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Development and validation of a multivariable risk score for prolonged length of stay in the surgical intensive care unit.

Wesch C, Denhaerynck K, Barandun Schaefer U, Siegemund M, Wehrli M, Pargger H, Look S.

Swiss Med Wkly. 2019 Sep 30;149:w20122. doi: 10.4414/smw.2019.20122. eCollection 2019 Sep 9.


Prolonged respiratory failure due to pulmonary embolism in a young woman: a case report.

Tuchscherer D, Hollinger A, Bremerich J, Siegemund M.

J Med Case Rep. 2019 Jul 24;13(1):225. doi: 10.1186/s13256-019-2169-6.


Serum biomarkers of delirium in the elderly: a narrative review.

Toft K, Tontsch J, Abdelhamid S, Steiner L, Siegemund M, Hollinger A.

Ann Intensive Care. 2019 Jul 1;9(1):76. doi: 10.1186/s13613-019-0548-1. Review.


Sublingual microcirculation: a case report.

Scheuzger JD, Zehnder A, Yeginsoy D, Siegemund M.

J Med Case Rep. 2019 Jun 12;13(1):179. doi: 10.1186/s13256-019-2118-4.


A preoperative single dose of methadone for moderate-to-severely painful surgery reduces postoperative morphine consumption.

Bastian K, Buehler PK, Slizyte D, Rüst CA, Toft K, Studer W, Lecheler L, Aguirre J, Siegemund M, Hollinger A.

Minerva Anestesiol. 2019 Oct;85(10):1053-1061. doi: 10.23736/S0375-9393.19.13136-7. Epub 2019 May 14.


Bedside hand vein inspection for noninvasive central venous pressure assessment.

Vogel F, Staub D, Aschwanden M, Siegemund M, Imfeld S, Balestra G, Keo HH, Uthoff H.

Am J Emerg Med. 2019 Apr 26. pii: S0735-6757(19)30269-4. doi: 10.1016/j.ajem.2019.04.044. [Epub ahead of print]


Handling Oxygenation Targets in the Intensive Care Unit (HOT-ICU)-Protocol for a randomised clinical trial comparing a lower vs a higher oxygenation target in adults with acute hypoxaemic respiratory failure.

Schjørring OL, Perner A, Wetterslev J, Lange T, Keus F, Laake JH, Okkonen M, Siegemund M, Morgan M, Thormar KM, Rasmussen BS; HOT-ICU Investigators.

Acta Anaesthesiol Scand. 2019 Aug;63(7):956-965. doi: 10.1111/aas.13356. Epub 2019 Mar 18. Review.


Vasoactive agents to improve brain perfusion: pathophysiology and clinical utilization.

Steiner LA, Siegemund M.

Curr Opin Crit Care. 2019 Apr;25(2):110-116. doi: 10.1097/MCC.0000000000000586.


The value of volume substitution in patients with septic and haemorrhagic shock with respect to the microcirculation.

Siegemund M, Hollinger A, Gebhard EC, Scheuzger JD, Bolliger D.

Swiss Med Wkly. 2019 Feb 4;149:w20007. doi: 10.4414/smw.2019.20007. eCollection 2019 Jan 28. Review.


Discontinuation of dual antiplatelet therapy and bleeding in intensive care in patients undergoing urgent coronary artery bypass grafting: a retrospective analysis.

Vuilliomenet T, Gebhard C, Bizzozero C, Glauser S, Blum S, Buser A, Bolliger D, Grapow MTR, Siegemund M.

Interact Cardiovasc Thorac Surg. 2019 May 1;28(5):665-673. doi: 10.1093/icvts/ivy330.


High Mortality of Non-Fournier Necrotizing Fasciitis With Enterobacteriales: Time to Rethink Classification?

Kuehl R, Tschudin-Sutter S, Siegemund M, Marsch S, Battegay M, Wetterauer C, Seifert HH, Schaefer DJ, Erb S, Egli A.

Clin Infect Dis. 2019 Jun 18;69(1):147-150. doi: 10.1093/cid/ciy1011.


Systemic network analysis identifies XIAP and IκBα as potential drug targets in TRAIL resistant BRAF mutated melanoma.

Del Mistro G, Lucarelli P, Müller I, De Landtsheer S, Zinoveva A, Hutt M, Siegemund M, Kontermann RE, Beissert S, Sauter T, Kulms D.

NPJ Syst Biol Appl. 2018 Nov 5;4:39. doi: 10.1038/s41540-018-0075-y. eCollection 2018.


Pantoprazole in Patients at Risk for Gastrointestinal Bleeding in the ICU.

Krag M, Marker S, Perner A, Wetterslev J, Wise MP, Schefold JC, Keus F, Guttormsen AB, Bendel S, Borthwick M, Lange T, Rasmussen BS, Siegemund M, Bundgaard H, Elkmann T, Jensen JV, Nielsen RD, Liboriussen L, Bestle MH, Elkjær JM, Palmqvist DF, Bäcklund M, Laake JH, Bådstøløkken PM, Grönlund J, Breum O, Walli A, Winding R, Iversen S, Jarnvig IL, White JO, Brand B, Madsen MB, Quist L, Thornberg KJ, Møller A, Wiis J, Granholm A, Anthon CT, Meyhoff TS, Hjortrup PB, Aagaard SR, Andreasen JB, Sørensen CA, Haure P, Hauge J, Hollinger A, Scheuzger J, Tuchscherer D, Vuilliomenet T, Takala J, Jakob SM, Vang ML, Pælestik KB, Andersen KLD, van der Horst ICC, Dieperink W, Fjølner J, Kjer CKW, Sølling C, Sølling CG, Karttunen J, Morgan MPG, Sjøbø B, Engstrøm J, Agerholm-Larsen B, Møller MH; SUP-ICU trial group.

N Engl J Med. 2018 Dec 6;379(23):2199-2208. doi: 10.1056/NEJMoa1714919. Epub 2018 Oct 24.


Association of social deprivation with 1-year outcome of ICU survivors: results from the FROG-ICU study.

Bastian K, Hollinger A, Mebazaa A, Azoulay E, Féliot E, Chevreul K, Fournier MC, Guidet B, Michel M, Montravers P, Pili-Floury S, Sonneville R, Siegemund M, Gayat E; FROG-ICU Study Investigators.

Intensive Care Med. 2018 Dec;44(12):2025-2037. doi: 10.1007/s00134-018-5412-5. Epub 2018 Oct 23.


Between a Rock and a Hard Place: Coagulation Management in Venoarterial Extracorporeal Membrane Oxygenation Patients.

Bolliger D, Siegemund M.

J Cardiothorac Vasc Anesth. 2019 May;33(5):1221-1223. doi: 10.1053/j.jvca.2018.09.003. Epub 2018 Sep 12. No abstract available.


Dexmedetomidine in prevention and treatment of postoperative and intensive care unit delirium: a systematic review and meta-analysis.

Flükiger J, Hollinger A, Speich B, Meier V, Tontsch J, Zehnder T, Siegemund M.

Ann Intensive Care. 2018 Sep 20;8(1):92. doi: 10.1186/s13613-018-0437-z.


Production, Purification, and Characterization of Antibody-TNF Superfamily Ligand Fusion Proteins.

Siegemund M, Beha N, Müller D.

Methods Mol Biol. 2018;1827:351-364. doi: 10.1007/978-1-4939-8648-4_18.


IgG-single-chain TRAIL fusion proteins for tumour therapy.

Siegemund M, Schneider F, Hutt M, Seifert O, Müller I, Kulms D, Pfizenmaier K, Kontermann RE.

Sci Rep. 2018 May 17;8(1):7808. doi: 10.1038/s41598-018-24450-8.


The More, the Merrier? - Urinary Biomarkers for Prediction of Acute Kidney Injury After Cardiac Surgery.

Bolliger D, Siegemund M.

J Cardiothorac Vasc Anesth. 2018 Oct;32(5):2201-2202. doi: 10.1053/j.jvca.2018.02.018. Epub 2018 Feb 13. No abstract available.


Superior Properties of Fc-comprising scTRAIL Fusion Proteins.

Hutt M, Marquardt L, Seifert O, Siegemund M, Müller I, Kulms D, Pfizenmaier K, Kontermann RE.

Mol Cancer Ther. 2017 Dec;16(12):2792-2802. doi: 10.1158/1535-7163.MCT-17-0551. Epub 2017 Sep 13.


Independent Predictors of the Duration and Overall Burden of Postoperative Delirium After Cardiac Surgery in Adults: An Observational Cohort Study.

Cereghetti C, Siegemund M, Schaedelin S, Fassl J, Seeberger MD, Eckstein FS, Steiner LA, Goettel N.

J Cardiothorac Vasc Anesth. 2017 Dec;31(6):1966-1973. doi: 10.1053/j.jvca.2017.03.042. Epub 2017 Mar 31.


Comparison of propofol and dexmedetomidine infused overnight to treat hyperactive and mixed ICU delirium: a protocol for the Basel ProDex clinical trial.

Hollinger A, Ledergerber K, von Felten S, Sutter R, Rüegg S, Gantner L, Zimmermann S, Blum A, Steiner LA, Marsch S, Siegemund M.

BMJ Open. 2017 Jul 13;7(7):e015783. doi: 10.1136/bmjopen-2016-015783.


Antitumor Activity of a Mesenchymal Stem Cell Line Stably Secreting a Tumor-Targeted TNF-Related Apoptosis-Inducing Ligand Fusion Protein.

Marini I, Siegemund M, Hutt M, Kontermann RE, Pfizenmaier K.

Front Immunol. 2017 May 11;8:536. doi: 10.3389/fimmu.2017.00536. eCollection 2017.


The EMPIRICUS trial-the final nail in the coffin of empirical antifungal therapy in the intensive care unit?

Osthoff M, Khanna N, Siegemund M.

J Thorac Dis. 2017 Mar;9(3):E269-E273. doi: 10.21037/jtd.2017.02.78. No abstract available.


Anatomic changes after repair of traumatic bilateral diaphragmatic rupture impede bi-caval dual lumen catheter insertion for veno-venous extracorporeal membrane oxygenation treatment.

Hollinger A, Tuchscherer D, Bremerich J, Siegemund M.

Crit Care. 2017 Apr 4;21(1):80. doi: 10.1186/s13054-017-1667-4. No abstract available.


Modified frozen elephant trunk for acute type A aortic dissection: a comparative study with standard repair technique.

Matt P, Banerjee P, Grapow M, Rueter F, Schurr U, Siegemund M, Fassl J, Reuthebuch O, Eckstein F.

Eur J Cardiothorac Surg. 2017 Apr 1;51(4):754-760. doi: 10.1093/ejcts/ezw412.


Prolonged administration of β-lactam antibiotics - a comprehensive review and critical appraisal.

Osthoff M, Siegemund M, Balestra G, Abdul-Aziz MH, Roberts JA.

Swiss Med Wkly. 2016 Oct 10;146:w14368. doi: 10.4414/smw.2016.14368. eCollection 2016. Review.


An optimized antibody-single-chain TRAIL fusion protein for cancer therapy.

Siegemund M, Seifert O, Zarani M, Džinić T, De Leo V, Göttsch D, Münkel S, Hutt M, Pfizenmaier K, Kontermann RE.

MAbs. 2016 Jul;8(5):879-91. doi: 10.1080/19420862.2016.1172163. Epub 2016 Apr 11.


Postoperative Delirium in Cardiac Surgery: An Unavoidable Menace?

Hollinger A, Siegemund M, Goettel N, Steiner LA.

J Cardiothorac Vasc Anesth. 2015 Dec;29(6):1677-87. doi: 10.1053/j.jvca.2014.08.021. Epub 2015 Oct 9. Review. No abstract available.


Postoperative care of the neurosurgical patient.

Siegemund M, Steiner LA.

Curr Opin Anaesthesiol. 2015 Oct;28(5):487-93. doi: 10.1097/ACO.0000000000000229. Review.


The physiologic perspective in fluid management in vascular anesthesiology.

Knotzer H, Filipovic M, Siegemund M, Kleinsasser A.

J Cardiothorac Vasc Anesth. 2014 Dec;28(6):1604-8. doi: 10.1053/j.jvca.2014.04.016. Epub 2014 Sep 18. Review.


EGFR-targeted TRAIL and a Smac mimetic synergize to overcome apoptosis resistance in KRAS mutant colorectal cancer cells.

Möller Y, Siegemund M, Beyes S, Herr R, Lecis D, Delia D, Kontermann R, Brummer T, Pfizenmaier K, Olayioye MA.

PLoS One. 2014 Sep 8;9(9):e107165. doi: 10.1371/journal.pone.0107165. eCollection 2014.


Effect of n-3 fatty acids on markers of brain injury and incidence of sepsis-associated delirium in septic patients.

Burkhart CS, Dell-Kuster S, Siegemund M, Pargger H, Marsch S, Strebel SP, Steiner LA.

Acta Anaesthesiol Scand. 2014 Jul;58(6):689-700. doi: 10.1111/aas.12313. Epub 2014 Mar 24.


Polymorphisms in tumor necrosis factor-α increase susceptibility to intra-abdominal Candida infection in high-risk surgical ICU patients*.

Wójtowicz A, Tissot F, Lamoth F, Orasch C, Eggimann P, Siegemund M, Zimmerli S, Flueckiger UM, Bille J, Calandra T, Marchetti O, Bochud PY; Fungal Infection Network of Switzerland (FUNGINOS).

Crit Care Med. 2014 Apr;42(4):e304-8. doi: 10.1097/CCM.0000000000000208.


Expression and purification of recombinant antibody formats and antibody fusion proteins.

Siegemund M, Richter F, Seifert O, Unverdorben F, Kontermann RE.

Methods Mol Biol. 2014;1131:273-95. doi: 10.1007/978-1-62703-992-5_18.


Tetravalent antibody-scTRAIL fusion proteins with improved properties.

Seifert O, Plappert A, Fellermeier S, Siegemund M, Pfizenmaier K, Kontermann RE.

Mol Cancer Ther. 2014 Jan;13(1):101-11. doi: 10.1158/1535-7163.MCT-13-0396. Epub 2013 Oct 3.


Re-evaluating currently available data and suggestions for planning randomised controlled studies regarding the use of hydroxyethyl starch in critically ill patients - a multidisciplinary statement.

Meybohm P, Van Aken H, De Gasperi A, De Hert S, Della Rocca G, Girbes AR, Gombotz H, Guidet B, Hasibeder W, Hollmann MW, Ince C, Jacob M, Kranke P, Kozek-Langenecker S, Loer SA, Martin C, Siegemund M, Wunder C, Zacharowski K.

Crit Care. 2013 Jul 26;17(4):R166. doi: 10.1186/cc12845.


β-glucan antigenemia anticipates diagnosis of blood culture-negative intraabdominal candidiasis.

Tissot F, Lamoth F, Hauser PM, Orasch C, Flückiger U, Siegemund M, Zimmerli S, Calandra T, Bille J, Eggimann P, Marchetti O; Fungal Infection Network of Switzerland (FUNGINOS).

Am J Respir Crit Care Med. 2013 Nov 1;188(9):1100-9. doi: 10.1164/rccm.201211-2069OC.


Hydroxyethyl starch 130/0.38-0.45 versus crystalloid or albumin in patients with sepsis: systematic review with meta-analysis and trial sequential analysis.

Haase N, Perner A, Hennings LI, Siegemund M, Lauridsen B, Wetterslev M, Wetterslev J.

BMJ. 2013 Feb 15;346:f839. doi: 10.1136/bmj.f839. Review.


Increased apoptosis induction in hepatocellular carcinoma by a novel tumor-targeted TRAIL fusion protein combined with bortezomib.

Wahl K, Siegemund M, Lehner F, Vondran F, Nüssler A, Länger F, Krech T, Kontermann R, Manns MP, Schulze-Osthoff K, Pfizenmaier K, Bantel H.

Hepatology. 2013 Feb;57(2):625-36. doi: 10.1002/hep.26082. Epub 2013 Jan 8.


Prospective comparison of noninvasive, bedside ultrasound methods for assessing central venous pressure.

Uthoff H, Siegemund M, Aschwanden M, Hunziker L, Fabbro T, Baumann U, Jaeger KA, Imfeld S, Staub D.

Ultraschall Med. 2012 Dec;33(7):E256-E262. doi: 10.1055/s-0031-1299506. Epub 2012 Jun 1.


Superior antitumoral activity of dimerized targeted single-chain TRAIL fusion proteins under retention of tumor selectivity.

Siegemund M, Pollak N, Seifert O, Wahl K, Hanak K, Vogel A, Nussler AK, Göttsch D, Münkel S, Bantel H, Kontermann RE, Pfizenmaier K.

Cell Death Dis. 2012 Apr 12;3:e295. doi: 10.1038/cddis.2012.29.


Microcirculation follows macrocirculation in heart and gut in the acute phase of hemorrhagic shock and isovolemic autologous whole blood resuscitation in pigs.

van Iterson M, Bezemer R, Heger M, Siegemund M, Ince C.

Transfusion. 2012 Jul;52(7):1552-9. doi: 10.1111/j.1537-2995.2011.03471.x. Epub 2011 Dec 13.


A TNF receptor 2 selective agonist rescues human neurons from oxidative stress-induced cell death.

Fischer R, Maier O, Siegemund M, Wajant H, Scheurich P, Pfizenmaier K.

PLoS One. 2011;6(11):e27621. doi: 10.1371/journal.pone.0027621. Epub 2011 Nov 14.


Catheter related blood stream infections in critically ill patients with continuous haemo(dia)filtration and temporary non-tunnelled vascular access.

Schönenberger M, Forster C, Siegemund M, Woodtli S, Widmer AF, Dickenmann M.

Swiss Med Wkly. 2011 Nov 21;141:w13294. doi: 10.4414/smw.2011.13294. eCollection 2011.


The Sequential Organ Failure Assessment score and copeptin for predicting survival in ventilator-associated pneumonia.

Boeck L, Eggimann P, Smyrnios N, Pargger H, Thakkar N, Siegemund M, Morgenthaler NG, Rakic J, Tamm M, Stolz D.

J Crit Care. 2012 Oct;27(5):523.e1-9. doi: 10.1016/j.jcrc.2011.07.081. Epub 2011 Sep 29.


Succinylcholine versus rocuronium for rapid sequence intubation in intensive care: a prospective, randomized controlled trial.

Marsch SC, Steiner L, Bucher E, Pargger H, Schumann M, Aebi T, Hunziker PR, Siegemund M.

Crit Care. 2011 Aug 16;15(4):R199. doi: 10.1186/cc10367.


Pancreatic stone protein: a marker of organ failure and outcome in ventilator-associated pneumonia.

Boeck L, Graf R, Eggimann P, Pargger H, Raptis DA, Smyrnios N, Thakkar N, Siegemund M, Rakic J, Tamm M, Stolz D.

Chest. 2011 Oct;140(4):925-932. doi: 10.1378/chest.11-0018. Epub 2011 Aug 11.


Effect of age on intraoperative cerebrovascular autoregulation and near-infrared spectroscopy-derived cerebral oxygenation.

Burkhart CS, Rossi A, Dell-Kuster S, Gamberini M, Möckli A, Siegemund M, Czosnyka M, Strebel SP, Steiner LA.

Br J Anaesth. 2011 Nov;107(5):742-8. doi: 10.1093/bja/aer252. Epub 2011 Aug 10.

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