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Items: 1 to 50 of 93

1.

Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning.

Rozbesky D, Robinson RA, Jain V, Renner M, Malinauskas T, Harlos K, Siebold C, Jones EY.

Nat Commun. 2019 Aug 15;10(1):3691. doi: 10.1038/s41467-019-11683-y.

2.

iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition.

Chen S, Wu J, Zhong S, Li Y, Zhang P, Ma J, Ren J, Tan Y, Wang Y, Au KF, Siebold C, Bond GL, Chen Z, Lu M, Jones EY, Lu X.

Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17470-17479. doi: 10.1073/pnas.1909393116. Epub 2019 Aug 8.

3.

Structures of vertebrate Patched and Smoothened reveal intimate links between cholesterol and Hedgehog signalling.

Kowatsch C, Woolley RE, Kinnebrew M, Rohatgi R, Siebold C.

Curr Opin Struct Biol. 2019 Aug;57:204-214. doi: 10.1016/j.sbi.2019.05.015. Epub 2019 Jun 24. Review.

PMID:
31247512
4.

Biochemical mechanisms of vertebrate hedgehog signaling.

Kong JH, Siebold C, Rohatgi R.

Development. 2019 May 15;146(10). pii: dev166892. doi: 10.1242/dev.166892. Review.

PMID:
31092502
5.

Cholesterol Interaction Sites on the Transmembrane Domain of the Hedgehog Signal Transducer and Class F G Protein-Coupled Receptor Smoothened.

Hedger G, Koldsø H, Chavent M, Siebold C, Rohatgi R, Sansom MSP.

Structure. 2019 Mar 5;27(3):549-559.e2. doi: 10.1016/j.str.2018.11.003. Epub 2018 Dec 27.

6.

Lentiviral transduction of mammalian cells for fast, scalable and high-level production of soluble and membrane proteins.

Elegheert J, Behiels E, Bishop B, Scott S, Woolley RE, Griffiths SC, Byrne EFX, Chang VT, Stuart DI, Jones EY, Siebold C, Aricescu AR.

Nat Protoc. 2018 Dec;13(12):2991-3017. doi: 10.1038/s41596-018-0075-9.

7.

Cilia-Associated Oxysterols Activate Smoothened.

Raleigh DR, Sever N, Choksi PK, Sigg MA, Hines KM, Thompson BM, Elnatan D, Jaishankar P, Bisignano P, Garcia-Gonzalo FR, Krup AL, Eberl M, Byrne EFX, Siebold C, Wong SY, Renslo AR, Grabe M, McDonald JG, Xu L, Beachy PA, Reiter JF.

Mol Cell. 2018 Oct 18;72(2):316-327.e5. doi: 10.1016/j.molcel.2018.08.034.

8.

Calibration-free In Vitro Quantification of Protein Homo-oligomerization Using Commercial Instrumentation and Free, Open Source Brightness Analysis Software.

Nolan R, Alvarez LA, Griffiths SC, Elegheert J, Siebold C, Padilla-Parra S.

J Vis Exp. 2018 Jul 17;(137). doi: 10.3791/58157.

PMID:
30080195
9.

Calcium-sensing receptor residues with loss- and gain-of-function mutations are located in regions of conformational change and cause signalling bias.

Gorvin CM, Frost M, Malinauskas T, Cranston T, Boon H, Siebold C, Jones EY, Hannan FM, Thakker RV.

Hum Mol Genet. 2018 Nov 1;27(21):3720-3733. doi: 10.1093/hmg/ddy263.

10.

A calcium-sensing receptor mutation causing hypocalcemia disrupts a transmembrane salt bridge to activate β-arrestin-biased signaling.

Gorvin CM, Babinsky VN, Malinauskas T, Nissen PH, Schou AJ, Hanyaloglu AC, Siebold C, Jones EY, Hannan FM, Thakker RV.

Sci Signal. 2018 Feb 20;11(518). pii: eaan3714. doi: 10.1126/scisignal.aan3714.

11.

Multiple ligand binding sites regulate the Hedgehog signal transducer Smoothened in vertebrates.

Byrne EF, Luchetti G, Rohatgi R, Siebold C.

Curr Opin Cell Biol. 2018 Apr;51:81-88. doi: 10.1016/j.ceb.2017.10.004. Epub 2017 Dec 18. Review.

12.

RGMs: Structural Insights, Molecular Regulation, and Downstream Signaling.

Siebold C, Yamashita T, Monnier PP, Mueller BK, Pasterkamp RJ.

Trends Cell Biol. 2017 May;27(5):365-378. doi: 10.1016/j.tcb.2016.11.009. Epub 2016 Dec 19. Review.

13.

Restoring p53 Function in Human Melanoma Cells by Inhibiting MDM2 and Cyclin B1/CDK1-Phosphorylated Nuclear iASPP.

Lu M, Breyssens H, Salter V, Zhong S, Hu Y, Baer C, Ratnayaka I, Sullivan A, Brown NR, Endicott J, Knapp S, Kessler BM, Middleton MR, Siebold C, Jones EY, Sviderskaya EV, Cebon J, John T, Caballero OL, Goding CR, Lu X.

Cancer Cell. 2016 Nov 14;30(5):822-823. doi: 10.1016/j.ccell.2016.09.019. No abstract available.

14.

Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling.

Luchetti G, Sircar R, Kong JH, Nachtergaele S, Sagner A, Byrne EF, Covey DF, Siebold C, Rohatgi R.

Elife. 2016 Oct 5;5. pii: e20304. doi: 10.7554/eLife.20304.

15.

Structural basis of Smoothened regulation by its extracellular domains.

Byrne EFX, Sircar R, Miller PS, Hedger G, Luchetti G, Nachtergaele S, Tully MD, Mydock-McGrane L, Covey DF, Rambo RP, Sansom MSP, Newstead S, Rohatgi R, Siebold C.

Nature. 2016 Jul 28;535(7613):517-522. doi: 10.1038/nature18934. Epub 2016 Jul 20.

16.

Structural basis for integration of GluD receptors within synaptic organizer complexes.

Elegheert J, Kakegawa W, Clay JE, Shanks NF, Behiels E, Matsuda K, Kohda K, Miura E, Rossmann M, Mitakidis N, Motohashi J, Chang VT, Siebold C, Greger IH, Nakagawa T, Yuzaki M, Aricescu AR.

Science. 2016 Jul 15;353(6296):295-9. doi: 10.1126/science.aae0104.

17.

Initiation of T cell signaling by CD45 segregation at 'close contacts'.

Chang VT, Fernandes RA, Ganzinger KA, Lee SF, Siebold C, McColl J, Jönsson P, Palayret M, Harlos K, Coles CH, Jones EY, Lui Y, Huang E, Gilbert RJC, Klenerman D, Aricescu AR, Davis SJ.

Nat Immunol. 2016 May;17(5):574-582. doi: 10.1038/ni.3392. Epub 2016 Mar 21.

18.

Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.

van Erp S, van den Heuvel DMA, Fujita Y, Robinson RA, Hellemons AJCGM, Adolfs Y, Van Battum EY, Blokhuis AM, Kuijpers M, Demmers JAA, Hedman H, Hoogenraad CC, Siebold C, Yamashita T, Pasterkamp RJ.

Dev Cell. 2015 Dec 7;35(5):537-552. doi: 10.1016/j.devcel.2015.11.008.

19.

Secreted HHIP1 interacts with heparan sulfate and regulates Hedgehog ligand localization and function.

Holtz AM, Griffiths SC, Davis SJ, Bishop B, Siebold C, Allen BL.

J Cell Biol. 2015 Jun 8;209(5):739-57. doi: 10.1083/jcb.201411024.

20.

Repulsive guidance molecule is a structural bridge between neogenin and bone morphogenetic protein.

Healey EG, Bishop B, Elegheert J, Bell CH, Padilla-Parra S, Siebold C.

Nat Struct Mol Biol. 2015 Jun;22(6):458-65. doi: 10.1038/nsmb.3016. Epub 2015 May 4.

21.

Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling.

Nachtergaele S, Whalen DM, Mydock LK, Zhao Z, Malinauskas T, Krishnan K, Ingham PW, Covey DF, Siebold C, Rohatgi R.

Elife. 2013 Oct 29;2:e01340. doi: 10.7554/eLife.01340.

22.

Structural insights into proteoglycan-shaped Hedgehog signaling.

Whalen DM, Malinauskas T, Gilbert RJ, Siebold C.

Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16420-5. doi: 10.1073/pnas.1310097110. Epub 2013 Sep 23.

23.

Structure of the repulsive guidance molecule (RGM)-neogenin signaling hub.

Bell CH, Healey E, van Erp S, Bishop B, Tang C, Gilbert RJC, Aricescu AR, Pasterkamp RJ, Siebold C.

Science. 2013 Jul 5;341(6141):77-80. doi: 10.1126/science.1232322. Epub 2013 Jun 6.

24.

Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPP.

Lu M, Breyssens H, Salter V, Zhong S, Hu Y, Baer C, Ratnayaka I, Sullivan A, Brown NR, Endicott J, Knapp S, Kessler BM, Middleton MR, Siebold C, Jones EY, Sviderskaya EV, Cebon J, John T, Caballero OL, Goding CR, Lu X.

Cancer Cell. 2013 May 13;23(5):618-33. doi: 10.1016/j.ccr.2013.03.013. Epub 2013 Apr 25. Erratum in: Cancer Cell. 2016 Nov 14;30(5):822-823.

25.

Structural insights into semaphorins and their receptors.

Siebold C, Jones EY.

Semin Cell Dev Biol. 2013 Mar;24(3):139-45. doi: 10.1016/j.semcdb.2012.11.003. Epub 2012 Dec 17. Review.

PMID:
23253452
26.

Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex.

Janssen BJ, Malinauskas T, Weir GA, Cader MZ, Siebold C, Jones EY.

Nat Struct Mol Biol. 2012 Dec;19(12):1293-9. doi: 10.1038/nsmb.2416. Epub 2012 Oct 28.

27.

Structural and functional studies of LRP6 ectodomain reveal a platform for Wnt signaling.

Chen S, Bubeck D, MacDonald BT, Liang WX, Mao JH, Malinauskas T, Llorca O, Aricescu AR, Siebold C, He X, Jones EY.

Dev Cell. 2011 Nov 15;21(5):848-61. doi: 10.1016/j.devcel.2011.09.007. Epub 2011 Oct 13.

28.

A dual binding mode for RhoGTPases in plexin signalling.

Bell CH, Aricescu AR, Jones EY, Siebold C.

PLoS Biol. 2011 Aug;9(8):e1001134. doi: 10.1371/journal.pbio.1001134. Epub 2011 Aug 30.

29.

Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1.

Malinauskas T, Aricescu AR, Lu W, Siebold C, Jones EY.

Nat Struct Mol Biol. 2011 Jul 10;18(8):886-93. doi: 10.1038/nsmb.2081.

30.

Factors influencing young women's sexual and reproductive health.

Siebold C.

Contemp Nurse. 2011 Feb;37(2):124-36. doi: 10.5172/conu.2011.37.2.124.

PMID:
21692584
31.

Recording information on protein complexes in an information management system.

Savitsky M, Diprose JM, Morris C, Griffiths SL, Daniel E, Lin B, Daenke S, Bishop B, Siebold C, Wilson KS, Blake R, Stuart DI, Esnouf RM.

J Struct Biol. 2011 Aug;175(2):224-9. doi: 10.1016/j.jsb.2011.05.009. Epub 2011 May 14.

32.

Automation of large scale transient protein expression in mammalian cells.

Zhao Y, Bishop B, Clay JE, Lu W, Jones M, Daenke S, Siebold C, Stuart DI, Jones EY, Aricescu AR.

J Struct Biol. 2011 Aug;175(2):209-15. doi: 10.1016/j.jsb.2011.04.017. Epub 2011 May 6.

33.

Structure of HLA-A*0301 in complex with a peptide of proteolipid protein: insights into the role of HLA-A alleles in susceptibility to multiple sclerosis.

McMahon RM, Friis L, Siebold C, Friese MA, Fugger L, Jones EY.

Acta Crystallogr D Biol Crystallogr. 2011 May;67(Pt 5):447-54. doi: 10.1107/S0907444911007888. Epub 2011 Apr 13.

34.

Proteoglycan-specific molecular switch for RPTPσ clustering and neuronal extension.

Coles CH, Shen Y, Tenney AP, Siebold C, Sutton GC, Lu W, Gallagher JT, Jones EY, Flanagan JG, Aricescu AR.

Science. 2011 Apr 22;332(6028):484-8. doi: 10.1126/science.1200840. Epub 2011 Mar 31.

35.

Structural basis of semaphorin-plexin signalling.

Janssen BJ, Robinson RA, Pérez-Brangulí F, Bell CH, Mitchell KJ, Siebold C, Jones EY.

Nature. 2010 Oct 28;467(7319):1118-22. doi: 10.1038/nature09468. Epub 2010 Sep 26.

36.

Interactions between Hedgehog proteins and their binding partners come into view.

Beachy PA, Hymowitz SG, Lazarus RA, Leahy DJ, Siebold C.

Genes Dev. 2010 Sep 15;24(18):2001-12. doi: 10.1101/gad.1951710. Review.

37.

Structural Plasticity of Eph-Receptor A4 Facilitates Cross-Class Ephrin Signaling.

Bowden TA, Aricescu AR, Nettleship JE, Siebold C, Rahman-Huq N, Owens RJ, Stuart DI, Jones EY.

Structure. 2009 Dec 9;17(12):1679. doi: 10.1016/j.str.2009.11.004. Epub 2009 Dec 8. No abstract available.

38.

Structural plasticity of eph receptor A4 facilitates cross-class ephrin signaling.

Bowden TA, Aricescu AR, Nettleship JE, Siebold C, Rahman-Huq N, Owens RJ, Stuart DI, Jones EY.

Structure. 2009 Oct 14;17(10):1386-97. doi: 10.1016/j.str.2009.07.018.

39.

Crystal structure of enzyme I of the phosphoenolpyruvate sugar phosphotransferase system in the dephosphorylated state.

Oberholzer AE, Schneider P, Siebold C, Baumann U, Erni B.

J Biol Chem. 2009 Nov 27;284(48):33169-76. doi: 10.1074/jbc.M109.057612. Epub 2009 Sep 28.

40.

Crystal structure of the GluR2 amino-terminal domain provides insights into the architecture and assembly of ionotropic glutamate receptors.

Clayton A, Siebold C, Gilbert RJ, Sutton GC, Harlos K, McIlhinney RA, Jones EY, Aricescu AR.

J Mol Biol. 2009 Oct 9;392(5):1125-32. doi: 10.1016/j.jmb.2009.07.082. Epub 2009 Aug 3.

PMID:
19651138
41.

Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP.

Bishop B, Aricescu AR, Harlos K, O'Callaghan CA, Jones EY, Siebold C.

Nat Struct Mol Biol. 2009 Jul;16(7):698-703. doi: 10.1038/nsmb.1607. Epub 2009 Jun 28.

42.

Evidence for the specificity for platelet HPA-1a alloepitope and the presenting HLA-DR52a of diverse antigen-specific helper T cell clones from alloimmunized mothers.

Rayment R, Kooij TW, Zhang W, Siebold C, Murphy MF, Allen D, Willcox N, Roberts DJ.

J Immunol. 2009 Jul 1;183(1):677-86. doi: 10.4049/jimmunol.0801473. Epub 2009 Jun 17.

43.

An ion-channel modulator from the saliva of the brown ear tick has a highly modified Kunitz/BPTI structure.

Paesen GC, Siebold C, Dallas ML, Peers C, Harlos K, Nuttall PA, Nunn MA, Stuart DI, Esnouf RM.

J Mol Biol. 2009 Jun 19;389(4):734-47. doi: 10.1016/j.jmb.2009.04.045. Epub 2009 Apr 24.

PMID:
19394347
44.

Walk a mile in my shoes: an auto-ethnographic study.

White S, Siebold C.

Contemp Nurse. 2008 Aug;30(1):57-68.

PMID:
19072191
45.

Receptor protein tyrosine phosphatase micro: measuring where to stick.

Aricescu AR, Siebold C, Jones EY.

Biochem Soc Trans. 2008 Apr;36(Pt 2):167-72. doi: 10.1042/BST0360167. Review.

PMID:
18363557
46.

Biochemical and structural studies of ASPP proteins reveal differential binding to p53, p63, and p73.

Robinson RA, Lu X, Jones EY, Siebold C.

Structure. 2008 Feb;16(2):259-68. doi: 10.1016/j.str.2007.11.012.

47.

Structure and functional analysis of the IGF-II/IGF2R interaction.

Brown J, Delaine C, Zaccheo OJ, Siebold C, Gilbert RJ, van Boxel G, Denley A, Wallace JC, Hassan AB, Forbes BE, Jones EY.

EMBO J. 2008 Jan 9;27(1):265-76. Epub 2007 Nov 29.

48.

Effects of initial eye position on saccade-related behavior of abducens nucleus neurons in the primate.

Ling L, Fuchs A, Siebold C, Dean P.

J Neurophysiol. 2007 Dec;98(6):3581-99. Epub 2007 Oct 3.

49.

Structure of a tyrosine phosphatase adhesive interaction reveals a spacer-clamp mechanism.

Aricescu AR, Siebold C, Choudhuri K, Chang VT, Lu W, Davis SJ, van der Merwe PA, Jones EY.

Science. 2007 Aug 31;317(5842):1217-20.

50.

Large spectrum of lissencephaly and pachygyria phenotypes resulting from de novo missense mutations in tubulin alpha 1A (TUBA1A).

Poirier K, Keays DA, Francis F, Saillour Y, Bahi N, Manouvrier S, Fallet-Bianco C, Pasquier L, Toutain A, Tuy FP, Bienvenu T, Joriot S, Odent S, Ville D, Desguerre I, Goldenberg A, Moutard ML, Fryns JP, van Esch H, Harvey RJ, Siebold C, Flint J, Beldjord C, Chelly J.

Hum Mutat. 2007 Nov;28(11):1055-64.

PMID:
17584854

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