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Items: 9


The Multifaceted Antibacterial Mechanisms of the Pioneering Peptide Antibiotics Tyrocidine and Gramicidin S.

Wenzel M, Rautenbach M, Vosloo JA, Siersma T, Aisenbrey CHM, Zaitseva E, Laubscher WE, van Rensburg W, Behrends JC, Bechinger B, Hamoen LW.

mBio. 2018 Oct 9;9(5). pii: e00802-18. doi: 10.1128/mBio.00802-18.


Daptomycin inhibits cell envelope synthesis by interfering with fluid membrane microdomains.

Müller A, Wenzel M, Strahl H, Grein F, Saaki TNV, Kohl B, Siersma T, Bandow JE, Sahl HG, Schneider T, Hamoen LW.

Proc Natl Acad Sci U S A. 2016 Nov 8;113(45):E7077-E7086. doi: 10.1073/pnas.1611173113. Epub 2016 Oct 24.


Isosteric substitution in cationic-amphiphilic polymers reveals an important role for hydrogen bonding in bacterial membrane interactions.

Uppu DSSM, Konai MM, Baul U, Singh P, Siersma TK, Samaddar S, Vemparala S, Hamoen LW, Narayana C, Haldar J.

Chem Sci. 2016 Jul 1;7(7):4613-4623. doi: 10.1039/c6sc00615a. Epub 2016 Apr 7.


The conserved DNA-binding protein WhiA is involved in cell division in Bacillus subtilis.

Surdova K, Gamba P, Claessen D, Siersma T, Jonker MJ, Errington J, Hamoen LW.

J Bacteriol. 2013 Dec;195(24):5450-60. doi: 10.1128/JB.00507-13. Epub 2013 Oct 4.


The use of a stringent selection system allows the identification of DNA elements that augment gene expression.

Hoeksema F, van Blokland R, Siep M, Hamer K, Siersma T, den Blaauwen J, Verhees J, Otte AP.

Mol Biotechnol. 2011 May;48(1):19-29. doi: 10.1007/s12033-010-9344-8.


Various expression-augmenting DNA elements benefit from STAR-Select, a novel high stringency selection system for protein expression.

Otte AP, Kwaks TH, van Blokland RJ, Sewalt RG, Verhees J, Klaren VN, Siersma TK, Korse HW, Teunissen NC, Botschuijver S, van Mer C, Man SY.

Biotechnol Prog. 2007 Jul-Aug;23(4):801-7. Epub 2007 Jun 22.


A novel, high stringency selection system allows screening of few clones for high protein expression.

van Blokland HJ, Kwaks TH, Sewalt RG, Verhees JA, Klaren VN, Siersma TK, Korse JW, Teunissen NC, Botschuijver S, van Mer C, Man SY, Otte AP.

J Biotechnol. 2007 Feb 1;128(2):237-45. Epub 2006 Oct 10.


Targeting of a histone acetyltransferase domain to a promoter enhances protein expression levels in mammalian cells.

Kwaks TH, Sewalt RG, van Blokland R, Siersma TJ, Kasiem M, Kelder A, Otte AP.

J Biotechnol. 2005 Jan 12;115(1):35-46.


Identification of anti-repressor elements that confer high and stable protein production in mammalian cells.

Kwaks TH, Barnett P, Hemrika W, Siersma T, Sewalt RG, Satijn DP, Brons JF, van Blokland R, Kwakman P, Kruckeberg AL, Kelder A, Otte AP.

Nat Biotechnol. 2003 May;21(5):553-8. Epub 2003 Apr 7. Erratum in: Nat Biotechnol. 2003 Jul;21(7):822.


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