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Items: 12

1.

Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen.

Fannin RD, Gerrish K, Sieber SO, Bushel PR, Watkins PB, Paules RS.

Clin Pharmacol Ther. 2016 Apr;99(4):432-41. doi: 10.1002/cpt.328. Epub 2016 Feb 22.

2.

Acetaminophen dosing of humans results in blood transcriptome and metabolome changes consistent with impaired oxidative phosphorylation.

Fannin RD, Russo M, O'Connell TM, Gerrish K, Winnike JH, Macdonald J, Newton J, Malik S, Sieber SO, Parker J, Shah R, Zhou T, Watkins PB, Paules RS.

Hepatology. 2010 Jan;51(1):227-36. doi: 10.1002/hep.23330.

3.

Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype.

Lobenhofer EK, Auman JT, Blackshear PE, Boorman GA, Bushel PR, Cunningham ML, Fostel JM, Gerrish K, Heinloth AN, Irwin RD, Malarkey DE, Merrick BA, Sieber SO, Tucker CJ, Ward SM, Wilson RE, Hurban P, Tennant RW, Paules RS.

Genome Biol. 2008;9(6):R100. doi: 10.1186/gb-2008-9-6-r100. Epub 2008 Jun 20.

4.

Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses.

Beyer RP, Fry RC, Lasarev MR, McConnachie LA, Meira LB, Palmer VS, Powell CL, Ross PK, Bammler TK, Bradford BU, Cranson AB, Cunningham ML, Fannin RD, Higgins GM, Hurban P, Kayton RJ, Kerr KF, Kosyk O, Lobenhofer EK, Sieber SO, Vliet PA, Weis BK, Wolfinger R, Woods CG, Freedman JH, Linney E, Kaufmann WK, Kavanagh TJ, Paules RS, Rusyn I, Samson LD, Spencer PS, Suk W, Tennant RJ, Zarbl H; Members of the Toxicogenomics Research Consortium.

Toxicol Sci. 2007 Sep;99(1):326-37. Epub 2007 Jun 11.

PMID:
17562736
5.

ATM requirement in gene expression responses to ionizing radiation in human lymphoblasts and fibroblasts.

Innes CL, Heinloth AN, Flores KG, Sieber SO, Deming PB, Bushel PR, Kaufmann WK, Paules RS.

Mol Cancer Res. 2006 Mar;4(3):197-207.

6.

Standardizing global gene expression analysis between laboratories and across platforms.

Bammler T, Beyer RP, Bhattacharya S, Boorman GA, Boyles A, Bradford BU, Bumgarner RE, Bushel PR, Chaturvedi K, Choi D, Cunningham ML, Deng S, Dressman HK, Fannin RD, Farin FM, Freedman JH, Fry RC, Harper A, Humble MC, Hurban P, Kavanagh TJ, Kaufmann WK, Kerr KF, Jing L, Lapidus JA, Lasarev MR, Li J, Li YJ, Lobenhofer EK, Lu X, Malek RL, Milton S, Nagalla SR, O'malley JP, Palmer VS, Pattee P, Paules RS, Perou CM, Phillips K, Qin LX, Qiu Y, Quigley SD, Rodland M, Rusyn I, Samson LD, Schwartz DA, Shi Y, Shin JL, Sieber SO, Slifer S, Speer MC, Spencer PS, Sproles DI, Swenberg JA, Suk WA, Sullivan RC, Tian R, Tennant RW, Todd SA, Tucker CJ, Van Houten B, Weis BK, Xuan S, Zarbl H; Members of the Toxicogenomics Research Consortium.

Nat Methods. 2005 May;2(5):351-6. Epub 2005 Apr 21. Erratum in: Nat Methods. 2005 Jun;2(6):477.

PMID:
15846362
7.

Differential renal gene expression in prehypertensive and hypertensive spontaneously hypertensive rats.

Seubert JM, Xu F, Graves JP, Collins JB, Sieber SO, Paules RS, Kroetz DL, Zeldin DC.

Am J Physiol Renal Physiol. 2005 Sep;289(3):F552-61. Epub 2005 Mar 29.

8.

Differential gene expression profiling in whole blood during acute systemic inflammation in lipopolysaccharide-treated rats.

Fannin RD, Auman JT, Bruno ME, Sieber SO, Ward SM, Tucker CJ, Merrick BA, Paules RS.

Physiol Genomics. 2005 Mar 21;21(1):92-104.

PMID:
15781589
9.

Gene expression profiling of rat livers reveals indicators of potential adverse effects.

Heinloth AN, Irwin RD, Boorman GA, Nettesheim P, Fannin RD, Sieber SO, Snell ML, Tucker CJ, Li L, Travlos GS, Vansant G, Blackshear PE, Tennant RW, Cunningham ML, Paules RS.

Toxicol Sci. 2004 Jul;80(1):193-202. Epub 2004 Apr 14.

PMID:
15084756
10.

ATM-dependent and -independent gene expression changes in response to oxidative stress, gamma irradiation, and UV irradiation.

Heinloth AN, Shackelford RE, Innes CL, Bennett L, Li L, Amin RP, Sieber SO, Flores KG, Bushel PR, Paules RS.

Radiat Res. 2003 Sep;160(3):273-90.

PMID:
12926986
11.

Identification of distinct and common gene expression changes after oxidative stress and gamma and ultraviolet radiation.

Heinloth AN, Shackelford RE, Innes CL, Bennett L, Li L, Amin RP, Sieber SO, Flores KG, Bushel PR, Paules RS.

Mol Carcinog. 2003 Jun;37(2):65-82.

PMID:
12766906
12.

The Ataxia telangiectasia gene product is required for oxidative stress-induced G1 and G2 checkpoint function in human fibroblasts.

Shackelford RE, Innes CL, Sieber SO, Heinloth AN, Leadon SA, Paules RS.

J Biol Chem. 2001 Jun 15;276(24):21951-9. Epub 2001 Apr 4.

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