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Items: 42


Strategies, design, and chemistry in siRNA delivery systems.

Dong Y, Siegwart DJ, Anderson DG.

Adv Drug Deliv Rev. 2019 May 15. pii: S0169-409X(19)30054-7. doi: 10.1016/j.addr.2019.05.004. [Epub ahead of print]


Degradable redox-responsive disulfide-based nanogel drug carriers via dithiol oxidation polymerization.

Elkassih SA, Kos P, Xiong H, Siegwart DJ.

Biomater Sci. 2019 Jan 29;7(2):607-617. doi: 10.1039/c8bm01120f.


The Polyploid State Plays a Tumor-Suppressive Role in the Liver.

Zhang S, Zhou K, Luo X, Li L, Tu HC, Sehgal A, Nguyen LH, Zhang Y, Gopal P, Tarlow BD, Siegwart DJ, Zhu H.

Dev Cell. 2018 Nov 5;47(3):390. doi: 10.1016/j.devcel.2018.10.020. No abstract available.


Dendrimer-Based Lipid Nanoparticles Deliver Therapeutic FAH mRNA to Normalize Liver Function and Extend Survival in a Mouse Model of Hepatorenal Tyrosinemia Type I.

Cheng Q, Wei T, Jia Y, Farbiak L, Zhou K, Zhang S, Wei Y, Zhu H, Siegwart DJ.

Adv Mater. 2018 Dec;30(52):e1805308. doi: 10.1002/adma.201805308. Epub 2018 Oct 25.


Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti-PD-L1 to eliminate melanoma in mice.

Wang Y, Su L, Morin MD, Jones BT, Mifune Y, Shi H, Wang KW, Zhan X, Liu A, Wang J, Li X, Tang M, Ludwig S, Hildebrand S, Zhou K, Siegwart DJ, Moresco EMY, Zhang H, Boger DL, Beutler B.

Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):E8698-E8706. doi: 10.1073/pnas.1809232115. Epub 2018 Aug 27.


Tumor-Activated Water-Soluble Photosensitizers for Near-Infrared Photodynamic Cancer Therapy.

Xiong H, Zhou K, Yan Y, Miller JB, Siegwart DJ.

ACS Appl Mater Interfaces. 2018 May 16;10(19):16335-16343. doi: 10.1021/acsami.8b04710. Epub 2018 May 3.


The Polyploid State Plays a Tumor-Suppressive Role in the Liver.

Zhang S, Zhou K, Luo X, Li L, Tu HC, Sehgal A, Nguyen LH, Zhang Y, Gopal P, Tarlow BD, Siegwart DJ, Zhu H.

Dev Cell. 2018 Feb 26;44(4):447-459.e5. doi: 10.1016/j.devcel.2018.01.010. Epub 2018 Feb 8. Erratum in: Dev Cell. 2018 Nov 5;47(3):390.


Development of Cationic Quaternary Ammonium Sulfonamide Amino Lipids for Nucleic Acid Delivery.

Miller JB, Kos P, Tieu V, Zhou K, Siegwart DJ.

ACS Appl Mater Interfaces. 2018 Jan 24;10(3):2302-2311. doi: 10.1021/acsami.7b15982. Epub 2018 Jan 11.


Translational research to enable personalized treatment of cystic fibrosis.

Hagemeijer MC, Siegwart DJ, Strug LJ, Cebotaru L, Torres MJ, Sofoluwe A, Beekman JM.

J Cyst Fibros. 2018 Mar;17(2S):S46-S51. doi: 10.1016/j.jcf.2017.10.017. Epub 2017 Dec 21. Review.


Knockdown of Anillin Actin Binding Protein Blocks Cytokinesis in Hepatocytes and Reduces Liver Tumor Development in Mice Without Affecting Regeneration.

Zhang S, Nguyen LH, Zhou K, Tu HC, Sehgal A, Nassour I, Li L, Gopal P, Goodman J, Singal AG, Yopp A, Zhang Y, Siegwart DJ, Zhu H.

Gastroenterology. 2018 Apr;154(5):1421-1434. doi: 10.1053/j.gastro.2017.12.013. Epub 2017 Dec 21. Erratum in: Gastroenterology. 2018 Dec;155(6):2027.


Systemic mRNA Delivery to the Lungs by Functional Polyester-based Carriers.

Yan Y, Xiong H, Zhang X, Cheng Q, Siegwart DJ.

Biomacromolecules. 2017 Dec 11;18(12):4307-4315. doi: 10.1021/acs.biomac.7b01356. Epub 2017 Nov 27.


HDAC Inhibitor Conjugated Polymeric Prodrug Micelles for Doxorubicin Delivery.

Senevirathne SA, Washington KE, Miller JB, Biewer MC, Oupicky D, Siegwart DJ, Stefan MC.

J Mater Chem B. 2017 Mar 21;5(11):2106-2114. doi: 10.1039/C6TB03038F. Epub 2017 Feb 20.


High-Contrast Fluorescence Detection of Metastatic Breast Cancer Including Bone and Liver Micrometastases via Size-Controlled pH-Activatable Water-Soluble Probes.

Xiong H, Zuo H, Yan Y, Occhialini G, Zhou K, Wan Y, Siegwart DJ.

Adv Mater. 2017 Aug;29(29). doi: 10.1002/adma.201700131. Epub 2017 May 31.


Gpr132 sensing of lactate mediates tumor-macrophage interplay to promote breast cancer metastasis.

Chen P, Zuo H, Xiong H, Kolar MJ, Chu Q, Saghatelian A, Siegwart DJ, Wan Y.

Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):580-585. doi: 10.1073/pnas.1614035114. Epub 2017 Jan 3.


Non-Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co-Delivery of Cas9 mRNA and sgRNA.

Miller JB, Zhang S, Kos P, Xiong H, Zhou K, Perelman SS, Zhu H, Siegwart DJ.

Angew Chem Int Ed Engl. 2017 Jan 19;56(4):1059-1063. doi: 10.1002/anie.201610209. Epub 2016 Dec 16.


Aerosol delivery of stabilized polyester-siRNA nanoparticles to silence gene expression in orthotopic lung tumors.

Yan Y, Zhou K, Xiong H, Miller JB, Motea EA, Boothman DA, Liu L, Siegwart DJ.

Biomaterials. 2017 Feb;118:84-93. doi: 10.1016/j.biomaterials.2016.12.001. Epub 2016 Dec 2.


Intercalation-mediated nucleic acid nanoparticles for siRNA delivery.

Zhou K, Kos P, Yan Y, Xiong H, Min YL, Kinghorn KA, Minnig JT, Miller JB, Siegwart DJ.

Chem Commun (Camb). 2016 Oct 6;52(82):12155-12158.


Functional polyesters enable selective siRNA delivery to lung cancer over matched normal cells.

Yan Y, Liu L, Xiong H, Miller JB, Zhou K, Kos P, Huffman KE, Elkassih S, Norman JW, Carstens R, Kim J, Minna JD, Siegwart DJ.

Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):E5702-10. doi: 10.1073/pnas.1606886113. Epub 2016 Sep 12.


Activatable Water-Soluble Probes Enhance Tumor Imaging by Responding to Dysregulated pH and Exhibiting High Tumor-to-Liver Fluorescence Emission Contrast.

Xiong H, Kos P, Yan Y, Zhou K, Miller JB, Elkassih S, Siegwart DJ.

Bioconjug Chem. 2016 Jul 20;27(7):1737-44. doi: 10.1021/acs.bioconjchem.6b00242. Epub 2016 Jun 20.


Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer model.

Zhou K, Nguyen LH, Miller JB, Yan Y, Kos P, Xiong H, Li L, Hao J, Minnig JT, Zhu H, Siegwart DJ.

Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):520-5. doi: 10.1073/pnas.1520756113. Epub 2016 Jan 4.


One-pot Synthesis of Functional Poly(amino ester sulfide)s and Utility in Delivering pDNA and siRNA.

Yan Y, Xue L, Miller JB, Zhou K, Kos P, Elkassih S, Liu L, Nagai A, Xiong H, Siegwart DJ.

Polymer (Guildf). 2015 Aug 18;72:271-280.


Correction: biocompatible organic charge transfer complex nanoparticles based on a semi-crystalline cellulose template.

Nagai A, Miller JB, Du J, Kos P, Stefan MC, Siegwart DJ.

Chem Commun (Camb). 2015 Dec 14;51(96):17178. doi: 10.1039/c5cc90504d.


Precise let-7 expression levels balance organ regeneration against tumor suppression.

Wu L, Nguyen LH, Zhou K, de Soysa TY, Li L, Miller JB, Tian J, Locker J, Zhang S, Shinoda G, Seligson MT, Zeitels LR, Acharya A, Wang SC, Mendell JT, He X, Nishino J, Morrison SJ, Siegwart DJ, Daley GQ, Shyh-Chang N, Zhu H.

Elife. 2015 Oct 7;4:e09431. doi: 10.7554/eLife.09431.


Rapid Synthesis of a Lipocationic Polyester Library via Ring-Opening Polymerization of Functional Valerolactones for Efficacious siRNA Delivery.

Hao J, Kos P, Zhou K, Miller JB, Xue L, Yan Y, Xiong H, Elkassih S, Siegwart DJ.

J Am Chem Soc. 2015 Jul 29;137(29):9206-9. doi: 10.1021/jacs.5b03429. Epub 2015 Jul 17.


Biocompatible organic charge transfer complex nanoparticles based on a semi-crystalline cellulose template.

Nagai A, Miller JB, Du J, Kos P, Stefan MC, Siegwart DJ.

Chem Commun (Camb). 2015 Jul 28;51(59):11868-71. doi: 10.1039/c5cc03822g. Erratum in: Chem Commun (Camb). 2015 Dec 14;51(96):17178.


Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates.

Dong Y, Love KT, Dorkin JR, Sirirungruang S, Zhang Y, Chen D, Bogorad RL, Yin H, Chen Y, Vegas AJ, Alabi CA, Sahay G, Olejnik KT, Wang W, Schroeder A, Lytton-Jean AK, Siegwart DJ, Akinc A, Barnes C, Barros SA, Carioto M, Fitzgerald K, Hettinger J, Kumar V, Novobrantseva TI, Qin J, Querbes W, Koteliansky V, Langer R, Anderson DG.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):3955-60. doi: 10.1073/pnas.1322937111. Epub 2014 Feb 10. Erratum in: Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5753.


Preparation of cationic nanogels for nucleic acid delivery.

Averick SE, Paredes E, Irastorza A, Shrivats AR, Srinivasan A, Siegwart DJ, Magenau AJ, Cho HY, Hsu E, Averick AA, Kim J, Liu S, Hollinger JO, Das SR, Matyjaszewski K.

Biomacromolecules. 2012 Nov 12;13(11):3445-9. doi: 10.1021/bm301166s. Epub 2012 Oct 2.


Effect of molecular weight of amine end-modified poly(β-amino ester)s on gene delivery efficiency and toxicity.

Eltoukhy AA, Siegwart DJ, Alabi CA, Rajan JS, Langer R, Anderson DG.

Biomaterials. 2012 May;33(13):3594-603. doi: 10.1016/j.biomaterials.2012.01.046. Epub 2012 Feb 14.


Automated ARGET ATRP Accelerates Catalyst Optimization for the Synthesis of Thiol-Functionalized Polymers.

Siegwart DJ, Leiendecker M, Langer R, Anderson DG.

Macromolecules. 2012 Feb 14;45(3):1254-1261.


ATRP in the design of functional materials for biomedical applications.

Siegwart DJ, Oh JK, Matyjaszewski K.

Prog Polym Sci. 2012 Jan 1;37(1):18-37. Epub 2011 Aug 25.


Combinatorial synthesis of chemically diverse core-shell nanoparticles for intracellular delivery.

Siegwart DJ, Whitehead KA, Nuhn L, Sahay G, Cheng H, Jiang S, Ma M, Lytton-Jean A, Vegas A, Fenton P, Levins CG, Love KT, Lee H, Cortez C, Collins SP, Li YF, Jang J, Querbes W, Zurenko C, Novobrantseva T, Langer R, Anderson DG.

Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):12996-3001. doi: 10.1073/pnas.1106379108. Epub 2011 Jul 22.


Development of cationic polymer coatings to regulate foreign-body responses.

Ma M, Liu WF, Hill PS, Bratlie KM, Siegwart DJ, Chin J, Park M, Guerreiro J, Anderson DG.

Adv Mater. 2011 Jun 24;23(24):H189-94. doi: 10.1002/adma.201100513. Epub 2011 May 13. No abstract available.


A novel family of biodegradable poly(ester amide) elastomers.

Cheng H, Hill PS, Siegwart DJ, Vacanti N, Lytton-Jean AK, Cho SW, Ye A, Langer R, Anderson DG.

Adv Mater. 2011 Mar 25;23(12):H95-100. doi: 10.1002/adma.201003482. Epub 2011 Mar 10. No abstract available.


An injectable thiol-acrylate poly(ethylene glycol) hydrogel for sustained release of methylprednisolone sodium succinate.

Pritchard CD, O'Shea TM, Siegwart DJ, Calo E, Anderson DG, Reynolds FM, Thomas JA, Slotkin JR, Woodard EJ, Langer R.

Biomaterials. 2011 Jan;32(2):587-97. doi: 10.1016/j.biomaterials.2010.08.106. Epub 2010 Sep 28.


Rapid cellular internalization of multifunctional star polymers prepared by atom transfer radical polymerization.

Cho HY, Gao H, Srinivasan A, Hong J, Bencherif SA, Siegwart DJ, Paik HJ, Hollinger JO, Matyjaszewski K.

Biomacromolecules. 2010 Sep 13;11(9):2199-203. doi: 10.1021/bm1006272.


Nanoparticulate cellular patches for cell-mediated tumoritropic delivery.

Cheng H, Kastrup CJ, Ramanathan R, Siegwart DJ, Ma M, Bogatyrev SR, Xu Q, Whitehead KA, Langer R, Anderson DG.

ACS Nano. 2010 Feb 23;4(2):625-31. doi: 10.1021/nn901319y.


Nanostructured hybrid hydrogels prepared by a combination of atom transfer radical polymerization and free radical polymerization.

Bencherif SA, Siegwart DJ, Srinivasan A, Horkay F, Hollinger JO, Washburn NR, Matyjaszewski K.

Biomaterials. 2009 Oct;30(29):5270-8. doi: 10.1016/j.biomaterials.2009.06.011. Epub 2009 Jul 9.


Cellular uptake of functional nanogels prepared by inverse miniemulsion ATRP with encapsulated proteins, carbohydrates, and gold nanoparticles.

Siegwart DJ, Srinivasan A, Bencherif SA, Karunanidhi A, Oh JK, Vaidya S, Jin R, Hollinger JO, Matyjaszewski K.

Biomacromolecules. 2009 Aug 10;10(8):2300-9. doi: 10.1021/bm9004904.


Cell-adhesive star polymers prepared by ATRP.

Bencherif SA, Gao H, Srinivasan A, Siegwart DJ, Hollinger JO, Washburn NR, Matyjaszewski K.

Biomacromolecules. 2009 Jul 13;10(7):1795-803. doi: 10.1021/bm900213u. Epub 2009 Jun 11.


Synthesis, characterization, and in vitro cell culture viability of degradable poly(N-isopropylacrylamide-co-5,6-benzo-2-methylene-1,3-dioxepane)-based polymers and crosslinked gels.

Siegwart DJ, Bencherif SA, Srinivasan A, Hollinger JO, Matyjaszewski K.

J Biomed Mater Res A. 2008 Nov;87(2):345-58. doi: 10.1002/jbm.a.31708.


Synthesis and biodegradation of nanogels as delivery carriers for carbohydrate drugs.

Oh JK, Siegwart DJ, Matyjaszewski K.

Biomacromolecules. 2007 Nov;8(11):3326-31. Epub 2007 Sep 26.


Biodegradable nanogels prepared by atom transfer radical polymerization as potential drug delivery carriers: synthesis, biodegradation, in vitro release, and bioconjugation.

Oh JK, Siegwart DJ, Lee HI, Sherwood G, Peteanu L, Hollinger JO, Kataoka K, Matyjaszewski K.

J Am Chem Soc. 2007 May 9;129(18):5939-45. Epub 2007 Apr 18.


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