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CRISPR-engineered T cells in patients with refractory cancer.

Stadtmauer EA, Fraietta JA, Davis MM, Cohen AD, Weber KL, Lancaster E, Mangan PA, Kulikovskaya I, Gupta M, Chen F, Tian L, Gonzalez VE, Xu J, Jung IY, Melenhorst JJ, Plesa G, Shea J, Matlawski T, Cervini A, Gaymon AL, Desjardins S, Lamontagne A, Salas-Mckee J, Fesnak A, Siegel DL, Levine BL, Jadlowsky JK, Young RM, Chew A, Hwang WT, Hexner EO, Carreno BM, Nobles CL, Bushman FD, Parker KR, Qi Y, Satpathy AT, Chang HY, Zhao Y, Lacey SF, June CH.

Science. 2020 Feb 6. pii: eaba7365. doi: 10.1126/science.aba7365. [Epub ahead of print]


Bi-specific and Split CAR T Cells Targeting CD13 and TIM3 Eradicate Acute Myeloid Leukemia.

He X, Feng Z, Ma J, Ling S, Cao Y, Gurung B, Wu Y, Katona BW, O'Dwyer KP, Siegel DL, June CH, Hua X.

Blood. 2020 Jan 17. pii: blood.2019002779. doi: 10.1182/blood.2019002779. [Epub ahead of print]


CD19-targeting CAR T cell immunotherapy outcomes correlate with genomic modification by vector integration.

Nobles CL, Sherrill-Mix S, Everett JK, Reddy S, Fraietta JA, Porter DL, Frey N, Gill SI, Grupp SA, Maude SL, Siegel DL, Levine BL, June CH, Lacey SF, Melenhorst JJ, Bushman FD.

J Clin Invest. 2020 Feb 3;130(2):673-685. doi: 10.1172/JCI130144.


Synthetic nucleic acid antibody prophylaxis confers rapid and durable protective immunity against Zika virus challenge.

Choi H, Kudchodkar SB, Reuschel EL, Asija K, Borole P, Agarwal S, Van Gorder L, Reed CC, Gulendran G, Ramos S, Broderick KE, Kim JJ, Ugen KE, Kobinger G, Siegel DL, Weiner DB, Muthumani K.

Hum Vaccin Immunother. 2019 Dec 4:1-12. doi: 10.1080/21645515.2019.1688038. [Epub ahead of print]


T-cell phenotypes associated with effective CAR T-cell therapy in postinduction vs relapsed multiple myeloma.

Garfall AL, Dancy EK, Cohen AD, Hwang WT, Fraietta JA, Davis MM, Levine BL, Siegel DL, Stadtmauer EA, Vogl DT, Waxman A, Rapoport AP, Milone MC, June CH, Melenhorst JJ.

Blood Adv. 2019 Oct 8;3(19):2812-2815. doi: 10.1182/bloodadvances.2019000600. No abstract available.


CAR T cell viability release testing and clinical outcomes: is there a lower limit?

Chong EA, Levine BL, Grupp SA, Davis MM, Siegel DL, Maude SL, Gladney WL, Frey NV, Porter DL, Hwang WT, Chong ER, June CH, Schuster SJ.

Blood. 2019 Nov 21;134(21):1873-1875. doi: 10.1182/blood.2019002258. No abstract available.


Bullous pemphigoid autoantibody-mediated complement fixation is abolished by the low-molecular-weight heparin tinzaparin sodium.

Gutjahr A, Heck F, Emtenani S, Hammers AK, Hundt JE, Muck P, Siegel DL, Schmidt E, Stanley JR, Zillikens D, Hammers CM.

Br J Dermatol. 2019 Sep;181(3):593-594. doi: 10.1111/bjd.18156. Epub 2019 Jun 5. No abstract available.


B cell maturation antigen-specific CAR T cells are clinically active in multiple myeloma.

Cohen AD, Garfall AL, Stadtmauer EA, Melenhorst JJ, Lacey SF, Lancaster E, Vogl DT, Weiss BM, Dengel K, Nelson A, Plesa G, Chen F, Davis MM, Hwang WT, Young RM, Brogdon JL, Isaacs R, Pruteanu-Malinici I, Siegel DL, Levine BL, June CH, Milone MC.

J Clin Invest. 2019 Mar 21;129(6):2210-2221. doi: 10.1172/JCI126397.


Anti-CD19 CAR T cells with high-dose melphalan and autologous stem cell transplantation for refractory multiple myeloma.

Garfall AL, Stadtmauer EA, Hwang WT, Lacey SF, Melenhorst JJ, Krevvata M, Carroll MP, Matsui WH, Wang Q, Dhodapkar MV, Dhodapkar K, Das R, Vogl DT, Weiss BM, Cohen AD, Mangan PA, Ayers EC, Nunez-Cruz S, Kulikovskaya I, Davis MM, Lamontagne A, Dengel K, Kerr ND, Young RM, Siegel DL, Levine BL, Milone MC, Maus MV, June CH.

JCI Insight. 2019 Feb 21;4(4). pii: 127684. doi: 10.1172/jci.insight.127684. eCollection 2019 Feb 21. No abstract available.


Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia.

Fraietta JA, Lacey SF, Orlando EJ, Pruteanu-Malinici I, Gohil M, Lundh S, Boesteanu AC, Wang Y, O'Connor RS, Hwang WT, Pequignot E, Ambrose DE, Zhang C, Wilcox N, Bedoya F, Dorfmeier C, Chen F, Tian L, Parakandi H, Gupta M, Young RM, Johnson FB, Kulikovskaya I, Liu L, Xu J, Kassim SH, Davis MM, Levine BL, Frey NV, Siegel DL, Huang AC, Wherry EJ, Bitter H, Brogdon JL, Porter DL, June CH, Melenhorst JJ.

Nat Med. 2018 May;24(5):563-571. doi: 10.1038/s41591-018-0010-1. Epub 2018 Apr 30.


Anti-CD19 CAR T cells with high-dose melphalan and autologous stem cell transplantation for refractory multiple myeloma.

Garfall AL, Stadtmauer EA, Hwang WT, Lacey SF, Melenhorst JJ, Krevvata M, Carroll MP, Matsui WH, Wang Q, Dhodapkar MV, Dhodapkar K, Das R, Vogl DT, Weiss BM, Cohen AD, Mangan PA, Ayers EC, Nunez-Cruz S, Kulikovskaya I, Davis MM, Lamontagne A, Dengel K, Kerr ND, Young RM, Siegel DL, Levine BL, Milone MC, Maus MV, June CH.

JCI Insight. 2018 Apr 19;3(8). pii: 120505. doi: 10.1172/jci.insight.120505. eCollection 2018 Apr 19. Erratum in: JCI Insight. 2019 Feb 21;4(4):.


Biocompatible coupling of therapeutic fusion proteins to human erythrocytes.

Villa CH, Pan DC, Johnston IH, Greineder CF, Walsh LR, Hood ED, Cines DB, Poncz M, Siegel DL, Muzykantov VR.

Blood Adv. 2018 Feb 13;2(3):165-176. doi: 10.1182/bloodadvances.2017011734.


Proteomic Analysis of Pemphigus Autoantibodies Indicates a Larger, More Diverse, and More Dynamic Repertoire than Determined by B Cell Genetics.

Chen J, Zheng Q, Hammers CM, Ellebrecht CT, Mukherjee EM, Tang HY, Lin C, Yuan H, Pan M, Langenhan J, Komorowski L, Siegel DL, Payne AS, Stanley JR.

Cell Rep. 2017 Jan 3;18(1):237-247. doi: 10.1016/j.celrep.2016.12.013.


Targeting thrombomodulin to circulating red blood cells augments its protective effects in models of endotoxemia and ischemia-reperfusion injury.

Carnemolla R, Villa CH, Greineder CF, Zaitsev S, Patel KR, Kowalska MA, Atochin DN, Cines DB, Siegel DL, Esmon CT, Muzykantov VR.

FASEB J. 2017 Feb;31(2):761-770. doi: 10.1096/fj.201600912R. Epub 2016 Nov 11.


Erythrocytes as Carriers for Drug Delivery in Blood Transfusion and Beyond.

Villa CH, Cines DB, Siegel DL, Muzykantov V.

Transfus Med Rev. 2017 Jan;31(1):26-35. doi: 10.1016/j.tmrv.2016.08.004. Epub 2016 Aug 17. Review.


Modulation of natural IgM autoantibodies to oxidative stress-related neo-epitopes on apoptotic cells in newborns of mothers with anti-Ro autoimmunity.

Grönwall C, Clancy RM, Getu L, Lloyd KA, Siegel DL, Reed JH, Buyon JP, Silverman GJ.

J Autoimmun. 2016 Sep;73:30-41. doi: 10.1016/j.jaut.2016.05.014. Epub 2016 Jun 8.


CAR-T Cell Therapies From the Transfusion Medicine Perspective.

Fesnak A, Lin C, Siegel DL, Maus MV.

Transfus Med Rev. 2016 Jul;30(3):139-45. doi: 10.1016/j.tmrv.2016.03.001. Epub 2016 Mar 28. Review.


ADAMTS13 autoantibodies cloned from patients with acquired thrombotic thrombocytopenic purpura: 1. Structural and functional characterization in vitro.

Ostertag EM, Kacir S, Thiboutot M, Gulendran G, Zheng XL, Cines DB, Siegel DL.

Transfusion. 2016 Jul;56(7):1763-74. doi: 10.1111/trf.13584. Epub 2016 Apr 4.


ADAMTS13 autoantibodies cloned from patients with acquired thrombotic thrombocytopenic purpura: 2. Pathogenicity in an animal model.

Ostertag EM, Bdeir K, Kacir S, Thiboutot M, Gulendran G, Yunk L, Hayes VM, Motto DG, Poncz M, Zheng XL, Cines DB, Siegel DL.

Transfusion. 2016 Jul;56(7):1775-85. doi: 10.1111/trf.13583. Epub 2016 Apr 4.


A chimeric platelet-targeted urokinase prodrug selectively blocks new thrombus formation.

Fuentes RE, Zaitsev S, Ahn HS, Hayes V, Kowalska MA, Lambert MP, Wang Y, Siegel DL, Bougie DW, Aster RH, Myers DD, Stepanova V, Cines DB, Muzykantov VR, Poncz M.

J Clin Invest. 2016 Feb;126(2):483-94.


Dog erythrocyte antigen 1: mode of inheritance and initial characterization.

Polak K, Acierno MM, Raj K, Mizukami K, Siegel DL, Giger U.

Vet Clin Pathol. 2015 Sep;44(3):369-79. doi: 10.1111/vcp.12284. Epub 2015 Aug 20.


Delivery of drugs bound to erythrocytes: new avenues for an old intravascular carrier.

Villa CH, Pan DC, Zaitsev S, Cines DB, Siegel DL, Muzykantov VR.

Ther Deliv. 2015 Jul;6(7):795-826. doi: 10.4155/tde.15.34. Review.


High-resolution epitope mapping by HX MS reveals the pathogenic mechanism and a possible therapy for autoimmune TTP syndrome.

Casina VC, Hu W, Mao JH, Lu RN, Hanby HA, Pickens B, Kan ZY, Lim WK, Mayne L, Ostertag EM, Kacir S, Siegel DL, Englander SW, Zheng XL.

Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):9620-5. doi: 10.1073/pnas.1512561112. Epub 2015 Jul 22.


NY-ESO-1-specific TCR-engineered T cells mediate sustained antigen-specific antitumor effects in myeloma.

Rapoport AP, Stadtmauer EA, Binder-Scholl GK, Goloubeva O, Vogl DT, Lacey SF, Badros AZ, Garfall A, Weiss B, Finklestein J, Kulikovskaya I, Sinha SK, Kronsberg S, Gupta M, Bond S, Melchiori L, Brewer JE, Bennett AD, Gerry AB, Pumphrey NJ, Williams D, Tayton-Martin HK, Ribeiro L, Holdich T, Yanovich S, Hardy N, Yared J, Kerr N, Philip S, Westphal S, Siegel DL, Levine BL, Jakobsen BK, Kalos M, June CH.

Nat Med. 2015 Aug;21(8):914-921. doi: 10.1038/nm.3910. Epub 2015 Jul 20.


Platelet-delivered ADAMTS13 inhibits arterial thrombosis and prevents thrombotic thrombocytopenic purpura in murine models.

Pickens B, Mao Y, Li D, Siegel DL, Poncz M, Cines DB, Zheng XL.

Blood. 2015 May 21;125(21):3326-34. doi: 10.1182/blood-2014-07-587139. Epub 2015 Mar 23.


Phage antibody display libraries: a powerful antibody discovery platform for immunotherapy.

Zhao A, Tohidkia MR, Siegel DL, Coukos G, Omidi Y.

Crit Rev Biotechnol. 2016;36(2):276-89. doi: 10.3109/07388551.2014.958978. Epub 2014 Nov 14. Review.


Persistence of anti-desmoglein 3 IgG(+) B-cell clones in pemphigus patients over years.

Hammers CM, Chen J, Lin C, Kacir S, Siegel DL, Payne AS, Stanley JR.

J Invest Dermatol. 2015 Mar;135(3):742-749. doi: 10.1038/jid.2014.291. Epub 2014 Jul 14.


Carbohydrate sequence of the prostate cancer-associated antigen F77 assigned by a mucin O-glycome designer array.

Gao C, Liu Y, Zhang H, Zhang Y, Fukuda MN, Palma AS, Kozak RP, Childs RA, Nonaka M, Li Z, Siegel DL, Hanfland P, Peehl DM, Chai W, Greene MI, Feizi T.

J Biol Chem. 2014 Jun 6;289(23):16462-77. doi: 10.1074/jbc.M114.558932. Epub 2014 Apr 21.


The receptor for advanced glycation end products mediates lung endothelial activation by RBCs.

Mangalmurti NS, Friedman JL, Wang LC, Stolz D, Muthukumaran G, Siegel DL, Schmidt AM, Lee JS, Albelda SM.

Am J Physiol Lung Cell Mol Physiol. 2013 Feb 15;304(4):L250-63. doi: 10.1152/ajplung.00278.2012. Epub 2012 Dec 28.


Antigen and substrate withdrawal in the management of autoimmune thrombotic disorders.

Cines DB, McCrae KR, Zheng XL, Sachais BS, Luning Prak ET, Siegel DL.

Blood. 2012 Nov 15;120(20):4134-42. doi: 10.1182/blood-2012-06-389445. Epub 2012 Sep 10. Review.


Validation of glypican-3-specific scFv isolated from paired display/secretory yeast display library.

Li Y, Siegel DL, Scholler N, Kaplan DE.

BMC Biotechnol. 2012 May 7;12:23. doi: 10.1186/1472-6750-12-23.


Mannose receptor (MR) engagement by mesothelin GPI anchor polarizes tumor-associated macrophages and is blocked by anti-MR human recombinant antibody.

Dangaj D, Abbott KL, Mookerjee A, Zhao A, Kirby PS, Sandaltzopoulos R, Powell DJ Jr, Lamazière A, Siegel DL, Wolf C, Scholler N.

PLoS One. 2011;6(12):e28386. doi: 10.1371/journal.pone.0028386. Epub 2011 Dec 6.


Impact of pre-existing immunity on gene transfer to nonhuman primate liver with adeno-associated virus 8 vectors.

Wang L, Calcedo R, Bell P, Lin J, Grant RL, Siegel DL, Wilson JM.

Hum Gene Ther. 2011 Nov;22(11):1389-401. doi: 10.1089/hum.2011.031. Epub 2011 Jun 8.


Homologous regions of autoantibody heavy chain complementarity-determining region 3 (H-CDR3) in patients with pemphigus cause pathogenicity.

Yamagami J, Payne AS, Kacir S, Ishii K, Siegel DL, Stanley JR.

J Clin Invest. 2010 Nov;120(11):4111-7. doi: 10.1172/JCI44425. Epub 2010 Oct 18.


Rapid isolation of high-affinity human antibodies against the tumor vascular marker Endosialin/TEM1, using a paired yeast-display/secretory scFv library platform.

Zhao A, Nunez-Cruz S, Li C, Coukos G, Siegel DL, Scholler N.

J Immunol Methods. 2011 Jan 5;363(2):221-32. doi: 10.1016/j.jim.2010.09.001. Epub 2010 Sep 15.


Generation and validation of canine single chain variable fragment phage display libraries.

Braganza A, Wallace K, Pell L, Parrish CR, Siegel DL, Mason NJ.

Vet Immunol Immunopathol. 2011 Jan;139(1):27-40. doi: 10.1016/j.vetimm.2010.07.026. Epub 2010 Aug 7.


Anaphylactoid-like reactions in a patient with HyperLp(a)lipidemia undergoing LDL apheresis with dextran sulfate adsorption and herbal therapy with the spice turmeric.

Adamski J, Jamensky L, Ross J, Siegel DL, Sachais BS.

J Clin Apher. 2010;25(6):354-7. doi: 10.1002/jca.20254. Epub 2010 Aug 30.


Synthesis and SAR of 2-aryl-3-aminomethylquinolines as agonists of the bile acid receptor TGR5.

Herbert MR, Siegel DL, Staszewski L, Cayanan C, Banerjee U, Dhamija S, Anderson J, Fan A, Wang L, Rix P, Shiau AK, Rao TS, Noble SA, Heyman RA, Bischoff E, Guha M, Kabakibi A, Pinkerton AB.

Bioorg Med Chem Lett. 2010 Oct 1;20(19):5718-21. doi: 10.1016/j.bmcl.2010.08.014. Epub 2010 Aug 10.


Advanced glycation end products on stored red blood cells increase endothelial reactive oxygen species generation through interaction with receptor for advanced glycation end products.

Mangalmurti NS, Chatterjee S, Cheng G, Andersen E, Mohammed A, Siegel DL, Schmidt AM, Albelda SM, Lee JS.

Transfusion. 2010 Nov;50(11):2353-61. doi: 10.1111/j.1537-2995.2010.02689.x.


Update on the cloning of monoclonal anti-desmoglein antibodies from human pemphigus patients: implications for targeted therapy.

Stanley JR, Ishii K, Siegel DL, Payne AS.

Vet Dermatol. 2009 Oct;20(5-6):327-30. doi: 10.1111/j.1365-3164.2009.00836.x.


Antibodies to the desmoglein 1 precursor proprotein but not to the mature cell surface protein cloned from individuals without pemphigus.

Yamagami J, Kacir S, Ishii K, Payne AS, Siegel DL, Stanley JR.

J Immunol. 2009 Nov 1;183(9):5615-21. doi: 10.4049/jimmunol.0901691.


Second auto-SCT is safe and effective salvage therapy for relapsed multiple myeloma.

Olin RL, Vogl DT, Porter DL, Luger SM, Schuster SJ, Tsai DE, Siegel DL, Cook RJ, Mangan PA, Cunningham K, Stadtmauer EA.

Bone Marrow Transplant. 2009 Mar;43(5):417-22. doi: 10.1038/bmt.2008.334. Epub 2008 Oct 13.


Translational applications of antibody phage display.

Siegel DL.

Immunol Res. 2008;42(1-3):118-31. doi: 10.1007/s12026-008-8044-y. Review.


Isolation of pathogenic monoclonal anti-desmoglein 1 human antibodies by phage display of pemphigus foliaceus autoantibodies.

Ishii K, Lin C, Siegel DL, Stanley JR.

J Invest Dermatol. 2008 Apr;128(4):939-48. Epub 2007 Nov 15.


Post-transplant outcomes of induction therapy for myeloma: thalidomide and dexamethasone versus doxorubicin, vincristine, and dexamethasone prior to high-dose melphalan with autologous stem cell support.

Vogl DT, Liu SV, Chong EA, Luger SM, Porter DL, Schuster SJ, Tsai DE, Perl A, Loren AW, Goldstein SC, Nasta SD, Andreadis C, Mangan PA, Hummel K, Siegel DL, Glatstein E, Stadtmauer EA.

Am J Hematol. 2007 Dec;82(12):1071-5.


Phage display-based molecular methods in immunohematology.

Siegel DL.

Transfusion. 2007 Jul;47(1 Suppl):89S-94S. Review. No abstract available.


Targeting pemphigus autoantibodies through their heavy-chain variable region genes.

Payne AS, Siegel DL, Stanley JR.

J Invest Dermatol. 2007 Jul;127(7):1681-91. Epub 2007 Mar 29.


Prognostic value of FDG-PET scan imaging in lymphoma patients undergoing autologous stem cell transplantation.

Svoboda J, Andreadis C, Elstrom R, Chong EA, Downs LH, Berkowitz A, Luger SM, Porter DL, Nasta S, Tsai D, Loren AW, Siegel DL, Glatstein E, Alavi A, Stadtmauer EA, Schuster SJ.

Bone Marrow Transplant. 2006 Aug;38(3):211-6. Epub 2006 Jun 12.


Nephrogenic fibrosing dermopathy/nephrogenic systemic fibrosis with diaphragmatic involvement in a patient with respiratory failure.

Kucher C, Steere J, Elenitsas R, Siegel DL, Xu X.

J Am Acad Dermatol. 2006 Feb;54(2 Suppl):S31-4.


Phage display tools for blood typing.

Siegel DL.

Curr Hematol Rep. 2005 Nov;4(6):459-64. Review.


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