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Technical considerations of multi-parametric tissue outcome prediction methods in acute ischemic stroke patients.

Winder AJ, Siemonsen S, Flottmann F, Thomalla G, Fiehler J, Forkert ND.

Sci Rep. 2019 Sep 13;9(1):13208. doi: 10.1038/s41598-019-49460-y.


[Acute diseases of the brain and heart : A reciprocal culprit-victim relationship].

Egerer E, Siemonsen S, Erbguth F.

Med Klin Intensivmed Notfmed. 2018 Sep;113(6):456-463. doi: 10.1007/s00063-018-0465-3. Epub 2018 Aug 13. Review. German.


Using 3D spatial correlations to improve the noise robustness of multi component analysis of 3D multi echo quantitative T2 relaxometry data.

Kumar D, Hariharan H, Faizy TD, Borchert P, Siemonsen S, Fiehler J, Reddy R, Sedlacik J.

Neuroimage. 2018 Sep;178:583-601. doi: 10.1016/j.neuroimage.2018.05.026. Epub 2018 May 12.


Evaluation and reduction of magnetic resonance imaging artefacts induced by distinct plates for osseous fixation: an in vitro study @ 3 T.

Rendenbach C, Schoellchen M, Bueschel J, Gauer T, Sedlacik J, Kutzner D, Vallittu PK, Heiland M, Smeets R, Fiehler J, Siemonsen S.

Dentomaxillofac Radiol. 2018 Oct;47(7):20170361. doi: 10.1259/dmfr.20170361. Epub 2018 May 23.


Hemodynamic Forces Tune the Arrest, Adhesion, and Extravasation of Circulating Tumor Cells.

Follain G, Osmani N, Azevedo AS, Allio G, Mercier L, Karreman MA, Solecki G, Garcia Leòn MJ, Lefebvre O, Fekonja N, Hille C, Chabannes V, Dollé G, Metivet T, Hovsepian F, Prudhomme C, Pichot A, Paul N, Carapito R, Bahram S, Ruthensteiner B, Kemmling A, Siemonsen S, Schneider T, Fiehler J, Glatzel M, Winkler F, Schwab Y, Pantel K, Harlepp S, Goetz JG.

Dev Cell. 2018 Apr 9;45(1):33-52.e12. doi: 10.1016/j.devcel.2018.02.015.


Rapid fully automatic segmentation of subcortical brain structures by shape-constrained surface adaptation.

Wenzel F, Meyer C, Stehle T, Peters J, Siemonsen S, Thaler C, Zagorchev L; Alzheimer’s Disease Neuroimaging Initiative.

Med Image Anal. 2018 May;46:146-161. doi: 10.1016/ Epub 2018 Mar 9.


Patients with primary biliary cholangitis and fatigue present with depressive symptoms and selected cognitive deficits, but with normal attention performance and brain structure.

Zenouzi R, von der Gablentz J, Heldmann M, Göttlich M, Weiler-Normann C, Sebode M, Ehlken H, Hartl J, Fellbrich A, Siemonsen S, Schramm C, Münte TF, Lohse AW.

PLoS One. 2018 Jan 10;13(1):e0190005. doi: 10.1371/journal.pone.0190005. eCollection 2018.


Computed Tomography-Based Imaging of Voxel-Wise Lesion Water Uptake in Ischemic Brain: Relationship Between Density and Direct Volumetry.

Broocks G, Flottmann F, Ernst M, Faizy TD, Minnerup J, Siemonsen S, Fiehler J, Kemmling A.

Invest Radiol. 2018 Apr;53(4):207-213. doi: 10.1097/RLI.0000000000000430.


Comprehensive analysis of early fractional anisotropy changes in acute ischemic stroke.

Alegiani AC, MacLean S, Braass H, Siemonsen S, Gerloff C, Fiehler J, Cho TH, Derex L, Hermier M, Berthezene Y, Nighoghossian N, Thomalla G.

PLoS One. 2017 Nov 30;12(11):e0188318. doi: 10.1371/journal.pone.0188318. eCollection 2017.


The use of multiparametric quantitative magnetic resonance imaging for evaluating visually assigned lesion groups in patients with multiple sclerosis.

Thaler C, Faizy TD, Sedlacik J, Bester M, Stellmann JP, Heesen C, Fiehler J, Siemonsen S.

J Neurol. 2018 Jan;265(1):127-133. doi: 10.1007/s00415-017-8683-9. Epub 2017 Nov 20.


Low clinical conversion rate in clinically isolated syndrome patients - diagnostic benefit of McDonald 2010 criteria?

Rosenkranz SC, Kaulen B, Neuhaus A, Siemonsen S, Köpke S, Daumer M, Stellmann JP, Heesen C.

Eur J Neurol. 2018 Feb;25(2):247-e9. doi: 10.1111/ene.13476. Epub 2017 Dec 2.


Neuroradiologic Characteristics of Primary Angiitis of the Central Nervous System According to the Affected Vessel Size.

Thaler C, Kaufmann-Bühler AK, Gansukh T, Gansukh A, Schuster S, Bachmann H, Thomalla G, Magnus T, Matschke J, Fiehler J, Siemonsen S.

Clin Neuroradiol. 2019 Mar;29(1):37-44. doi: 10.1007/s00062-017-0622-8. Epub 2017 Sep 5.


Reduced rich-club connectivity is related to disability in primary progressive MS.

Stellmann JP, Hodecker S, Cheng B, Wanke N, Young KL, Hilgetag C, Gerloff C, Heesen C, Thomalla G, Siemonsen S.

Neurol Neuroimmunol Neuroinflamm. 2017 Jul 27;4(5):e375. doi: 10.1212/NXI.0000000000000375. eCollection 2017 Sep.


T1w dark blood imaging improves detection of contrast enhancing lesions in multiple sclerosis.

Thaler C, Schneider T, Sedlacik J, Kutzner D, Stellmann JP, Heesen C, Fiehler J, Siemonsen S.

PLoS One. 2017 Aug 10;12(8):e0183099. doi: 10.1371/journal.pone.0183099. eCollection 2017.


Transit time homogenization in ischemic stroke - A novel biomarker of penumbral microvascular failure?

Engedal TS, Hjort N, Hougaard KD, Simonsen CZ, Andersen G, Mikkelsen IK, Boldsen JK, Eskildsen SF, Hansen MB, Angleys H, Jespersen SN, Pedraza S, Cho TH, Serena J, Siemonsen S, Thomalla G, Nighoghossian N, Fiehler J, Mouridsen K, Østergaard L.

J Cereb Blood Flow Metab. 2018 Nov;38(11):2006-2020. doi: 10.1177/0271678X17721666. Epub 2017 Jul 31.


Can resistance training impact MRI outcomes in relapsing-remitting multiple sclerosis?

Kjølhede T, Siemonsen S, Wenzel D, Stellmann JP, Ringgaard S, Pedersen BG, Stenager E, Petersen T, Vissing K, Heesen C, Dalgas U.

Mult Scler. 2018 Sep;24(10):1356-1365. doi: 10.1177/1352458517722645. Epub 2017 Jul 28.


CT-perfusion stroke imaging: a threshold free probabilistic approach to predict infarct volume compared to traditional ischemic thresholds.

Flottmann F, Broocks G, Faizy TD, Ernst M, Forkert ND, Grosser M, Thomalla G, Siemonsen S, Fiehler J, Kemmling A.

Sci Rep. 2017 Jul 27;7(1):6679. doi: 10.1038/s41598-017-06882-w.


ERic Acute StrokE Recanalization: A study using predictive analytics to assess a new device for mechanical thrombectomy.

Siemonsen S, Forkert ND, Bernhardt M, Thomalla G, Bendszus M, Fiehler J.

Int J Stroke. 2017 Aug;12(6):659-666. doi: 10.1177/1747493017700661. Epub 2017 Mar 22.


Subtypes of primary angiitis of the CNS identified by MRI patterns reflect the size of affected vessels.

Schuster S, Bachmann H, Thom V, Kaufmann-Buehler AK, Matschke J, Siemonsen S, Glatzel M, Fiehler J, Gerloff C, Magnus T, Thomalla G.

J Neurol Neurosurg Psychiatry. 2017 Sep;88(9):749-755. doi: 10.1136/jnnp-2017-315691. Epub 2017 Jul 13.


Edema is not a reliable diagnostic sign to exclude small brain metastases.

Schneider T, Kuhne JF, Bittrich P, Schroeder J, Magnus T, Mohme M, Grosser M, Schoen G, Fiehler J, Siemonsen S.

PLoS One. 2017 May 11;12(5):e0177217. doi: 10.1371/journal.pone.0177217. eCollection 2017.


Pattern of gray matter volumes related to retinal thickness and its association with cognitive function in relapsing-remitting MS.

Stellmann JP, Cetin H, Young KL, Hodecker S, Pöttgen J, Bittersohl D, Hassenstein A, Oberwahrenbrock T, Heesen C, Siemonsen S.

Brain Behav. 2016 Dec 20;7(2):e00614. doi: 10.1002/brb3.614. eCollection 2017 Feb.


Reliability of cortical lesion detection on double inversion recovery MRI applying the MAGNIMS-Criteria in multiple sclerosis patients within a 16-months period.

Faizy TD, Thaler C, Ceyrowski T, Broocks G, Treffler N, Sedlacik J, Stürner K, Stellmann JP, Heesen C, Fiehler J, Siemonsen S.

PLoS One. 2017 Feb 24;12(2):e0172923. doi: 10.1371/journal.pone.0172923. eCollection 2017.


T1 Recovery Is Predominantly Found in Black Holes and Is Associated with Clinical Improvement in Patients with Multiple Sclerosis.

Thaler C, Faizy TD, Sedlacik J, Holst B, Stürner K, Heesen C, Stellmann JP, Fiehler J, Siemonsen S.

AJNR Am J Neuroradiol. 2017 Feb;38(2):264-269. doi: 10.3174/ajnr.A5004. Epub 2016 Nov 10.


Artefacts in multimodal imaging of titanium, zirconium and binary titanium-zirconium alloy dental implants: an in vitro study.

Smeets R, Schöllchen M, Gauer T, Aarabi G, Assaf AT, Rendenbach C, Beck-Broichsitter B, Semmusch J, Sedlacik J, Heiland M, Fiehler J, Siemonsen S.

Dentomaxillofac Radiol. 2017 Feb;46(2):20160267. doi: 10.1259/dmfr.20160267. Epub 2016 Dec 2.


Short-term MRI measurements as predictors of EDSS progression in relapsing-remitting multiple sclerosis: grey matter atrophy but not lesions are predictive in a real-life setting.

von Gumberz J, Mahmoudi M, Young K, Schippling S, Martin R, Heesen C, Siemonsen S, Stellmann JP.

PeerJ. 2016 Sep 20;4:e2442. doi: 10.7717/peerj.2442. eCollection 2016.


Intraparenchymal Hyperattenuations on Flat-Panel CT Directly After Mechanical Thrombectomy are Restricted to the Initial Infarct Core on Diffusion-Weighted Imaging.

Schneider T, Mahraun T, Schroeder J, Frölich A, Hoelter P, Wagner M, Darcourt J, Cognard C, Bonafé A, Fiehler J, Siemonsen S, Buhk JH.

Clin Neuroradiol. 2018 Mar;28(1):91-97. doi: 10.1007/s00062-016-0543-y. Epub 2016 Sep 16.


Heterogeneity of Multiple Sclerosis Lesions in Multislice Myelin Water Imaging.

Faizy TD, Thaler C, Kumar D, Sedlacik J, Broocks G, Grosser M, Stellmann JP, Heesen C, Fiehler J, Siemonsen S.

PLoS One. 2016 Mar 18;11(3):e0151496. doi: 10.1371/journal.pone.0151496. eCollection 2016.


Improved Lesion Detection by Using Axial T2-Weighted MRI with Full Spinal Cord Coverage in Multiple Sclerosis.

Galler S, Stellmann JP, Young KL, Kutzner D, Heesen C, Fiehler J, Siemonsen S.

AJNR Am J Neuroradiol. 2016 May;37(5):963-9. doi: 10.3174/ajnr.A4638. Epub 2016 Jan 7.


T1- Thresholds in Black Holes Increase Clinical-Radiological Correlation in Multiple Sclerosis Patients.

Thaler C, Faizy T, Sedlacik J, Holst B, Stellmann JP, Young KL, Heesen C, Fiehler J, Siemonsen S.

PLoS One. 2015 Dec 11;10(12):e0144693. doi: 10.1371/journal.pone.0144693. eCollection 2015.


Quantitative T2* mapping reveals early temporo-spatial dynamics in an ischemic stroke model.

Gersing AS, Faymonville AM, Schwaiger BJ, Leypoldt F, Siemonsen S, Zimmer C, Magnus T, Fiehler J.

J Neurosci Methods. 2016 Feb 1;259:83-89. doi: 10.1016/j.jneumeth.2015.11.018. Epub 2015 Nov 29.


Correction: Increased Perfusion in Normal Appearing White Matter in High Inflammatory Multiple Sclerosis Patients.

Bester M, Forkert ND, Stellmann JP, Stürner K, Aly L, Drabik A, Young KL, Heesen C, Fiehler J, Siemonsen S.

PLoS One. 2015 Nov 4;10(11):e0142464. doi: 10.1371/journal.pone.0142464. eCollection 2015. No abstract available.


Noise robust spatially regularized myelin water fraction mapping with the intrinsic B1-error correction based on the linearized version of the extended phase graph model.

Kumar D, Siemonsen S, Heesen C, Fiehler J, Sedlacik J.

J Magn Reson Imaging. 2016 Apr;43(4):800-17. doi: 10.1002/jmri.25078. Epub 2015 Oct 19.


Chronic T2 Lesions in Multiple Sclerosis are Heterogeneous Regarding Phase MR Imaging.

Siemonsen S, Young KL, Bester M, Sedlacik J, Heesen C, Fiehler J, Stellmann JP.

Clin Neuroradiol. 2016 Dec;26(4):457-464. Epub 2015 Apr 18.


Increased perfusion in normal appearing white matter in high inflammatory multiple sclerosis patients.

Bester M, Forkert ND, Stellmann JP, Stürner K, Aly L, Drabik A, Young KL, Heesen C, Fiehler J, Siemonsen S.

PLoS One. 2015 Mar 16;10(3):e0119356. doi: 10.1371/journal.pone.0119356. eCollection 2015. Erratum in: PLoS One. 2015;10(11):e0142464. Stürner, Klarissa [added].


Regression to the mean and predictors of MRI disease activity in RRMS placebo cohorts--is there a place for baseline-to-treatment studies in MS?

Stellmann JP, Stürner KH, Young KL, Siemonsen S, Friede T, Heesen C.

PLoS One. 2015 Feb 6;10(2):e0116559. doi: 10.1371/journal.pone.0116559. eCollection 2015. Review.


Prediction of infarction and reperfusion in stroke by flow- and volume-weighted collateral signal in MR angiography.

Ernst M, Forkert ND, Brehmer L, Thomalla G, Siemonsen S, Fiehler J, Kemmling A.

AJNR Am J Neuroradiol. 2015 Feb;36(2):275-82. doi: 10.3174/ajnr.A4145. Epub 2014 Dec 11.


Magnetic resonance imaging in multiple sclerosis--patients' experiences, information interests and responses to an education programme.

Brand J, Köpke S, Kasper J, Rahn A, Backhus I, Poettgen J, Stellmann JP, Siemonsen S, Heesen C.

PLoS One. 2014 Nov 21;9(11):e113252. doi: 10.1371/journal.pone.0113252. eCollection 2014.


3T MRI reveals extra- and intracranial involvement in giant cell arteritis.

Siemonsen S, Brekenfeld C, Holst B, Kaufmann-Buehler AK, Fiehler J, Bley TA.

AJNR Am J Neuroradiol. 2015 Jan;36(1):91-7. doi: 10.3174/ajnr.A4086. Epub 2014 Aug 28.


Aligning 3D time-of-flight MRA datasets for quantitative longitudinal studies: evaluation of rigid registration techniques.

Verleger T, Schönfeld M, Säring D, Siemonsen S, Fiehler J, Forkert ND.

Magn Reson Imaging. 2014 Dec;32(10):1390-5. doi: 10.1016/j.mri.2014.08.011. Epub 2014 Aug 15.


Influence of stroke infarct location on functional outcome measured by the modified rankin scale.

Cheng B, Forkert ND, Zavaglia M, Hilgetag CC, Golsari A, Siemonsen S, Fiehler J, Pedraza S, Puig J, Cho TH, Alawneh J, Baron JC, Ostergaard L, Gerloff C, Thomalla G.

Stroke. 2014 Jun;45(6):1695-702. doi: 10.1161/STROKEAHA.114.005152. Epub 2014 Apr 29.


Visual and region of interest-based inter-rater agreement in the assessment of the diffusion-weighted imaging- fluid-attenuated inversion recovery mismatch.

Galinovic I, Puig J, Neeb L, Guibernau J, Kemmling A, Siemonsen S, Pedraza S, Cheng B, Thomalla G, Fiehler J, Fiebach JB.

Stroke. 2014 Apr;45(4):1170-2. doi: 10.1161/STROKEAHA.113.002661. Epub 2014 Feb 20.


Spatial distribution of perfusion abnormality in acute MCA occlusion is associated with likelihood of later recanalization.

Siemonsen S, Forkert ND, Hansen A, Kemmling A, Thomalla G, Fiehler J.

J Cereb Blood Flow Metab. 2014 May;34(5):813-9. doi: 10.1038/jcbfm.2014.13. Epub 2014 Jan 29.


Reversible, irreversible and effective transverse relaxation rates in normal aging brain at 3T.

Sedlacik J, Boelmans K, Löbel U, Holst B, Siemonsen S, Fiehler J.

Neuroimage. 2014 Jan 1;84:1032-41. doi: 10.1016/j.neuroimage.2013.08.051. Epub 2013 Sep 1.


Comparison of 10 TTP and Tmax estimation techniques for MR perfusion-diffusion mismatch quantification in acute stroke.

Forkert ND, Kaesemann P, Treszl A, Siemonsen S, Cheng B, Handels H, Fiehler J, Thomalla G.

AJNR Am J Neuroradiol. 2013 Sep;34(9):1697-703. doi: 10.3174/ajnr.A3460. Epub 2013 Mar 28.


The role of the cerebral capillaries in acute ischemic stroke: the extended penumbra model.

Østergaard L, Jespersen SN, Mouridsen K, Mikkelsen IK, Jonsdottír KÝ, Tietze A, Blicher JU, Aamand R, Hjort N, Iversen NK, Cai C, Hougaard KD, Simonsen CZ, Von Weitzel-Mudersbach P, Modrau B, Nagenthiraja K, Riisgaard Ribe L, Hansen MB, Bekke SL, Dahlman MG, Puig J, Pedraza S, Serena J, Cho TH, Siemonsen S, Thomalla G, Fiehler J, Nighoghossian N, Andersen G.

J Cereb Blood Flow Metab. 2013 May;33(5):635-48. doi: 10.1038/jcbfm.2013.18. Epub 2013 Feb 27. Review.


Elevated T2-values in MRI of stroke patients shortly after symptom onset do not predict irreversible tissue infarction.

Siemonsen S, Löbel U, Sedlacik J, Forkert ND, Mouridsen K, Østergaard L, Thomalla G, Fiehler J.

Brain. 2012 Jun;135(Pt 6):1981-9. doi: 10.1093/brain/aws079. Epub 2012 Apr 13.


Visual assessment of magnetic resonance imaging perfusion lesions in a large patient group.

Siemonsen S, Fitting T, Thomalla G, Krützelmann A, Fiehler J.

Clin Neuroradiol. 2012 Dec;22(4):305-13. doi: 10.1007/s00062-012-0143-4. Epub 2012 Apr 8.


Macromolecule content influences proton diffusibility in gliomas.

Goebell E, Fiehler J, Siemonsen S, Vaeterlein O, Heese O, Hagel C, Ding XQ, Buhk JH, Groth M, Kucinski T.

Eur Radiol. 2011 Dec;21(12):2626-32. doi: 10.1007/s00330-011-2206-3. Epub 2011 Jul 16.


Infarction of 'non-core-non-penumbral' tissue after stroke: multivariate modelling of clinical impact.

Alawneh JA, Jones PS, Mikkelsen IK, Cho TH, Siemonsen S, Mouridsen K, Ribe L, Morris RS, Hjort N, Antoun N, Gillard JH, Fiehler J, Nighoghossian N, Warburton EA, Ostergaard L, Baron JC.

Brain. 2011 Jun;134(Pt 6):1765-76. doi: 10.1093/brain/awr100.


Predicting infarction within the diffusion-weighted imaging lesion: does the mean transit time have added value?

Carrera E, Jones PS, Alawneh JA, Klærke Mikkelsen I, Cho TH, Siemonsen S, Guadagno JV, Mouridsen K, Ribe L, Hjort N, Fryer TD, Carpenter TA, Aigbirhio FI, Fiehler J, Nighoghossian N, Warburton EA, Ostergaard L, Baron JC.

Stroke. 2011 Jun;42(6):1602-7. doi: 10.1161/STROKEAHA.110.606970. Epub 2011 Apr 21.


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