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Items: 1 to 50 of 164

1.

IL-25 Orchestrates Activation of Th Cells via Conventional Dendritic Cells in Tissue to Exacerbate Chronic House Dust Mite-Induced Asthma Pathology.

Claudio E, Wang H, Kamenyeva O, Tang W, Ha HL, Siebenlist U.

J Immunol. 2019 Oct 15;203(8):2319-2327. doi: 10.4049/jimmunol.1900254. Epub 2019 Sep 11.

PMID:
31511356
2.

A detrimental role of RelB in mature oligodendrocytes during experimental acute encephalomyelitis.

Gupta AS, Biswas DD, Brown SN, Mockenhaupt K, Marone M, Hoskins A, Siebenlist U, Kordula T.

J Neuroinflammation. 2019 Jul 30;16(1):161. doi: 10.1186/s12974-019-1548-7.

3.

IL-20-Receptor Signaling Delimits IL-17 Production in Psoriatic Inflammation.

Ha HL, Wang H, Claudio E, Tang W, Siebenlist U.

J Invest Dermatol. 2019 Jun 26. pii: S0022-202X(19)31793-2. doi: 10.1016/j.jid.2019.06.127. [Epub ahead of print]

PMID:
31252033
4.

RECK suppresses interleukin-17/TRAF3IP2-mediated MMP-13 activation and human aortic smooth muscle cell migration and proliferation.

Mummidi S, Das NA, Carpenter AJ, Yoshida T, Yariswamy M, Mostany R, Izadpanah R, Higashi Y, Sukhanov S, Noda M, Siebenlist U, Rector RS, Chandrasekar B.

J Cell Physiol. 2019 Dec;234(12):22242-22259. doi: 10.1002/jcp.28792. Epub 2019 May 9.

PMID:
31074012
5.

IL-17 metabolically reprograms activated fibroblastic reticular cells for proliferation and survival.

Majumder S, Amatya N, Revu S, Jawale CV, Wu D, Rittenhouse N, Menk A, Kupul S, Du F, Raphael I, Bhattacharjee A, Siebenlist U, Hand TW, Delgoffe GM, Poholek AC, Gaffen SL, Biswas PS, McGeachy MJ.

Nat Immunol. 2019 May;20(5):534-545. doi: 10.1038/s41590-019-0367-4. Epub 2019 Apr 8.

6.

RelB controls adaptive responses of astrocytes during sterile inflammation.

Gupta AS, Waters MR, Biswas DD, Brown LN, Surace MJ, Floros C, Siebenlist U, Kordula T.

Glia. 2019 Aug;67(8):1449-1461. doi: 10.1002/glia.23619. Epub 2019 Apr 7.

PMID:
30957303
7.

TRAF3IP2 mediates TWEAK/TWEAKR-induced pro-fibrotic responses in cultured cardiac fibroblasts and the heart.

Das NA, Carpenter AJ, Yoshida T, Kumar SA, Gautam S, Mostany R, Izadpanah R, Kumar A, Mummidi S, Siebenlist U, Chandrasekar B.

J Mol Cell Cardiol. 2018 Aug;121:107-123. doi: 10.1016/j.yjmcc.2018.07.003. Epub 2018 Jul 5.

8.

VT-1598 inhibits the in vitro growth of mucosal Candida strains and protects against fluconazole-susceptible and -resistant oral candidiasis in IL-17 signalling-deficient mice.

Break TJ, Desai JV, Healey KR, Natarajan M, Ferre EMN, Henderson C, Zelazny A, Siebenlist U, Yates CM, Cohen OJ, Schotzinger RJ, Perlin DS, Garvey EP, Lionakis MS.

J Antimicrob Chemother. 2018 Aug 1;73(8):2089-2094. doi: 10.1093/jac/dky170.

9.

VT-1161 protects mice against oropharyngeal candidiasis caused by fluconazole-susceptible and -resistant Candida albicans.

Break TJ, Desai JV, Natarajan M, Ferre EMN, Henderson C, Zelazny AM, Siebenlist U, Hoekstra WJ, Schotzinger RJ, Garvey EP, Lionakis MS.

J Antimicrob Chemother. 2018 Jan 1;73(1):151-155. doi: 10.1093/jac/dkx352.

10.

TRAF3IP2 mediates high glucose-induced endothelin-1 production as well as endothelin-1-induced inflammation in endothelial cells.

Padilla J, Carpenter AJ, Das NA, Kandikattu HK, López-Ongil S, Martinez-Lemus LA, Siebenlist U, DeMarco VG, Chandrasekar B.

Am J Physiol Heart Circ Physiol. 2018 Jan 1;314(1):H52-H64. doi: 10.1152/ajpheart.00478.2017. Epub 2017 Sep 29.

11.

Targeting TRAF3IP2 by Genetic and Interventional Approaches Inhibits Ischemia/Reperfusion-induced Myocardial Injury and Adverse Remodeling.

Erikson JM, Valente AJ, Mummidi S, Kandikattu HK, DeMarco VG, Bender SB, Fay WP, Siebenlist U, Chandrasekar B.

J Biol Chem. 2017 Feb 10;292(6):2345-2358. doi: 10.1074/jbc.M116.764522. Epub 2017 Jan 4.

12.

Bcl-3 regulates TGFβ signaling by stabilizing Smad3 during breast cancer pulmonary metastasis.

Chen X, Cao X, Sun X, Lei R, Chen P, Zhao Y, Jiang Y, Yin J, Chen R, Ye D, Wang Q, Liu Z, Liu S, Cheng C, Mao J, Hou Y, Wang M, Siebenlist U, Eugene Chin Y, Wang Y, Cao L, Hu G, Zhang X.

Cell Death Dis. 2016 Dec 1;7(12):e2508. doi: 10.1038/cddis.2016.405.

13.

Cardiac-restricted Overexpression of TRAF3 Interacting Protein 2 (TRAF3IP2) Results in Spontaneous Development of Myocardial Hypertrophy, Fibrosis, and Dysfunction.

Yariswamy M, Yoshida T, Valente AJ, Kandikattu HK, Sakamuri SS, Siddesha JM, Sukhanov S, Saifudeen Z, Ma L, Siebenlist U, Gardner JD, Chandrasekar B.

J Biol Chem. 2016 Sep 9;291(37):19425-36. doi: 10.1074/jbc.M116.724138. Epub 2016 Jul 27.

14.

Metformin inhibits aldosterone-induced cardiac fibroblast activation, migration and proliferation in vitro, and reverses aldosterone+salt-induced cardiac fibrosis in vivo.

Mummidi S, Das NA, Carpenter AJ, Kandikattu H, Krenz M, Siebenlist U, Valente AJ, Chandrasekar B.

J Mol Cell Cardiol. 2016 Sep;98:95-102. doi: 10.1016/j.yjmcc.2016.07.006. Epub 2016 Jul 14.

PMID:
27423273
15.

TRAF3IP2 mediates atherosclerotic plaque development and vulnerability in ApoE(-/-) mice.

Sakamuri SSVP, Higashi Y, Sukhanov S, Siddesha JM, Delafontaine P, Siebenlist U, Chandrasekar B.

Atherosclerosis. 2016 Sep;252:153-160. doi: 10.1016/j.atherosclerosis.2016.05.029. Epub 2016 May 19.

16.

The B-cell tumor promoter Bcl-3 suppresses inflammation-associated colon tumorigenesis in epithelial cells.

Tang W, Wang H, Ha HL, Tassi I, Bhardwaj R, Claudio E, Siebenlist U.

Oncogene. 2016 Dec 1;35(48):6203-6211. doi: 10.1038/onc.2016.152. Epub 2016 May 2.

17.

TRAF3IP2 mediates aldosterone/salt-induced cardiac hypertrophy and fibrosis.

Sakamuri SS, Valente AJ, Siddesha JM, Delafontaine P, Siebenlist U, Gardner JD, Bysani C.

Mol Cell Endocrinol. 2016 Jul 5;429:84-92. doi: 10.1016/j.mce.2016.03.038. Epub 2016 Apr 1.

18.

mTOR-Dependent and Independent Survival Signaling by PI3K in B Lymphocytes.

Kaileh M, Vazquez E, MacFarlane AW 4th, Campbell K, Kurosaki T, Siebenlist U, Sen R.

PLoS One. 2016 Jan 19;11(1):e0146955. doi: 10.1371/journal.pone.0146955. eCollection 2016.

19.

Antibody blockade of IL-17 family cytokines in immunity to acute murine oral mucosal candidiasis.

Whibley N, Tritto E, Traggiai E, Kolbinger F, Moulin P, Brees D, Coleman BM, Mamo AJ, Garg AV, Jaycox JR, Siebenlist U, Kammüller M, Gaffen SL.

J Leukoc Biol. 2016 Jun;99(6):1153-64. doi: 10.1189/jlb.4A0915-428R. Epub 2016 Jan 4. Erratum in: J Leukoc Biol. 2017 Apr;101(4):1065.

20.

Cutting Edge: IL-25 Targets Dendritic Cells To Attract IL-9-Producing T Cells in Acute Allergic Lung Inflammation.

Claudio E, Tassi I, Wang H, Tang W, Ha HL, Siebenlist U.

J Immunol. 2015 Oct 15;195(8):3525-9. doi: 10.4049/jimmunol.1500436. Epub 2015 Sep 14.

21.

Aldosterone-induced cardiomyocyte growth, and fibroblast migration and proliferation are mediated by TRAF3IP2.

Somanna NK, Yariswamy M, Garagliano JM, Siebenlist U, Mummidi S, Valente AJ, Chandrasekar B.

Cell Signal. 2015 Oct;27(10):1928-38. doi: 10.1016/j.cellsig.2015.07.001. Epub 2015 Jul 4.

PMID:
26148936
22.

Impact of loss of NF-κB1, NF-κB2 or c-REL on SLE-like autoimmune disease and lymphadenopathy in Fas(lpr/lpr) mutant mice.

Low JT, Hughes P, Lin A, Siebenlist U, Jain R, Yaprianto K, Gray DH, Gerondakis S, Strasser A, O'Reilly LA.

Immunol Cell Biol. 2016 Jan;94(1):66-78. doi: 10.1038/icb.2015.66. Epub 2015 Jun 18.

PMID:
26084385
23.

Adaptive immune-mediated host resistance to Toxoplasma gondii is governed by the NF-κB regulator Bcl-3 in dendritic cells.

Tassi I, Claudio E, Wang H, Tang W, Ha HL, Saret S, Sher A, Jankovic D, Siebenlist U.

Eur J Immunol. 2015 Jul;45(7):1972-9. doi: 10.1002/eji.201445045. Epub 2015 May 12.

24.

CIKS/DDX3X interaction controls the stability of the Zc3h12a mRNA induced by IL-17.

Somma D, Mastrovito P, Grieco M, Lavorgna A, Pignalosa A, Formisano L, Salzano AM, Scaloni A, Pacifico F, Siebenlist U, Leonardi A.

J Immunol. 2015 Apr 1;194(7):3286-94. doi: 10.4049/jimmunol.1401589. Epub 2015 Feb 20.

25.

The NF-κB regulator Bcl-3 modulates inflammation during contact hypersensitivity reactions in radioresistant cells.

Tassi I, Rikhi N, Claudio E, Wang H, Tang W, Ha HL, Saret S, Kaplan DH, Siebenlist U.

Eur J Immunol. 2015 Apr;45(4):1059-1068. doi: 10.1002/eji.201444994. Epub 2015 Feb 12.

26.

IL-25-responsive, lineage-negative KLRG1(hi) cells are multipotential 'inflammatory' type 2 innate lymphoid cells.

Huang Y, Guo L, Qiu J, Chen X, Hu-Li J, Siebenlist U, Williamson PR, Urban JF Jr, Paul WE.

Nat Immunol. 2015 Feb;16(2):161-9. doi: 10.1038/ni.3078. Epub 2014 Dec 22.

27.

BRD4 assists elongation of both coding and enhancer RNAs by interacting with acetylated histones.

Kanno T, Kanno Y, LeRoy G, Campos E, Sun HW, Brooks SR, Vahedi G, Heightman TD, Garcia BA, Reinberg D, Siebenlist U, O'Shea JJ, Ozato K.

Nat Struct Mol Biol. 2014 Dec;21(12):1047-57. doi: 10.1038/nsmb.2912. Epub 2014 Nov 10.

28.

The oncoprotein and transcriptional regulator Bcl-3 governs plasticity and pathogenicity of autoimmune T cells.

Tang W, Wang H, Claudio E, Tassi I, Ha HL, Saret S, Siebenlist U.

Immunity. 2014 Oct 16;41(4):555-66. doi: 10.1016/j.immuni.2014.09.017.

29.

Loss of c-REL but not NF-κB2 prevents autoimmune disease driven by FasL mutation.

O'Reilly LA, Hughes P, Lin A, Waring P, Siebenlist U, Jain R, Gray DH, Gerondakis S, Strasser A.

Cell Death Differ. 2015 May;22(5):767-78. doi: 10.1038/cdd.2014.168. Epub 2014 Oct 31.

30.

The NF-κB regulator Bcl-3 governs dendritic cell antigen presentation functions in adaptive immunity.

Tassi I, Claudio E, Wang H, Tang W, Ha HL, Saret S, Ramaswamy M, Siegel R, Siebenlist U.

J Immunol. 2014 Nov 1;193(9):4303-11. doi: 10.4049/jimmunol.1401505. Epub 2014 Sep 22.

31.

Oral-resident natural Th17 cells and γδ T cells control opportunistic Candida albicans infections.

Conti HR, Peterson AC, Brane L, Huppler AR, Hernández-Santos N, Whibley N, Garg AV, Simpson-Abelson MR, Gibson GA, Mamo AJ, Osborne LC, Bishu S, Ghilardi N, Siebenlist U, Watkins SC, Artis D, McGeachy MJ, Gaffen SL.

J Exp Med. 2014 Sep 22;211(10):2075-84. doi: 10.1084/jem.20130877. Epub 2014 Sep 8.

32.

IL-17 drives psoriatic inflammation via distinct, target cell-specific mechanisms.

Ha HL, Wang H, Pisitkun P, Kim JC, Tassi I, Tang W, Morasso MI, Udey MC, Siebenlist U.

Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):E3422-31. doi: 10.1073/pnas.1400513111. Epub 2014 Aug 4.

33.

A microRNA 221- and 222-mediated feedback loop maintains constitutive activation of NFκB and STAT3 in colorectal cancer cells.

Liu S, Sun X, Wang M, Hou Y, Zhan Y, Jiang Y, Liu Z, Cao X, Chen P, Liu Z, Chen X, Tao Y, Xu C, Mao J, Cheng C, Li C, Hu Y, Wang L, Chin YE, Shi Y, Siebenlist U, Zhang X.

Gastroenterology. 2014 Oct;147(4):847-859.e11. doi: 10.1053/j.gastro.2014.06.006. Epub 2014 Jun 12.

34.

OxLDL induces endothelial dysfunction and death via TRAF3IP2: inhibition by HDL3 and AMPK activators.

Valente AJ, Irimpen AM, Siebenlist U, Chandrasekar B.

Free Radic Biol Med. 2014 May;70:117-28. doi: 10.1016/j.freeradbiomed.2014.02.014. Epub 2014 Feb 20.

35.

Interleukin-17-induced protein lipocalin 2 is dispensable for immunity to oral candidiasis.

Ferreira MC, Whibley N, Mamo AJ, Siebenlist U, Chan YR, Gaffen SL.

Infect Immun. 2014 Mar;82(3):1030-5. doi: 10.1128/IAI.01389-13. Epub 2013 Dec 16.

36.

TRAF3 enforces the requirement for T cell cross-talk in thymic medullary epithelial development.

Jenkinson SR, Williams JA, Jeon H, Zhang J, Nitta T, Ohigashi I, Kruhlak M, Zuklys S, Sharrow S, Adams A, Granger L, Choi Y, Siebenlist U, Bishop GA, Hollander GA, Takahama Y, Hodes RJ.

Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):21107-12. doi: 10.1073/pnas.1314859111. Epub 2013 Dec 9.

37.

The tumor promoter and NF-κB modulator Bcl-3 regulates splenic B cell development.

Zhang X, Paun A, Claudio E, Wang H, Siebenlist U.

J Immunol. 2013 Dec 15;191(12):5984-92. doi: 10.4049/jimmunol.1300611. Epub 2013 Nov 15.

38.

Impaired HCV clearance in HIV/HCV coinfected subjects treated with PegIFN and RBV due to interference of IFN signaling by IFNαR2a.

Lee YJ, Zhang X, Vazquez E, Shivasabesan G, Young HA, Murphy A, Wang H, Suffredini AF, Siebenlist U, Kottilil S.

J Interferon Cytokine Res. 2014 Jan;34(1):28-34. doi: 10.1089/jir.2013.0032. Epub 2013 Oct 30.

39.

Established thymic epithelial progenitor/stem cell-like cell lines differentiate into mature thymic epithelial cells and support T cell development.

Chen P, Zhang J, Zhan Y, Su J, Du Y, Xu G, Shi Y, Siebenlist U, Zhang X.

PLoS One. 2013 Sep 23;8(9):e75222. doi: 10.1371/journal.pone.0075222. eCollection 2013. Erratum in: PLoS One. 2013;8(11). doi:10.1371/annotation/8d68730b-e348-413a-9d06-a1bf90629bde.

40.

TRAF3IP2 mediates interleukin-18-induced cardiac fibroblast migration and differentiation.

Valente AJ, Sakamuri SS, Siddesha JM, Yoshida T, Gardner JD, Prabhu R, Siebenlist U, Chandrasekar B.

Cell Signal. 2013 Nov;25(11):2176-84. doi: 10.1016/j.cellsig.2013.07.013. Epub 2013 Jul 18.

41.

The IκB family member Bcl-3 stabilizes c-Myc in colorectal cancer.

Liu Z, Jiang Y, Hou Y, Hu Y, Cao X, Tao Y, Xu C, Liu S, Wang S, Wang L, Shi Y, Siebenlist U, Zhang X.

J Mol Cell Biol. 2013 Aug;5(4):280-2. doi: 10.1093/jmcb/mjt020. Epub 2013 Jun 20. No abstract available.

PMID:
23794716
42.

Interleukin-18 enhances IL-18R/Nox1 binding, and mediates TRAF3IP2-dependent smooth muscle cell migration. Inhibition by simvastatin.

Valente AJ, Yoshida T, Izadpanah R, Delafontaine P, Siebenlist U, Chandrasekar B.

Cell Signal. 2013 Jun;25(6):1447-56. doi: 10.1016/j.cellsig.2013.03.007. Epub 2013 Mar 27.

43.

Advanced oxidation protein products induce cardiomyocyte death via Nox2/Rac1/superoxide-dependent TRAF3IP2/JNK signaling.

Valente AJ, Yoshida T, Clark RA, Delafontaine P, Siebenlist U, Chandrasekar B.

Free Radic Biol Med. 2013 Jul;60:125-35. doi: 10.1016/j.freeradbiomed.2013.02.012. Epub 2013 Feb 20.

44.

Interleukin-17 cytokines are critical in development of fatal lupus glomerulonephritis.

Pisitkun P, Ha HL, Wang H, Claudio E, Tivy CC, Zhou H, Mayadas TN, Illei GG, Siebenlist U.

Immunity. 2012 Dec 14;37(6):1104-15. doi: 10.1016/j.immuni.2012.08.014. Epub 2012 Nov 1.

45.

CIKS (Act1 or TRAF3IP2) mediates high glucose-induced endothelial dysfunction.

Venkatesan B, Valente AJ, Das NA, Carpenter AJ, Yoshida T, Delafontaine JL, Siebenlist U, Chandrasekar B.

Cell Signal. 2013 Jan;25(1):359-71. doi: 10.1016/j.cellsig.2012.10.009. Epub 2012 Oct 17.

46.

CIKS/Act1-mediated signaling by IL-17 cytokines in context: implications for how a CIKS gene variant may predispose to psoriasis.

Sønder SU, Paun A, Ha HL, Johnson PF, Siebenlist U.

J Immunol. 2012 Jun 15;188(12):5906-14. doi: 10.4049/jimmunol.1103233. Epub 2012 May 11.

47.

CIKS (Act1 or TRAF3IP2) mediates Angiotensin-II-induced Interleukin-18 expression, and Nox2-dependent cardiomyocyte hypertrophy.

Valente AJ, Clark RA, Siddesha JM, Siebenlist U, Chandrasekar B.

J Mol Cell Cardiol. 2012 Jul;53(1):113-24. doi: 10.1016/j.yjmcc.2012.04.009. Epub 2012 Apr 26.

48.

Conditional deletion of Ccm2 causes hemorrhage in the adult brain: a mouse model of human cerebral cavernous malformations.

Cunningham K, Uchida Y, O'Donnell E, Claudio E, Li W, Soneji K, Wang H, Mukouyama YS, Siebenlist U.

Hum Mol Genet. 2011 Aug 15;20(16):3198-206. doi: 10.1093/hmg/ddr225. Epub 2011 May 19.

49.

IL-17-induced NF-kappaB activation via CIKS/Act1: physiologic significance and signaling mechanisms.

Sønder SU, Saret S, Tang W, Sturdevant DE, Porcella SF, Siebenlist U.

J Biol Chem. 2011 Apr 15;286(15):12881-90. doi: 10.1074/jbc.M110.199547. Epub 2011 Feb 18.

50.

The IκB family member Bcl-3 coordinates the pulmonary defense against Klebsiella pneumoniae infection.

Pène F, Paun A, Sønder SU, Rikhi N, Wang H, Claudio E, Siebenlist U.

J Immunol. 2011 Feb 15;186(4):2412-21. doi: 10.4049/jimmunol.1001331. Epub 2011 Jan 12.

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