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Items: 1 to 50 of 128

1.

Colloidal stability versus self-assembly of nanoparticles controlled by coiled-coil protein interactions.

Siehr A, Xu B, Siegel RA, Shen W.

Soft Matter. 2019 Sep 18;15(36):7122-7126. doi: 10.1039/c9sm01314h.

PMID:
31498366
2.

Intranasal Coadministration of a Diazepam Prodrug with a Converting Enzyme Results in Rapid Absorption of Diazepam in Rats.

Rautiola D, Maglalang PD, Cheryala N, Nelson KM, Georg GI, Fine JM, Svitak AL, Faltesek KA, Hanson LR, Mishra U, Coles LD, Cloyd JC, Siegel RA.

J Pharmacol Exp Ther. 2019 Sep;370(3):796-805. doi: 10.1124/jpet.118.255943. Epub 2019 Mar 5.

PMID:
30837282
3.

Swelling, Mechanics, and Thermal/Chemical Stability of Hydrogels Containing Phenylboronic Acid Side Chains.

Kim A, Lee H, Jones CF, Mujumdar SK, Gu Y, Siegel RA.

Gels. 2017 Dec 29;4(1). pii: E4. doi: 10.3390/gels4010004.

4.

Investigation of morphological, mechanical and biological properties of cellulose nanocrystal reinforced electrospun gelatin nanofibers.

Hivechi A, Hajir Bahrami S, Siegel RA.

Int J Biol Macromol. 2019 Mar 1;124:411-417. doi: 10.1016/j.ijbiomac.2018.11.214. Epub 2018 Nov 24.

PMID:
30476513
5.

Drug release and biodegradability of electrospun cellulose nanocrystal reinforced polycaprolactone.

Hivechi A, Bahrami SH, Siegel RA.

Mater Sci Eng C Mater Biol Appl. 2019 Jan 1;94:929-937. doi: 10.1016/j.msec.2018.10.037. Epub 2018 Oct 9.

PMID:
30423781
6.

Conversion of a soluble diazepam prodrug to supersaturated diazepam for rapid intranasal delivery: Kinetics and stability.

Rautiola D, Cloyd JC, Siegel RA.

J Control Release. 2018 Nov 10;289:1-9. doi: 10.1016/j.jconrel.2018.09.013. Epub 2018 Sep 15.

PMID:
30227158
7.

Rescue therapies for seizure emergencies: New modes of administration.

Maglalang PD, Rautiola D, Siegel RA, Fine JM, Hanson LR, Coles LD, Cloyd JC.

Epilepsia. 2018 Oct;59 Suppl 2:207-215. doi: 10.1111/epi.14479. Epub 2018 Aug 29.

8.

B'reshith.

Siegel RA, Brown L, Edelman ER, Linhardt RJ.

J Control Release. 2018 Sep 10;285:252-257. doi: 10.1016/j.jconrel.2018.07.005. Epub 2018 Jul 3.

PMID:
30078756
9.

Assessing the Benefits of Drug Delivery by Nanocarriers: A Partico/Pharmacokinetic Framework.

Siegel RA, Kirtane AR, Panyam J.

IEEE Trans Biomed Eng. 2017 Sep;64(9):2176-2185. doi: 10.1109/TBME.2016.2632733. Epub 2016 Nov 29.

PMID:
27913319
10.

A review of intranasal formulations for the treatment of seizure emergencies.

Kapoor M, Cloyd JC, Siegel RA.

J Control Release. 2016 Sep 10;237:147-59. doi: 10.1016/j.jconrel.2016.07.001. Epub 2016 Jul 7. Review.

PMID:
27397490
11.

Chirally Pure Prodrugs and Their Converting Enzymes Lead to High Supersaturation and Rapid Transcellular Permeation of Benzodiazepines.

Kapoor M, Cheryala N, Rautiola D, Georg GI, Cloyd JC, Siegel RA.

J Pharm Sci. 2016 Aug;105(8):2365-71. doi: 10.1016/j.xphs.2016.05.011. Epub 2016 Jun 22.

PMID:
27342435
12.

Water-soluble benzodiazepine prodrug/enzyme combinations for intranasal rescue therapies.

Siegel RA, Kapoor M, Cheryala N, Georg GI, Cloyd JC.

Epilepsy Behav. 2015 Aug;49:347-50. doi: 10.1016/j.yebeh.2015.05.004. Epub 2015 Jun 24.

PMID:
26115606
13.

A pharmacokinetic model for quantifying the effect of vascular permeability on the choice of drug carrier: a framework for personalized nanomedicine.

Kirtane AR, Siegel RA, Panyam J.

J Pharm Sci. 2015 Mar;104(3):1174-86. doi: 10.1002/jps.24302. Epub 2015 Jan 12.

PMID:
25583443
14.

Mechanistic studies of an autonomously pulsing hydrogel/enzyme system for rhythmic hormone delivery.

Bhalla AS, Siegel RA.

J Control Release. 2014 Dec 28;196:261-71. doi: 10.1016/j.jconrel.2014.10.019. Epub 2014 Oct 24.

15.

Stimuli sensitive polymers and self regulated drug delivery systems: a very partial review.

Siegel RA.

J Control Release. 2014 Sep 28;190:337-51. doi: 10.1016/j.jconrel.2014.06.035. Epub 2014 Jun 28. Review.

16.

Rapid delivery of diazepam from supersaturated solutions prepared using prodrug/enzyme mixtures: toward intranasal treatment of seizure emergencies.

Kapoor M, Winter T, Lis L, Georg GI, Siegel RA.

AAPS J. 2014 May;16(3):577-85. doi: 10.1208/s12248-014-9596-5. Epub 2014 Apr 4.

17.

Prodrug/Enzyme based acceleration of absorption of hydrophobic drugs: an in vitro study.

Kapoor M, Siegel RA.

Mol Pharm. 2013 Sep 3;10(9):3519-24. doi: 10.1021/mp400272m. Epub 2013 Aug 12.

PMID:
23937162
18.

What is unique about nanomedicine? The significance of the mesoscale.

Khushf G, Siegel RA.

J Law Med Ethics. 2012 Winter;40(4):780-94. doi: 10.1111/j.1748-720X.2012.00706.x.

PMID:
23289680
19.

Recommendations for nanomedicine human subjects research oversight: an evolutionary approach for an emerging field.

Fatehi L, Wolf SM, McCullough J, Hall R, Lawrenz F, Kahn JP, Jones C, Campbell SA, Dresser RS, Erdman AG, Haynes CL, Hoerr RA, Hogle LF, Keane MA, Khushf G, King NM, Kokkoli E, Marchant G, Maynard AD, Philbert M, Ramachandran G, Siegel RA, Wickline S.

J Law Med Ethics. 2012 Winter;40(4):716-50. doi: 10.1111/j.1748-720X.2012.00703.x.

20.

Time to normalization of intracranial pressure secondary to intraventricular hemorrhage and the need for retinopathy of prematurity treatment in infants diagnosed with both conditions.

Kella YR, Snir M, Ehrlich R, Siegel RA, Sirota L, Erhenberg M, Osovsky M, Friling R.

J AAPOS. 2012 Dec;16(6):515-7. doi: 10.1016/j.jaapos.2012.07.011.

PMID:
23237746
21.

ABC triblock terpolymers exhibiting both temperature- and pH-sensitive micellar aggregation and gelation in aqueous solution.

Koonar I, Zhou C, Hillmyer MA, Lodge TP, Siegel RA.

Langmuir. 2012 Dec 21;28(51):17785-94. doi: 10.1021/la303712b. Epub 2012 Dec 11.

PMID:
23189918
22.

Intravitreal bevacizumab treatment for macular edema due to branch retinal vein occlusion in a clinical setting.

Siegel RA, Dreznik A, Mimouni K, Bor E, Weinberger D, Bourla DH.

Curr Eye Res. 2012 Sep;37(9):823-9. doi: 10.3109/02713683.2012.678542. Epub 2012 Jun 5.

PMID:
22668201
23.

Convection and retro-convection enhanced delivery: some theoretical considerations related to drug targeting.

Motion JP, Huynh GH, Szoka FC Jr, Siegel RA.

Pharm Res. 2011 Mar;28(3):472-9. doi: 10.1007/s11095-010-0296-2. Epub 2010 Oct 21.

24.

Cooperative binding isotherms for nearest neighbor interacting ligands on platonic solids: a simple model for viral capture nanotherapy.

Siegel RA, Linstad JL.

J Phys Chem B. 2010 Nov 11;114(44):14071-6. doi: 10.1021/jp1066378.

PMID:
20949931
25.

Macromolecular Diffusion in Self-Assembling Biodegradable Thermosensitive Hydrogels.

Vermonden T, Jena SS, Barriet D, Censi R, van der Gucht J, Hennink WE, Siegel RA.

Macromolecules. 2010 Jan 26;43(2):782-789.

26.

Magnetic deposition of aerosols composed of aggregated superparamagnetic nanoparticles.

Xie Y, Zeng P, Siegel RA, Wiedmann TS, Hammer BE, Longest PW.

Pharm Res. 2010 May;27(5):855-65. doi: 10.1007/s11095-010-0078-x. Epub 2010 Mar 3.

PMID:
20198407
27.

Composite block polymer-microfabricated silicon nanoporous membrane.

Nuxoll EE, Hillmyer MA, Wang R, Leighton C, Siegel RA.

ACS Appl Mater Interfaces. 2009 Apr;1(4):888-93. doi: 10.1021/am900013v.

28.

A comparative study on two phenylboronic acid based glucose-sensitive hydrogels.

Xu F, Liu G, Zhang Q, Siegel RA.

Front Biosci (Elite Ed). 2010 Jan 1;2:657-67.

PMID:
20036909
29.

Hard and soft micro- and nanofabrication: An integrated approach to hydrogel-based biosensing and drug delivery.

Siegel RA, Gu Y, Lei M, Baldi A, Nuxoll EE, Ziaie B.

J Control Release. 2010 Feb 15;141(3):303-13. doi: 10.1016/j.jconrel.2009.12.012. Epub 2009 Dec 24. Review.

30.

Top-down and bottom-up fabrication techniques for hydrogel based sensing and hormone delivery microdevices.

Siegel RA, Nuxoll EE, Hillmyer MA, Ziaie B.

Conf Proc IEEE Eng Med Biol Soc. 2009;2009:232-5. doi: 10.1109/IEMBS.2009.5332511.

PMID:
19963454
31.
32.

Bioavailability and tolerability of intranasal diazepam in healthy adult volunteers.

Ivaturi VD, Riss JR, Kriel RL, Siegel RA, Cloyd JC.

Epilepsy Res. 2009 Apr;84(2-3):120-6. doi: 10.1016/j.eplepsyres.2009.01.001. Epub 2009 Feb 20.

PMID:
19231138
33.

BioMEMS devices for drug delivery.

Nuxoll EE, Siegel RA.

IEEE Eng Med Biol Mag. 2009 Jan-Feb;28(1):31-9. doi: 10.1109/MEMB.2008.931014. Review. No abstract available.

PMID:
19150769
34.

Hydrogel-based microsensors for wireless chemical monitoring.

Lei M, Baldi A, Nuxoll E, Siegel RA, Ziaie B.

Biomed Microdevices. 2009 Jun;11(3):529-38. doi: 10.1007/s10544-008-9168-5.

PMID:
18335316
35.

Hydrogel-Based BioMEMS platforms for smart drug delivery.

Ziaie B, Siegel RA.

Conf Proc IEEE Eng Med Biol Soc. 2004;4:2670.

PMID:
17511110
36.

Integration of hydrogels with hard and soft microstructures.

Lei M, Ziaie B, Nuxoll E, Iván K, Noszticzius Z, Siegel RA.

J Nanosci Nanotechnol. 2007 Mar;7(3):780-9.

PMID:
17450833
37.

Investigation of a cellular pharmacodynamic model exhibiting sharp response sensitivity and tolerance.

Siegel RA.

J Pharmacokinet Pharmacodyn. 2007 Feb;34(1):87-101. Epub 2006 Dec 12.

PMID:
17160695
38.
39.

Chemically controlled self-assembly of protein nanorings.

Carlson JC, Jena SS, Flenniken M, Chou TF, Siegel RA, Wagner CR.

J Am Chem Soc. 2006 Jun 14;128(23):7630-8.

PMID:
16756320
40.

Commentary: stochastic phenomena in pharmacokinetic, pharmacodynamic and pharmacogenomic models.

Siegel RA, Ramanathan M.

AAPS J. 2005;7(1):E141-2. No abstract available.

41.
42.

A hydrogel-based implantable micromachined transponder for wireless glucose measurement.

Lei M, Baldi A, Nuxoll E, Siegel RA, Ziaie B.

Diabetes Technol Ther. 2006 Feb;8(1):112-22.

PMID:
16472058
43.

High-resolution technique for fabricating environmentally sensitive hydrogel microstructures.

Lei M, Gu Y, Baldi A, Siegel RA, Ziaie B.

Langmuir. 2004 Oct 12;20(21):8947-51. No abstract available.

PMID:
15461469
44.

Rational design of contact guiding, neurotrophic matrices for peripheral nerve regeneration.

Rosner BI, Siegel RA, Grosberg A, Tranquillo RT.

Ann Biomed Eng. 2003 Dec;31(11):1383-401.

PMID:
14758929
45.

Hard and soft micromachining for BioMEMS: review of techniques and examples of applications in microfluidics and drug delivery.

Ziaie B, Baldi A, Lei M, Gu Y, Siegel RA.

Adv Drug Deliv Rev. 2004 Feb 10;56(2):145-72. Review.

PMID:
14741113
46.

Biosensing and drug delivery at the microscale.

Siegel RA, Ziaie B.

Adv Drug Deliv Rev. 2004 Feb 10;56(2):121-3. No abstract available.

PMID:
14741111
47.
48.
49.

Ionizable drugs and pH oscillators: buffering effects.

Misra GP, Siegel RA.

J Pharm Sci. 2002 Sep;91(9):2003-15.

PMID:
12210047
50.

New mode of drug delivery: long term autonomous rhythmic hormone release across a hydrogel membrane.

Misra GP, Siegel RA.

J Control Release. 2002 May 17;81(1-2):1-6.

PMID:
11992673

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