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Items: 1 to 50 of 134


Postsynaptic integrative properties of dorsal CA1 pyramidal neuron subpopulations.

Masurkar AV, Tian C, Warren R, Reyes I, Lowes DC, Brann DH, Siegelbaum SA.

J Neurophysiol. 2020 Mar 1;123(3):980-992. doi: 10.1152/jn.00397.2019. Epub 2020 Jan 22.


Input-Timing-Dependent Plasticity in the Hippocampal CA2 Region and Its Potential Role in Social Memory.

Leroy F, Brann DH, Meira T, Siegelbaum SA.

Neuron. 2019 Apr 3;102(1):260-262. doi: 10.1016/j.neuron.2019.03.021. No abstract available.


A circuit from hippocampal CA2 to lateral septum disinhibits social aggression.

Leroy F, Park J, Asok A, Brann DH, Meira T, Boyle LM, Buss EW, Kandel ER, Siegelbaum SA.

Nature. 2018 Dec;564(7735):213-218. doi: 10.1038/s41586-018-0772-0. Epub 2018 Dec 5.


A hippocampal circuit linking dorsal CA2 to ventral CA1 critical for social memory dynamics.

Meira T, Leroy F, Buss EW, Oliva A, Park J, Siegelbaum SA.

Nat Commun. 2018 Oct 9;9(1):4163. doi: 10.1038/s41467-018-06501-w.


Hippocampal 5-HT Input Regulates Memory Formation and Schaffer Collateral Excitation.

Teixeira CM, Rosen ZB, Suri D, Sun Q, Hersh M, Sargin D, Dincheva I, Morgan AA, Spivack S, Krok AC, Hirschfeld-Stoler T, Lambe EK, Siegelbaum SA, Ansorge MS.

Neuron. 2018 Jun 6;98(5):992-1004.e4. doi: 10.1016/j.neuron.2018.04.030. Epub 2018 May 10.


Input-Timing-Dependent Plasticity in the Hippocampal CA2 Region and Its Potential Role in Social Memory.

Leroy F, Brann DH, Meira T, Siegelbaum SA.

Neuron. 2017 Aug 30;95(5):1089-1102.e5. doi: 10.1016/j.neuron.2017.07.036. Epub 2017 Aug 17. Erratum in: Neuron. 2019 Apr 3;102(1):260-262.


Proximodistal Heterogeneity of Hippocampal CA3 Pyramidal Neuron Intrinsic Properties, Connectivity, and Reactivation during Memory Recall.

Sun Q, Sotayo A, Cazzulino AS, Snyder AM, Denny CA, Siegelbaum SA.

Neuron. 2017 Aug 2;95(3):656-672.e3. doi: 10.1016/j.neuron.2017.07.012.


The Dendrites of CA2 and CA1 Pyramidal Neurons Differentially Regulate Information Flow in the Cortico-Hippocampal Circuit.

Srinivas KV, Buss EW, Sun Q, Santoro B, Takahashi H, Nicholson DA, Siegelbaum SA.

J Neurosci. 2017 Mar 22;37(12):3276-3293. doi: 10.1523/JNEUROSCI.2219-16.2017. Epub 2017 Feb 17.


Medial and Lateral Entorhinal Cortex Differentially Excite Deep versus Superficial CA1 Pyramidal Neurons.

Masurkar AV, Srinivas KV, Brann DH, Warren R, Lowes DC, Siegelbaum SA.

Cell Rep. 2017 Jan 3;18(1):148-160. doi: 10.1016/j.celrep.2016.12.012.


Age-Dependent Specific Changes in Area CA2 of the Hippocampus and Social Memory Deficit in a Mouse Model of the 22q11.2 Deletion Syndrome.

Piskorowski RA, Nasrallah K, Diamantopoulou A, Mukai J, Hassan SI, Siegelbaum SA, Gogos JA, Chevaleyre V.

Neuron. 2016 Jan 6;89(1):163-76. doi: 10.1016/j.neuron.2015.11.036.


Gating of hippocampal activity, plasticity, and memory by entorhinal cortex long-range inhibition.

Basu J, Zaremba JD, Cheung SK, Hitti FL, Zemelman BV, Losonczy A, Siegelbaum SA.

Science. 2016 Jan 8;351(6269):aaa5694. doi: 10.1126/science.aaa5694. Erratum in: Science. 2016 May 27;352(6289):1066. Erratum in: Science. 2016 Jan 29;351(6272). pii: aaf2878. doi: 10.1126/science.aaf2878.


The Corticohippocampal Circuit, Synaptic Plasticity, and Memory.

Basu J, Siegelbaum SA.

Cold Spring Harb Perspect Biol. 2015 Nov 2;7(11). pii: a021733. doi: 10.1101/cshperspect.a021733. Review.


Midbrain dopamine neurons bidirectionally regulate CA3-CA1 synaptic drive.

Rosen ZB, Cheung S, Siegelbaum SA.

Nat Neurosci. 2015 Dec;18(12):1763-71. doi: 10.1038/nn.4152. Epub 2015 Nov 2.


Dendritic Na+ spikes enable cortical input to drive action potential output from hippocampal CA2 pyramidal neurons.

Sun Q, Srinivas KV, Sotayo A, Siegelbaum SA.

Elife. 2014 Nov 12;3. doi: 10.7554/eLife.04551.


Differential contribution of TRPM4 and TRPM5 nonselective cation channels to the slow afterdepolarization in mouse prefrontal cortex neurons.

Lei YT, Thuault SJ, Launay P, Margolskee RF, Kandel ER, Siegelbaum SA.

Front Cell Neurosci. 2014 Sep 4;8:267. doi: 10.3389/fncel.2014.00267. eCollection 2014.


Reelin signaling specifies the molecular identity of the pyramidal neuron distal dendritic compartment.

Kupferman JV, Basu J, Russo MJ, Guevarra J, Cheung SK, Siegelbaum SA.

Cell. 2014 Sep 11;158(6):1335-1347. doi: 10.1016/j.cell.2014.07.035. Epub 2014 Sep 4.


The hippocampal CA2 region is essential for social memory.

Hitti FL, Siegelbaum SA.

Nature. 2014 Apr 3;508(7494):88-92. doi: 10.1038/nature13028. Epub 2014 Feb 23.


A cortico-hippocampal learning rule shapes inhibitory microcircuit activity to enhance hippocampal information flow.

Basu J, Srinivas KV, Cheung SK, Taniguchi H, Huang ZJ, Siegelbaum SA.

Neuron. 2013 Sep 18;79(6):1208-21. doi: 10.1016/j.neuron.2013.07.001.


Prefrontal cortex HCN1 channels enable intrinsic persistent neural firing and executive memory function.

Thuault SJ, Malleret G, Constantinople CM, Nicholls R, Chen I, Zhu J, Panteleyev A, Vronskaya S, Nolan MF, Bruno R, Siegelbaum SA, Kandel ER.

J Neurosci. 2013 Aug 21;33(34):13583-99. doi: 10.1523/JNEUROSCI.2427-12.2013.


Synapses and memory storage.

Mayford M, Siegelbaum SA, Kandel ER.

Cold Spring Harb Perspect Biol. 2012 Jun 1;4(6). pii: a005751. doi: 10.1101/cshperspect.a005751. Review.


Increased size and stability of CA1 and CA3 place fields in HCN1 knockout mice.

Hussaini SA, Kempadoo KA, Thuault SJ, Siegelbaum SA, Kandel ER.

Neuron. 2011 Nov 17;72(4):643-53. doi: 10.1016/j.neuron.2011.09.007.


Recurrent circuitry dynamically shapes the activation of piriform cortex.

Franks KM, Russo MJ, Sosulski DL, Mulligan AA, Siegelbaum SA, Axel R.

Neuron. 2011 Oct 6;72(1):49-56. doi: 10.1016/j.neuron.2011.08.020.


TRIP8b splice forms act in concert to regulate the localization and expression of HCN1 channels in CA1 pyramidal neurons.

Piskorowski R, Santoro B, Siegelbaum SA.

Neuron. 2011 May 12;70(3):495-509. doi: 10.1016/j.neuron.2011.03.023.


TRIP8b regulates HCN1 channel trafficking and gating through two distinct C-terminal interaction sites.

Santoro B, Hu L, Liu H, Saponaro A, Pian P, Piskorowski RA, Moroni A, Siegelbaum SA.

J Neurosci. 2011 Mar 16;31(11):4074-86. doi: 10.1523/JNEUROSCI.5707-10.2011.


Homologue structure of the SLAC1 anion channel for closing stomata in leaves.

Chen YH, Hu L, Punta M, Bruni R, Hillerich B, Kloss B, Rost B, Love J, Siegelbaum SA, Hendrickson WA.

Nature. 2010 Oct 28;467(7319):1074-80. doi: 10.1038/nature09487.


Strong CA2 pyramidal neuron synapses define a powerful disynaptic cortico-hippocampal loop.

Chevaleyre V, Siegelbaum SA.

Neuron. 2010 May 27;66(4):560-72. doi: 10.1016/j.neuron.2010.04.013.


Increased seizure severity and seizure-related death in mice lacking HCN1 channels.

Santoro B, Lee JY, Englot DJ, Gildersleeve S, Piskorowski RA, Siegelbaum SA, Winawer MR, Blumenfeld H.

Epilepsia. 2010 Aug;51(8):1624-7. doi: 10.1111/j.1528-1167.2010.02554.x.


12-Lipoxygenase regulates hippocampal long-term potentiation by modulating L-type Ca2+ channels.

DeCostanzo AJ, Voloshyna I, Rosen ZB, Feinmark SJ, Siegelbaum SA.

J Neurosci. 2010 Feb 3;30(5):1822-31. doi: 10.1523/JNEUROSCI.2168-09.2010.


Recruitment of N-Type Ca(2+) channels during LTP enhances low release efficacy of hippocampal CA1 perforant path synapses.

Ahmed MS, Siegelbaum SA.

Neuron. 2009 Aug 13;63(3):372-85. doi: 10.1016/j.neuron.2009.07.013.


TRIP8b splice variants form a family of auxiliary subunits that regulate gating and trafficking of HCN channels in the brain.

Santoro B, Piskorowski RA, Pian P, Hu L, Liu H, Siegelbaum SA.

Neuron. 2009 Jun 25;62(6):802-13. doi: 10.1016/j.neuron.2009.05.009.


HCN hyperpolarization-activated cation channels inhibit EPSPs by interactions with M-type K(+) channels.

George MS, Abbott LF, Siegelbaum SA.

Nat Neurosci. 2009 May;12(5):577-84. doi: 10.1038/nn.2307. Epub 2009 Apr 12.


Probing S4 and S5 segment proximity in mammalian hyperpolarization-activated HCN channels by disulfide bridging and Cd2+ coordination.

Bell DC, Turbendian HK, Valley MT, Zhou L, Riley JH, Siegelbaum SA, Tibbs GR.

Pflugers Arch. 2009 Jun;458(2):259-72. doi: 10.1007/s00424-008-0613-3. Epub 2008 Nov 26.


Pathway and endpoint free energy calculations for cyclic nucleotide binding to HCN channels.

Zhou L, Siegelbaum SA.

Biophys J. 2008 Jun;94(12):L90-2. doi: 10.1529/biophysj.108.130872. Epub 2008 Apr 11.


Effects of surface water on protein dynamics studied by a novel coarse-grained normal mode approach.

Zhou L, Siegelbaum SA.

Biophys J. 2008 May 1;94(9):3461-74. doi: 10.1529/biophysj.107.115956. Epub 2008 Jan 22.


Modulation of cyclic nucleotide-regulated HCN channels by PIP(2) and receptors coupled to phospholipase C.

Pian P, Bucchi A, Decostanzo A, Robinson RB, Siegelbaum SA.

Pflugers Arch. 2007 Oct;455(1):125-45. Epub 2007 Jun 29.


Regulation of gating and rundown of HCN hyperpolarization-activated channels by exogenous and endogenous PIP2.

Pian P, Bucchi A, Robinson RB, Siegelbaum SA.

J Gen Physiol. 2006 Nov;128(5):593-604.


Making the grade with models of persistent activity.

Dudman JT, Siegelbaum SA.

Neuron. 2006 Mar 2;49(5):649-51.


Transcriptional and behavioral interaction between 22q11.2 orthologs modulates schizophrenia-related phenotypes in mice.

Paterlini M, Zakharenko SS, Lai WS, Qin J, Zhang H, Mukai J, Westphal KG, Olivier B, Sulzer D, Pavlidis P, Siegelbaum SA, Karayiorgou M, Gogos JA.

Nat Neurosci. 2005 Nov;8(11):1586-94. Epub 2005 Oct 23.


Genetic evidence for a protein-kinase-A-mediated presynaptic component in NMDA-receptor-dependent forms of long-term synaptic potentiation.

Huang YY, Zakharenko SS, Schoch S, Kaeser PS, Janz R, Südhof TC, Siegelbaum SA, Kandel ER.

Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9365-70. Epub 2005 Jun 20.


A conserved tripeptide in CNG and HCN channels regulates ligand gating by controlling C-terminal oligomerization.

Zhou L, Olivier NB, Yao H, Young EC, Siegelbaum SA.

Neuron. 2004 Dec 2;44(5):823-34.


Regulation of HCN channel surface expression by a novel C-terminal protein-protein interaction.

Santoro B, Wainger BJ, Siegelbaum SA.

J Neurosci. 2004 Nov 24;24(47):10750-62.


A behavioral role for dendritic integration: HCN1 channels constrain spatial memory and plasticity at inputs to distal dendrites of CA1 pyramidal neurons.

Nolan MF, Malleret G, Dudman JT, Buhl DL, Santoro B, Gibbs E, Vronskaya S, Buzsáki G, Siegelbaum SA, Kandel ER, Morozov A.

Cell. 2004 Nov 24;119(5):719-32. Erratum in: Cell. 2005 Jan 14;120(1):151-2.


Transient expansion of synaptically connected dendritic spines upon induction of hippocampal long-term potentiation.

Lang C, Barco A, Zablow L, Kandel ER, Siegelbaum SA, Zakharenko SS.

Proc Natl Acad Sci U S A. 2004 Nov 23;101(47):16665-70. Epub 2004 Nov 12.


Changes in local S4 environment provide a voltage-sensing mechanism for mammalian hyperpolarization-activated HCN channels.

Bell DC, Yao H, Saenger RC, Riley JH, Siegelbaum SA.

J Gen Physiol. 2004 Jan;123(1):5-19. Epub 2003 Dec 15.


12-lipoxygenase metabolites of arachidonic acid mediate metabotropic glutamate receptor-dependent long-term depression at hippocampal CA3-CA1 synapses.

Feinmark SJ, Begum R, Tsvetkov E, Goussakov I, Funk CD, Siegelbaum SA, Bolshakov VY.

J Neurosci. 2003 Dec 10;23(36):11427-35.

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