz R, Calatzis A, Siess W.

Thromb J. 2010 May 13;8:9. doi: 10.1186/1477-9560-8-9.

29.

The EP3-agonist sulprostone, but not prostaglandin E2 potentiates platelet aggregation in human blood.

Schober LJ, Khandoga AL, Penz SM, Siess W.

Thromb Haemost. 2010 Jun;103(6):1268-9. doi: 10.1160/TH09-12-0815. Epub 2010 Apr 29. No abstract available.

PMID:
20431854
30.

A 2-step mechanism of arterial thrombus formation induced by human atherosclerotic plaques.

Reininger AJ, Bernlochner I, Penz SM, Ravanat C, Smethurst P, Farndale RW, Gachet C, Brandl R, Siess W.

J Am Coll Cardiol. 2010 Mar 16;55(11):1147-58. doi: 10.1016/j.jacc.2009.11.051.

31.

Identifying and characterizing a novel protein kinase STK35L1 and deciphering its orthologs and close-homologs in vertebrates.

Goyal P, Behring A, Kumar A, Siess W.

PLoS One. 2009 Sep 16;4(9):e6981. doi: 10.1371/journal.pone.0006981.

32.

Unraveling a novel Rac1-mediated signaling pathway that regulates cofilin dephosphorylation and secretion in thrombin-stimulated platelets.

Pandey D, Goyal P, Dwivedi S, Siess W.

Blood. 2009 Jul 9;114(2):415-24. doi: 10.1182/blood-2008-10-183582. Epub 2009 May 8.

PMID:
19429871
33.

Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activation.

Williams JR, Khandoga AL, Goyal P, Fells JI, Perygin DH, Siess W, Parrill AL, Tigyi G, Fujiwara Y.

J Biol Chem. 2009 Jun 19;284(25):17304-19. doi: 10.1074/jbc.M109.003194. Epub 2009 Apr 14.

34.

Lysophosphatidic acid-induced platelet shape change revealed through LPA(1-5) receptor-selective probes and albumin.

Khandoga AL, Fujiwara Y, Goyal P, Pandey D, Tsukahara R, Bolen A, Guo H, Wilke N, Liu J, Valentine WJ, Durgam GG, Miller DD, Jiang G, Prestwich GD, Tigyi G, Siess W.

Platelets. 2008 Sep;19(6):415-27. doi: 10.1080/09537100802220468.

35.

Platelet GPVI binds to collagenous structures in the core region of human atheromatous plaque and is critical for atheroprogression in vivo.

Schulz C, Penz S, Hoffmann C, Langer H, Gillitzer A, Schneider S, Brandl R, Seidl S, Massberg S, Pichler B, Kremmer E, Stellos K, Schönberger T, Siess W, Gawaz M.

Basic Res Cardiol. 2008 Jul;103(4):356-67. doi: 10.1007/s00395-008-0722-3. Epub 2008 Apr 22.

PMID:
18431526
36.

FTY720 inhibits S1P-mediated endothelial healing: relationship to S1P1-receptor surface expression.

Krump-Konvalinkova V, Chwalla I, Siess W.

Biochem Biophys Res Commun. 2008 Jun 13;370(4):603-8. doi: 10.1016/j.bbrc.2008.03.144. Epub 2008 Apr 8.

PMID:
18402775
37.

D-Glucose-recognition and phlorizin-binding sites in human sodium/D-glucose cotransporter 1 (hSGLT1): a tryptophan scanning study.

Tyagi NK, Kumar A, Goyal P, Pandey D, Siess W, Kinne RK.

Biochemistry. 2007 Nov 27;46(47):13616-28. Epub 2007 Nov 6.

PMID:
17983207
38.
39.
40.

Sodium-independent low-affinity D-glucose transport by human sodium/D-glucose cotransporter 1: critical role of tryptophan 561.

Kumar A, Tyagi NK, Goyal P, Pandey D, Siess W, Kinne RK.

Biochemistry. 2007 Mar 13;46(10):2758-66. Epub 2007 Feb 9.

PMID:
17288452
41.

Multiple electrode aggregometry: a new device to measure platelet aggregation in whole blood.

Tóth O, Calatzis A, Penz S, Losonczy H, Siess W.

Thromb Haemost. 2006 Dec;96(6):781-8.

PMID:
17139373
42.

Platelet interaction with bioactive lipids formed by mild oxidation of low-density lipoprotein.

Siess W.

Pathophysiol Haemost Thromb. 2006;35(3-4):292-304. Review.

PMID:
16877878
43.
45.

Regulation of LIM-kinase 1 and cofilin in thrombin-stimulated platelets.

Pandey D, Goyal P, Bamburg JR, Siess W.

Blood. 2006 Jan 15;107(2):575-83. Epub 2005 Oct 11.

46.

Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin.

Durgam GG, Virag T, Walker MD, Tsukahara R, Yasuda S, Liliom K, van Meeteren LA, Moolenaar WH, Wilke N, Siess W, Tigyi G, Miller DD.

J Med Chem. 2005 Jul 28;48(15):4919-30.

PMID:
16033271
47.

Human atheromatous plaques stimulate thrombus formation by activating platelet glycoprotein VI.

Penz S, Reininger AJ, Brandl R, Goyal P, Rabie T, Bernlochner I, Rother E, Goetz C, Engelmann B, Smethurst PA, Ouwehand WH, Farndale R, Nieswandt B, Siess W.

FASEB J. 2005 Jun;19(8):898-909.

PMID:
15923400
48.

Inhibition of nuclear import of LIMK2 in endothelial cells by protein kinase C-dependent phosphorylation at Ser-283.

Goyal P, Pandey D, Behring A, Siess W.

J Biol Chem. 2005 Jul 29;280(30):27569-77. Epub 2005 May 27.

49.

Structural identification of oxidized acyl-phosphatidylcholines that induce platelet activation.

Göpfert MS, Siedler F, Siess W, Sellmayer A.

J Vasc Res. 2005 Mar-Apr;42(2):120-32. Epub 2005 Jan 20.

PMID:
15665547
50.

Stable knock-down of the sphingosine 1-phosphate receptor S1P1 influences multiple functions of human endothelial cells.

Krump-Konvalinkova V, Yasuda S, Rubic T, Makarova N, Mages J, Erl W, Vosseler C, Kirkpatrick CJ, Tigyi G, Siess W.

Arterioscler Thromb Vasc Biol. 2005 Mar;25(3):546-52. Epub 2004 Dec 23.

PMID:
15618544

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