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Items: 42

1.

Notch-1 Inhibition Promotes Immune Regulation in Transplantation via Treg-Dependent Mechanisms.

Magee CN, Murakami N, Borges TJ, Shimizu T, Safa K, Ohori S, Cai S, Uffing A, Azzi J, Elyaman W, Charbonnier LM, Liu K, Toprak D, Visner G, Chatila TA, Siebel CW, Najafian N, Riella LV.

Circulation. 2019 Jul 3. doi: 10.1161/CIRCULATIONAHA.119.040563. [Epub ahead of print]

PMID:
31266349
2.

An antibody to Notch3 reverses the skeletal phenotype of lateral meningocele syndrome in male mice.

Yu J, Siebel CW, Schilling L, Canalis E.

J Cell Physiol. 2019 Jun 12. doi: 10.1002/jcp.28960. [Epub ahead of print]

PMID:
31188489
3.

Early Notch Signals Induce a Pathogenic Molecular Signature during Priming of Alloantigen-Specific Conventional CD4+ T Cells in Graft-versus-Host Disease.

Chung J, Radojcic V, Perkey E, Parnell TJ, Niknafs Y, Jin X, Friedman A, Labrecque N, Blazar BR, Brennan TV, Siebel CW, Maillard I.

J Immunol. 2019 Jul 15;203(2):557-568. doi: 10.4049/jimmunol.1900192. Epub 2019 Jun 10.

PMID:
31182480
4.

NRG1 is a critical regulator of differentiation in TP63-driven squamous cell carcinoma.

Hegde GV, de la Cruz C, Giltnane JM, Crocker L, Venkatanarayan A, Schaefer G, Dunlap D, Hoeck JD, Piskol R, Gnad F, Modrusan Z, de Sauvage FJ, Siebel CW, Jackson EL.

Elife. 2019 May 30;8. pii: e46551. doi: 10.7554/eLife.46551.

5.

Notch signaling mediated by Delta-like ligands 1 and 4 controls the pathogenesis of chronic GVHD in mice.

Radojcic V, Paz K, Chung J, Du J, Perkey ET, Flynn R, Ivcevic S, Zaiken M, Friedman A, Yan M, Pletneva MA, Sarantopoulos S, Siebel CW, Blazar BR, Maillard I.

Blood. 2018 Nov 15;132(20):2188-2200. doi: 10.1182/blood-2018-03-841155. Epub 2018 Sep 4.

PMID:
30181175
6.

Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells.

López-Arribillaga E, Rodilla V, Colomer C, Vert A, Shelton A, Cheng JH, Yan B, Gonzalez-Perez A, Junttila MR, Iglesias M, Torres F, Albanell J, Villanueva A, Bigas A, Siebel CW, Espinosa L.

Nat Commun. 2018 Jul 31;9(1):2992. doi: 10.1038/s41467-018-05385-0.

7.

Notch Signaling Facilitates In Vitro Generation of Cross-Presenting Classical Dendritic Cells.

Kirkling ME, Cytlak U, Lau CM, Lewis KL, Resteu A, Khodadadi-Jamayran A, Siebel CW, Salmon H, Merad M, Tsirigos A, Collin M, Bigley V, Reizis B.

Cell Rep. 2018 Jun 19;23(12):3658-3672.e6. doi: 10.1016/j.celrep.2018.05.068.

8.

Inhibition of Endothelial NOTCH1 Signaling Attenuates Inflammation by Reducing Cytokine-Mediated Histone Acetylation at Inflammatory Enhancers.

Poulsen LC, Edelmann RJ, Krüger S, Diéguez-Hurtado R, Shah A, Stav-Noraas TE, Renzi A, Szymanska M, Wang J, Ehling M, Benedito R, Kasprzycka M, Bækkevold E, Sundnes O, Midwood KS, Scott H, Collas P, Siebel CW, Adams RH, Haraldsen G, Sundlisæter E, Hol J.

Arterioscler Thromb Vasc Biol. 2018 Apr;38(4):854-869. doi: 10.1161/ATVBAHA.117.310388. Epub 2018 Feb 15.

PMID:
29449332
9.

An aberrant NOTCH2-BCR signaling axis in B cells from patients with chronic GVHD.

Poe JC, Jia W, Su H, Anand S, Rose JJ, Tata PV, Suthers AN, Jones CD, Kuan PF, Vincent BG, Serody JS, Horwitz ME, Ho VT, Pavletic SZ, Hakim FT, Owzar K, Zhang D, Blazar BR, Siebel CW, Chao NJ, Maillard I, Sarantopoulos S.

Blood. 2017 Nov 9;130(19):2131-2145. doi: 10.1182/blood-2017-05-782466. Epub 2017 Aug 29.

10.

Notch2 blockade enhances hematopoietic stem cell mobilization and homing.

Wang W, Yu S, Myers J, Wang Y, Xin WW, Albakri M, Xin AW, Li M, Huang AY, Xin W, Siebel CW, Lazarus HM, Zhou L.

Haematologica. 2017 Oct;102(10):1785-1795. doi: 10.3324/haematol.2017.168674. Epub 2017 Jul 20.

11.

Therapeutic antibody targeting of Notch3 signaling prevents mural cell loss in CADASIL.

Machuca-Parra AI, Bigger-Allen AA, Sanchez AV, Boutabla A, Cardona-Vélez J, Amarnani D, Saint-Geniez M, Siebel CW, Kim LA, D'Amore PA, Arboleda-Velasquez JF.

J Exp Med. 2017 Aug 7;214(8):2271-2282. doi: 10.1084/jem.20161715. Epub 2017 Jul 11.

12.

Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands.

Chung J, Ebens CL, Perkey E, Radojcic V, Koch U, Scarpellino L, Tong A, Allen F, Wood S, Feng J, Friedman A, Granadier D, Tran IT, Chai Q, Onder L, Yan M, Reddy P, Blazar BR, Huang AY, Brennan TV, Bishop DK, Ludewig B, Siebel CW, Radtke F, Luther SA, Maillard I.

J Clin Invest. 2017 Apr 3;127(4):1574-1588. doi: 10.1172/JCI89535. Epub 2017 Mar 20.

13.

Endothelial Notch1 Activity Facilitates Metastasis.

Wieland E, Rodriguez-Vita J, Liebler SS, Mogler C, Moll I, Herberich SE, Espinet E, Herpel E, Menuchin A, Chang-Claude J, Hoffmeister M, Gebhardt C, Brenner H, Trumpp A, Siebel CW, Hecker M, Utikal J, Sprinzak D, Fischer A.

Cancer Cell. 2017 Mar 13;31(3):355-367. doi: 10.1016/j.ccell.2017.01.007. Epub 2017 Feb 23.

14.

Cutting Edge: Notch Signaling Promotes the Plasticity of Group-2 Innate Lymphoid Cells.

Zhang K, Xu X, Pasha MA, Siebel CW, Costello A, Haczku A, MacNamara K, Liang T, Zhu J, Bhandoola A, Maillard I, Yang Q.

J Immunol. 2017 Mar 1;198(5):1798-1803. doi: 10.4049/jimmunol.1601421. Epub 2017 Jan 23.

15.

Constitutive NOTCH3 Signaling Promotes the Growth of Basal Breast Cancers.

Choy L, Hagenbeek TJ, Solon M, French D, Finkle D, Shelton A, Venook R, Brauer MJ, Siebel CW.

Cancer Res. 2017 Mar 15;77(6):1439-1452. doi: 10.1158/0008-5472.CAN-16-1022. Epub 2017 Jan 20.

16.

NOTCH1 and NOTCH2 regulate epithelial cell proliferation in mouse and human gastric corpus.

Demitrack ES, Gifford GB, Keeley TM, Horita N, Todisco A, Turgeon DK, Siebel CW, Samuelson LC.

Am J Physiol Gastrointest Liver Physiol. 2017 Feb 1;312(2):G133-G144. doi: 10.1152/ajpgi.00325.2016. Epub 2016 Dec 8.

17.

Notch1 and Notch2 receptors regulate mouse and human gastric antral epithelial cell homoeostasis.

Gifford GB, Demitrack ES, Keeley TM, Tam A, La Cunza N, Dedhia PH, Spence JR, Simeone DM, Saotome I, Louvi A, Siebel CW, Samuelson LC.

Gut. 2017 Jun;66(6):1001-1011. doi: 10.1136/gutjnl-2015-310811. Epub 2016 Mar 1.

18.

Prolyl-isomerase Pin1 controls Notch3 protein expression and regulates T-ALL progression.

Franciosa G, Diluvio G, Gaudio FD, Giuli MV, Palermo R, Grazioli P, Campese AF, Talora C, Bellavia D, D'Amati G, Besharat ZM, Nicoletti C, Siebel CW, Choy L, Rustighi A, Sal GD, Screpanti I, Checquolo S.

Oncogene. 2016 Sep 8;35(36):4741-51. doi: 10.1038/onc.2016.5. Epub 2016 Feb 15.

19.

Therapeutic antibodies reveal Notch control of transdifferentiation in the adult lung.

Lafkas D, Shelton A, Chiu C, de Leon Boenig G, Chen Y, Stawicki SS, Siltanen C, Reichelt M, Zhou M, Wu X, Eastham-Anderson J, Moore H, Roose-Girma M, Chinn Y, Hang JQ, Warming S, Egen J, Lee WP, Austin C, Wu Y, Payandeh J, Lowe JB, Siebel CW.

Nature. 2015 Dec 3;528(7580):127-31. doi: 10.1038/nature15715. Epub 2015 Nov 18.

PMID:
26580007
20.

The Hedgehog Hold on Homeostasis.

Metcalfe C, Siebel CW.

Cell Stem Cell. 2015 Nov 5;17(5):505-6. doi: 10.1016/j.stem.2015.10.010.

21.

Inhibition of Notch Signaling During Mouse Incisor Renewal Leads to Enamel Defects.

Jheon AH, Prochazkova M, Meng B, Wen T, Lim YJ, Naveau A, Espinoza R, Cox TC, Sone ED, Ganss B, Siebel CW, Klein OD.

J Bone Miner Res. 2016 Jan;31(1):152-62. doi: 10.1002/jbmr.2591. Epub 2015 Aug 6.

22.

Notch Receptor-Ligand Engagement Maintains Hematopoietic Stem Cell Quiescence and Niche Retention.

Wang W, Yu S, Zimmerman G, Wang Y, Myers J, Yu VW, Huang D, Huang X, Shim J, Huang Y, Xin W, Qiao P, Yan M, Xin W, Scadden DT, Stanley P, Lowe JB, Huang AY, Siebel CW, Zhou L.

Stem Cells. 2015 Jul;33(7):2280-93. doi: 10.1002/stem.2031. Epub 2015 May 13.

23.

Opposing activities of Notch and Wnt signaling regulate intestinal stem cells and gut homeostasis.

Tian H, Biehs B, Chiu C, Siebel CW, Wu Y, Costa M, de Sauvage FJ, Klein OD.

Cell Rep. 2015 Apr 7;11(1):33-42. doi: 10.1016/j.celrep.2015.03.007. Epub 2015 Mar 26.

24.

Transient blockade of delta-like Notch ligands prevents allograft rejection mediated by cellular and humoral mechanisms in a mouse model of heart transplantation.

Wood S, Feng J, Chung J, Radojcic V, Sandy-Sloat AR, Friedman A, Shelton A, Yan M, Siebel CW, Bishop DK, Maillard I.

J Immunol. 2015 Mar 15;194(6):2899-908. doi: 10.4049/jimmunol.1402034. Epub 2015 Feb 16.

25.

Systematic evaluation of antibody-mediated siRNA delivery using an industrial platform of THIOMAB-siRNA conjugates.

Cuellar TL, Barnes D, Nelson C, Tanguay J, Yu SF, Wen X, Scales SJ, Gesch J, Davis D, van Brabant Smith A, Leake D, Vandlen R, Siebel CW.

Nucleic Acids Res. 2015 Jan;43(2):1189-203. doi: 10.1093/nar/gku1362. Epub 2014 Dec 30.

26.

Differential effects of targeting Notch receptors in a mouse model of liver cancer.

Huntzicker EG, Hötzel K, Choy L, Che L, Ross J, Pau G, Sharma N, Siebel CW, Chen X, French DM.

Hepatology. 2015 Mar;61(3):942-52. doi: 10.1002/hep.27566. Epub 2015 Jan 28.

27.

Murine Pten(-/-) T-ALL requires non-redundant PI3K/mTOR and DLL4/Notch1 signals for maintenance and γc/TCR signals for thymic exit.

Hagenbeek TJ, Wu X, Choy L, Sanchez-Irizarry C, Seshagiri S, Stinson J, Siebel CW, Spits H.

Cancer Lett. 2014 May 1;346(2):237-48. doi: 10.1016/j.canlet.2013.12.027. Epub 2013 Dec 30.

PMID:
24384093
28.

IRF4 controls the positioning of mature B cells in the lymphoid microenvironments by regulating NOTCH2 expression and activity.

Simonetti G, Carette A, Silva K, Wang H, De Silva NS, Heise N, Siebel CW, Shlomchik MJ, Klein U.

J Exp Med. 2013 Dec 16;210(13):2887-902. doi: 10.1084/jem.20131026. Epub 2013 Dec 9.

29.

Insights into Notch3 activation and inhibition mediated by antibodies directed against its negative regulatory region.

Tiyanont K, Wales TE, Siebel CW, Engen JR, Blacklow SC.

J Mol Biol. 2013 Sep 9;425(17):3192-204. doi: 10.1016/j.jmb.2013.05.025. Epub 2013 Jun 6.

30.

Blockade of individual Notch ligands and receptors controls graft-versus-host disease.

Tran IT, Sandy AR, Carulli AJ, Ebens C, Chung J, Shan GT, Radojcic V, Friedman A, Gridley T, Shelton A, Reddy P, Samuelson LC, Yan M, Siebel CW, Maillard I.

J Clin Invest. 2013 Apr;123(4):1590-604.

31.

The Notch1-Dll4 signaling pathway regulates mouse postnatal lymphatic development.

Niessen K, Zhang G, Ridgway JB, Chen H, Kolumam G, Siebel CW, Yan M.

Blood. 2011 Aug 18;118(7):1989-97. doi: 10.1182/blood-2010-11-319129. Epub 2011 Jun 23.

32.

Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia.

Hodson DJ, Janas ML, Galloway A, Bell SE, Andrews S, Li CM, Pannell R, Siebel CW, MacDonald HR, De Keersmaecker K, Ferrando AA, Grutz G, Turner M.

Nat Immunol. 2010 Aug;11(8):717-24. doi: 10.1038/ni.1901. Epub 2010 Jul 11. Erratum in: Nat Immunol. 2010 Oct;11(10):969.

33.

Therapeutic antibody targeting of individual Notch receptors.

Wu Y, Cain-Hom C, Choy L, Hagenbeek TJ, de Leon GP, Chen Y, Finkle D, Venook R, Wu X, Ridgway J, Schahin-Reed D, Dow GJ, Shelton A, Stawicki S, Watts RJ, Zhang J, Choy R, Howard P, Kadyk L, Yan M, Zha J, Callahan CA, Hymowitz SG, Siebel CW.

Nature. 2010 Apr 15;464(7291):1052-7. doi: 10.1038/nature08878.

PMID:
20393564
34.

Identification of putative noncoding polyadenylated transcripts in Drosophila melanogaster.

Tupy JL, Bailey AM, Dailey G, Evans-Holm M, Siebel CW, Misra S, Celniker SE, Rubin GM.

Proc Natl Acad Sci U S A. 2005 Apr 12;102(15):5495-500. Epub 2005 Apr 4. Erratum in: Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8392.

35.

Phosphorylation by Sky1p promotes Npl3p shuttling and mRNA dissociation.

Gilbert W, Siebel CW, Guthrie C.

RNA. 2001 Feb;7(2):302-13.

36.

Conservation in budding yeast of a kinase specific for SR splicing factors.

Siebel CW, Feng L, Guthrie C, Fu XD.

Proc Natl Acad Sci U S A. 1999 May 11;96(10):5440-5.

37.

The essential yeast RNA binding protein Np13p is methylated.

Siebel CW, Guthrie C.

Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13641-6.

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42.

Ras p21 as a potential mediator of insulin action in Xenopus oocytes.

Korn LJ, Siebel CW, McCormick F, Roth RA.

Science. 1987 May 15;236(4803):840-3.

PMID:
3554510

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