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Items: 1 to 50 of 193

1.

Mutational signatures in colon cancer.

Pandey P, Yang Z, Shibata D, Marjoram P, Siegmund KD.

BMC Res Notes. 2019 Dec 3;12(1):788. doi: 10.1186/s13104-019-4820-0.

2.

Loss-of-function phenotype of a PKCθT219A knockin mouse strain.

Thuille N, Siegmund K, Klepsch V, Schörgenhuber J, Danklmaier S, Leitges M, Baier G.

Cell Commun Signal. 2019 Nov 6;17(1):141. doi: 10.1186/s12964-019-0466-8.

3.

Systematic Review and Meta-analysis of Testicular Germ Cell Tumors Following In Utero Exposure to Diethylstilbestrol.

Hom M, Sriprasert I, Ihenacho U, Castelao JE, Siegmund K, Bernstein L, Cortessis VK.

JNCI Cancer Spectr. 2019 Jun 28;3(3):pkz045. doi: 10.1093/jncics/pkz045. eCollection 2019 Sep.

4.

HiLDA: a statistical approach to investigate differences in mutational signatures.

Yang Z, Pandey P, Shibata D, Conti DV, Marjoram P, Siegmund KD.

PeerJ. 2019 Aug 28;7:e7557. doi: 10.7717/peerj.7557. eCollection 2019.

5.

Mutations in a conserved loop in the PSST subunit of respiratory complex I affect ubiquinone binding and dynamics.

Galemou Yoga E, Haapanen O, Wittig I, Siegmund K, Sharma V, Zickermann V.

Biochim Biophys Acta Bioenerg. 2019 Jul 1;1860(7):573-581. doi: 10.1016/j.bbabio.2019.06.006. Epub 2019 Jun 19.

6.

Novel mutant mouse line emphasizes the importance of protein kinase C theta for CD4+ T lymphocyte activation.

Siegmund K, Thuille N, Posch N, Fresser F, Leitges M, Baier G.

Cell Commun Signal. 2019 May 28;17(1):56. doi: 10.1186/s12964-019-0364-0.

7.

Deregulation of Biologically Significant Genes and Associated Molecular Pathways in the Oral Epithelium of Electronic Cigarette Users.

Tommasi S, Caliri AW, Caceres A, Moreno DE, Li M, Chen Y, Siegmund KD, Besaratinia A.

Int J Mol Sci. 2019 Feb 10;20(3). pii: E738. doi: 10.3390/ijms20030738.

8.

DNA methylation patterns of adult survivors of adolescent/young adult Hodgkin lymphoma compared to their unaffected monozygotic twin.

Wang J, Van Den Berg D, Hwang AE, Weisenberger D, Triche T, Nathwani BN, Conti DV, Siegmund K, Mack TM, Horvath S, Cozen W.

Leuk Lymphoma. 2019 Jun;60(6):1429-1437. doi: 10.1080/10428194.2018.1533128. Epub 2019 Jan 22.

PMID:
30668190
9.

Disruption of Coronin 1 Signaling in T Cells Promotes Allograft Tolerance while Maintaining Anti-Pathogen Immunity.

Jayachandran R, Gumienny A, Bolinger B, Ruehl S, Lang MJ, Fucile G, Mazumder S, Tchang V, Woischnig AK, Stiess M, Kunz G, Claudi B, Schmaler M, Siegmund K, Li J, Dertschnig S, Holländer G, Medina E, Karrer U, Moshous D, Bumann D, Khanna N, Rossi SW, Pieters J.

Immunity. 2019 Jan 15;50(1):152-165.e8. doi: 10.1016/j.immuni.2018.12.011. Epub 2019 Jan 2.

PMID:
30611611
10.

Epigenetic Heterogeneity in Human Colorectal Tumors Reveals Preferential Conservation And Evidence of Immune Surveillance.

Ryser MD, Yu M, Grady W, Siegmund K, Shibata D.

Sci Rep. 2018 Nov 23;8(1):17292. doi: 10.1038/s41598-018-35621-y.

11.

Locking loop movement in the ubiquinone pocket of complex I disengages the proton pumps.

Cabrera-Orefice A, Yoga EG, Wirth C, Siegmund K, Zwicker K, Guerrero-Castillo S, Zickermann V, Hunte C, Brandt U.

Nat Commun. 2018 Oct 29;9(1):4500. doi: 10.1038/s41467-018-06955-y.

12.

Data integration by multi-tuning parameter elastic net regression.

Liu J, Liang G, Siegmund KD, Lewinger JP.

BMC Bioinformatics. 2018 Oct 10;19(1):369. doi: 10.1186/s12859-018-2401-1.

13.

Cryo-EM structure of respiratory complex I at work.

Parey K, Brandt U, Xie H, Mills DJ, Siegmund K, Vonck J, Kühlbrandt W, Zickermann V.

Elife. 2018 Oct 2;7. pii: e39213. doi: 10.7554/eLife.39213.

14.

Association between AXL promoter methylation and lung function growth during adolescence.

Gao L, Urman R, Millstein J, Siegmund KD, Dubeau L, Breton CV.

Epigenetics. 2018;13(10-11):1027-1038. doi: 10.1080/15592294.2018.1529517. Epub 2018 Oct 19.

15.

Association of internal smoking dose with blood DNA methylation in three racial/ethnic populations.

Park SL, Patel YM, Loo LWM, Mullen DJ, Offringa IA, Maunakea A, Stram DO, Siegmund K, Murphy SE, Tiirikainen M, Le Marchand L.

Clin Epigenetics. 2018 Aug 23;10(1):110. doi: 10.1186/s13148-018-0543-7.

16.

Self-reported prenatal tobacco smoke exposure, AXL gene-body methylation, and childhood asthma phenotypes.

Gao L, Liu X, Millstein J, Siegmund KD, Dubeau L, Maguire RL, Jim Zhang J, Fuemmeler BF, Kollins SH, Hoyo C, Murphy SK, Breton CV.

Clin Epigenetics. 2018 Jul 20;10(1):98. doi: 10.1186/s13148-018-0532-x.

17.

Spatial mutation patterns as markers of early colorectal tumor cell mobility.

Ryser MD, Min BH, Siegmund KD, Shibata D.

Proc Natl Acad Sci U S A. 2018 May 29;115(22):5774-5779. doi: 10.1073/pnas.1716552115. Epub 2018 May 14.

18.

Comprehensive meta-analysis reveals association between multiple imprinting disorders and conception by assisted reproductive technology.

Cortessis VK, Azadian M, Buxbaum J, Sanogo F, Song AY, Sriprasert I, Wei PC, Yu J, Chung K, Siegmund KD.

J Assist Reprod Genet. 2018 Jun;35(6):943-952. doi: 10.1007/s10815-018-1173-x. Epub 2018 Apr 25. Review.

19.

Epigenetic regulation of AXL and risk of childhood asthma symptoms.

Gao L, Millstein J, Siegmund KD, Dubeau L, Maguire R, Gilliland FD, Murphy SK, Hoyo C, Breton CV.

Clin Epigenetics. 2017 Nov 7;9:121. doi: 10.1186/s13148-017-0421-8. eCollection 2017.

20.

Impact of Chromosomal Rearrangement upon DNA Methylation Patterns in Leukemia.

Byun HM, Eshaghian S, Douer D, Trent J, Garcia-Manero G, Bhatia R, Siegmund K, Yang AS.

Open Med (Wars). 2017 May 4;12:76-85. doi: 10.1515/med-2017-0014. eCollection 2017.

21.

Protein kinase C theta is dispensable for suppression mediated by CD25+CD4+ regulatory T cells.

Siegmund K, Thuille N, Wachowicz K, Hermann-Kleiter N, Baier G.

PLoS One. 2017 May 22;12(5):e0175463. doi: 10.1371/journal.pone.0175463. eCollection 2017.

22.

Early mutation bursts in colorectal tumors.

Zhao J, Salomon MP, Shibata D, Curtis C, Siegmund K, Marjoram P.

PLoS One. 2017 Mar 3;12(3):e0172516. doi: 10.1371/journal.pone.0172516. eCollection 2017.

23.

Identifying aggressive prostate cancer foci using a DNA methylation classifier.

Mundbjerg K, Chopra S, Alemozaffar M, Duymich C, Lakshminarasimhan R, Nichols PW, Aron M, Siegmund KD, Ukimura O, Aron M, Stern M, Gill P, Carpten JD, Ørntoft TF, Sørensen KD, Weisenberger DJ, Jones PA, Duddalwar V, Gill I, Liang G.

Genome Biol. 2017 Jan 12;18(1):3. doi: 10.1186/s13059-016-1129-3.

24.

Genetic complexity at expression quantitative trait loci.

Cantor RM, Pan C, Siegmund K.

BMC Proc. 2016 Oct 18;10(Suppl 7):85-89. eCollection 2016.

25.

Cross-Species Transcriptome Profiling Identifies New Alveolar Epithelial Type I Cell-Specific Genes.

Marconett CN, Zhou B, Sunohara M, Pouldar TM, Wang H, Liu Y, Rieger ME, Tran E, Flodby P, Siegmund KD, Crandall ED, Laird-Offringa IA, Borok Z.

Am J Respir Cell Mol Biol. 2017 Mar;56(3):310-321. doi: 10.1165/rcmb.2016-0071OC.

26.

Role for coronin 1 in mouse NK cell function.

Tchang VSY, Stiess M, Siegmund K, Karrer U, Pieters J.

Immunobiology. 2017 Feb;222(2):291-300. doi: 10.1016/j.imbio.2016.09.011. Epub 2016 Sep 20.

PMID:
27717523
27.

Improving needle biopsy accuracy in small renal mass using tumor-specific DNA methylation markers.

Chopra S, Liu J, Alemozaffar M, Nichols PW, Aron M, Weisenberger DJ, Collings CK, Syan S, Hu B, Desai M, Aron M, Duddalwar V, Gill I, Liang G, Siegmund KD.

Oncotarget. 2017 Jan 17;8(3):5439-5448. doi: 10.18632/oncotarget.12276.

28.

Proof of Principle for a T Lymphocyte Intrinsic Function of Coronin 1A.

Siegmund K, Klepsch V, Hermann-Kleiter N, Baier G.

J Biol Chem. 2016 Oct 14;291(42):22086-22092. Epub 2016 Aug 26.

29.

Role of PKCtheta in macrophage-mediated immune response to Salmonella typhimurium infection in mice.

Pfeifhofer-Obermair C, Albrecht-Schgoer K, Peer S, Nairz M, Siegmund K, Klepsch V, Haschka D, Thuille N, Hermann-Kleiter N, Gruber T, Weiss G, Baier G.

Cell Commun Signal. 2016 Jul 28;14(1):14. doi: 10.1186/s12964-016-0137-y.

30.

An evaluation of processing methods for HumanMethylation450 BeadChip data.

Liu J, Siegmund KD.

BMC Genomics. 2016 Jun 22;17:469. doi: 10.1186/s12864-016-2819-7.

31.

Particulate matter, the newborn methylome, and cardio-respiratory health outcomes in childhood.

Breton CV, Gao L, Yao J, Siegmund KD, Lurmann F, Gilliland F.

Environ Epigenet. 2016 Jun 12;2(2):dvw005. doi: 10.1093/eep/dvw005. eCollection 2016 Apr.

32.

Prenatal Air Pollution Exposures, DNA Methyl Transferase Genotypes, and Associations with Newborn LINE1 and Alu Methylation and Childhood Blood Pressure and Carotid Intima-Media Thickness in the Children's Health Study.

Breton CV, Yao J, Millstein J, Gao L, Siegmund KD, Mack W, Whitfield-Maxwell L, Lurmann F, Hodis H, Avol E, Gilliland FD.

Environ Health Perspect. 2016 Dec;124(12):1905-1912. Epub 2016 May 24.

33.

At least two well-spaced samples are needed to genotype a solid tumor.

Siegmund K, Shibata D.

BMC Cancer. 2016 Mar 25;16:250. doi: 10.1186/s12885-016-2202-8.

34.

Identification of DNA Methylation-Independent Epigenetic Events Underlying Clear Cell Renal Cell Carcinoma.

Becket E, Chopra S, Duymich CE, Lin JJ, You JS, Pandiyan K, Nichols PW, Siegmund KD, Charlet J, Weisenberger DJ, Jones PA, Liang G.

Cancer Res. 2016 Apr 1;76(7):1954-64. doi: 10.1158/0008-5472.CAN-15-2622. Epub 2016 Jan 12.

35.

"Lung packing" in breath hold-diving: An impressive case of pulmo-cardiac interaction.

Schipke JD, Kelm M, Siegmund K, Muth T, Sievers B, Steiner S.

Respir Med Case Rep. 2015 Sep 16;16:120-1. doi: 10.1016/j.rmcr.2015.09.007. eCollection 2015.

36.

The Nuclear Orphan Receptor NR2F6 Is a Central Checkpoint for Cancer Immune Surveillance.

Hermann-Kleiter N, Klepsch V, Wallner S, Siegmund K, Klepsch S, Tuzlak S, Villunger A, Kaminski S, Pfeifhofer-Obermair C, Gruber T, Wolf D, Baier G.

Cell Rep. 2015 Sep 29;12(12):2072-85. doi: 10.1016/j.celrep.2015.08.035. Epub 2015 Sep 17.

37.

Many private mutations originate from the first few divisions of a human colorectal adenoma.

Kang H, Salomon MP, Sottoriva A, Zhao J, Toy M, Press MF, Curtis C, Marjoram P, Siegmund K, Shibata D.

J Pathol. 2015 Nov;237(3):355-62. doi: 10.1002/path.4581. Epub 2015 Aug 3.

38.

Loss of consciousness via oculocardiac reflex during deep breath-hold diving. A case report.

Schipke JD, Siegmund K, Taher A, Krüll M, Cleveland S, Kelm M, Steiner S.

Int J Cardiol. 2015 Aug 15;193:56-7. doi: 10.1016/j.ijcard.2015.05.054. Epub 2015 May 12. No abstract available.

PMID:
26005177
39.

Identifying differential transcription factor binding in ChIP-seq.

Wu DY, Bittencourt D, Stallcup MR, Siegmund KD.

Front Genet. 2015 Apr 29;6:169. doi: 10.3389/fgene.2015.00169. eCollection 2015.

40.

Novel protein kinase C θ: coronin 1A complex in T lymphocytes.

Siegmund K, Thuille N, Posch N, Fresser F, Baier G.

Cell Commun Signal. 2015 Mar 31;13:22. doi: 10.1186/s12964-015-0100-3.

41.

A Big Bang model of human colorectal tumor growth.

Sottoriva A, Kang H, Ma Z, Graham TA, Salomon MP, Zhao J, Marjoram P, Siegmund K, Press MF, Shibata D, Curtis C.

Nat Genet. 2015 Mar;47(3):209-16. doi: 10.1038/ng.3214. Epub 2015 Feb 9.

42.

Association of the colorectal CpG island methylator phenotype with molecular features, risk factors, and family history.

Weisenberger DJ, Levine AJ, Long TI, Buchanan DD, Walters R, Clendenning M, Rosty C, Joshi AD, Stern MC, LeMarchand L, Lindor NM, Daftary D, Gallinger S, Selander T, Bapat B, Newcomb PA, Campbell PT, Casey G, Ahnen DJ, Baron JA, Haile RW, Hopper JL, Young JP, Laird PW, Siegmund KD; Colon Cancer Family Registry.

Cancer Epidemiol Biomarkers Prev. 2015 Mar;24(3):512-519. doi: 10.1158/1055-9965.EPI-14-1161. Epub 2015 Jan 13.

43.

Structural biology. Mechanistic insight from the crystal structure of mitochondrial complex I.

Zickermann V, Wirth C, Nasiri H, Siegmund K, Schwalbe H, Hunte C, Brandt U.

Science. 2015 Jan 2;347(6217):44-9. doi: 10.1126/science.1259859.

44.

Distinct, genome-wide, gene-specific selectivity patterns of four glucocorticoid receptor coregulators.

Wu DY, Ou CY, Chodankar R, Siegmund KD, Stallcup MR.

Nucl Recept Signal. 2014 Nov 4;12:e002. doi: 10.1621/nrs.12002. eCollection 2014.

45.

Transcriptomic Profiling of Primary Alveolar Epithelial Cell Differentiation in Human and Rat.

Marconett CN, Zhou B, Siegmund KD, Borok Z, Laird-Offringa IA.

Genom Data. 2014 Dec 1;2:105-109.

46.

Corrigendum to "Coronin 1 is dispensable for leukocyte recruitment and liver injury in concanavalin A-induced hepatitis" [Immunol. Lett. 153 (1-2) (2013) 62-70].

Siegmund K, Lee WY, Tchang VS, Stiess M, Terracciano L, Kubes P, Pieters J.

Immunol Lett. 2014 Jul;160(1):105. doi: 10.1016/j.imlet.2014.04.002. Epub 2014 Apr 13. No abstract available.

PMID:
28859836
47.

Prenatal tobacco smoke exposure is associated with childhood DNA CpG methylation.

Breton CV, Siegmund KD, Joubert BR, Wang X, Qui W, Carey V, Nystad W, Håberg SE, Ober C, Nicolae D, Barnes KC, Martinez F, Liu A, Lemanske R, Strunk R, Weiss S, London S, Gilliland F, Raby B; Asthma BRIDGE consortium.

PLoS One. 2014 Jun 25;9(6):e99716. doi: 10.1371/journal.pone.0099716. eCollection 2014. Erratum in: PLoS One. 2014;9(10):e112422.

48.

Non-specific filtering of beta-distributed data.

Wang X, Laird PW, Hinoue T, Groshen S, Siegmund KD.

BMC Bioinformatics. 2014 Jun 19;15:199. doi: 10.1186/1471-2105-15-199.

49.

Ancestral inference in tumors: how much can we know?

Zhao J, Siegmund KD, Shibata D, Marjoram P.

J Theor Biol. 2014 Oct 21;359:136-45. doi: 10.1016/j.jtbi.2014.05.027. Epub 2014 Jun 5.

50.

Protein kinase C θ regulates the phenotype of murine CD4+ Th17 cells.

Wachowicz K, Hermann-Kleiter N, Meisel M, Siegmund K, Thuille N, Baier G.

PLoS One. 2014 May 2;9(5):e96401. doi: 10.1371/journal.pone.0096401. eCollection 2014.

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