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Items: 1 to 50 of 207

1.

Beyond Cell Death: New Functions for TNF Family Cytokines in Autoimmunity and Tumor Immunotherapy.

Yi F, Frazzette N, Cruz AC, Klebanoff CA, Siegel RM.

Trends Mol Med. 2018 Jul;24(7):642-653. doi: 10.1016/j.molmed.2018.05.004. Epub 2018 Jun 4. Review.

PMID:
29880309
2.

Community Healthcare and Technology to Enhance Communication in Pediatric Obesity Care: Expert Exchange Workgroup's Views.

Siegel RM, Haemer M, Kharofa RY, Christison AL, Hampl SE, Tinajero-Deck L, Lockhart MK, Reich S, Pont SJ, Stratbucker W, Robinson TN, Shaffer LA, Woolford SJ.

Child Obes. 2018 Jun 7. doi: 10.1089/chi.2017.0339. [Epub ahead of print]

PMID:
29878851
3.

Somatic activating mutations in MAP2K1 cause melorheostosis.

Kang H, Jha S, Deng Z, Fratzl-Zelman N, Cabral WA, Ivovic A, Meylan F, Hanson EP, Lange E, Katz J, Roschger P, Klaushofer K, Cowen EW, Siegel RM, Marini JC, Bhattacharyya T.

Nat Commun. 2018 Apr 11;9(1):1390. doi: 10.1038/s41467-018-03720-z.

4.

Fas Ligand localizes to intraluminal vesicles within NK cell cytolytic granules and is enriched at the immune synapse.

Lee J, Dieckmann NMG, Edgar JR, Griffiths GM, Siegel RM.

Immun Inflamm Dis. 2018 Jun;6(2):312-321. doi: 10.1002/iid3.219. Epub 2018 Apr 11.

5.

Identifying the best methods to assess adiposity and metabolic risk in children.

Gordon KE, Siegel RM.

Acta Paediatr. 2018 Jun;107(6):921-922. doi: 10.1111/apa.14307. Epub 2018 Mar 30. No abstract available.

PMID:
29600807
6.

RORα-expressing T regulatory cells restrain allergic skin inflammation.

Malhotra N, Leyva-Castillo JM, Jadhav U, Barreiro O, Kam C, O'Neill NK, Meylan F, Chambon P, von Andrian UH, Siegel RM, Wang EC, Shivdasani R, Geha RS.

Sci Immunol. 2018 Mar 2;3(21). pii: eaao6923. doi: 10.1126/sciimmunol.aao6923.

PMID:
29500225
7.

Obesity class does not further stratify outcome in overweight and obese pediatric patients after heart transplantation.

Ryan TD, Zafar F, Siegel RM, Villa CR, Bryant R 3rd, Chin C.

Pediatr Transplant. 2018 Mar;22(2). doi: 10.1111/petr.13161. Epub 2018 Jan 29.

PMID:
29377429
8.

Cleavage of TL1A Differentially Regulates Its Effects on Innate and Adaptive Immune Cells.

Ferdinand JR, Richard AC, Meylan F, Al-Shamkhani A, Siegel RM.

J Immunol. 2018 Feb 15;200(4):1360-1369. doi: 10.4049/jimmunol.1700891. Epub 2018 Jan 15.

9.

Nudging Healthier Choices in a Hospital Cafeteria: Results From a Field Study.

Mazza MC, Dynan L, Siegel RM, Tucker AL.

Health Promot Pract. 2017 Nov 1:1524839917740119. doi: 10.1177/1524839917740119. [Epub ahead of print]

PMID:
29169270
10.

Challenges in Screening for Pediatric Nonalcoholic Fatty Liver Disease.

Ferguson AE, Xanthakos SA, Siegel RM.

Clin Pediatr (Phila). 2018 May;57(5):558-562. doi: 10.1177/0009922817733300. Epub 2017 Oct 12.

PMID:
29022357
11.

Spontaneous Secretion of the Citrullination Enzyme PAD2 and Cell Surface Exposure of PAD4 by Neutrophils.

Zhou Y, Chen B, Mittereder N, Chaerkady R, Strain M, An LL, Rahman S, Ma W, Low CP, Chan D, Neal F, Bingham CO 3rd, Sampson K, Darrah E, Siegel RM, Hasni S, Andrade F, Vousden KA, Mustelin T, Sims GP.

Front Immunol. 2017 Sep 25;8:1200. doi: 10.3389/fimmu.2017.01200. eCollection 2017.

12.

Factors associated with long-term weight-loss maintenance following bariatric surgery in adolescents with severe obesity.

Ryder JR, Gross AC, Fox CK, Kaizer AM, Rudser KD, Jenkins TM, Ratcliff MB, Kelly AS, Kirk S, Siegel RM, Inge TH.

Int J Obes (Lond). 2018 Jan;42(1):102-107. doi: 10.1038/ijo.2017.193. Epub 2017 Aug 14.

13.

Psychosocial Screening Among Youth Seeking Weight Management Treatment.

Ratcliff MB, Catlin PA, Peugh JL, Siegel RM, Kirk S, Tamm L.

Clin Pediatr (Phila). 2018 Mar;57(3):277-284. doi: 10.1177/0009922817715936. Epub 2017 Jul 11.

PMID:
28695753
14.

Prolonged fasting suppresses mitochondrial NLRP3 inflammasome assembly and activation via SIRT3-mediated activation of superoxide dismutase 2.

Traba J, Geiger SS, Kwarteng-Siaw M, Han K, Ra OH, Siegel RM, Gius D, Sack MN.

J Biol Chem. 2017 Jul 21;292(29):12153-12164. doi: 10.1074/jbc.M117.791715. Epub 2017 Jun 5.

15.

Beyond TNF: TNF superfamily cytokines as targets for the treatment of rheumatic diseases.

Croft M, Siegel RM.

Nat Rev Rheumatol. 2017 Apr;13(4):217-233. doi: 10.1038/nrrheum.2017.22. Epub 2017 Mar 9. Review.

16.

Small Prizes Improve Food Selection in a School Cafeteria Without Increasing Waste.

Hudgens ME, Barnes AS, Lockhart MK, Ellsworth SC, Beckford M, Siegel RM.

Clin Pediatr (Phila). 2017 Feb;56(2):123-126. doi: 10.1177/0009922816677546. Epub 2016 Nov 16.

PMID:
28145128
17.

A Comparison of Four Submaximal Tests for Evaluating Change in Fitness in Youth With Obesity.

Emerson M, Lockhart MK, Kist C, Mays W, Edwards NM, Kirk S, Siegel RM.

Clin Pediatr (Phila). 2017 Nov;56(13):1256-1259. doi: 10.1177/0009922816684610. Epub 2017 Jan 5. No abstract available.

PMID:
28056543
18.

Fas/CD95 prevents autoimmunity independently of lipid raft localization and efficient apoptosis induction.

Cruz AC, Ramaswamy M, Ouyang C, Klebanoff CA, Sengupta P, Yamamoto TN, Meylan F, Thomas SK, Richoz N, Eil R, Price S, Casellas R, Rao VK, Lippincott-Schwartz J, Restifo NP, Siegel RM.

Nat Commun. 2016 Dec 23;7:13895. doi: 10.1038/ncomms13895.

19.

TNF superfamily cytokines in the promotion of Th9 differentiation and immunopathology.

Meylan F, Siegel RM.

Semin Immunopathol. 2017 Jan;39(1):21-28. doi: 10.1007/s00281-016-0612-y. Epub 2016 Nov 28. Review.

20.

Severe Obesity Decreasing in Children in Cincinnati, Ohio.

Kharofa RY, Klein JA, Khoury P, Siegel RM.

Clin Pediatr (Phila). 2017 Jul;56(8):752-758. doi: 10.1177/0009922816674519. Epub 2016 Nov 22.

PMID:
27872358
21.

Breaking the Mold: Partnering with the National Institutes of Health Intramural Research Program to Accelerate PhD Training.

Soucy K, Fairhurst RM, Lynn GM, Fomalont K, Wynn TA, Siegel RM.

Trends Immunol. 2016 Dec;37(12):813-815. doi: 10.1016/j.it.2016.10.005. Epub 2016 Nov 9.

PMID:
27838188
22.

Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex.

Fu TM, Li Y, Lu A, Li Z, Vajjhala PR, Cruz AC, Srivastava DB, DiMaio F, Penczek PA, Siegel RM, Stacey KJ, Egelman EH, Wu H.

Mol Cell. 2016 Oct 20;64(2):236-250. doi: 10.1016/j.molcel.2016.09.009. Epub 2016 Oct 13.

23.

Targeted genomic analysis reveals widespread autoimmune disease association with regulatory variants in the TNF superfamily cytokine signalling network.

Richard AC, Peters JE, Lee JC, Vahedi G, Schäffer AA, Siegel RM, Lyons PA, Smith KG.

Genome Med. 2016 Jul 19;8(1):76. doi: 10.1186/s13073-016-0329-5.

24.

Critical role of fatty acid metabolism in ILC2-mediated barrier protection during malnutrition and helminth infection.

Wilhelm C, Harrison OJ, Schmitt V, Pelletier M, Spencer SP, Urban JF Jr, Ploch M, Ramalingam TR, Siegel RM, Belkaid Y.

J Exp Med. 2016 Jul 25;213(8):1409-18. doi: 10.1084/jem.20151448. Epub 2016 Jul 18.

25.

Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4.

Gomez-Rodriguez J, Meylan F, Handon R, Hayes ET, Anderson SM, Kirby MR, Siegel RM, Schwartzberg PL.

Nat Commun. 2016 Mar 3;7:10857. doi: 10.1038/ncomms10857.

26.

Structural Basis and Functional Role of Intramembrane Trimerization of the Fas/CD95 Death Receptor.

Fu Q, Fu TM, Cruz AC, Sengupta P, Thomas SK, Wang S, Siegel RM, Wu H, Chou JJ.

Mol Cell. 2016 Feb 18;61(4):602-613. doi: 10.1016/j.molcel.2016.01.009. Epub 2016 Feb 4.

27.

Distinct Functions of Autoantibodies Against Interferon in Systemic Lupus Erythematosus: A Comprehensive Analysis of Anticytokine Autoantibodies in Common Rheumatic Diseases.

Gupta S, Tatouli IP, Rosen LB, Hasni S, Alevizos I, Manna ZG, Rivera J, Jiang C, Siegel RM, Holland SM, Moutsopoulos HM, Browne SK.

Arthritis Rheumatol. 2016 Jul;68(7):1677-87. doi: 10.1002/art.39607.

28.

Recruitment of A20 by the C-terminal domain of NEMO suppresses NF-κB activation and autoinflammatory disease.

Zilberman-Rudenko J, Shawver LM, Wessel AW, Luo Y, Pelletier M, Tsai WL, Lee Y, Vonortas S, Cheng L, Ashwell JD, Orange JS, Siegel RM, Hanson EP.

Proc Natl Acad Sci U S A. 2016 Feb 9;113(6):1612-7. doi: 10.1073/pnas.1518163113. Epub 2016 Jan 22.

29.

Memory T cell-driven differentiation of naive cells impairs adoptive immunotherapy.

Klebanoff CA, Scott CD, Leonardi AJ, Yamamoto TN, Cruz AC, Ouyang C, Ramaswamy M, Roychoudhuri R, Ji Y, Eil RL, Sukumar M, Crompton JG, Palmer DC, Borman ZA, Clever D, Thomas SK, Patel S, Yu Z, Muranski P, Liu H, Wang E, Marincola FM, Gros A, Gattinoni L, Rosenberg SA, Siegel RM, Restifo NP.

J Clin Invest. 2016 Jan;126(1):318-34. doi: 10.1172/JCI81217. Epub 2015 Dec 14.

30.

Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease.

Zhou Q, Wang H, Schwartz DM, Stoffels M, Park YH, Zhang Y, Yang D, Demirkaya E, Takeuchi M, Tsai WL, Lyons JJ, Yu X, Ouyang C, Chen C, Chin DT, Zaal K, Chandrasekharappa SC, P Hanson E, Yu Z, Mullikin JC, Hasni SA, Wertz IE, Ombrello AK, Stone DL, Hoffmann P, Jones A, Barham BK, Leavis HL, van Royen-Kerkof A, Sibley C, Batu ED, Gül A, Siegel RM, Boehm M, Milner JD, Ozen S, Gadina M, Chae J, Laxer RM, Kastner DL, Aksentijevich I.

Nat Genet. 2016 Jan;48(1):67-73. doi: 10.1038/ng.3459. Epub 2015 Dec 7.

31.

Correction: The TNF-Family Ligand TL1A and Its Receptor DR3 Promote T Cell-Mediated Allergic Immunopathology by Enhancing Differentiation and Pathogenicity of IL-9-Producing T Cells.

Richard AC, Tan C, Hawley ET, Gomez-Rodriguez J, Goswami R, Yang XP, Cruz AC, Penumetcha P, Hayes ET, Pelletier M, Gabay O, Walsh M, Ferdinand JR, Keane-Myers A, Choi Y, O'Shea JJ, Al-Shamkhani A, Kaplan MH, Gery I, Siegel RM, Meylan F.

J Immunol. 2015 Dec 15;195(12):5839-40. doi: 10.4049/jimmunol.1502026. No abstract available.

32.

Fasting and refeeding differentially regulate NLRP3 inflammasome activation in human subjects.

Traba J, Kwarteng-Siaw M, Okoli TC, Li J, Huffstutler RD, Bray A, Waclawiw MA, Han K, Pelletier M, Sauve AA, Siegel RM, Sack MN.

J Clin Invest. 2015 Nov 3;125(12):4592-600. doi: 10.1172/JCI83260.

33.

Reducing lifestyle risk in childhood cancer survivors.

Siegel RM, Lockhart MK, Kist C.

Acta Paediatr. 2015 Oct;104(10):969-70. doi: 10.1111/apa.13113. No abstract available.

PMID:
26378635
34.

Using weight-for-age percentiles to screen for overweight and obese children and adolescents.

Gamliel A, Ziv-Baran T, Siegel RM, Fogelman Y, Dubnov-Raz G.

Prev Med. 2015 Dec;81:174-9. doi: 10.1016/j.ypmed.2015.08.017. Epub 2015 Sep 5.

PMID:
26348454
35.

Chrono-immunology: progress and challenges in understanding links between the circadian and immune systems.

Geiger SS, Fagundes CT, Siegel RM.

Immunology. 2015 Nov;146(3):349-58. doi: 10.1111/imm.12525. Epub 2015 Sep 28. Review.

36.

Emoticon use Increases Plain Milk and Vegetable Purchase in a School Cafeteria without Adversely Affecting Total Milk Purchase.

Siegel RM, Anneken A, Duffy C, Simmons K, Hudgens M, Kate Lockhart M, Shelly J.

Clin Ther. 2015 Sep 1;37(9):1938-43. doi: 10.1016/j.clinthera.2015.07.016. Epub 2015 Aug 18.

PMID:
26297572
37.

The TNF-family cytokine TL1A: from lymphocyte costimulator to disease co-conspirator.

Richard AC, Ferdinand JR, Meylan F, Hayes ET, Gabay O, Siegel RM.

J Leukoc Biol. 2015 Sep;98(3):333-45. doi: 10.1189/jlb.3RI0315-095R. Epub 2015 Jul 17. Review.

38.

Protein misfolding and dysregulated protein homeostasis in autoinflammatory diseases and beyond.

Agyemang AF, Harrison SR, Siegel RM, McDermott MF.

Semin Immunopathol. 2015 Jul;37(4):335-47. doi: 10.1007/s00281-015-0496-2. Epub 2015 May 21. Review.

39.

The TNF-family ligand TL1A and its receptor DR3 promote T cell-mediated allergic immunopathology by enhancing differentiation and pathogenicity of IL-9-producing T cells.

Richard AC, Tan C, Hawley ET, Gomez-Rodriguez J, Goswami R, Yang XP, Cruz AC, Penumetcha P, Hayes ET, Pelletier M, Gabay O, Walsh M, Ferdinand JR, Keane-Myers A, Choi Y, O'Shea JJ, Al-Shamkhani A, Kaplan MH, Gery I, Siegel RM, Meylan F.

J Immunol. 2015 Apr 15;194(8):3567-82. doi: 10.4049/jimmunol.1401220. Epub 2015 Mar 18. Erratum in: J Immunol. 2015 Dec 15;195(12):5839-40.

40.

Increased frequency of dietitian visits is associated with improved body mass index outcomes in obese youth participating in a comprehensive pediatric weight management program.

Kirk S, Woo JG, Jones MN, Siegel RM.

Child Obes. 2015 Apr;11(2):202-8. doi: 10.1089/chi.2014.0079. Epub 2015 Feb 24.

PMID:
25710601
41.

Outcomes in patients with various forms of aortic stenosis including those with low-flow low-gradient normal and low ejection fraction.

Romero J, Chavez P, Goodman-Meza D, Holmes AA, Ostfeld RJ, Manheimer ED, Siegel RM, Lupercio F, Shulman EH, Liakos M, Garcia MJ, Spevack DM.

Am J Cardiol. 2014 Oct 1;114(7):1069-74. doi: 10.1016/j.amjcard.2014.07.020. Epub 2014 Jul 17.

PMID:
25212548
42.

Outflanking RANK with a designer antagonist cytokine.

Ou-Yang CW, Siegel RM.

Sci Signal. 2014 Aug 19;7(339):pe20. doi: 10.1126/scisignal.2005674. Review.

PMID:
25140052
43.

Comparison of gene expression microarray data with count-based RNA measurements informs microarray interpretation.

Richard AC, Lyons PA, Peters JE, Biasci D, Flint SM, Lee JC, McKinney EF, Siegel RM, Smith KG.

BMC Genomics. 2014 Aug 4;15:649. doi: 10.1186/1471-2164-15-649.

44.

Weight loss maintenance: a hard nut to crack.

Inge TH, Siegel RM, Xanthakos SA.

JAMA Pediatr. 2014 Sep;168(9):796-7. doi: 10.1001/jamapediatrics.2014.672. No abstract available.

PMID:
25022564
45.

Spatial effects of shifting prisms on properties of posterior parietal cortex neurons.

Karkhanis AN, Heider B, Silva FM, Siegel RM.

J Physiol. 2014 Aug 15;592(16):3625-46. doi: 10.1113/jphysiol.2014.270942. Epub 2014 Jun 13.

46.

Extracellular flux analysis to monitor glycolytic rates and mitochondrial oxygen consumption.

Pelletier M, Billingham LK, Ramaswamy M, Siegel RM.

Methods Enzymol. 2014;542:125-49. doi: 10.1016/B978-0-12-416618-9.00007-8.

PMID:
24862264
47.

The feasibility of high-intensity interval exercise in obese adolescents.

Murphy A, Kist C, Gier AJ, Edwards NM, Gao Z, Siegel RM.

Clin Pediatr (Phila). 2015 Jan;54(1):87-90. doi: 10.1177/0009922814528038. Epub 2014 Mar 24. No abstract available.

48.

The TNF-family cytokine TL1A promotes allergic immunopathology through group 2 innate lymphoid cells.

Meylan F, Hawley ET, Barron L, Barlow JL, Penumetcha P, Pelletier M, Sciumè G, Richard AC, Hayes ET, Gomez-Rodriguez J, Chen X, Paul WE, Wynn TA, McKenzie AN, Siegel RM.

Mucosal Immunol. 2014 Jul;7(4):958-68. doi: 10.1038/mi.2013.114. Epub 2013 Dec 25.

49.

Obese children in a community YMCA "Fun 2B Fit" program have a reduction in BMI Z-scores.

Siegel RM, Pitner HE, Kist C, Woo JG, Gier A, Sewell M, Lattin B, Rooney A, Kirk S.

Clin Pediatr (Phila). 2014 Jun;53(7):698-700. doi: 10.1177/0009922813506258. Epub 2013 Oct 17. No abstract available.

PMID:
24137026
50.

Inhibition of caspase-8 activity promotes protective Th1- and Th2-mediated immunity to Leishmania major infection.

Pereira-Manfro WF, Ribeiro-Gomes FL, Filardy AA, Vellozo NS, Guillermo LV, Silva EM, Siegel RM, Dosreis GA, Lopes MF.

J Leukoc Biol. 2014 Feb;95(2):347-55. doi: 10.1189/jlb.0912463. Epub 2013 Sep 26.

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