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Items: 1 to 50 of 83

1.

Mycobacterium bovis Bacillus Calmette-Guérin Alters Melanoma Microenvironment Favoring Antitumor T Cell Responses and Improving M2 Macrophage Function.

Lardone RD, Chan AA, Lee AF, Foshag LJ, Faries MB, Sieling PA, Lee DJ.

Front Immunol. 2017 Aug 11;8:965. doi: 10.3389/fimmu.2017.00965. eCollection 2017.

2.

Insights into Local Tumor Microenvironment Immune Factors Associated with Regression of Cutaneous Melanoma Metastases by Mycobacterium bovis Bacille Calmette-Guérin.

Yang J, Jones MS, Ramos RI, Chan AA, Lee AF, Foshag LJ, Sieling PA, Faries MB, Lee DJ.

Front Oncol. 2017 Apr 5;7:61. doi: 10.3389/fonc.2017.00061. eCollection 2017.

3.

Characterization of the microbiome of nipple aspirate fluid of breast cancer survivors.

Chan AA, Bashir M, Rivas MN, Duvall K, Sieling PA, Pieber TR, Vaishampayan PA, Love SM, Lee DJ.

Sci Rep. 2016 Jun 21;6:28061. doi: 10.1038/srep28061.

4.

Cross-platform comparison of independent datasets identifies an immune signature associated with improved survival in metastatic melanoma.

Lardone RD, Plaisier SB, Navarrete MS, Shamonki JM, Jalas JR, Sieling PA, Lee DJ.

Oncotarget. 2016 Mar 22;7(12):14415-28. doi: 10.18632/oncotarget.7361.

5.

Clinical Benefit from Ipilimumab Therapy in Melanoma Patients may be Associated with Serum CTLA4 Levels.

Leung AM, Lee AF, Ozao-Choy J, Ramos RI, Hamid O, O'Day SJ, Shin-Sim M, Morton DL, Faries MB, Sieling PA, Lee DJ.

Front Oncol. 2014 May 16;4:110. doi: 10.3389/fonc.2014.00110. eCollection 2014. Review.

6.

Microbial dysbiosis is associated with human breast cancer.

Xuan C, Shamonki JM, Chung A, Dinome ML, Chung M, Sieling PA, Lee DJ.

PLoS One. 2014 Jan 8;9(1):e83744. doi: 10.1371/journal.pone.0083744. eCollection 2014.

7.

Interleukin-1β triggers the differentiation of macrophages with enhanced capacity to present mycobacterial antigen to T cells.

Schenk M, Fabri M, Krutzik SR, Lee DJ, Vu DM, Sieling PA, Montoya D, Liu PT, Modlin RL.

Immunology. 2014 Feb;141(2):174-80. doi: 10.1111/imm.12167.

8.

Immune correlates of melanoma survival in adoptive cell therapy.

Lee AF, Sieling PA, Lee DJ.

Oncoimmunology. 2013 Feb 1;2(2):e22889.

9.

Galectin-3 regulates the innate immune response of human monocytes.

Chung AW, Sieling PA, Schenk M, Teles RM, Krutzik SR, Hsu DK, Liu FT, Sarno EN, Rea TH, Stenger S, Modlin RL, Lee DJ.

J Infect Dis. 2013 Mar 15;207(6):947-56. doi: 10.1093/infdis/jis920. Epub 2012 Dec 18.

10.

Isolation of a distinct Mycobacterium tuberculosis mannose-capped lipoarabinomannan isoform responsible for recognition by CD1b-restricted T cells.

Torrelles JB, Sieling PA, Zhang N, Keen MA, McNeil MR, Belisle JT, Modlin RL, Brennan PJ, Chatterjee D.

Glycobiology. 2012 Aug;22(8):1118-27. doi: 10.1093/glycob/cws078. Epub 2012 Apr 25.

11.

NOD2 triggers an interleukin-32-dependent human dendritic cell program in leprosy.

Schenk M, Krutzik SR, Sieling PA, Lee DJ, Teles RM, Ochoa MT, Komisopoulou E, Sarno EN, Rea TH, Graeber TG, Kim S, Cheng G, Modlin RL.

Nat Med. 2012 Mar 25;18(4):555-63. doi: 10.1038/nm.2650.

12.

Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages.

Fabri M, Stenger S, Shin DM, Yuk JM, Liu PT, Realegeno S, Lee HM, Krutzik SR, Schenk M, Sieling PA, Teles R, Montoya D, Iyer SS, Bruns H, Lewinsohn DM, Hollis BW, Hewison M, Adams JS, Steinmeyer A, Zügel U, Cheng G, Jo EK, Bloom BR, Modlin RL.

Sci Transl Med. 2011 Oct 12;3(104):104ra102. doi: 10.1126/scitranslmed.3003045.

13.

Structural differences in lipomannans from pathogenic and nonpathogenic mycobacteria that impact CD1b-restricted T cell responses.

Torrelles JB, Sieling PA, Arcos J, Knaup R, Bartling C, Rajaram MV, Stenger S, Modlin RL, Schlesinger LS.

J Biol Chem. 2011 Oct 14;286(41):35438-46. doi: 10.1074/jbc.M111.232587. Epub 2011 Aug 22.

14.

Activation of Fc gamma RI on monocytes triggers differentiation into immature dendritic cells that induce autoreactive T cell responses.

Tanaka M, Krutzik SR, Sieling PA, Lee DJ, Rea TH, Modlin RL.

J Immunol. 2009 Aug 15;183(4):2349-55. doi: 10.4049/jimmunol.0801683. Epub 2009 Jul 27.

15.

Host-derived oxidized phospholipids and HDL regulate innate immunity in human leprosy.

Cruz D, Watson AD, Miller CS, Montoya D, Ochoa MT, Sieling PA, Gutierrez MA, Navab M, Reddy ST, Witztum JL, Fogelman AM, Rea TH, Eisenberg D, Berliner J, Modlin RL.

J Clin Invest. 2008 Aug;118(8):2917-28. doi: 10.1172/JCI34189.

16.

Conserved mycobacterial lipoglycoproteins activate TLR2 but also require glycosylation for MHC class II-restricted T cell activation.

Sieling PA, Hill PJ, Dobos KM, Brookman K, Kuhlman AM, Fabri M, Krutzik SR, Rea TH, Heaslip DG, Belisle JT, Modlin RL.

J Immunol. 2008 May 1;180(9):5833-42.

17.

LILRA2 activation inhibits dendritic cell differentiation and antigen presentation to T cells.

Lee DJ, Sieling PA, Ochoa MT, Krutzik SR, Guo B, Hernandez M, Rea TH, Cheng G, Colonna M, Modlin RL.

J Immunol. 2007 Dec 15;179(12):8128-36.

18.

Cross-talk between CD31 and the signaling lymphocytic activation molecule-associated protein during interferon- gamma production against Mycobacterium tuberculosis.

Quiroga MF, Jurado JO, Martínez GJ, Pasquinelli V, Musella RM, Abbate E, Issekutz AC, Bracco MM, Malbran A, Sieling PA, Chuluyan E, García VE.

J Infect Dis. 2007 Nov 1;196(9):1369-78. Epub 2007 Sep 26.

PMID:
17922402
19.

Activation of human CD4+ T cells by targeting MHC class II epitopes to endosomal compartments using human CD1 tail sequences.

Niazi KR, Ochoa MT, Sieling PA, Rooke NE, Peter AK, Mollahan P, Dickey M, Rabizadeh S, Rea TH, Modlin RL.

Immunology. 2007 Dec;122(4):522-31. Epub 2007 Jul 16.

20.

Regulation of human T-cell homing receptor expression in cutaneous bacterial infection.

Sieling PA, Legaspi A, Ochoa MT, Rea TH, Modlin RL.

Immunology. 2007 Apr;120(4):518-25.

21.

Ito cells are liver-resident antigen-presenting cells for activating T cell responses.

Winau F, Hegasy G, Weiskirchen R, Weber S, Cassan C, Sieling PA, Modlin RL, Liblau RS, Gressner AM, Kaufmann SH.

Immunity. 2007 Jan;26(1):117-29.

22.

Functional characterization of a T-cell receptor BV6+ T-cell clone derived from a leprosy lesion.

Sabet S, Ochoa MT, Sieling PA, Rea TH, Modlin RL.

Immunology. 2007 Mar;120(3):354-61. Epub 2006 Nov 28.

23.

Expression of CD1d molecules by human schwann cells and potential interactions with immunoregulatory invariant NK T cells.

Im JS, Tapinos N, Chae GT, Illarionov PA, Besra GS, DeVries GH, Modlin RL, Sieling PA, Rambukkana A, Porcelli SA.

J Immunol. 2006 Oct 15;177(8):5226-35.

24.

TLR activation of Langerhans cell-like dendritic cells triggers an antiviral immune response.

Renn CN, Sanchez DJ, Ochoa MT, Legaspi AJ, Oh CK, Liu PT, Krutzik SR, Sieling PA, Cheng G, Modlin RL.

J Immunol. 2006 Jul 1;177(1):298-305.

25.

Inducible costimulator: a modulator of IFN-gamma production in human tuberculosis.

Quiroga MF, Pasquinelli V, Martínez GJ, Jurado JO, Zorrilla LC, Musella RM, Abbate E, Sieling PA, García VE.

J Immunol. 2006 May 15;176(10):5965-74.

26.

Immunology. Now presenting: gammadelta T cells.

Modlin RL, Sieling PA.

Science. 2005 Jul 8;309(5732):252-3. No abstract available.

PMID:
16002604
27.

TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells.

Krutzik SR, Tan B, Li H, Ochoa MT, Liu PT, Sharfstein SE, Graeber TG, Sieling PA, Liu YJ, Rea TH, Bloom BR, Modlin RL.

Nat Med. 2005 Jun;11(6):653-60. Epub 2005 May 8.

28.

TGF-alpha regulates TLR expression and function on epidermal keratinocytes.

Miller LS, Sørensen OE, Liu PT, Jalian HR, Eshtiaghpour D, Behmanesh BE, Chung W, Starner TD, Kim J, Sieling PA, Ganz T, Modlin RL.

J Immunol. 2005 May 15;174(10):6137-43.

29.

The human CD1-restricted T cell repertoire is limited to cross-reactive antigens: implications for host responses against immunologically related pathogens.

Sieling PA, Torrelles JB, Stenger S, Chung W, Burdick AE, Rea TH, Brennan PJ, Belisle JT, Porcelli SA, Modlin RL.

J Immunol. 2005 Mar 1;174(5):2637-44.

30.

Activation of signaling lymphocytic activation molecule triggers a signaling cascade that enhances Th1 responses in human intracellular infection.

Quiroga MF, Martínez GJ, Pasquinelli V, Costas MA, Bracco MM, Malbrán A, Olivares LM, Sieling PA, García VE.

J Immunol. 2004 Sep 15;173(6):4120-9.

31.

Truncated structural variants of lipoarabinomannan in Mycobacterium leprae and an ethambutol-resistant strain of Mycobacterium tuberculosis.

Torrelles JB, Khoo KH, Sieling PA, Modlin RL, Zhang N, Marques AM, Treumann A, Rithner CD, Brennan PJ, Chatterjee D.

J Biol Chem. 2004 Sep 24;279(39):41227-39. Epub 2004 Jul 19.

32.

Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells.

Hunger RE, Sieling PA, Ochoa MT, Sugaya M, Burdick AE, Rea TH, Brennan PJ, Belisle JT, Blauvelt A, Porcelli SA, Modlin RL.

J Clin Invest. 2004 Mar;113(5):701-8.

33.

Saposin C is required for lipid presentation by human CD1b.

Winau F, Schwierzeck V, Hurwitz R, Remmel N, Sieling PA, Modlin RL, Porcelli SA, Brinkmann V, Sugita M, Sandhoff K, Kaufmann SH, Schaible UE.

Nat Immunol. 2004 Feb;5(2):169-74. Epub 2004 Jan 11. Erratum in: Nat Immunol. 2004 Mar;5(3):344.

PMID:
14716313
34.

Expression of signaling lymphocytic activation molecule-associated protein interrupts IFN-gamma production in human tuberculosis.

Pasquinelli V, Quiroga MF, Martínez GJ, Zorrilla LC, Musella RM, Bracco MM, Belmonte L, Malbrán A, Fainboim L, Sieling PA, García VE.

J Immunol. 2004 Jan 15;172(2):1177-85.

35.

Apoptosis facilitates antigen presentation to T lymphocytes through MHC-I and CD1 in tuberculosis.

Schaible UE, Winau F, Sieling PA, Fischer K, Collins HL, Hagens K, Modlin RL, Brinkmann V, Kaufmann SH.

Nat Med. 2003 Aug;9(8):1039-46. Epub 2003 Jul 20.

PMID:
12872166
36.

Activation and regulation of Toll-like receptors 2 and 1 in human leprosy.

Krutzik SR, Ochoa MT, Sieling PA, Uematsu S, Ng YW, Legaspi A, Liu PT, Cole ST, Godowski PJ, Maeda Y, Sarno EN, Norgard MV, Brennan PJ, Akira S, Rea TH, Modlin RL.

Nat Med. 2003 May;9(5):525-32. Epub 2003 Apr 14.

PMID:
12692544
37.

A role for triggering receptor expressed on myeloid cells-1 in host defense during the early-induced and adaptive phases of the immune response.

Bleharski JR, Kiessler V, Buonsanti C, Sieling PA, Stenger S, Colonna M, Modlin RL.

J Immunol. 2003 Apr 1;170(7):3812-8.

38.

Expression of Toll-like receptor 2 on human Schwann cells: a mechanism of nerve damage in leprosy.

Oliveira RB, Ochoa MT, Sieling PA, Rea TH, Rambukkana A, Sarno EN, Modlin RL.

Infect Immun. 2003 Mar;71(3):1427-33.

39.

Distribution of Toll-like receptor 1 and Toll-like receptor 2 in human lymphoid tissue.

Ochoa MT, Legaspi AJ, Hatziris Z, Godowski PJ, Modlin RL, Sieling PA.

Immunology. 2003 Jan;108(1):10-5.

40.

Toll-like receptor 2 ligands as adjuvants for human Th1 responses.

Sieling PA, Chung W, Duong BT, Godowski PJ, Modlin RL.

J Immunol. 2003 Jan 1;170(1):194-200.

41.

Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses.

Kim J, Ochoa MT, Krutzik SR, Takeuchi O, Uematsu S, Legaspi AJ, Brightbill HD, Holland D, Cunliffe WJ, Akira S, Sieling PA, Godowski PJ, Modlin RL.

J Immunol. 2002 Aug 1;169(3):1535-41.

42.

Toll-like receptors: mammalian "taste receptors" for a smorgasbord of microbial invaders.

Sieling PA, Modlin RL.

Curr Opin Microbiol. 2002 Feb;5(1):70-5. Review.

PMID:
11834372
43.

Signaling lymphocytic activation molecule expression and regulation in human intracellular infection correlate with Th1 cytokine patterns.

García VE, Quiroga MF, Ochoa MT, Ochoa L, Pasquinelli V, Fainboim L, Olivares LM, Valdez R, Sordelli DO, Aversa G, Modlin RL, Sieling PA.

J Immunol. 2001 Nov 15;167(10):5719-24.

44.
45.

Activation of toll-like receptors by microbial lipoproteins.

Sieling PA, Modlin RL.

Scand J Infect Dis. 2001;33(2):97-100. Review.

PMID:
11233858
46.

Induction of direct antimicrobial activity through mammalian toll-like receptors.

Thoma-Uszynski S, Stenger S, Takeuchi O, Ochoa MT, Engele M, Sieling PA, Barnes PF, Rollinghoff M, Bolcskei PL, Wagner M, Akira S, Norgard MV, Belisle JT, Godowski PJ, Bloom BR, Modlin RL.

Science. 2001 Feb 23;291(5508):1544-7.

47.

Role of granulysin in immunity to leprosy.

Ochoa MT, Thoma-Uszynski S, Sieling PA, Sabet S, Cho S, Krensky AM, Burdick A, Rea TH, Modlin RL.

Lepr Rev. 2000 Dec;71 Suppl:S115; discussion S115-6. No abstract available.

PMID:
11201866
48.

T-cell release of granulysin contributes to host defense in leprosy.

Ochoa MT, Stenger S, Sieling PA, Thoma-Uszynski S, Sabet S, Cho S, Krensky AM, Rollinghoff M, Nunes Sarno E, Burdick AE, Rea TH, Modlin RL.

Nat Med. 2001 Feb;7(2):174-9.

PMID:
11175847
49.

Bacterial lipopolysaccharide activates NF-kappaB through toll-like receptor 4 (TLR-4) in cultured human dermal endothelial cells. Differential expression of TLR-4 and TLR-2 in endothelial cells.

Faure E, Equils O, Sieling PA, Thomas L, Zhang FX, Kirschning CJ, Polentarutti N, Muzio M, Arditi M.

J Biol Chem. 2000 Apr 14;275(15):11058-63.

50.

The role of Toll-like receptors in host defense against microbial infection.

Krutzik SR, Sieling PA, Modlin RL.

Curr Opin Immunol. 2001 Feb;13(1):104-8.

PMID:
11154925

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