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Items: 1 to 50 of 66

1.

Phytochemicals Rosmarinic Acid, Ampelopsin, and Amorfrutin-A Can Modulate Age-Related Phenotype of Serially Passaged Human Skin Fibroblasts in vitro.

Sodagam L, Lewinska A, Kwasniewicz E, Kokhanovska S, Wnuk M, Siems K, Rattan SIS.

Front Genet. 2019 Feb 21;10:81. doi: 10.3389/fgene.2019.00081. eCollection 2019.

2.

Tonantzitlolone is a nanomolar potency activator of transient receptor potential canonical 1/4/5 channels.

Rubaiy HN, Ludlow MJ, Siems K, Norman K, Foster R, Wolf D, Beutler JA, Beech DJ.

Br J Pharmacol. 2018 Aug;175(16):3361-3368. doi: 10.1111/bph.14379. Epub 2018 Jun 28.

3.

Human cell-based taste perception - a bittersweet job for industry.

Riedel K, Sombroek D, Fiedler B, Siems K, Krohn M.

Nat Prod Rep. 2017 May 10;34(5):484-495. doi: 10.1039/c6np00123h. Review.

PMID:
28393162
4.

Effects of extracts and compounds from Tricholoma populinum Lange on degranulation and IL-2/IL-8 secretion of immune cells.

Merdivan S, Jenett-Siems K, Siems K, Niedermeyer THJ, Schultze N, Steinborn C, Gründemann C, Lindequist U.

Z Naturforsch C. 2017 Jul 14;72(7-8):277-283. doi: 10.1515/znc-2016-0247.

PMID:
28315853
5.

Flavonol Glycosides and Cytotoxic Steroidal Saponins from Furcraea tuberosa (Agavaceae).

Tapondjou LA, Jenett-Siems K, Siems K, Weng A, Melzig MF.

Nat Prod Commun. 2017 Mar;12(3):347-350.

PMID:
30549882
6.

Sesquiterpene Lactone Composition and Cellular Nrf2 Induction of Taraxacum officinale Leaves and Roots and Taraxinic Acid β-d-Glucopyranosyl Ester.

Esatbeyoglu T, Obermair B, Dorn T, Siems K, Rimbach G, Birringer M.

J Med Food. 2017 Jan;20(1):71-78. doi: 10.1089/jmf.2016.0105. Epub 2016 Dec 27.

PMID:
28026992
7.

Long-Lasting WNT-TCF Response Blocking and Epigenetic Modifying Activities of Withanolide F in Human Cancer Cells.

Seth C, Mas C, Conod A, Mueller J, Siems K, Kuciak M, Borges I, Ruiz I Altaba A.

PLoS One. 2016 Dec 14;11(12):e0168170. doi: 10.1371/journal.pone.0168170. eCollection 2016.

8.

Synthesis and antiproliferative activity of new tonantzitlolone-derived diterpene derivatives.

Busch T, Dräger G, Kunst E, Benson H, Sasse F, Siems K, Kirschning A.

Org Biomol Chem. 2016 Oct 14;14(38):9040-5. doi: 10.1039/c6ob01697a. Epub 2016 Sep 7.

PMID:
27604289
9.

Ageing with elegans: a research proposal to map healthspan pathways.

Luyten W, Antal P, Braeckman BP, Bundy J, Cirulli F, Fang-Yen C, Fuellen G, Leroi A, Liu Q, Martorell P, Metspalu A, Perola M, Ristow M, Saul N, Schoofs L, Siems K, Temmerman L, Smets T, Wolk A, Rattan SI.

Biogerontology. 2016 Aug;17(4):771-82. doi: 10.1007/s10522-016-9644-x. Epub 2016 Apr 4.

PMID:
27040825
10.

Steroidal Saponins from the Mesocarp of the Fruits of Raphia farinifera (Arecaceae) and their Cytotoxic Activity.

Tapondjou LA, Siems KJ, Böttger S, Melzig MF.

Nat Prod Commun. 2015 Nov;10(11):1941-4.

PMID:
26749832
11.

Amorfrutin C Induces Apoptosis and Inhibits Proliferation in Colon Cancer Cells through Targeting Mitochondria.

Weidner C, Rousseau M, Micikas RJ, Fischer C, Plauth A, Wowro SJ, Siems K, Hetterling G, Kliem M, Schroeder FC, Sauer S.

J Nat Prod. 2016 Jan 22;79(1):2-12. doi: 10.1021/acs.jnatprod.5b00072. Epub 2016 Jan 5.

PMID:
26731300
12.

Tonantzitlolone cytotoxicity toward renal cancer cells is PKCθ- and HSF1-dependent.

Sourbier C, Scroggins BT, Mannes PZ, Liao PJ, Siems K, Wolf D, Beutler JA, Linehan WM, Neckers L.

Oncotarget. 2015 Oct 6;6(30):29963-74. doi: 10.18632/oncotarget.4676.

13.

Cytotoxic saponins from the seeds of Pittosporum angustifolium.

Bäcker C, Jenett-Siems K, Siems K, Wurster M, Bodtke A, Lindequist U.

Z Naturforsch C. 2014 May-Jun;69(5-6):191-8.

PMID:
25069157
14.

Protein kinase and HDAC inhibitors from the endophytic fungus Epicoccum nigrum.

El Amrani M, Lai D, Debbab A, Aly AH, Siems K, Seidel C, Schnekenburger M, Gaigneaux A, Diederich M, Feger D, Lin W, Proksch P.

J Nat Prod. 2014 Jan 24;77(1):49-56. doi: 10.1021/np4005745. Epub 2013 Dec 16.

PMID:
24328302
15.

Triterpene glycosides from the leaves of Pittosporum angustifolium.

Bäcker C, Jenett-Siems K, Siems K, Wurster M, Bodtke A, Chamseddin C, Crüsemann M, Lindequist U.

Planta Med. 2013 Oct;79(15):1461-9. doi: 10.1055/s-0033-1350806. Epub 2013 Sep 17.

PMID:
24046217
16.

Structure-activity relationships of saponins enhancing the cytotoxicity of ribosome-inactivating proteins type I (RIP-I).

Böttger S, Westhof E, Siems K, Melzig MF.

Toxicon. 2013 Oct;73:144-50. doi: 10.1016/j.toxicon.2013.07.011. Epub 2013 Jul 25.

PMID:
23891686
17.

Ipvelutine, 7β-Acetoxy-2α-(tigloyloxy)tropane, an Unusual Tropane Alkaloid from Ipomoea velutina R. Br. (Convolvulaceae).

Ott SC, Jenett-Siems K, Siems K, Müller F, Hilker M, Eich E.

Sci Pharm. 2013 Apr-Jun;81(2):543-8. doi: 10.3797/scipharm.1303-13. Epub 2013 Jun 4.

18.

Amorfrutin B is an efficient natural peroxisome proliferator-activated receptor gamma (PPARγ) agonist with potent glucose-lowering properties.

Weidner C, Wowro SJ, Freiwald A, Kawamoto K, Witzke A, Kliem M, Siems K, Müller-Kuhrt L, Schroeder FC, Sauer S.

Diabetologia. 2013 Aug;56(8):1802-12. doi: 10.1007/s00125-013-2920-2. Epub 2013 May 18.

PMID:
23680913
19.

Chemical composition and biological activity of Paris quadrifolia L.

Jenett-Siems K, Krause N, Siems K, Jakupovic S, Wallukat G, Melzig ME.

Z Naturforsch C. 2012 Nov-Dec;67(11-12):565-70.

PMID:
23413750
20.

Characterisation of Nox4 inhibitors from edible plants.

Kofler PA, Pircher H, von Grafenstein S, Diener T, Höll M, Liedl KR, Siems K, Jansen-Dürr P.

Planta Med. 2013 Mar;79(3-4):244-52. doi: 10.1055/s-0032-1328129. Epub 2013 Jan 23.

PMID:
23345167
21.

Major constituents and cytotoxic effects of Ajuga chamaecistus ssp. tomentella.

Sadati N, Jenett-Siems K, Siems K, Ardekani MR, Hadjiakhoondi A, Akbarzadeh T, Ostad SN, Khanavi M.

Z Naturforsch C. 2012 May-Jun;67(5-6):275-81.

PMID:
22888532
22.

Amorfrutins are potent antidiabetic dietary natural products.

Weidner C, de Groot JC, Prasad A, Freiwald A, Quedenau C, Kliem M, Witzke A, Kodelja V, Han CT, Giegold S, Baumann M, Klebl B, Siems K, Müller-Kuhrt L, Schürmann A, Schüler R, Pfeiffer AF, Schroeder FC, Büssow K, Sauer S.

Proc Natl Acad Sci U S A. 2012 May 8;109(19):7257-62. doi: 10.1073/pnas.1116971109. Epub 2012 Apr 16.

23.

The phytochemical glaucarubinone promotes mitochondrial metabolism, reduces body fat, and extends lifespan of Caenorhabditis elegans.

Zarse K, Bossecker A, Müller-Kuhrt L, Siems K, Hernandez MA, Berendsohn WG, Birringer M, Ristow M.

Horm Metab Res. 2011 Apr;43(4):241-3. doi: 10.1055/s-0030-1270524. Epub 2011 Jan 24.

PMID:
21264793
24.

New cucurbitane-type triterpenoids from Bryonia aspera.

Sahranavard S, Naghibi F, Siems K, Jenett-Siems K.

Planta Med. 2010 Jul;76(10):1014-7. doi: 10.1055/s-0029-1240840. Epub 2010 Jan 27.

PMID:
20108178
25.

Revisiting old drugs as novel agents for retinoblastoma: in vitro and in vivo antitumor activity of cardenolides.

Antczak C, Kloepping C, Radu C, Genski T, Müller-Kuhrt L, Siems K, de Stanchina E, Abramson DH, Djaballah H.

Invest Ophthalmol Vis Sci. 2009 Jul;50(7):3065-73. doi: 10.1167/iovs.08-3158. Epub 2009 Jan 17.

26.

Structure-based pharmacophore screening for natural-product-derived PPARgamma agonists.

Tanrikulu Y, Rau O, Schwarz O, Proschak E, Siems K, Müller-Kuhrt L, Schubert-Zsilavecz M, Schneider G.

Chembiochem. 2009 Jan 5;10(1):75-8. doi: 10.1002/cbic.200800520. No abstract available.

PMID:
19067454
27.

A cell-based high-throughput assay system reveals modulation of oxidative and nonoxidative glucose metabolism due to commonly used organic solvents.

Zimmermann S, Zarse K, Schulz TJ, Siems K, Müller-Kuhrt L, Birringer M, Ristow M.

Horm Metab Res. 2008 Jan;40(1):29-37. doi: 10.1055/s-2007-1004542.

PMID:
18197582
28.

Bonabiline A, a monoterpenoid 3alpha-acyloxytropane from the roots of Bonamia spectabilis showing M3 receptor antagonist activity.

Ott SC, Jenett-Siems K, Pertz HH, Siems K, Witte L, Eich E.

Planta Med. 2006 Dec;72(15):1403-6. Epub 2006 Nov 6. Erratum in: Planta Med. 2013 Apr;79(6):512.

PMID:
17089324
29.

Rational approaches to natural-product-based drug design.

Haustedt LO, Mang C, Siems K, Schiewe H.

Curr Opin Drug Discov Devel. 2006 Jul;9(4):445-62. Review.

PMID:
16889228
30.

Phenolic glycosides from Exostema mexicanum leaves.

Froelich S, Siems K, Hernández MA, Ibarra RA, Berendsohn WG, Jenett-Siems K.

Pharmazie. 2006 Jul;61(7):641-4.

PMID:
16889074
31.

N1,N10-ditigloylspermidine, a novel alkaloid from the seeds of Ipomoea nil.

Schimming T, Jenett-Siems K, Siems K, Witte L, Eich E.

Pharmazie. 2005 Dec;60(12):958-9.

PMID:
16398277
32.

New prenylated benzoic acid derivatives of Piper hispidum.

Friedrich U, Siems K, Solis PN, Gupta MP, Jenett-Siems K.

Pharmazie. 2005 Jun;60(6):455-7.

PMID:
15997836
33.

Chemotaxonomy of the pantropical genus Merremia (Convolvulaceae) based on the distribution of tropane alkaloids.

Jenett-Siems K, Weigl R, Böhm A, Mann P, Tofern-Reblin B, Ott SC, Ghomian A, Kaloga M, Siems K, Witte L, Hilker M, Müller F, Eich E.

Phytochemistry. 2005 Jun;66(12):1448-64.

PMID:
15922373
34.

Ipangulines and minalobines, chemotaxonomic markers of the infrageneric Ipomoea taxon subgenus Quamoclit, section Mina.

Jenett-Siems K, Ott SC, Schimming T, Siems K, Müller F, Hilker M, Witte L, Hartmann T, Austin DF, Eich E.

Phytochemistry. 2005 Jan;66(2):223-31.

PMID:
15652579
35.

Cornutins C-L, neo-clerodane-type diterpenoids from Cornutia grandifolia var. intermedia.

Jenett-Siems K, Köhler I, Kraft C, Siems K, Solis PN, Gupta MP, Bienzle U.

Phytochemistry. 2003 Oct;64(3):797-804.

PMID:
13679104
36.

Sipaucins A-C, sesquiterpenoids from Siparuna pauciflora.

Jenett-Siems K, Kraft C, Siems K, Jakupovic J, Solis PN, Gupta MP, Bienzle U.

Phytochemistry. 2003 Jun;63(4):377-81.

PMID:
12770583
37.

In vitro antiplasmodial evaluation of medicinal plants from Zimbabwe.

Kraft C, Jenett-Siems K, Siems K, Jakupovic J, Mavi S, Bienzle U, Eich E.

Phytother Res. 2003 Feb;17(2):123-8.

PMID:
12601673
38.

Herbal remedies traditionally used against malaria in Ghana: bioassay-guided fractionation of Microglossa pyrifolia (Asteraceae).

Köhler I, Jenett-Siems K, Kraft C, Siems K, Abbiw D, Bienzle U, Eich E.

Z Naturforsch C. 2002 Nov-Dec;57(11-12):1022-7.

PMID:
12562088
39.

Andirol A and B, two unique 6-hydroxymethylpterocarpenes from Andira inermis.

Kraft C, Jenett-Siems K, Köhler I, Siems K, Abbiw D, Bienzle U, Eich E.

Z Naturforsch C. 2002 Sep-Oct;57(9-10):785-90.

PMID:
12440712
40.

In vitro antiplasmodial investigation of medicinal plants from El Salvador.

Köhler I, Jenett-Siems K, Siems K, Hernández MA, Ibarra RA, Berendsohn WG, Bienzle U, Eich E.

Z Naturforsch C. 2002 Mar-Apr;57(3-4):277-81.

PMID:
12064726
41.

Antiplasmodial activity of sesquilignans and sesquineolignans from Bonamia spectabilis.

Kraft C, Jenett-Siems K, Köhler I, Tofern-Reblin B, Siems K, Bienzle U, Eich E.

Phytochemistry. 2002 May;60(2):167-73.

PMID:
12009320
42.

Antiplasmodial activity of naphthoquinones and one anthraquinone from Stereospermum kunthianum.

Onegi B, Kraft C, Köhler I, Freund M, Jenett-Siems K, Siems K, Beyer G, Melzig MF, Bienzle U, Eich E.

Phytochemistry. 2002 May;60(1):39-44.

PMID:
11985850
43.
44.

Merrekentrones A-D, ipomeamarone-like furanosesquiterpenes from Merremia kentrocaulos.

Jenett-Siems K, Siems K, Witte L, Eich E.

J Nat Prod. 2001 Nov;64(11):1471-3.

PMID:
11720538
45.

Andinermals A-C, antiplasmodial constituents from Andira inermis.

Kraft C, Jenett-Siems K, Siems K, Solis PN, Gupta MP, Bienzle U, Eich E.

Phytochemistry. 2001 Nov;58(5):769-74.

PMID:
11672743
46.

In vitro antiplasmodial activity of 4-phenylcoumarins from Exostema mexicanum.

Köhler I, Jenett-Siems K, Mockenhaupt FP, Siems K, Jakupovic J, González JC, Hernández MA, Ibarra RA, Berendsohn WG, Bienzle U, Eich E.

Planta Med. 2001 Feb;67(1):89-91.

PMID:
11270733
47.

Iseluxine: a novel isoquinolinone alkaloid from Iseia luxurians.

Schimming T, Jenett-Siems K, Siems K, Witte L, Gupta MP, Eich E.

Z Naturforsch C. 2000 Nov-Dec;55(11-12):1023-5.

PMID:
11204180
48.

Antileishmanial activities of aphidicolin and its semisynthetic derivatives.

Kayser O, Kiderlen AF, Bertels S, Siems K.

Antimicrob Agents Chemother. 2001 Jan;45(1):288-92.

49.

Antiplasmodial activity of isoflavones from Andira inermis.

Kraft C, Jenett-Siems K, Siems K, Gupta MP, Bienzle U, Eich E.

J Ethnopharmacol. 2000 Nov;73(1-2):131-5.

PMID:
11025148
50.

Sipandinolide: a butenolide including a novel type of carbon skeleton from Siparuna andina.

Jenett-Siems K, Siems K, Jakupovic J, Solis PN, Gupta MP, Mockenhaupt FP, Bienzle U, Eich E.

Planta Med. 2000 May;66(4):384-5.

PMID:
10865465

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