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Items: 1 to 50 of 365

1.

Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice.

Tao Y, Mis M, Blazer L, Ustav M Jnr, Steinhart Z, Chidiac R, Kubarakos E, O'Brien S, Wang X, Jarvik N, Patel N, Adams J, Moffat J, Angers S, Sidhu SS.

Elife. 2019 Aug 27;8. pii: e46134. doi: 10.7554/eLife.46134.

2.

Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site.

Watson ER, Grace CRR, Zhang W, Miller DJ, Davidson IF, Prabu JR, Yu S, Bolhuis DL, Kulko ET, Vollrath R, Haselbach D, Stark H, Peters JM, Brown NG, Sidhu SS, Schulman BA.

Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17280-17289. doi: 10.1073/pnas.1902889116. Epub 2019 Jul 26.

PMID:
31350353
3.

Identification and Characterization of Mutations in Ubiquitin Required for Non-covalent Dimer Formation.

Gabrielsen M, Buetow L, Kowalczyk D, Zhang W, Sidhu SS, Huang DT.

Structure. 2019 Sep 3;27(9):1452-1459.e4. doi: 10.1016/j.str.2019.06.008. Epub 2019 Jul 11.

4.

Growing Up With an Undocumented Parent in America: Psychosocial Adversity in Domestically-Residing Immigrant Children.

Sidhu SS, Song SJ.

J Am Acad Child Adolesc Psychiatry. 2019 Jun 25. pii: S0890-8567(19)30417-4. doi: 10.1016/j.jaac.2019.05.032. [Epub ahead of print] No abstract available.

PMID:
31251984
5.

Optimization of peptidic HIV-1 fusion inhibitor T20 by phage display.

Chen G, Cook JD, Ye W, Lee JE, Sidhu SS.

Protein Sci. 2019 Aug;28(8):1501-1512. doi: 10.1002/pro.3669.

PMID:
31228294
6.

Inhibition of Marburg Virus RNA Synthesis by a Synthetic Anti-VP35 Antibody.

Amatya P, Wagner N, Chen G, Luthra P, Shi L, Borek D, Pavlenco A, Rohrs H, Basler CF, Sidhu SS, Gross ML, Leung DW.

ACS Infect Dis. 2019 Aug 9;5(8):1385-1396. doi: 10.1021/acsinfecdis.9b00091. Epub 2019 Jun 4.

PMID:
31120240
7.

Early feeding after esophageal variceal band ligation in cirrhotics is safe: Randomized controlled trial.

Sidhu SS, Goyal O, Singh S, Kishore H, Chhina RS, Sidhu SS.

Dig Endosc. 2019 Apr 30. doi: 10.1111/den.13423. [Epub ahead of print]

PMID:
31038792
8.

Potent Neutralization of Staphylococcal Enterotoxin B In Vivo by Antibodies that Block Binding to the T-Cell Receptor.

Chen G, Karauzum H, Long H, Carranza D, Holtsberg FW, Howell KA, Abaandou L, Zhang B, Jarvik N, Ye W, Liao GC, Gross ML, Leung DW, Amarasinghe GK, Aman MJ, Sidhu SS.

J Mol Biol. 2019 Mar 27. pii: S0022-2836(19)30148-2. doi: 10.1016/j.jmb.2019.03.017. [Epub ahead of print]

PMID:
30928493
9.

Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies.

Raman S, Beilschmidt M, To M, Lin K, Lui F, Jmeian Y, Ng M, Fernandez M, Fu Y, Mascall K, Duque A, Wang X, Pan G, Angers S, Moffat J, Sidhu SS, Magram J, Sinclair AM, Fransson J, Julien JP.

Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6812-6817. doi: 10.1073/pnas.1817246116. Epub 2019 Mar 20.

10.

The ubiquitin interacting motifs of USP37 act on the proximal Ub of a di-Ub chain to enhance catalytic efficiency.

Manczyk N, Veggiani G, Teyra J, Strilchuk AW, Sidhu SS, Sicheri F.

Sci Rep. 2019 Mar 11;9(1):4119. doi: 10.1038/s41598-019-40815-z.

11.

Emerging drug development technologies targeting ubiquitination for cancer therapeutics.

Veggiani G, Gerpe MCR, Sidhu SS, Zhang W.

Pharmacol Ther. 2019 Jul;199:139-154. doi: 10.1016/j.pharmthera.2019.03.003. Epub 2019 Mar 7. Review.

PMID:
30851297
12.

Innate Control of Tissue-Reparative Human Regulatory T Cells.

Lam AJ, MacDonald KN, Pesenacker AM, Juvet SC, Morishita KA, Bressler B; iGenoMed Consortium, Pan JG, Sidhu SS, Rioux JD, Levings MK.

J Immunol. 2019 Apr 15;202(8):2195-2209. doi: 10.4049/jimmunol.1801330. Epub 2019 Mar 8.

PMID:
30850479
13.

Dimerization of a ubiquitin variant leads to high affinity interactions with a ubiquitin interacting motif.

Manczyk N, Veggiani G, Gish GD, Yates BP, Ernst A, Sidhu SS, Sicheri F.

Protein Sci. 2019 May;28(5):848-856. doi: 10.1002/pro.3593. Epub 2019 Mar 12.

PMID:
30793400
14.

Yeast Two-Hybrid Analysis for Ubiquitin Variant Inhibitors of Human Deubiquitinases.

Pascoe N, Seetharaman A, Teyra J, Manczyk N, Satori MA, Tjandra D, Makhnevych T, Schwerdtfeger C, Brasher BB, Moffat J, Costanzo M, Boone C, Sicheri F, Sidhu SS.

J Mol Biol. 2019 Mar 15;431(6):1160-1171. doi: 10.1016/j.jmb.2019.02.007. Epub 2019 Feb 11.

PMID:
30763569
15.

Blockade of TGF-β signaling with novel synthetic antibodies limits immune exclusion and improves chemotherapy response in metastatic ovarian cancer models.

Newsted D, Banerjee S, Watt K, Nersesian S, Truesdell P, Blazer LL, Cardarelli L, Adams JJ, Sidhu SS, Craig AW.

Oncoimmunology. 2018 Nov 20;8(2):e1539613. doi: 10.1080/2162402X.2018.1539613. eCollection 2019.

PMID:
30713798
16.

Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15.

Teyra J, Singer AU, Schmitges FW, Jaynes P, Kit Leng Lui S, Polyak MJ, Fodil N, Krieger JR, Tong J, Schwerdtfeger C, Brasher BB, Ceccarelli DFJ, Moffat J, Sicheri F, Moran MF, Gros P, Eichhorn PJA, Lenter M, Boehmelt G, Sidhu SS.

Structure. 2019 Apr 2;27(4):590-605.e5. doi: 10.1016/j.str.2019.01.002. Epub 2019 Jan 31.

PMID:
30713027
17.

A rapid in vitro methodology for simultaneous target discovery and antibody generation against functional cell subpopulations.

Nixon AML, Duque A, Yelle N, McLaughlin M, Davoudi S, Pedley NM, Haynes J, Brown KR, Pan J, Hart T, Gilbert PM, Singh SK, O'Brien CA, Sidhu SS, Moffat J.

Sci Rep. 2019 Jan 29;9(1):842. doi: 10.1038/s41598-018-37462-1.

18.

Biosynthetic Oligoclonal Antivenom (BOA) for Snakebite and Next-Generation Treatments for Snakebite Victims.

Kini RM, Sidhu SS, Laustsen AH.

Toxins (Basel). 2018 Dec 13;10(12). pii: E534. doi: 10.3390/toxins10120534.

19.

Functional genomic characterization of a synthetic anti-HER3 antibody reveals a role for ubiquitination by RNF41 in the anti-proliferative response.

Turowec JP, Lau EWT, Wang X, Brown KR, Fellouse FA, Jawanda KK, Pan J, Moffat J, Sidhu SS.

J Biol Chem. 2019 Jan 25;294(4):1396-1409. doi: 10.1074/jbc.RA118.004420. Epub 2018 Dec 6.

PMID:
30523157
20.

Allosteric Modulation of Binding Specificity by Alternative Packing of Protein Cores.

Ben-David M, Huang H, Sun MGF, Corbi-Verge C, Petsalaki E, Liu K, Gfeller D, Garg P, Tempel W, Sochirca I, Shifman JM, Davidson A, Min J, Kim PM, Sidhu SS.

J Mol Biol. 2019 Jan 18;431(2):336-350. doi: 10.1016/j.jmb.2018.11.018. Epub 2018 Nov 22.

PMID:
30471255
21.

Protocadherin-1 is essential for cell entry by New World hantaviruses.

Jangra RK, Herbert AS, Li R, Jae LT, Kleinfelter LM, Slough MM, Barker SL, Guardado-Calvo P, Román-Sosa G, Dieterle ME, Kuehne AI, Muena NA, Wirchnianski AS, Nyakatura EK, Fels JM, Ng M, Mittler E, Pan J, Bharrhan S, Wec AZ, Lai JR, Sidhu SS, Tischler ND, Rey FA, Moffat J, Brummelkamp TR, Wang Z, Dye JM, Chandran K.

Nature. 2018 Nov;563(7732):559-563. doi: 10.1038/s41586-018-0702-1. Epub 2018 Nov 21.

22.

Engineered SH2 domains with tailored specificities and enhanced affinities for phosphoproteome analysis.

Veggiani G, Huang H, Yates BP, Tong J, Kaneko T, Joshi R, Li SSC, Moran MF, Gish G, Sidhu SS.

Protein Sci. 2019 Feb;28(2):403-413. doi: 10.1002/pro.3551. Epub 2018 Dec 24.

PMID:
30431205
23.

EPH Profiling of BTIC Populations in Glioblastoma Multiforme Using CyTOF.

Hu AX, Adams JJ, Vora P, Qazi M, Singh SK, Moffat J, Sidhu SS.

Methods Mol Biol. 2019;1869:155-168. doi: 10.1007/978-1-4939-8805-1_14.

PMID:
30324522
24.

L-Ornithine L-Aspartate is Effective and Safe for the Treatment of Hepatic Encephalopathy in Cirrhosis.

Sidhu SS.

J Clin Exp Hepatol. 2018 Sep;8(3):219-221. doi: 10.1016/j.jceh.2018.08.007. Epub 2018 Sep 5. No abstract available.

25.

Generating Intracellular Modulators of E3 Ligases and Deubiquitinases from Phage-Displayed Ubiquitin Variant Libraries.

Zhang W, Sidhu SS.

Methods Mol Biol. 2018;1844:101-119. doi: 10.1007/978-1-4939-8706-1_8.

PMID:
30242706
26.

Intracellular Delivery of Human Purine Nucleoside Phosphorylase by Engineered Diphtheria Toxin Rescues Function in Target Cells.

Park M, Xu X, Min W, Sugiman-Marangos SN, Beilhartz GL, Adams JJ, Sidhu SS, Grunebaum E, Melnyk RA.

Mol Pharm. 2018 Nov 5;15(11):5217-5226. doi: 10.1021/acs.molpharmaceut.8b00735. Epub 2018 Sep 26.

PMID:
30212635
27.

Fc Engineering: Tailored Synthetic Human IgG1-Fc Repertoire for High-Affinity Interaction with FcRn at pH 6.0.

Saxena A, Bai B, Hou SC, Jiang L, Ying T, Miersch S, Sidhu SS, Wu D.

Methods Mol Biol. 2018;1827:399-417. doi: 10.1007/978-1-4939-8648-4_21.

PMID:
30196509
28.

A synthetic anti-Frizzled antibody engineered for broadened specificity exhibits enhanced anti-tumor properties.

Pavlovic Z, Adams JJ, Blazer LL, Gakhal AK, Jarvik N, Steinhart Z, Robitaille M, Mascall K, Pan J, Angers S, Moffat J, Sidhu SS.

MAbs. 2018 Nov-Dec;10(8):1157-1167. doi: 10.1080/19420862.2018.1515565. Epub 2018 Sep 25.

PMID:
30183492
29.

Humanized Mice for the Study of Immuno-Oncology.

De La Rochere P, Guil-Luna S, Decaudin D, Azar G, Sidhu SS, Piaggio E.

Trends Immunol. 2018 Sep;39(9):748-763. doi: 10.1016/j.it.2018.07.001. Epub 2018 Aug 2. Review.

PMID:
30077656
30.

A Structure-Based Strategy for Engineering Selective Ubiquitin Variant Inhibitors of Skp1-Cul1-F-Box Ubiquitin Ligases.

Gorelik M, Manczyk N, Pavlenco A, Kurinov I, Sidhu SS, Sicheri F.

Structure. 2018 Sep 4;26(9):1226-1236.e3. doi: 10.1016/j.str.2018.06.004. Epub 2018 Jul 19.

31.

Host Protein BAG3 is a Negative Regulator of Lassa VLP Egress.

Han Z, Schwoerer MP, Hicks P, Liang J, Ruthel G, Berry CT, Freedman BD, Sagum CA, Bedford MT, Sidhu SS, Sudol M, Harty RN.

Diseases. 2018 Jul 13;6(3). pii: E64. doi: 10.3390/diseases6030064.

32.

Construction of Synthetic Phage Displayed Fab Library with Tailored Diversity.

Huang G, Zhong Z, Miersch S, Sidhu SS, Hou SC, Wu D.

J Vis Exp. 2018 May 1;(135). doi: 10.3791/57357.

PMID:
29782009
33.

Structure-Guided Combinatorial Engineering Facilitates Affinity and Specificity Optimization of Anti-CD81 Antibodies.

Nelson B, Adams J, Kuglstatter A, Li Z, Harris SF, Liu Y, Bohini S, Ma H, Klumpp K, Gao J, Sidhu SS.

J Mol Biol. 2018 Jul 6;430(14):2139-2152. doi: 10.1016/j.jmb.2018.05.018. Epub 2018 May 17.

PMID:
29778602
34.

L-ornithine L-aspartate for prevention and treatment of hepatic encephalopathy in people with cirrhosis.

Goh ET, Stokes CS, Sidhu SS, Vilstrup H, Gluud LL, Morgan MY.

Cochrane Database Syst Rev. 2018 May 15;5:CD012410. doi: 10.1002/14651858.CD012410.pub2. Review.

35.

Corticosteroids Reduce Risk of Death Within 28 Days for Patients With Severe Alcoholic Hepatitis, Compared With Pentoxifylline or Placebo-a Meta-analysis of Individual Data From Controlled Trials.

Louvet A, Thursz MR, Kim DJ, Labreuche J, Atkinson SR, Sidhu SS, O'Grady JG, Akriviadis E, Sinakos E, Carithers RL Jr, Ramond MJ, Maddrey WC, Morgan TR, Duhamel A, Mathurin P.

Gastroenterology. 2018 Aug;155(2):458-468.e8. doi: 10.1053/j.gastro.2018.05.011. Epub 2018 May 5.

36.

Dynamics of PARKIN-Dependent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics.

Ordureau A, Paulo JA, Zhang W, Ahfeldt T, Zhang J, Cohn EF, Hou Z, Heo JM, Rubin LL, Sidhu SS, Gygi SP, Harper JW.

Mol Cell. 2018 Apr 19;70(2):211-227.e8. doi: 10.1016/j.molcel.2018.03.012. Epub 2018 Apr 12.

37.

Sorafenib induced hepatic encephalopathy.

Sidhu SS, Agarwal S, Goyal O, Kishore H, Sidhu S.

Acta Gastroenterol Belg. 2017 Oct-Dec;80(4):537-538.

PMID:
29560652
38.

Electronic Screen Media Use in Youth With Autism Spectrum Disorder.

Gwynette MF, Sidhu SS, Ceranoglu TA.

Child Adolesc Psychiatr Clin N Am. 2018 Apr;27(2):203-219. doi: 10.1016/j.chc.2017.11.013. Review.

PMID:
29502747
39.

Highly multiplexed and quantitative cell-surface protein profiling using genetically barcoded antibodies.

Pollock SB, Hu A, Mou Y, Martinko AJ, Julien O, Hornsby M, Ploder L, Adams JJ, Geng H, Müschen M, Sidhu SS, Moffat J, Wells JA.

Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):2836-2841. doi: 10.1073/pnas.1721899115. Epub 2018 Feb 23.

40.

Drug development: Allosteric inhibitors hit USP7 hard.

Zhang W, Sidhu SS.

Nat Chem Biol. 2018 Jan 16;14(2):110-111. doi: 10.1038/nchembio.2557. No abstract available.

PMID:
29337966
41.

Effects of erythropoietin receptor activity on angiogenesis, tubular injury, and fibrosis in acute kidney injury: a "U-shaped" relationship.

Shi M, Flores B, Li P, Gillings N, McMillan KL, Ye J, Huang LJ, Sidhu SS, Zhong YP, Grompe MT, Streeter PR, Moe OW, Hu MC.

Am J Physiol Renal Physiol. 2018 Apr 1;314(4):F501-F516. doi: 10.1152/ajprenal.00306.2017. Epub 2017 Nov 29.

42.

Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR-Cas9 genome-editing efficiency.

Canny MD, Moatti N, Wan LCK, Fradet-Turcotte A, Krasner D, Mateos-Gomez PA, Zimmermann M, Orthwein A, Juang YC, Zhang W, Noordermeer SM, Seclen E, Wilson MD, Vorobyov A, Munro M, Ernst A, Ng TF, Cho T, Cannon PM, Sidhu SS, Sicheri F, Durocher D.

Nat Biotechnol. 2018 Jan;36(1):95-102. doi: 10.1038/nbt.4021. Epub 2017 Nov 27.

43.

Structural basis for arginine methylation-independent recognition of PIWIL1 by TDRD2.

Zhang H, Liu K, Izumi N, Huang H, Ding D, Ni Z, Sidhu SS, Chen C, Tomari Y, Min J.

Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):12483-12488. doi: 10.1073/pnas.1711486114. Epub 2017 Nov 8.

44.

Construction of Synthetic Antibody Phage-Display Libraries.

Nilvebrant J, Sidhu SS.

Methods Mol Biol. 2018;1701:45-60. doi: 10.1007/978-1-4939-7447-4_3.

PMID:
29116499
45.

The influence of microRNAs and poly(A) tail length on endogenous mRNA-protein complexes.

Rissland OS, Subtelny AO, Wang M, Lugowski A, Nicholson B, Laver JD, Sidhu SS, Smibert CA, Lipshitz HD, Bartel DP.

Genome Biol. 2017 Oct 31;18(1):211. doi: 10.1186/s13059-017-1330-z.

46.

A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants.

Gabrielsen M, Buetow L, Nakasone MA, Ahmed SF, Sibbet GJ, Smith BO, Zhang W, Sidhu SS, Huang DT.

Mol Cell. 2017 Oct 19;68(2):456-470.e10. doi: 10.1016/j.molcel.2017.09.027.

47.

Reply.

Sidhu SS, Sharma BC, Goyal O, Kishore H, Kaur N.

Hepatology. 2018 Feb;67(2):797-798. doi: 10.1002/hep.29571. Epub 2018 Jan 2. No abstract available.

PMID:
29023956
48.

A panel of synthetic antibodies that selectively recognize and antagonize members of the interferon alpha family.

Miersch S, Kuruganti S, Walter MR, Sidhu SS.

Protein Eng Des Sel. 2017 Sep 1;30(9):697-704. doi: 10.1093/protein/gzx048.

49.

A synthetic intrabody-based selective and generic inhibitor of GPCR endocytosis.

Ghosh E, Srivastava A, Baidya M, Kumari P, Dwivedi H, Nidhi K, Ranjan R, Dogra S, Koide A, Yadav PN, Sidhu SS, Koide S, Shukla AK.

Nat Nanotechnol. 2017 Dec;12(12):1190-1198. doi: 10.1038/nnano.2017.188. Epub 2017 Oct 2.

50.

Impact of Recent Executive Actions on Minority Youth and Families.

Sidhu SS.

J Am Acad Child Adolesc Psychiatry. 2017 Oct;56(10):805-807. doi: 10.1016/j.jaac.2017.07.779. No abstract available.

PMID:
28942800

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