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Preclinical Testing of Nalfurafine as an Opioid-sparing Adjuvant that Potentiates Analgesia by the Mu Opioid Receptor-targeting Agonist Morphine.

Kaski SW, White AN, Gross JD, Trexler KR, Wix K, Harland AA, Prisinzano TE, Aubé J, Kinsey SG, Kenakin T, Siderovski DP, Setola V.

J Pharmacol Exp Ther. 2019 Nov;371(2):487-499. doi: 10.1124/jpet.118.255661. Epub 2019 Sep 6.


A role for Regulator of G protein Signaling-12 (RGS12) in the balance between myoblast proliferation and differentiation.

Schroer AB, Mohamed JS, Willard MD, Setola V, Oestreich E, Siderovski DP.

PLoS One. 2019 Aug 13;14(8):e0216167. doi: 10.1371/journal.pone.0216167. eCollection 2019.


Role of RGS12 in the differential regulation of kappa opioid receptor-dependent signaling and behavior.

Gross JD, Kaski SW, Schmidt KT, Cogan ES, Boyt KM, Wix K, Schroer AB, McElligott ZA, Siderovski DP, Setola V.

Neuropsychopharmacology. 2019 Sep;44(10):1728-1741. doi: 10.1038/s41386-019-0423-7. Epub 2019 May 29.


Single Nucleotide Polymorphisms in Chemosensory Pathway Genes GNB3, TAS2R19, and TAS2R38 Are Associated with Chronic Rhinosinusitis.

Purnell PR, Addicks BL, Zalzal HG, Shapiro S, Wen S, Ramadan HH, Setola V, Siderovski DP.

Int Arch Allergy Immunol. 2019;180(1):72-78. doi: 10.1159/000499875. Epub 2019 May 28.


Four single nucleotide polymorphisms in genes involved in neuronal signaling are associated with Opioid Use Disorder in West Virginia.

Kaski SW, Brooks S, Wen S, Haut MW, Siderovski DP, Berry JH, Lander LR, Setola V.

J Opioid Manag. 2019 Mar-Apr;15(2):103-109. doi: 10.5055/jom.2019.0491.


Chemerin-activated functions of CMKLR1 are regulated by G protein-coupled receptor kinase 6 (GRK6) and β-arrestin 2 in inflammatory macrophages.

Serafin DS, Allyn B, Sassano MF, Timoshchenko RG, Mattox D, Brozowski JM, Siderovski DP, Truong YK, Esserman D, Tarrant TK, Billard MJ.

Mol Immunol. 2019 Feb;106:12-21. doi: 10.1016/j.molimm.2018.12.016. Epub 2018 Dec 18.


Novel behavioral assays of spontaneous and precipitated THC withdrawal in mice.

Trexler KR, Nass SR, Crowe MS, Gross JD, Jones MS, McKitrick AW, Siderovski DP, Kinsey SG.

Drug Alcohol Depend. 2018 Oct 1;191:14-24. doi: 10.1016/j.drugalcdep.2018.05.029. Epub 2018 Jul 7.


Development of Full Sweet, Umami, and Bitter Taste Responsiveness Requires Regulator of G protein Signaling-21 (RGS21).

Schroer AB, Gross JD, Kaski SW, Wix K, Siderovski DP, Vandenbeuch A, Setola V.

Chem Senses. 2018 May 23;43(5):367-378. doi: 10.1093/chemse/bjy024.


Regulator of G protein signaling-12 modulates the dopamine transporter in ventral striatum and locomotor responses to psychostimulants.

Gross JD, Kaski SW, Schroer AB, Wix KA, Siderovski DP, Setola V.

J Psychopharmacol. 2018 Feb;32(2):191-203. doi: 10.1177/0269881117742100. Epub 2018 Jan 24.


Protective Roles for RGS2 in a Mouse Model of House Dust Mite-Induced Airway Inflammation.

George T, Bell M, Chakraborty M, Siderovski DP, Giembycz MA, Newton R.

PLoS One. 2017 Jan 20;12(1):e0170269. doi: 10.1371/journal.pone.0170269. eCollection 2017.


Reduction of GPSM3 expression akin to the arthritis-protective SNP rs204989 differentially affects migration in a neutrophil model.

Gall BJ, Schroer AB, Gross JD, Setola V, Siderovski DP.

Genes Immun. 2016 Sep;17(6):321-7. doi: 10.1038/gene.2016.26. Epub 2016 Jun 16.


Genetic variations in GPSM3 associated with protection from rheumatoid arthritis affect its transcript abundance.

Gall BJ, Wilson A, Schroer AB, Gross JD, Stoilov P, Setola V, Watkins CM, Siderovski DP.

Genes Immun. 2016 Mar;17(2):139-47. doi: 10.1038/gene.2016.3. Epub 2016 Jan 28.


Correction: Exome Sequencing in 53 Sporadic Cases of Schizophrenia Identifies 18 Putative Candidate Genes.

Guipponi M, Santoni FA, Setola V, Gehrig C, Rotharmel M, Cuenca M, Guillin O, Dikeos D, Georgantopoulos G, Papadimitriou G, Curtis L, Méary A, Schürhoff F, Jamain S, Avramopoulos D, Leboyer M, Rujescu D, Pulver A, Campion D, Siderovski DP, Antonarakis SE.

PLoS One. 2015 Oct 21;10(10):e0141630. doi: 10.1371/journal.pone.0141630. eCollection 2015. No abstract available.


Modulating platelet reactivity through control of RGS18 availability.

Ma P, Ou K, Sinnamon AJ, Jiang H, Siderovski DP, Brass LF.

Blood. 2015 Dec 10;126(24):2611-20. doi: 10.1182/blood-2015-04-640037. Epub 2015 Sep 25.


A Non-Canonical Function of Gβ as a Subunit of E3 Ligase in Targeting GRK2 Ubiquitylation.

Zha Z, Han X, Smith MD, Liu Y, Giguère PM, Kopanja D, Raychaudhuri P, Siderovski DP, Guan KL, Lei QY, Xiong Y.

Mol Cell. 2015 Jun 4;58(5):794-803. doi: 10.1016/j.molcel.2015.04.017. Epub 2015 May 14.


Entamoeba histolytica RacC selectively engages p21-activated kinase effectors.

Bosch DE, Siderovski DP.

Biochemistry. 2015 Jan 20;54(2):404-12. doi: 10.1021/bi501226f. Epub 2015 Jan 2.


Exome sequencing in 53 sporadic cases of schizophrenia identifies 18 putative candidate genes.

Guipponi M, Santoni FA, Setola V, Gehrig C, Rotharmel M, Cuenca M, Guillin O, Dikeos D, Georgantopoulos G, Papadimitriou G, Curtis L, Méary A, Schürhoff F, Jamain S, Avramopoulos D, Leboyer M, Rujescu D, Pulver A, Campion D, Siderovski DP, Antonarakis SE.

PLoS One. 2014 Nov 24;9(11):e112745. doi: 10.1371/journal.pone.0112745. eCollection 2014. Erratum in: PLoS One. 2015;10(10):e0141630.


G Protein signaling modulator-3 inhibits the inflammasome activity of NLRP3.

Giguère PM, Gall BJ, Ezekwe EA Jr, Laroche G, Buckley BK, Kebaier C, Wilson JE, Ting JP, Siderovski DP, Duncan JA.

J Biol Chem. 2014 Nov 28;289(48):33245-57. doi: 10.1074/jbc.M114.578393. Epub 2014 Sep 30.


G protein signaling modulator-3: a leukocyte regulator of inflammation in health and disease.

Billard MJ, Gall BJ, Richards KL, Siderovski DP, Tarrant TK.

Am J Clin Exp Immunol. 2014 Aug 15;3(2):97-106. eCollection 2014. Review.


Regulation of protease-activated receptor 1 signaling by the adaptor protein complex 2 and R4 subfamily of regulator of G protein signaling proteins.

Chen B, Siderovski DP, Neubig RR, Lawson MA, Trejo J.

J Biol Chem. 2014 Jan 17;289(3):1580-91. doi: 10.1074/jbc.M113.528273. Epub 2013 Dec 2.


Induction of regulator of G-protein signaling 2 expression by long-acting β2-adrenoceptor agonists and glucocorticoids in human airway epithelial cells.

Holden NS, George T, Rider CF, Chandrasekhar A, Shah S, Kaur M, Johnson M, Siderovski DP, Leigh R, Giembycz MA, Newton R.

J Pharmacol Exp Ther. 2014 Jan;348(1):12-24. doi: 10.1124/jpet.113.204586. Epub 2013 Oct 25.


G protein-coupled receptor kinase-3-deficient mice exhibit WHIM syndrome features and attenuated inflammatory responses.

Tarrant TK, Billard MJ, Timoshchenko RG, McGinnis MW, Serafin DS, Foreman O, Esserman DA, Chao NJ, Lento WE, Lee DM, Patel D, Siderovski DP.

J Leukoc Biol. 2013 Dec;94(6):1243-51. doi: 10.1189/jlb.0213097. Epub 2013 Aug 9.


RGS21, a regulator of taste and mucociliary clearance?

Kimple AJ, Garland AL, Cohen SP, Setola V, Willard FS, Zielinski T, Lowery RG, Tarran R, Siderovski DP.

Laryngoscope. 2014 Mar;124(3):E56-63. doi: 10.1002/lary.24326. Epub 2013 Oct 2.


Inhibition of dopamine transporter activity by G protein βγ subunits.

Garcia-Olivares J, Torres-Salazar D, Owens WA, Baust T, Siderovski DP, Amara SG, Zhu J, Daws LC, Torres GE.

PLoS One. 2013;8(3):e59788. doi: 10.1371/journal.pone.0059788. Epub 2013 Mar 26.


G protein signaling in the parasite Entamoeba histolytica.

Bosch DE, Siderovski DP.

Exp Mol Med. 2013 Mar 22;45:e15. doi: 10.1038/emm.2013.30. Review.


G-protein signaling modulator-3, a gene linked to autoimmune diseases, regulates monocyte function and its deficiency protects from inflammatory arthritis.

Giguère PM, Billard MJ, Laroche G, Buckley BK, Timoshchenko RG, McGinnis MW, Esserman D, Foreman O, Liu P, Siderovski DP, Tarrant TK.

Mol Immunol. 2013 Jun;54(2):193-8. doi: 10.1016/j.molimm.2012.12.001. Epub 2012 Dec 29.


Structural determinants of RGS-RhoGEF signaling critical to Entamoeba histolytica pathogenesis.

Bosch DE, Kimple AJ, Manning AJ, Muller RE, Willard FS, Machius M, Rogers SL, Siderovski DP.

Structure. 2013 Jan 8;21(1):65-75. doi: 10.1016/j.str.2012.11.012. Epub 2012 Dec 20.


Structural determinants of ubiquitin conjugation in Entamoeba histolytica.

Bosch DE, Siderovski DP.

J Biol Chem. 2013 Jan 25;288(4):2290-302. doi: 10.1074/jbc.M112.417337. Epub 2012 Dec 3.


Heterotrimeric G-protein signaling is critical to pathogenic processes in Entamoeba histolytica.

Bosch DE, Kimple AJ, Muller RE, Giguère PM, Machius M, Willard FS, Temple BR, Siderovski DP.

PLoS Pathog. 2012;8(11):e1003040. doi: 10.1371/journal.ppat.1003040. Epub 2012 Nov 15.


Regulator of G-protein signaling-21 (RGS21) is an inhibitor of bitter gustatory signaling found in lingual and airway epithelia.

Cohen SP, Buckley BK, Kosloff M, Garland AL, Bosch DE, Cheng G Jr, Radhakrishna H, Brown MD, Willard FS, Arshavsky VY, Tarran R, Siderovski DP, Kimple AJ.

J Biol Chem. 2012 Dec 7;287(50):41706-19. doi: 10.1074/jbc.M112.423806. Epub 2012 Oct 24.


Entamoeba histolytica Rho1 regulates actin polymerization through a divergent, diaphanous-related formin.

Bosch DE, Yang B, Siderovski DP.

Biochemistry. 2012 Nov 6;51(44):8791-801. doi: 10.1021/bi300954g. Epub 2012 Oct 23.


Regulation of the subcellular localization of the G-protein subunit regulator GPSM3 through direct association with 14-3-3 protein.

Giguère PM, Laroche G, Oestreich EA, Duncan JA, Siderovski DP.

J Biol Chem. 2012 Sep 7;287(37):31270-9. doi: 10.1074/jbc.M112.394379. Epub 2012 Jul 26.


The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy.

Lei Y, Wen H, Yu Y, Taxman DJ, Zhang L, Widman DG, Swanson KV, Wen KW, Damania B, Moore CB, Giguère PM, Siderovski DP, Hiscott J, Razani B, Semenkovich CF, Chen X, Ting JP.

Immunity. 2012 Jun 29;36(6):933-46. doi: 10.1016/j.immuni.2012.03.025.


Retraction for Johnston and Siderovski. Structural basis for nucleotide exchange on Gαi subunits and receptor coupling specificity.

Johnston CA, Siderovski DP.

Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1808. No abstract available.


A P-loop mutation in Gα subunits prevents transition to the active state: implications for G-protein signaling in fungal pathogenesis.

Bosch DE, Willard FS, Ramanujam R, Kimple AJ, Willard MD, Naqvi NI, Siderovski DP.

PLoS Pathog. 2012 Feb;8(2):e1002553. doi: 10.1371/journal.ppat.1002553. Epub 2012 Feb 23.


Evaluating modulators of "Regulator of G-protein Signaling" (RGS) proteins.

Bosch DE, Zielinski T, Lowery RG, Siderovski DP.

Curr Protoc Pharmacol. 2012 Mar;Chapter 2:Unit2.8. doi: 10.1002/0471141755.ph0208s56.


G-protein signaling modulator-3 regulates heterotrimeric G-protein dynamics through dual association with Gβ and Gαi protein subunits.

Giguère PM, Laroche G, Oestreich EA, Siderovski DP.

J Biol Chem. 2012 Feb 10;287(7):4863-74. doi: 10.1074/jbc.M111.311712. Epub 2011 Dec 13.


β2-Adrenoceptor agonist-induced RGS2 expression is a genomic mechanism of bronchoprotection that is enhanced by glucocorticoids.

Holden NS, Bell MJ, Rider CF, King EM, Gaunt DD, Leigh R, Johnson M, Siderovski DP, Heximer SP, Giembycz MA, Newton R.

Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19713-8. doi: 10.1073/pnas.1110226108. Epub 2011 Nov 11.


Unique structural and nucleotide exchange features of the Rho1 GTPase of Entamoeba histolytica.

Bosch DE, Wittchen ES, Qiu C, Burridge K, Siderovski DP.

J Biol Chem. 2011 Nov 11;286(45):39236-46. doi: 10.1074/jbc.M111.253898. Epub 2011 Sep 19.


Regulators of G-protein signaling and their Gα substrates: promises and challenges in their use as drug discovery targets.

Kimple AJ, Bosch DE, Giguère PM, Siderovski DP.

Pharmacol Rev. 2011 Sep;63(3):728-49. doi: 10.1124/pr.110.003038. Epub 2011 Jul 7. Review.


Integrating energy calculations with functional assays to decipher the specificity of G protein-RGS protein interactions.

Kosloff M, Travis AM, Bosch DE, Siderovski DP, Arshavsky VY.

Nat Struct Mol Biol. 2011 Jun 19;18(7):846-53. doi: 10.1038/nsmb.2068.


Computational design of the sequence and structure of a protein-binding peptide.

Sammond DW, Bosch DE, Butterfoss GL, Purbeck C, Machius M, Siderovski DP, Kuhlman B.

J Am Chem Soc. 2011 Mar 30;133(12):4190-2. doi: 10.1021/ja110296z. Epub 2011 Mar 9.


Structural determinants of affinity enhancement between GoLoco motifs and G-protein alpha subunit mutants.

Bosch DE, Kimple AJ, Sammond DW, Muller RE, Miley MJ, Machius M, Kuhlman B, Willard FS, Siderovski DP.

J Biol Chem. 2011 Feb 4;286(5):3351-8. doi: 10.1074/jbc.M110.190496. Epub 2010 Nov 29.


A homogeneous method to measure nucleotide exchange by α-subunits of heterotrimeric G-proteins using fluorescence polarization.

Muller RE, Klein KR, Hutsell SQ, Siderovski DP, Kimple AJ.

Assay Drug Dev Technol. 2010 Oct;8(5):621-4. doi: 10.1089/adt.2010.0286. Epub 2010 Jul 27.


RNA interference screen for RGS protein specificity at muscarinic and protease-activated receptors reveals bidirectional modulation of signaling.

Laroche G, Giguère PM, Roth BL, Trejo J, Siderovski DP.

Am J Physiol Cell Physiol. 2010 Sep;299(3):C654-64. doi: 10.1152/ajpcell.00441.2009. Epub 2010 Jun 23.


LGN regulates mitotic spindle orientation during epithelial morphogenesis.

Zheng Z, Zhu H, Wan Q, Liu J, Xiao Z, Siderovski DP, Du Q.

J Cell Biol. 2010 Apr 19;189(2):275-88. doi: 10.1083/jcb.200910021. Epub 2010 Apr 12.


Regulators of G-protein signaling accelerate GPCR signaling kinetics and govern sensitivity solely by accelerating GTPase activity.

Lambert NA, Johnston CA, Cappell SD, Kuravi S, Kimple AJ, Willard FS, Siderovski DP.

Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):7066-71. doi: 10.1073/pnas.0912934107. Epub 2010 Mar 29. Erratum in: Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):2175.


A capture coupling method for the covalent immobilization of hexahistidine tagged proteins for surface plasmon resonance.

Kimple AJ, Muller RE, Siderovski DP, Willard FS.

Methods Mol Biol. 2010;627:91-100. doi: 10.1007/978-1-60761-670-2_5.


High-affinity immobilization of proteins using biotin- and GST-based coupling strategies.

Hutsell SQ, Kimple RJ, Siderovski DP, Willard FS, Kimple AJ.

Methods Mol Biol. 2010;627:75-90. doi: 10.1007/978-1-60761-670-2_4.


PB1 domain interaction of p62/sequestosome 1 and MEKK3 regulates NF-kappaB activation.

Nakamura K, Kimple AJ, Siderovski DP, Johnson GL.

J Biol Chem. 2010 Jan 15;285(3):2077-89. doi: 10.1074/jbc.M109.065102. Epub 2009 Nov 10.

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