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Items: 1 to 50 of 99

1.

TRAF2 Controls Death Receptor-Induced Caspase-8 Processing and Facilitates Proinflammatory Signaling.

Kreckel J, Anany MA, Siegmund D, Wajant H.

Front Immunol. 2019 Aug 29;10:2024. doi: 10.3389/fimmu.2019.02024. eCollection 2019.

2.

The NEDD8-activating enzyme inhibitor MLN4924 sensitizes a TNFR1+ subgroup of multiple myeloma cells for TNF-induced cell death.

El-Mesery M, Rosenthal T, Rauert-Wunderlich H, Schreder M, Stühmer T, Leich E, Schlosser A, Ehrenschwender M, Wajant H, Siegmund D.

Cell Death Dis. 2019 Aug 13;10(8):611. doi: 10.1038/s41419-019-1860-2.

3.

TNFR1 and TNFR2 in the Control of the Life and Death Balance of Macrophages.

Wajant H, Siegmund D.

Front Cell Dev Biol. 2019 May 29;7:91. doi: 10.3389/fcell.2019.00091. eCollection 2019. Review.

4.

Seleno-analogues of pentlandites (Fe4.5Ni4.5S8-YSeY, Y = 1-6): tuning bulk Fe/Ni sulphoselenides for hydrogen evolution.

Smialkowski M, Siegmund D, Pellumbi K, Hensgen L, Antoni H, Muhler M, Apfel UP.

Chem Commun (Camb). 2019 Jul 23;55(60):8792-8795. doi: 10.1039/c9cc01842e.

PMID:
31041942
5.

FexNi9-xS8 (x = 3-6) as potential photocatalysts for solar-driven hydrogen production?

Tetzlaff D, Simon C, Achilleos DS, Smialkowski M, Junge Puring K, Bloesser A, Piontek S, Kasap H, Siegmund D, Reisner E, Marschall R, Apfel UP.

Faraday Discuss. 2019 Jul 4;215(0):216-226. doi: 10.1039/c8fd00173a.

PMID:
30942205
6.

Bio-inspired design: bulk iron-nickel sulfide allows for efficient solvent-dependent CO2 reduction.

Piontek S, Junge Puring K, Siegmund D, Smialkowski M, Sinev I, Tetzlaff D, Roldan Cuenya B, Apfel UP.

Chem Sci. 2018 Nov 6;10(4):1075-1081. doi: 10.1039/c8sc03555e. eCollection 2019 Jan 28.

7.

Redundant and receptor-specific activities of TRADD, RIPK1 and FADD in death receptor signaling.

Füllsack S, Rosenthal A, Wajant H, Siegmund D.

Cell Death Dis. 2019 Feb 11;10(2):122. doi: 10.1038/s41419-019-1396-5.

8.

Sulfur substitution in a Ni(cyclam) derivative results in lower overpotential for CO2 reduction and enhanced proton reduction.

Gerschel P, Warm K, Farquhar ER, Englert U, Reback ML, Siegmund D, Ray K, Apfel UP.

Dalton Trans. 2019 May 7;48(18):5923-5932. doi: 10.1039/c8dt04740e.

PMID:
30624449
9.

Soluble TNF-like weak inducer of apoptosis (TWEAK) enhances poly(I:C)-induced RIPK1-mediated necroptosis.

Anany MA, Kreckel J, Füllsack S, Rosenthal A, Otto C, Siegmund D, Wajant H.

Cell Death Dis. 2018 Oct 22;9(11):1084. doi: 10.1038/s41419-018-1137-1.

10.
11.

Influence of the substituent on the phosphine ligand in novel rhenium(i) aldehydes. Synthesis, computational studies and first insights into the antiproliferative activity.

Muñoz-Osses M, Siegmund D, Gómez A, Godoy F, Fierro A, Llanos L, Aravena D, Metzler-Nolte N.

Dalton Trans. 2018 Oct 9;47(39):13861-13869. doi: 10.1039/c8dt03160f.

PMID:
30225486
12.

TNFR2 unlocks a RIPK1 kinase activity-dependent mode of proinflammatory TNFR1 signaling.

Siegmund D, Ehrenschwender M, Wajant H.

Cell Death Dis. 2018 Sep 11;9(9):921. doi: 10.1038/s41419-018-0973-3.

13.

Resistance-breaking profiling and gene expression analysis on an organometallic ReI-phenanthridine complex reveal parallel activation of two apoptotic pathways.

König M, Siegmund D, Raszeja LJ, Prokop A, Metzler-Nolte N.

Medchemcomm. 2017 Dec 20;9(1):173-180. doi: 10.1039/c7md00545h. eCollection 2018 Jan 1.

14.

Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation.

Cuchet-Lourenço D, Eletto D, Wu C, Plagnol V, Papapietro O, Curtis J, Ceron-Gutierrez L, Bacon CM, Hackett S, Alsaleem B, Maes M, Gaspar M, Alisaac A, Goss E, AlIdrissi E, Siegmund D, Wajant H, Kumararatne D, AlZahrani MS, Arkwright PD, Abinun M, Doffinger R, Nejentsev S.

Science. 2018 Aug 24;361(6404):810-813. doi: 10.1126/science.aar2641. Epub 2018 Jul 19.

15.

Hypertonicity-enforced BCL-2 addiction unleashes the cytotoxic potential of death receptors.

Sirtl S, Knoll G, Trinh DT, Lang I, Siegmund D, Gross S, Schuler-Thurner B, Neubert P, Jantsch J, Wajant H, Ehrenschwender M.

Oncogene. 2018 Jul;37(30):4122-4136. doi: 10.1038/s41388-018-0265-5. Epub 2018 Apr 30.

16.

Association analysis between SUFU polymorphism rs17114808 and acute graft versus host disease after hematopoietic stem cell transplantation.

Katz MC, Michaelis S, Siegmund DM, Koch R, Bethge W, Handgretinger R, Mezger M.

Bone Marrow Transplant. 2018 Apr;53(4):377-382. doi: 10.1038/s41409-017-0059-3. Epub 2018 Jan 12. No abstract available.

PMID:
29330404
17.

Benzannulated Re(i)-NHC complexes: synthesis, photophysical properties and antimicrobial activity.

Siegmund D, Lorenz N, Gothe Y, Spies C, Geissler B, Prochnow P, Nuernberger P, Bandow JE, Metzler-Nolte N.

Dalton Trans. 2017 Nov 14;46(44):15269-15279. doi: 10.1039/c7dt02874a.

PMID:
29068017
18.

Expression of checkpoint molecules on myeloid-derived suppressor cells.

Ballbach M, Dannert A, Singh A, Siegmund DM, Handgretinger R, Piali L, Rieber N, Hartl D.

Immunol Lett. 2017 Dec;192:1-6. doi: 10.1016/j.imlet.2017.10.001. Epub 2017 Oct 4.

PMID:
28987474
19.

Quantitative analysis of cell surface antigen-antibody interaction using Gaussia princeps luciferase antibody fusion proteins.

Kums J, Nelke J, Rüth B, Schäfer V, Siegmund D, Wajant H.

MAbs. 2017 Apr;9(3):506-520. doi: 10.1080/19420862.2016.1274844. Epub 2017 Jan 17.

20.

MRI-based mismatch detection in acute ischemic stroke: Optimal PWI maps and thresholds validated with PET.

Zaro-Weber O, Moeller-Hartmann W, Siegmund D, Kandziora A, Schuster A, Heiss WD, Sobesky J.

J Cereb Blood Flow Metab. 2017 Sep;37(9):3176-3183. doi: 10.1177/0271678X16685574. Epub 2016 Dec 28.

21.

Asymmetric rhenium tricarbonyl complexes show superior luminescence properties in live cell imaging.

Raszeja LJ, Siegmund D, Cordes AL, Güldenhaupt J, Gerwert K, Hahn S, Metzler-Nolte N.

Chem Commun (Camb). 2017 Jan 16;53(5):905-908. doi: 10.1039/c6cc07553c. Epub 2016 Dec 23.

PMID:
28008445
22.

Activation of TNFR2 sensitizes macrophages for TNFR1-mediated necroptosis.

Siegmund D, Kums J, Ehrenschwender M, Wajant H.

Cell Death Dis. 2016 Sep 22;7(9):e2375. doi: 10.1038/cddis.2016.285.

23.

Cell death-independent activities of the death receptors CD95, TRAILR1, and TRAILR2.

Siegmund D, Lang I, Wajant H.

FEBS J. 2017 Apr;284(8):1131-1159. doi: 10.1111/febs.13968. Epub 2016 Dec 14. Review.

24.

A Blocking Group Scan Using a Spherical Organometallic Complex Identifies an Unprecedented Binding Mode with Potent Activity In Vitro and In Vivo for the Opioid Peptide Dermorphin.

Strack M, Bedini A, Yip KT, Lombardi S, Siegmund D, Stoll R, Spampinato SM, Metzler-Nolte N.

Chemistry. 2016 Oct 4;22(41):14605-10. doi: 10.1002/chem.201602432. Epub 2016 Aug 24.

PMID:
27553294
25.

A genome-wide approach for detecting novel insertion-deletion variants of mid-range size.

Xia LC, Sakshuwong S, Hopmans ES, Bell JM, Grimes SM, Siegmund DO, Ji HP, Zhang NR.

Nucleic Acids Res. 2016 Sep 6;44(15):e126. doi: 10.1093/nar/gkw481. Epub 2016 Jun 20.

26.

A Remarkably Simple Class of Imidazolium-Based Lipids and Their Biological Properties.

Wang D, Richter C, Rühling A, Drücker P, Siegmund D, Metzler-Nolte N, Glorius F, Galla HJ.

Chemistry. 2015 Oct 19;21(43):15123-6. doi: 10.1002/chem.201502333. Epub 2015 Sep 2.

PMID:
26332168
27.

Blocking TWEAK-Fn14 interaction inhibits hematopoietic stem cell transplantation-induced intestinal cell death and reduces GVHD.

Chopra M, Brandl A, Siegmund D, Mottok A, Schäfer V, Biehl M, Kraus S, Bäuerlein CA, Ritz M, Mattenheimer K, Schwinn S, Seher A, Grabinger T, Einsele H, Rosenwald A, Brunner T, Beilhack A, Wajant H.

Blood. 2015 Jul 23;126(4):437-44. doi: 10.1182/blood-2015-01-620583. Epub 2015 May 26.

28.

MLN4924 sensitizes monocytes and maturing dendritic cells for TNF-dependent and -independent necroptosis.

El-Mesery M, Seher A, Stühmer T, Siegmund D, Wajant H.

Br J Pharmacol. 2015 Mar;172(5):1222-36. doi: 10.1111/bph.12998. Epub 2015 Jan 13.

29.

Targeted delivery of CD40L promotes restricted activation of antigen-presenting cells and induction of cancer cell death.

Brunekreeft KL, Strohm C, Gooden MJ, Rybczynska AA, Nijman HW, Grigoleit GU, Helfrich W, Bremer E, Siegmund D, Wajant H, de Bruyn M.

Mol Cancer. 2014 Apr 17;13:85. doi: 10.1186/1476-4598-13-85.

30.

TNF Receptor-Associated Factor 1 is a Major Target of Soluble TWEAK.

Carmona Arana JA, Seher A, Neumann M, Lang I, Siegmund D, Wajant H.

Front Immunol. 2014 Feb 18;5:63. doi: 10.3389/fimmu.2014.00063. eCollection 2014.

31.

CD70-restricted specific activation of TRAILR1 or TRAILR2 using scFv-targeted TRAIL mutants.

Trebing J, El-Mesery M, Schäfer V, Weisenberger D, Siegmund D, Silence K, Wajant H.

Cell Death Dis. 2014 Jan 30;5:e1035. doi: 10.1038/cddis.2013.555.

32.

CD40-directed scFv-TRAIL fusion proteins induce CD40-restricted tumor cell death and activate dendritic cells.

El-Mesery M, Trebing J, Schäfer V, Weisenberger D, Siegmund D, Wajant H.

Cell Death Dis. 2013 Nov 14;4:e916. doi: 10.1038/cddis.2013.402.

33.

A novel llama antibody targeting Fn14 exhibits anti-metastatic activity in vivo.

Trebing J, Lang I, Chopra M, Salzmann S, Moshir M, Silence K, Riedel SS, Siegmund D, Beilhack A, Otto C, Wajant H.

MAbs. 2014 Jan-Feb;6(1):297-308.

34.

TWEAK inhibits TRAF2-mediated CD40 signaling by destabilization of CD40 signaling complexes.

Salzmann S, Lang I, Rosenthal A, Schäfer V, Weisenberger D, Carmona Arana JA, Trebing J, Siegmund D, Neumann M, Wajant H.

J Immunol. 2013 Sep 1;191(5):2308-18. doi: 10.4049/jimmunol.1202899. Epub 2013 Aug 5.

35.

Fibroblast growth factor inducible (Fn14)-specific antibodies concomitantly display signaling pathway-specific agonistic and antagonistic activity.

Salzmann S, Seher A, Trebing J, Weisenberger D, Rosenthal A, Siegmund D, Wajant H.

J Biol Chem. 2013 May 10;288(19):13455-66. doi: 10.1074/jbc.M112.435917. Epub 2013 Mar 26.

36.

The IKK inhibitor Bay 11-7082 induces cell death independent from inhibition of activation of NFκB transcription factors.

Rauert-Wunderlich H, Siegmund D, Maier E, Giner T, Bargou RC, Wajant H, Stühmer T.

PLoS One. 2013;8(3):e59292. doi: 10.1371/journal.pone.0059292. Epub 2013 Mar 20.

37.

Integrin-linked kinase is dispensable for multiple myeloma cell survival.

Steinbrunn T, Siegmund D, Andrulis M, Grella E, Kortüm M, Einsele H, Wajant H, Bargou RC, Stühmer T.

Leuk Res. 2012 Sep;36(9):1165-71. doi: 10.1016/j.leukres.2012.05.005. Epub 2012 Jun 1.

PMID:
22658851
38.

Signaling active CD95 receptor molecules trigger co-translocation of inactive CD95 molecules into lipid rafts.

Lang I, Fick A, Schäfer V, Giner T, Siegmund D, Wajant H.

J Biol Chem. 2012 Jul 6;287(28):24026-42. doi: 10.1074/jbc.M111.328211. Epub 2012 May 29.

39.

TNFR1 and TNFR2 regulate the extrinsic apoptotic pathway in myeloma cells by multiple mechanisms.

Rauert H, Stühmer T, Bargou R, Wajant H, Siegmund D.

Cell Death Dis. 2011 Aug 18;2:e194. doi: 10.1038/cddis.2011.78.

40.

SMAC mimetic BV6 induces cell death in monocytes and maturation of monocyte-derived dendritic cells.

Müller-Sienerth N, Dietz L, Holtz P, Kapp M, Grigoleit GU, Schmuck C, Wajant H, Siegmund D.

PLoS One. 2011;6(6):e21556. doi: 10.1371/journal.pone.0021556. Epub 2011 Jun 30.

41.

Cellular FLICE-inhibitory protein (cFLIP) isoforms block CD95- and TRAIL death receptor-induced gene induction irrespective of processing of caspase-8 or cFLIP in the death-inducing signaling complex.

Kavuri SM, Geserick P, Berg D, Dimitrova DP, Feoktistova M, Siegmund D, Gollnick H, Neumann M, Wajant H, Leverkus M.

J Biol Chem. 2011 May 13;286(19):16631-46. doi: 10.1074/jbc.M110.148585. Epub 2011 Mar 22.

42.

Joint testing of genotype and ancestry association in admixed families.

Tang H, Siegmund DO, Johnson NA, Romieu I, London SJ.

Genet Epidemiol. 2010 Dec;34(8):783-91. doi: 10.1002/gepi.20520.

43.

Detecting simultaneous changepoints in multiple sequences.

Zhang NR, Siegmund DO, Ji H, Li JZ.

Biometrika. 2010 Sep;97(3):631-645. Epub 2010 Jun 16.

44.

Mutant PIK3CA licenses TRAIL and CD95L to induce non-apoptotic caspase-8-mediated ROCK activation.

Ehrenschwender M, Siegmund D, Wicovsky A, Kracht M, Dittrich-Breiholz O, Spindler V, Waschke J, Kalthoff H, Trauzold A, Wajant H.

Cell Death Differ. 2010 Sep;17(9):1435-47. doi: 10.1038/cdd.2010.36. Epub 2010 Apr 9.

45.

Membrane tumor necrosis factor (TNF) induces p100 processing via TNF receptor-2 (TNFR2).

Rauert H, Wicovsky A, Müller N, Siegmund D, Spindler V, Waschke J, Kneitz C, Wajant H.

J Biol Chem. 2010 Mar 5;285(10):7394-404. doi: 10.1074/jbc.M109.037341. Epub 2009 Dec 28.

46.

Oligomerized tumor necrosis factor-related apoptosis inducing ligand strongly induces cell death in myeloma cells, but also activates proinflammatory signaling pathways.

Berg D, Stühmer T, Siegmund D, Müller N, Giner T, Dittrich-Breiholz O, Kracht M, Bargou R, Wajant H.

FEBS J. 2009 Dec;276(23):6912-27. doi: 10.1111/j.1742-4658.2009.07388.x. Epub 2009 Nov 6.

47.

TNF-like weak inducer of apoptosis inhibits proinflammatory TNF receptor-1 signaling.

Wicovsky A, Salzmann S, Roos C, Ehrenschwender M, Rosenthal T, Siegmund D, Henkler F, Gohlke F, Kneitz C, Wajant H.

Cell Death Differ. 2009 Nov;16(11):1445-59. doi: 10.1038/cdd.2009.80. Epub 2009 Jun 26.

48.

Mapping quantitative traits in unselected families: algorithms and examples.

Dupuis J, Shi J, Manning AK, Benjamin EJ, Meigs JB, Cupples LA, Siegmund D.

Genet Epidemiol. 2009 Nov;33(7):617-27. doi: 10.1002/gepi.20413.

49.

Apoptosis is not required for acantholysis in pemphigus vulgaris.

Schmidt E, Gutberlet J, Siegmund D, Berg D, Wajant H, Waschke J.

Am J Physiol Cell Physiol. 2009 Jan;296(1):C162-72. doi: 10.1152/ajpcell.00161.2008. Epub 2008 Nov 5.

50.

Signalling profile and antitumour activity of the novel Hsp90 inhibitor NVP-AUY922 in multiple myeloma.

Stühmer T, Zöllinger A, Siegmund D, Chatterjee M, Grella E, Knop S, Kortüm M, Unzicker C, Jensen MR, Quadt C, Chène P, Schoepfer J, García-Echeverría C, Einsele H, Wajant H, Bargou RC.

Leukemia. 2008 Aug;22(8):1604-12. doi: 10.1038/leu.2008.111. Epub 2008 May 15.

PMID:
18480838

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