Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 201

1.

Simultaneous quantification of acidic and basic flupirtine metabolites by supercritical fluid chromatography according to European Medicines Agency validation.

Hofstetter RK, Hasan M, Fassauer GM, Bock C, Surur AS, Behnisch S, Grathwol CW, Potlitz F, Oergel T, Siegmund W, Link A.

J Chromatogr A. 2019 Apr 25. pii: S0021-9673(19)30452-2. doi: 10.1016/j.chroma.2019.04.067. [Epub ahead of print]

PMID:
31056272
2.

Flupirtine and retigabine as templates for ligand-based drug design of KV7.2/3 activators.

Surur AS, Bock C, Beirow K, Wurm K, Schulig L, Kindermann MK, Siegmund W, Bednarski PJ, Link A.

Org Biomol Chem. 2019 May 8;17(18):4512-4522. doi: 10.1039/c9ob00511k.

PMID:
30990511
3.

Effects of the P-Glycoprotein Inhibitor Clarithromycin on the Pharmacokinetics of Intravenous and Oral Trospium Chloride: A 4-Way Crossover Drug-Drug Interaction Study in Healthy Subjects.

Abebe BT, Weiss M, Modess C, Roustom T, Tadken T, Wegner D, Schwantes U, Neumeister C, Schulz HU, Scheuch E, Siegmund W.

J Clin Pharmacol. 2019 Apr 11. doi: 10.1002/jcph.1421. [Epub ahead of print]

PMID:
30973998
4.

Flupirtine Analogues: Explorative Synthesis and Influence of Chemical Structure on KV7.2/KV7.3 Channel Opening Activity.

Surur AS, Beirow K, Bock C, Schulig L, Kindermann MK, Bodtke A, Siegmund W, Bednarski PJ, Link A.

ChemistryOpen. 2019 Jan 15;8(1):41-44. doi: 10.1002/open.201800244. eCollection 2019 Jan.

5.

Preventable ADRs leading to hospitalization - results of a long-term prospective safety study with 6,427 ADR cases focusing on elderly patients.

Schmiedl S, Rottenkolber M, Szymanski J, Drewelow B, Siegmund W, Hippius M, Farker K, Guenther IR, Hasford J, Thuermann PA; German Net of Regional Pharmacovigilance Centers (NRPC).

Expert Opin Drug Saf. 2018 Feb;17(2):125-137. doi: 10.1080/14740338.2018.1415322. Epub 2017 Dec 19.

PMID:
29258401
6.

Intestinal and hepatic contributions to the pharmacokinetic interaction between gamithromycin and rifampicin after single-dose and multiple-dose administration in healthy foals.

Berlin S, Wallstabe S, Scheuch E, Oswald S, Hasan M, Wegner D, Grube M, Venner M, Ullrich A, Siegmund W.

Equine Vet J. 2018 Jul;50(4):525-531. doi: 10.1111/evj.12796. Epub 2018 Jan 8.

PMID:
29239016
7.

Ketamine metabolites with antidepressant effects: Fast, economical, and eco-friendly enantioselective separation based on supercritical-fluid chromatography (SFC) and single quadrupole MS detection.

Fassauer GM, Hofstetter R, Hasan M, Oswald S, Modeß C, Siegmund W, Link A.

J Pharm Biomed Anal. 2017 Nov 30;146:410-419. doi: 10.1016/j.jpba.2017.09.007. Epub 2017 Sep 8.

PMID:
28926735
8.

Clinically Relevant Multidrug Transporters Are Regulated by microRNAs along the Human Intestine.

Bruckmueller H, Martin P, Kähler M, Haenisch S, Ostrowski M, Drozdzik M, Siegmund W, Cascorbi I, Oswald S.

Mol Pharm. 2017 Jul 3;14(7):2245-2253. doi: 10.1021/acs.molpharmaceut.7b00076. Epub 2017 Jun 2.

PMID:
28510455
9.

Muscle Injury After Intramuscular Administration of Diclofenac: A Case Report Supported by Magnetic Resonance Imaging.

Probst M, Kühn JP, Modeß C, Scheuch E, Seidlitz A, Hosten N, Siegmund W, Weitschies W.

Drug Saf Case Rep. 2017 Dec;4(1):7. doi: 10.1007/s40800-017-0049-9.

10.

Pharmacokinetics and pulmonary distribution of gamithromycin after intravenous administration in foals.

Berlin S, Randow T, Scheuch E, Grube M, Venner M, Siegmund W.

J Vet Pharmacol Ther. 2017 Aug;40(4):406-410. doi: 10.1111/jvp.12402. Epub 2017 Mar 19.

PMID:
28317153
11.

Quantitative chiral and achiral determination of ketamine and its metabolites by LC-MS/MS in human serum, urine and fecal samples.

Hasan M, Hofstetter R, Fassauer GM, Link A, Siegmund W, Oswald S.

J Pharm Biomed Anal. 2017 May 30;139:87-97. doi: 10.1016/j.jpba.2017.02.035. Epub 2017 Feb 27.

PMID:
28279931
12.

Pharmacological indices and pulmonary distribution of rifampicin after repeated oral administration in healthy foals.

Berlin S, Kirschbaum A, Spieckermann L, Oswald S, Keiser M, Grube M, Venner M, Siegmund W.

Equine Vet J. 2017 Sep;49(5):618-623. doi: 10.1111/evj.12662. Epub 2017 Feb 25.

PMID:
28063154
13.

Effects of frequently used pharmaceutical excipients on the organic cation transporters 1-3 and peptide transporters 1/2 stably expressed in MDCKII cells.

Otter M, Oswald S, Siegmund W, Keiser M.

Eur J Pharm Biopharm. 2017 Mar;112:187-195. doi: 10.1016/j.ejpb.2016.11.028. Epub 2016 Nov 27.

PMID:
27903454
14.

Trospium chloride is absorbed from two intestinal "absorption windows" with different permeability in healthy subjects.

Tadken T, Weiss M, Modess C, Wegner D, Roustom T, Neumeister C, Schwantes U, Schulz HU, Weitschies W, Siegmund W.

Int J Pharm. 2016 Dec 30;515(1-2):367-373. doi: 10.1016/j.ijpharm.2016.10.030. Epub 2016 Oct 17.

PMID:
27765726
15.

Resolving the physiological conditions in bioavailability and bioequivalence studies: Comparison of fasted and fed state.

Schneider F, Grimm M, Koziolek M, Modeß C, Dokter A, Roustom T, Siegmund W, Weitschies W.

Eur J Pharm Biopharm. 2016 Nov;108:214-219. doi: 10.1016/j.ejpb.2016.09.009. Epub 2016 Sep 14.

PMID:
27639346
16.

Rapid LC-MS/MS method for the determination of 4-hydroxycholesterol/cholesterol ratio in serum as endogenous biomarker for CYP3A activity in human and foals.

Hasan M, Siegmund W, Oswald S.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Oct 15;1033-1034:193-199. doi: 10.1016/j.jchromb.2016.08.006. Epub 2016 Aug 5.

PMID:
27565568
17.

Expression of Organic Anion Transporting Polypeptide 1A2 in Red Blood Cells and Its Potential Impact on Antimalarial Therapy.

Hubeny A, Keiser M, Oswald S, Jedlitschky G, Kroemer HK, Siegmund W, Grube M.

Drug Metab Dispos. 2016 Oct;44(10):1562-8. doi: 10.1124/dmd.116.069807. Epub 2016 Aug 8.

PMID:
27504015
18.

Navigating the human gastrointestinal tract for oral drug delivery: Uncharted waters and new frontiers.

Koziolek M, Grimm M, Schneider F, Jedamzik P, Sager M, Kühn JP, Siegmund W, Weitschies W.

Adv Drug Deliv Rev. 2016 Jun 1;101:75-88. doi: 10.1016/j.addr.2016.03.009. Epub 2016 Mar 29. Review.

PMID:
27037063
19.

Simultaneous magnetic resonance imaging and pharmacokinetic analysis of intramuscular depots.

Probst M, Kühn JP, Scheuch E, Seidlitz A, Hadlich S, Evert K, Oswald S, Siegmund W, Weitschies W.

J Control Release. 2016 Apr 10;227:1-12. doi: 10.1016/j.jconrel.2016.02.029. Epub 2016 Feb 17.

PMID:
26899995
20.

Pharmacokinetics and Pulmonary Distribution of Clarithromycin and Rifampicin after Concomitant and Consecutive Administration in Foals.

Berlin S, Spieckermann L, Oswald S, Keiser M, Lumpe S, Ullrich A, Grube M, Hasan M, Venner M, Siegmund W.

Mol Pharm. 2016 Mar 7;13(3):1089-99. doi: 10.1021/acs.molpharmaceut.5b00907. Epub 2016 Feb 11.

PMID:
26808255
21.

Pharmacokinetics and pharmacodynamics of ch14.18/CHO in relapsed/refractory high-risk neuroblastoma patients treated by long-term infusion in combination with IL-2.

Siebert N, Eger C, Seidel D, Jüttner M, Zumpe M, Wegner D, Kietz S, Ehlert K, Veal GJ, Siegmund W, Weiss M, Loibner H, Ladenstein R, Lode HN.

MAbs. 2016;8(3):604-16. doi: 10.1080/19420862.2015.1130196. Epub 2016 Jan 19.

22.

Rapid Tolerance to Constipating Effects of Loperamide in Healthy Subjects.

Kolbow J, Weitschies W, Siegmund W.

J Clin Pharmacol. 2016 Feb;56(2):248-9. doi: 10.1002/jcph.659. No abstract available.

PMID:
26780488
23.

Intragastric pH and pressure profiles after intake of the high-caloric, high-fat meal as used for food effect studies.

Koziolek M, Schneider F, Grimm M, Modeβ C, Seekamp A, Roustom T, Siegmund W, Weitschies W.

J Control Release. 2015 Dec 28;220(Pt A):71-78. doi: 10.1016/j.jconrel.2015.10.022. Epub 2015 Oct 22.

PMID:
26476174
24.

Extended-release but not immediate-release and subcutaneous methylnaltrexone antagonizes the loperamide-induced delay of whole-gut transit time in healthy subjects.

Kolbow J, Modess C, Wegner D, Oswald S, Maritz MA, Rey H, Weitschies W, Siegmund W.

J Clin Pharmacol. 2016 Feb;56(2):239-45. doi: 10.1002/jcph.624. Epub 2015 Oct 20.

PMID:
26313157
25.

Modeling the heterogeneous intestinal absorption of propiverine extended-release.

Weiss M, Sermsappasuk P, Siegmund W.

Eur J Pharm Sci. 2015 Aug 30;76:133-7. doi: 10.1016/j.ejps.2015.05.010. Epub 2015 May 11.

PMID:
25976222
26.

Expression of drug transporters and drug metabolizing enzymes in the bladder urothelium in man and affinity of the bladder spasmolytic trospium chloride to transporters likely involved in its pharmacokinetics.

Bexten M, Oswald S, Grube M, Jia J, Graf T, Zimmermann U, Rodewald K, Zolk O, Schwantes U, Siegmund W, Keiser M.

Mol Pharm. 2015 Jan 5;12(1):171-8. doi: 10.1021/mp500532x. Epub 2014 Dec 10.

PMID:
25466967
27.

Quantitative LC-MS/MS determination of flupirtine, its N-acetylated and two mercapturic acid derivatives in man.

Scheuch E, Methling K, Bednarski PJ, Oswald S, Siegmund W.

J Pharm Biomed Anal. 2015 Jan;102:377-85. doi: 10.1016/j.jpba.2014.09.010. Epub 2014 Sep 21.

PMID:
25459937
28.

Function-impairing polymorphisms of the hepatic uptake transporter SLCO1B1 modify the therapeutic efficacy of statins in a population-based cohort.

Meyer zu Schwabedissen HE, Albers M, Baumeister SE, Rimmbach C, Nauck M, Wallaschofski H, Siegmund W, Völzke H, Kroemer HK.

Pharmacogenet Genomics. 2015 Jan;25(1):8-18. doi: 10.1097/FPC.0000000000000098.

PMID:
25379722
29.

Creatine kinase elevation caused by a combination of fluvastatin and telmisartan in a patient heterozygous for the CYP2C9*3 and ABCC2 -24C > T variants: a case report.

Meyer zu Schwabedissen HE, Siegmund W, Kroemer HK, Rollnik JD.

BMC Res Notes. 2014 Oct 3;7:688. doi: 10.1186/1756-0500-7-688.

30.

Metabolic activation and analgesic effect of flupirtine in healthy subjects, influence of the polymorphic NAT2, UGT1A1 and GSTP1.

Siegmund W, Modess C, Scheuch E, Methling K, Keiser M, Nassif A, Rosskopf D, Bednarski PJ, Borlak J, Terhaag B.

Br J Clin Pharmacol. 2015 Mar;79(3):501-13. doi: 10.1111/bcp.12522.

31.

Absolute protein quantification of clinically relevant cytochrome P450 enzymes and UDP-glucuronosyltransferases by mass spectrometry-based targeted proteomics.

Gröer C, Busch D, Patrzyk M, Beyer K, Busemann A, Heidecke CD, Drozdzik M, Siegmund W, Oswald S.

J Pharm Biomed Anal. 2014 Nov;100:393-401. doi: 10.1016/j.jpba.2014.08.016. Epub 2014 Aug 17.

PMID:
25218440
32.

LC-MS/MS method for the determination of clodronate in human plasma.

Hasan M, Schumacher G, Seekamp A, Taedken T, Siegmund W, Oswald S.

J Pharm Biomed Anal. 2014 Nov;100:341-347. doi: 10.1016/j.jpba.2014.08.022. Epub 2014 Aug 23.

PMID:
25194348
33.

Protein abundance of clinically relevant multidrug transporters along the entire length of the human intestine.

Drozdzik M, Gröer C, Penski J, Lapczuk J, Ostrowski M, Lai Y, Prasad B, Unadkat JD, Siegmund W, Oswald S.

Mol Pharm. 2014 Oct 6;11(10):3547-55. doi: 10.1021/mp500330y. Epub 2014 Sep 11.

PMID:
25158075
34.

Targeted adsorption of molecules in the colon with the novel adsorbent-based medicinal product, DAV132: A proof of concept study in healthy subjects.

de Gunzburg J, Ducher A, Modess C, Wegner D, Oswald S, Dressman J, Augustin V, Feger C, Andremont A, Weitschies W, Siegmund W.

J Clin Pharmacol. 2015 Jan;55(1):10-6. doi: 10.1002/jcph.359. Epub 2014 Jul 16.

PMID:
25042595
35.

Feasibility of gadoxetate disodium-enhanced MR cholangiography in chronic cholestatic biliary disease.

Kühn JP, Spoerl M, Nassif A, Mester M, Weitschies W, Siegmund W, Hosten N, Mensel B.

Clin Radiol. 2014 Oct;69(10):1027-33. doi: 10.1016/j.crad.2014.05.009. Epub 2014 Jun 21.

PMID:
24957855
36.

Cohort profile: Greifswald approach to individualized medicine (GANI_MED).

Grabe HJ, Assel H, Bahls T, Dörr M, Endlich K, Endlich N, Erdmann P, Ewert R, Felix SB, Fiene B, Fischer T, Flessa S, Friedrich N, Gadebusch-Bondio M, Salazar MG, Hammer E, Haring R, Havemann C, Hecker M, Hoffmann W, Holtfreter B, Kacprowski T, Klein K, Kocher T, Kock H, Krafczyk J, Kuhn J, Langanke M, Lendeckel U, Lerch MM, Lieb W, Lorbeer R, Mayerle J, Meissner K, zu Schwabedissen HM, Nauck M, Ott K, Rathmann W, Rettig R, Richardt C, Saljé K, Schminke U, Schulz A, Schwab M, Siegmund W, Stracke S, Suhre K, Ueffing M, Ungerer S, Völker U, Völzke H, Wallaschofski H, Werner V, Zygmunt MT, Kroemer HK.

J Transl Med. 2014 May 23;12:144. doi: 10.1186/1479-5876-12-144.

37.

T1 bias in chemical shift-encoded liver fat-fraction: role of the flip angle.

Kühn JP, Jahn C, Hernando D, Siegmund W, Hadlich S, Mayerle J, Pfannmöller J, Langner S, Reeder S.

J Magn Reson Imaging. 2014 Oct;40(4):875-83. doi: 10.1002/jmri.24457. Epub 2013 Nov 15.

38.

OATP1B3 is expressed in pancreatic β-islet cells and enhances the insulinotropic effect of the sulfonylurea derivative glibenclamide.

Meyer Zu Schwabedissen HE, Boettcher K, Steiner T, Schwarz UI, Keiser M, Kroemer HK, Siegmund W.

Diabetes. 2014 Feb;63(2):775-84. doi: 10.2337/db13-1005. Epub 2013 Oct 22.

39.

Characterization of the intestinal and hepatic uptake/efflux transport of the magnetic resonance imaging contrast agent gadolinium-ethoxylbenzyl-diethylenetriamine-pentaacetic acid.

Jia J, Puls D, Oswald S, Jedlitschky G, Kühn JP, Weitschies W, Hosten N, Siegmund W, Keiser M.

Invest Radiol. 2014 Feb;49(2):78-86. doi: 10.1097/RLI.0b013e3182a70043.

PMID:
24056116
40.

Mass spectrometry-based targeted proteomics as a tool to elucidate the expression and function of intestinal drug transporters.

Oswald S, Gröer C, Drozdzik M, Siegmund W.

AAPS J. 2013 Oct;15(4):1128-40. doi: 10.1208/s12248-013-9521-3. Epub 2013 Aug 28. Review.

41.

LC-MS/MS-based quantification of clinically relevant intestinal uptake and efflux transporter proteins.

Gröer C, Brück S, Lai Y, Paulick A, Busemann A, Heidecke CD, Siegmund W, Oswald S.

J Pharm Biomed Anal. 2013 Nov;85:253-61. doi: 10.1016/j.jpba.2013.07.031. Epub 2013 Aug 5.

PMID:
23973632
42.

Response.

Nassif A, Siegmund W, Keiser M, Weitschies W, Kühn JP.

Radiology. 2013 Apr;267(1):315. No abstract available.

PMID:
23641488
43.

Bleeding complications and liver injuries during phenprocoumon treatment: a multicentre prospective observational study in internal medicine departments.

Schmiedl S, Rottenkolber M, Szymanski J, Siegmund W, Hippius M, Farker K, Drewelow B, Hasford J, Thürmann P.

Dtsch Arztebl Int. 2013 Apr;110(14):244-52. doi: 10.3238/arztebl.2013.0244. Epub 2013 Apr 5.

44.

The role of individual gastric emptying of pellets in the prediction of diclofenac in vivo dissolution.

Klein S, Garbacz G, Pišlar M, Locatelli I, Liu C, Weitschies W, Siegmund W, Mrhar A, Bogataj M.

J Control Release. 2013 Mar 28;166(3):286-93. doi: 10.1016/j.jconrel.2012.12.032. Epub 2013 Jan 8.

PMID:
23306025
45.

Steroid hormones specifically modify the activity of organic anion transporting polypeptides.

Koenen A, Köck K, Keiser M, Siegmund W, Kroemer HK, Grube M.

Eur J Pharm Sci. 2012 Nov 20;47(4):774-80. doi: 10.1016/j.ejps.2012.08.017. Epub 2012 Sep 8.

PMID:
22982504
46.

Pharmaceutical excipients influence the function of human uptake transporting proteins.

Engel A, Oswald S, Siegmund W, Keiser M.

Mol Pharm. 2012 Sep 4;9(9):2577-81. doi: 10.1021/mp3001815. Epub 2012 Aug 1.

PMID:
22808947
47.

Visualization of hepatic uptake transporter function in healthy subjects by using gadoxetic acid-enhanced MR imaging.

Nassif A, Jia J, Keiser M, Oswald S, Modess C, Nagel S, Weitschies W, Hosten N, Siegmund W, Kühn JP.

Radiology. 2012 Sep;264(3):741-50. doi: 10.1148/radiol.12112061. Epub 2012 Jul 6.

PMID:
22771883
48.

Compartment-specific gene regulation of the CAR inducer efavirenz in vivo.

Meyer zu Schwabedissen HE, Oswald S, Bresser C, Nassif A, Modess C, Desta Z, Ogburn ET, Marinova M, Lütjohann D, Spielhagen C, Nauck M, Kroemer HK, Siegmund W.

Clin Pharmacol Ther. 2012 Jul;92(1):103-11. doi: 10.1038/clpt.2012.34. Epub 2012 May 16. Erratum in: Clin Pharmacol Ther. 2013 Jan;93(1):129. Dosage error in article text.

49.

Relative bioavailability and pharmacodynamic effects of methantheline compared with atropine in healthy subjects.

Müller C, Lötsch J, Giessmann T, Franke G, Walter R, Zschiesche M, Siegmund W.

Eur J Clin Pharmacol. 2012 Nov;68(11):1473-81. doi: 10.1007/s00228-012-1286-6. Epub 2012 Apr 21.

PMID:
22527350
50.

A LC-MS/MS method to evaluate the hepatic uptake of the liver-specific magnetic resonance imaging contrast agent gadoxetate (Gd-EOB-DTPA) in vitro and in humans.

Jia J, Keiser M, Nassif A, Siegmund W, Oswald S.

J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Apr 1;891-892:20-6. doi: 10.1016/j.jchromb.2012.02.014. Epub 2012 Feb 18.

PMID:
22391331

Supplemental Content

Loading ...
Support Center