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Epistatic Interactions in NS5A of Hepatitis C Virus Suggest Drug Resistance Mechanisms.

Knops E, Sierra S, Kalaghatgi P, Heger E, Kaiser R, Kalinina OV.

Genes (Basel). 2018 Jul 6;9(7). pii: E343. doi: 10.3390/genes9070343.


Biological evaluation of water soluble arene Ru(II) enantiomers with amino-oxime ligands.

de la Cueva-Alique I, Sierra S, Muñoz-Moreno L, Pérez-Redondo A, Bajo AM, Marzo I, Gude L, Cuenca T, Royo E.

J Inorg Biochem. 2018 Jun;183:32-42. doi: 10.1016/j.jinorgbio.2018.02.018. Epub 2018 Mar 6.


The endocannabinoid system in cardiovascular function: novel insights and clinical implications.

Sierra S, Luquin N, Navarro-Otano J.

Clin Auton Res. 2018 Feb;28(1):35-52. doi: 10.1007/s10286-017-0488-5. Epub 2017 Dec 8. Review.


Accurate hepatitis C virus genotyping and selection of optimal therapy: lessons from a St Petersburg strain infection.

Knops E, Heger E, Koenig C, Moebius U, Lübke N, Kaiser R, Di Cristanziano V, Hüsgen L, Kocyigit C, Rupp J, Sierra S.

Clin Microbiol Infect. 2018 Apr;24(4):440-441. doi: 10.1016/j.cmi.2017.10.025. Epub 2017 Dec 16. No abstract available.


Dynamics of Torque Teno virus viremia could predict risk of complications after allogeneic hematopoietic stem cell transplantation.

Gilles R, Herling M, Holtick U, Heger E, Awerkiew S, Fish I, Höller K, Sierra S, Knops E, Kaiser R, Scheid C, Di Cristanziano V.

Med Microbiol Immunol. 2017 Oct;206(5):355-362. doi: 10.1007/s00430-017-0511-4. Epub 2017 Jul 12.


Results of the first international HIV-1 coreceptor proficiency panel test.

Heger E, Kaiser R, Knops E, Neumann-Fraune M, Schuelter E, Pironti A, Lengauer T, Walter H, Sierra S.

J Clin Virol. 2017 Aug;93:53-56. doi: 10.1016/j.jcv.2017.06.002. Epub 2017 Jun 10.


HCV genotype-1 subtypes and resistance-associated substitutions in drug-naive and in direct-acting antiviral treatment failure patients.

Gozlan Y, Ben-Ari Z, Moscona R, Shirazi R, Rakovsky A, Kabat A, Veizman E, Berdichevski T, Weiss P, Cohen-Ezra O, Lurie Y, Gafanovich I, Braun M, Cohen-Naftaly M, Shlomai A, Shibolet O, Zigmond E, Zuckerman E, Carmiel-Haggai M, Nimer A, Hazzan R, Maor Y, Kitay-Cohen Y, Shemer-Avni Y, Kra-Oz Z, Schreiber L, Peleg O, Sierra S, Harrigan PR, Mendelson E, Mor O.

Antivir Ther. 2017;22(5):431-441. doi: 10.3851/IMP3123. Epub 2017 Jan 9.


Detection of Receptor Heteromerization Using In Situ Proximity Ligation Assay.

Gomes I, Sierra S, Devi LA.

Curr Protoc Pharmacol. 2016 Dec 13;75:2.16.1-2.16.31. doi: 10.1002/cpph.15.


The flora phenotype ontology (FLOPO): tool for integrating morphological traits and phenotypes of vascular plants.

Hoehndorf R, Alshahrani M, Gkoutos GV, Gosline G, Groom Q, Hamann T, Kattge J, de Oliveira SM, Schmidt M, Sierra S, Smets E, Vos RA, Weiland C.

J Biomed Semantics. 2016 Nov 14;7(1):65.


HCV Resistance Profile Evolution in a GT1b, DAA-Naive Patient Before, On, and After Failing Triple DAA Therapy.

Knops E, Schübel N, Heger E, Neumann-Fraune M, Kaiser R, Inden S, Kalaghatgi P, Sierra S.

Clin Gastroenterol Hepatol. 2017 Feb;15(2):307-309. doi: 10.1016/j.cgh.2016.09.139. Epub 2016 Sep 23. No abstract available.


Is biological aging accelerated in drug addiction?

Bachi K, Sierra S, Volkow ND, Goldstein RZ, Alia-Klein N.

Curr Opin Behav Sci. 2017 Feb;13:34-39.


New findings in HCV genotype distribution in selected West European, Russian and Israeli regions.

Kartashev V, Döring M, Nieto L, Coletta E, Kaiser R, Sierra S; HCV EuResist Study group.

J Clin Virol. 2016 Aug;81:82-9. doi: 10.1016/j.jcv.2016.05.010. Epub 2016 May 24.


Geno2pheno[HCV] - A Web-based Interpretation System to Support Hepatitis C Treatment Decisions in the Era of Direct-Acting Antiviral Agents.

Kalaghatgi P, Sikorski AM, Knops E, Rupp D, Sierra S, Heger E, Neumann-Fraune M, Beggel B, Walker A, Timm J, Walter H, Obermeier M, Kaiser R, Bartenschlager R, Lengauer T.

PLoS One. 2016 May 19;11(5):e0155869. doi: 10.1371/journal.pone.0155869. eCollection 2016.


Genotypic Prediction of Co-receptor Tropism of HIV-1 Subtypes A and C.

Riemenschneider M, Cashin KY, Budeus B, Sierra S, Shirvani-Dastgerdi E, Bayanolhagh S, Kaiser R, Gorry PR, Heider D.

Sci Rep. 2016 Apr 29;6:24883. doi: 10.1038/srep24883.


Identification of GPR83 as the receptor for the neuroendocrine peptide PEN.

Gomes I, Bobeck EN, Margolis EB, Gupta A, Sierra S, Fakira AK, Fujita W, Müller TD, Müller A, Tschöp MH, Kleinau G, Fricker LD, Devi LA.

Sci Signal. 2016 Apr 26;9(425):ra43. doi: 10.1126/scisignal.aad0694.


Cryptic diversity revealed by DNA barcoding in Colombian illegally traded bird species.

Mendoza ÁM, Torres MF, Paz A, Trujillo-Arias N, López-Alvarez D, Sierra S, Forero F, Gonzalez MA.

Mol Ecol Resour. 2016 Jul;16(4):862-73. doi: 10.1111/1755-0998.12515. Epub 2016 Mar 21.


Choosing between intraoral or extraoral, red or infrared laser irradiation after impacted third molar extraction.

Sierra SO, Deana AM, Bussadori SK, da Mota AC, Ferrari RA, do Vale KL, Fernandes KP.

Lasers Surg Med. 2016 Jul;48(5):511-8. doi: 10.1002/lsm.22488. Epub 2016 Feb 11.


ESTES guidelines: acute mesenteric ischaemia.

Tilsed JV, Casamassima A, Kurihara H, Mariani D, Martinez I, Pereira J, Ponchietti L, Shamiyeh A, Al-Ayoubi F, Barco LA, Ceolin M, D'Almeida AJ, Hilario S, Olavarria AL, Ozmen MM, Pinheiro LF, Poeze M, Triantos G, Fuentes FT, Sierra SU, Soreide K, Yanar H.

Eur J Trauma Emerg Surg. 2016 Apr;42(2):253-70. doi: 10.1007/s00068-016-0634-0.


Human telomeric G-quadruplex DNA interactions of N-phenanthroline glycosylamine copper(II) complexes.

Duskova K, Sierra S, Arias-Pérez MS, Gude L.

Bioorg Med Chem. 2016 Jan 1;24(1):33-41. doi: 10.1016/j.bmc.2015.11.037. Epub 2015 Nov 27.


Pregnancy outcomes in women with polycystic ovary syndrome undergoing in vitro fertilization.

Sterling L, Liu J, Okun N, Sakhuja A, Sierra S, Greenblatt E.

Fertil Steril. 2016 Mar;105(3):791-797.e2. doi: 10.1016/j.fertnstert.2015.11.019. Epub 2015 Dec 2.


Effect of low-intensity laser treatment on pain after extraction of impacted mandibular third molars: a randomised, controlled, clinical trial.

Sierra SO, Deana AM, Bussadori SK, da Mota AC, Motta LJ, Ferrari RA, Schalch TD, Fernandes KP.

Br J Oral Maxillofac Surg. 2015 Dec;53(10):996-1000. doi: 10.1016/j.bjoms.2015.09.006. Epub 2015 Sep 28.


Lethal leukoencephalopathy secondary to Tegafur, a 5-fluorouracil prodrug.

Sierra S, Luquin N, Carrato C.

J Neurol Sci. 2015 Oct 15;357(1-2):326-8. doi: 10.1016/j.jns.2015.07.040. Epub 2015 Jul 29. No abstract available.


Two Distinct Hepatitis C Virus Genotype 1a Clades Have Different Geographical Distribution and Association With Natural Resistance to NS3 Protease Inhibitors.

De Luca A, Di Giambenedetto S, Lo Presti A, Sierra S, Prosperi M, Cella E, Giovanetti M, Torti C, Caudai C, Vicenti I, Saladini F, Almi P, Grima P, Blanc P, Fabbiani M, Rossetti B, Gagliardini R, Kaiser R, Ciccozzi M, Zazzi M.

Open Forum Infect Dis. 2015 Mar 31;2(2):ofv043. doi: 10.1093/ofid/ofv043. eCollection 2015 Apr.


Proviral DNA as a Target for HIV-1 Resistance Analysis.

Lübke N, Di Cristanziano V, Sierra S, Knops E, Schülter E, Jensen B, Oette M, Lengauer T, Kaiser R.

Intervirology. 2015;58(3):184-9. doi: 10.1159/000431093. Epub 2015 Jun 27.


Integrating and visualizing primary data from prospective and legacy taxonomic literature.

Miller JA, Agosti D, Penev L, Sautter G, Georgiev T, Catapano T, Patterson D, King D, Pereira S, Vos RA, Sierra S.

Biodivers Data J. 2015 May 12;(3):e5063. doi: 10.3897/BDJ.3.e5063. eCollection 2015.


Are we doing well or oversizing follow-up in ovarian cancer? Searching for tailoring.

Sierra SM, De Santiago García FJ.

Int J Gynecol Cancer. 2015 Jun;25(5):760. doi: 10.1097/IGC.0000000000000457. No abstract available.


Parameters Influencing Baseline HIV-1 Genotypic Tropism Testing Related to Clinical Outcome in Patients on Maraviroc.

Sierra S, Dybowski JN, Pironti A, Heider D, Güney L, Thielen A, Reuter S, Esser S, Fätkenheuer G, Lengauer T, Hoffmann D, Pfister H, Jensen B, Kaiser R.

PLoS One. 2015 May 13;10(5):e0125502. doi: 10.1371/journal.pone.0125502. eCollection 2015.


Head-to-Head Comparison of the Neuropsychiatric Effect of Dopamine Agonists in Parkinson's Disease: A Prospective, Cross-Sectional Study in Non-demented Patients.

Pérez-Pérez J, Pagonabarraga J, Martínez-Horta S, Fernández-Bobadilla R, Sierra S, Pascual-Sedano B, Gironell A, Kulisevsky J.

Drugs Aging. 2015 May;32(5):401-7. doi: 10.1007/s40266-015-0264-y.


Effects of sequence alterations on results from genotypic tropism testing.

Pironti A, Sierra S, Kaiser R, Lengauer T, Pfeifer N.

J Clin Virol. 2015 Apr;65:68-73. doi: 10.1016/j.jcv.2015.02.006. Epub 2015 Feb 10.


Calbindin content and differential vulnerability of midbrain efferent dopaminergic neurons in macaques.

Dopeso-Reyes IG, Rico AJ, Roda E, Sierra S, Pignataro D, Lanz M, Sucunza D, Chang-Azancot L, Lanciego JL.

Front Neuroanat. 2014 Dec 3;8:146. doi: 10.3389/fnana.2014.00146. eCollection 2014.


Enriched biodiversity data as a resource and service.

Vos RA, Biserkov JV, Balech B, Beard N, Blissett M, Brenninkmeijer C, van Dooren T, Eades D, Gosline G, Groom QJ, Hamann TD, Hettling H, Hoehndorf R, Holleman A, Hovenkamp P, Kelbert P, King D, Kirkup D, Lammers Y, DeMeulemeester T, Mietchen D, Miller JA, Mounce R, Nicolson N, Page R, Pawlik A, Pereira S, Penev L, Richards K, Sautter G, Shorthouse DP, Tähtinen M, Weiland C, Williams AR, Sierra S.

Biodivers Data J. 2014 Jun 16;(2):e1125. doi: 10.3897/BDJ.2.e1125. eCollection 2014.


Detection of cannabinoid receptors CB1 and CB2 within basal ganglia output neurons in macaques: changes following experimental parkinsonism.

Sierra S, Luquin N, Rico AJ, Gómez-Bautista V, Roda E, Dopeso-Reyes IG, Vázquez A, Martínez-Pinilla E, Labandeira-García JL, Franco R, Lanciego JL.

Brain Struct Funct. 2015 Sep;220(5):2721-38. doi: 10.1007/s00429-014-0823-8. Epub 2014 Jun 28.


CB1 and GPR55 receptors are co-expressed and form heteromers in rat and monkey striatum.

Martínez-Pinilla E, Reyes-Resina I, Oñatibia-Astibia A, Zamarbide M, Ricobaraza A, Navarro G, Moreno E, Dopeso-Reyes IG, Sierra S, Rico AJ, Roda E, Lanciego JL, Franco R.

Exp Neurol. 2014 Nov;261:44-52. doi: 10.1016/j.expneurol.2014.06.017. Epub 2014 Jun 23.


Choroid plexitis as a unique neurological manifestation in granulomatosis with polyangiitis (Wegener's disease).

Sierra S, Luquin N, Tardáguila M, Olivé A.

J Rheumatol. 2014 Jun;41(6):1192-3. doi: 10.3899/jrheum.131302. No abstract available.


Pregnancy outcomes after assisted human reproduction.


J Obstet Gynaecol Can. 2014 Jan;36(1):64-83. doi: 10.1016/S1701-2163(15)30685-X.


L-DOPA-treatment in primates disrupts the expression of A(2A) adenosine-CB(1) cannabinoid-D(2) dopamine receptor heteromers in the caudate nucleus.

Bonaventura J, Rico AJ, Moreno E, Sierra S, Sánchez M, Luquin N, Farré D, Müller CE, Martínez-Pinilla E, Cortés A, Mallol J, Armentero MT, Pinna A, Canela EI, Lluís C, McCormick PJ, Lanciego JL, Casadó V, Franco R.

Neuropharmacology. 2014 Apr;79:90-100. doi: 10.1016/j.neuropharm.2013.10.036. Epub 2013 Nov 11.


Expression, functionality, and localization of apurinic/apyrimidinic endonucleases in replicative and non-replicative forms of Trypanosoma cruzi.

Sepúlveda S, Valenzuela L, Ponce I, Sierra S, Bahamondes P, Ramirez S, Rojas V, Kemmerling U, Galanti N, Cabrera G.

J Cell Biochem. 2014 Feb;115(2):397-409. doi: 10.1002/jcb.24675.


A decadal view of biodiversity informatics: challenges and priorities.

Hardisty A, Roberts D; Biodiversity Informatics Community, Addink W, Aelterman B, Agosti D, Amaral-Zettler L, Ariño AH, Arvanitidis C, Backeljau T, Bailly N, Belbin L, Berendsohn W, Bertrand N, Caithness N, Campbell D, Cochrane G, Conruyt N, Culham A, Damgaard C, Davies N, Fady B, Faulwetter S, Feest A, Field D, Garnier E, Geser G, Gilbert J, Grosche, Grosser D, Hardisty A, Herbinet B, Hobern D, Jones A, de Jong Y, King D, Knapp S, Koivula H, Los W, Meyer C, Morris RA, Morrison N, Morse D, Obst M, Pafilis E, Page LM, Page R, Pape T, Parr C, Paton A, Patterson D, Paymal E, Penev L, Pollet M, Pyle R, von Raab-Straube E, Robert V, Roberts D, Robertson T, Rovellotti O, Saarenmaa H, Schalk P, Schaminee J, Schofield P, Sier A, Sierra S, Smith V, van Spronsen E, Thornton-Wood S, van Tienderen P, van Tol J, Tuama ÉÓ, Uetz P, Vaas L, Vignes Lebbe R, Vision T, Vu D, De Wever A, White R, Willis K, Young F.

BMC Ecol. 2013 Apr 15;13:16. doi: 10.1186/1472-6785-13-16. Review.


Analysis of physicochemical and structural properties determining HIV-1 coreceptor usage.

Bozek K, Lengauer T, Sierra S, Kaiser R, Domingues FS.

PLoS Comput Biol. 2013;9(3):e1002977. doi: 10.1371/journal.pcbi.1002977. Epub 2013 Mar 21.


Synthesis and DNA interaction of ethylenediamine platinum(II) complexes linked to DNA intercalants.

Duskova K, Sierra S, Fernández MJ, Gude L, Lorente A.

Bioorg Med Chem. 2012 Dec 15;20(24):7112-8. doi: 10.1016/j.bmc.2012.09.055. Epub 2012 Oct 17.


An expanded model of HIV cell entry phenotype based on multi-parameter single-cell data.

Bozek K, Eckhardt M, Sierra S, Anders M, Kaiser R, Kräusslich HG, Müller B, Lengauer T.

Retrovirology. 2012 Jul 25;9:60. doi: 10.1186/1742-4690-9-60.


Unmasking adenosine 2A receptors (A2ARs) in monkey basal ganglia output neurons using cholera toxin subunit B (CTB).

Luquin N, Sierra S, Rico AJ, Gómez-Bautista V, Roda E, Conte-Perales L, Franco R, McCormick P, Labandeira-García JL, Lanciego JL.

Neurobiol Dis. 2012 Sep;47(3):347-57. doi: 10.1016/j.nbd.2012.05.006. Epub 2012 May 31.


Administration of docosahexaenoic acid before birth and until aging decreases kainate-induced seizures in adult zebrafish.

Sierra S, Alfaro JM, Sánchez S, Burgos JS.

Brain Res Bull. 2012 Aug 1;88(5):467-70. doi: 10.1016/j.brainresbull.2012.04.007. Epub 2012 Apr 21.


Advanced reproductive age and fertility: no. 269, November 2011.

Kimberly L, Case A, Cheung AP, Sierra S, AlAsiri S, Carranza-Mamane B, Case A, Dwyer C, Graham J, Havelock J, Hemmings R, Lee F, Liu K, Murdock W, Senikas V, Vause TD, Wong BC.

Int J Gynaecol Obstet. 2012 Apr;117(1):95-102.


Prediction of HIV-1 coreceptor usage (tropism) by sequence analysis using a genotypic approach.

Sierra S, Kaiser R, Lübke N, Thielen A, Schuelter E, Heger E, Däumer M, Reuter S, Esser S, Fätkenheuer G, Pfister H, Oette M, Lengauer T.

J Vis Exp. 2011 Dec 1;(58). pii: 3264. doi: 10.3791/3264.


Simvastatin modulates the Alzheimer's disease-related gene seladin-1.

Ramos MC, Sierra S, Ramirez C, Velasco J, Burgos JS.

J Alzheimers Dis. 2012;28(2):297-301. doi: 10.3233/JAD-2011-111118.


ApoB100/LDLR-/- hypercholesterolaemic mice as a model for mild cognitive impairment and neuronal damage.

Ramírez C, Sierra S, Tercero I, Vázquez JA, Pineda A, Manrique T, Burgos JS.

PLoS One. 2011;6(7):e22712. doi: 10.1371/journal.pone.0022712. Epub 2011 Jul 26.


Pallidothalamic-projecting neurons in Macaca fascicularis co-express GABAergic and glutamatergic markers as seen in control, MPTP-treated and dyskinetic monkeys.

Conte-Perales L, Rico AJ, Barroso-Chinea P, Gómez-Bautista V, Roda E, Luquin N, Sierra S, Lanciego JL.

Brain Struct Funct. 2011 Nov;216(4):371-86. doi: 10.1007/s00429-011-0319-8. Epub 2011 Apr 22.


Glutamatergic and cholinergic pedunculopontine neurons innervate the thalamic parafascicular nucleus in rats: changes following experimental parkinsonism.

Barroso-Chinea P, Rico AJ, Conte-Perales L, Gómez-Bautista V, Luquin N, Sierra S, Roda E, Lanciego JL.

Brain Struct Funct. 2011 Nov;216(4):319-30. doi: 10.1007/s00429-011-0317-x. Epub 2011 Apr 16.

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