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Items: 1 to 50 of 194

1.

Genomic Evidence for Local Adaptation of Hunter-Gatherers to the African Rainforest.

Lopez M, Choin J, Sikora M, Siddle K, Harmant C, Costa HA, Silvert M, Mouguiama-Daouda P, Hombert JM, Froment A, Le Bomin S, Perry GH, Barreiro LB, Bustamante CD, Verdu P, Patin E, Quintana-Murci L.

Curr Biol. 2019 Sep 9;29(17):2926-2935.e4. doi: 10.1016/j.cub.2019.07.013. Epub 2019 Aug 8.

PMID:
31402299
2.

Benchmarking Metagenomics Tools for Taxonomic Classification.

Ye SH, Siddle KJ, Park DJ, Sabeti PC.

Cell. 2019 Aug 8;178(4):779-794. doi: 10.1016/j.cell.2019.07.010. Review.

PMID:
31398336
3.

Capturing sequence diversity in metagenomes with comprehensive and scalable probe design.

Metsky HC, Siddle KJ, Gladden-Young A, Qu J, Yang DK, Brehio P, Goldfarb A, Piantadosi A, Wohl S, Carter A, Lin AE, Barnes KG, Tully DC, Corleis B, Hennigan S, Barbosa-Lima G, Vieira YR, Paul LM, Tan AL, Garcia KF, Parham LA, Odia I, Eromon P, Folarin OA, Goba A; Viral Hemorrhagic Fever Consortium, Simon-Lorière E, Hensley L, Balmaseda A, Harris E, Kwon DS, Allen TM, Runstadler JA, Smole S, Bozza FA, Souza TML, Isern S, Michael SF, Lorenzana I, Gehrke L, Bosch I, Ebel G, Grant DS, Happi CT, Park DJ, Gnirke A, Sabeti PC, Matranga CB.

Nat Biotechnol. 2019 Feb;37(2):160-168. doi: 10.1038/s41587-018-0006-x. Epub 2019 Feb 4.

4.

Clinicians' perceptions of the quality of outsourced radiology and actions taken around perceived imaging errors in practice.

Graham Y, Hayes C, Mehrotra P, Spratt J, Siddle K, Cox J.

Eur Radiol. 2019 Apr;29(4):1649-1654. doi: 10.1007/s00330-018-5873-5. Epub 2018 Dec 12.

PMID:
30542751
5.

Genomic Analysis of Lassa Virus during an Increase in Cases in Nigeria in 2018.

Siddle KJ, Eromon P, Barnes KG, Mehta S, Oguzie JU, Odia I, Schaffner SF, Winnicki SM, Shah RR, Qu J, Wohl S, Brehio P, Iruolagbe C, Aiyepada J, Uyigue E, Akhilomen P, Okonofua G, Ye S, Kayode T, Ajogbasile F, Uwanibe J, Gaye A, Momoh M, Chak B, Kotliar D, Carter A, Gladden-Young A, Freije CA, Omoregie O, Osiemi B, Muoebonam EB, Airende M, Enigbe R, Ebo B, Nosamiefan I, Oluniyi P, Nekoui M, Ogbaini-Emovon E, Garry RF, Andersen KG, Park DJ, Yozwiak NL, Akpede G, Ihekweazu C, Tomori O, Okogbenin S, Folarin OA, Okokhere PO, MacInnis BL, Sabeti PC, Happi CT.

N Engl J Med. 2018 Nov 1;379(18):1745-1753. doi: 10.1056/NEJMoa1804498. Epub 2018 Oct 17.

6.

Evaluation of anti-insulin receptor antibodies as potential novel therapies for human insulin receptoropathy using cell culture models.

Brierley GV, Siddle K, Semple RK.

Diabetologia. 2018 Jul;61(7):1662-1675. doi: 10.1007/s00125-018-4606-2. Epub 2018 Apr 27.

7.

Field validation of recombinant antigen immunoassays for diagnosis of Lassa fever.

Boisen ML, Hartnett JN, Shaffer JG, Goba A, Momoh M, Sandi JD, Fullah M, Nelson DKS, Bush DJ, Rowland MM, Heinrich ML, Koval AP, Cross RW, Barnes KG, Lachenauer AE, Lin AE, Nekoui M, Kotliar D, Winnicki SM, Siddle KJ, Gbakie M, Fonnie M, Koroma VJ, Kanneh L, Kulakosky PC, Hastie KM, Wilson RB, Andersen KG, Folarin OO, Happi CT, Sabeti PC, Geisbert TW, Saphire EO, Khan SH, Grant DS, Schieffelin JS, Branco LM, Garry RF.

Sci Rep. 2018 Apr 12;8(1):5939. doi: 10.1038/s41598-018-24246-w.

8.

Negative Selection by Spiral Inertial Microfluidics Improves Viral Recovery and Sequencing from Blood.

Choi K, Ryu H, Siddle KJ, Piantadosi A, Freimark L, Park DJ, Sabeti P, Han J.

Anal Chem. 2018 Apr 3;90(7):4657-4662. doi: 10.1021/acs.analchem.7b05200. Epub 2018 Mar 21.

9.

miR-222 isoforms are differentially regulated by type-I interferon.

Nejad C, Pillman KA, Siddle KJ, Pépin G, Änkö ML, McCoy CE, Beilharz TH, Quintana-Murci L, Goodall GJ, Bracken CP, Gantier MP.

RNA. 2018 Mar;24(3):332-341. doi: 10.1261/rna.064550.117. Epub 2017 Dec 20.

10.

Evidence of Ebola Virus Replication and High Concentration in Semen of a Patient During Recovery.

Barnes KG, Kindrachuk J, Lin AE, Wohl S, Qu J, Tostenson SD, Dorman WR, Busby M, Siddle KJ, Luo CY, Matranga CB, Davey RT, Sabeti PC, Chertow DS.

Clin Infect Dis. 2017 Oct 15;65(8):1400-1403. doi: 10.1093/cid/cix518.

11.

Widespread Shortening of 3' Untranslated Regions and Increased Exon Inclusion Are Evolutionarily Conserved Features of Innate Immune Responses to Infection.

Pai AA, Baharian G, Pagé Sabourin A, Brinkworth JF, Nédélec Y, Foley JW, Grenier JC, Siddle KJ, Dumaine A, Yotova V, Johnson ZP, Lanford RE, Burge CB, Barreiro LB.

PLoS Genet. 2016 Sep 30;12(9):e1006338. doi: 10.1371/journal.pgen.1006338. eCollection 2016 Sep.

12.

Cell-autonomous programming of rat adipose tissue insulin signalling proteins by maternal nutrition.

Martin-Gronert MS, Fernandez-Twinn DS, Bushell M, Siddle K, Ozanne SE.

Diabetologia. 2016 Jun;59(6):1266-75. doi: 10.1007/s00125-016-3905-8. Epub 2016 Mar 10.

13.

Acute knockdown of the insulin receptor or its substrates Irs1 and 2 in 3T3-L1 adipocytes suppresses adiponectin production.

Groeneveld MP, Brierley GV, Rocha NM, Siddle K, Semple RK.

Sci Rep. 2016 Feb 18;6:21105. doi: 10.1038/srep21105.

14.

The epigenomic landscape of African rainforest hunter-gatherers and farmers.

Fagny M, Patin E, MacIsaac JL, Rotival M, Flutre T, Jones MJ, Siddle KJ, Quach H, Harmant C, McEwen LM, Froment A, Heyer E, Gessain A, Betsem E, Mouguiama-Daouda P, Hombert JM, Perry GH, Barreiro LB, Kobor MS, Quintana-Murci L.

Nat Commun. 2015 Nov 30;6:10047. doi: 10.1038/ncomms10047.

15.

bacterial infection drives the expression dynamics of microRNAs and their isomiRs.

Siddle KJ, Tailleux L, Deschamps M, Loh YH, Deluen C, Gicquel B, Antoniewski C, Barreiro LB, Farinelli L, Quintana-Murci L.

PLoS Genet. 2015 Mar 20;11(3):e1005064. doi: 10.1371/journal.pgen.1005064. eCollection 2015 Mar. Erratum in: PLoS Genet. 2015 Jun;11(6):e1005321.

16.

The Red Queen's long race: human adaptation to pathogen pressure.

Siddle KJ, Quintana-Murci L.

Curr Opin Genet Dev. 2014 Dec;29:31-8. doi: 10.1016/j.gde.2014.07.004. Epub 2014 Aug 24. Review.

PMID:
25170983
17.

The impact of agricultural emergence on the genetic history of African rainforest hunter-gatherers and agriculturalists.

Patin E, Siddle KJ, Laval G, Quach H, Harmant C, Becker N, Froment A, Régnault B, Lemée L, Gravel S, Hombert JM, Van der Veen L, Dominy NJ, Perry GH, Barreiro LB, Verdu P, Heyer E, Quintana-Murci L.

Nat Commun. 2014;5:3163. doi: 10.1038/ncomms4163.

PMID:
24495941
18.

A genomic portrait of the genetic architecture and regulatory impact of microRNA expression in response to infection.

Siddle KJ, Deschamps M, Tailleux L, Nédélec Y, Pothlichet J, Lugo-Villarino G, Libri V, Gicquel B, Neyrolles O, Laval G, Patin E, Barreiro LB, Quintana-Murci L.

Genome Res. 2014 May;24(5):850-9. doi: 10.1101/gr.161471.113. Epub 2014 Jan 30.

19.

Evolution of the pygmy phenotype: evidence of positive selection fro genome-wide scans in African, Asian, and Melanesian pygmies.

Migliano AB, Romero IG, Metspalu M, Leavesley M, Pagani L, Antao T, Huang DW, Sherman BT, Siddle K, Scholes C, Hudjashov G, Kaitokai E, Babalu A, Belatti M, Cagan A, Hopkinshaw B, Shaw C, Nelis M, Metspalu E, Mägi R, Lempicki RA, Villems R, Lahr MM, Kivisild T.

Hum Biol. 2013 Feb-Jun;85(1-3):251-84.

PMID:
24297229
20.

Characterising women with obstetric fistula and urogenital tract injuries in Tanzania.

Siddle K, Vieren L, Fiander A.

Int Urogynecol J. 2014 Feb;25(2):249-55. doi: 10.1007/s00192-013-2185-9. Epub 2013 Aug 1.

PMID:
23903820
21.

Psychosocial impact of obstetric fistula in women presenting for surgical care in Tanzania.

Siddle K, Mwambingu S, Malinga T, Fiander A.

Int Urogynecol J. 2013 Jul;24(7):1215-20. doi: 10.1007/s00192-012-1994-6. Epub 2012 Nov 24.

PMID:
23179502
22.

Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advances.

Siddle K.

Front Endocrinol (Lausanne). 2012 Feb 28;3:34. doi: 10.3389/fendo.2012.00034. eCollection 2012.

23.

Two isoforms of the mRNA binding protein IGF2BP2 are generated by alternative translational initiation.

Le HT, Sorrell AM, Siddle K.

PLoS One. 2012;7(3):e33140. doi: 10.1371/journal.pone.0033140. Epub 2012 Mar 12.

24.

Programming of adipose tissue miR-483-3p and GDF-3 expression by maternal diet in type 2 diabetes.

Ferland-McCollough D, Fernandez-Twinn DS, Cannell IG, David H, Warner M, Vaag AA, Bork-Jensen J, Brøns C, Gant TW, Willis AE, Siddle K, Bushell M, Ozanne SE.

Cell Death Differ. 2012 Jun;19(6):1003-12. doi: 10.1038/cdd.2011.183. Epub 2012 Jan 6.

25.

Genetic diversity and evidence for population admixture in Batak Negritos from Palawan.

Scholes C, Siddle K, Ducourneau A, Crivellaro F, Järve M, Rootsi S, Bellatti M, Tabbada K, Mormina M, Reidla M, Villems R, Kivisild T, Lahr MM, Migliano AB.

Am J Phys Anthropol. 2011 Sep;146(1):62-72. doi: 10.1002/ajpa.21544.

PMID:
21796613
26.

Signalling by insulin and IGF receptors: supporting acts and new players.

Siddle K.

J Mol Endocrinol. 2011 Jun 17;47(1):R1-10. doi: 10.1530/JME-11-0022. Print 2011 Aug. Review.

PMID:
21498522
27.

Bases adjacent to mononucleotide repeats show an increased single nucleotide polymorphism frequency in the human genome.

Siddle KJ, Goodship JA, Keavney B, Santibanez-Koref MF.

Bioinformatics. 2011 Apr 1;27(7):895-8. doi: 10.1093/bioinformatics/btr067. Epub 2011 Feb 11.

PMID:
21317137
28.

The involvement of microRNAs in Type 2 diabetes.

Ferland-McCollough D, Ozanne SE, Siddle K, Willis AE, Bushell M.

Biochem Soc Trans. 2010 Dec;38(6):1565-70. doi: 10.1042/BST0381565. Review.

PMID:
21118127
29.

The human insulin receptor mRNA contains a functional internal ribosome entry segment.

Spriggs KA, Cobbold LC, Ridley SH, Coldwell M, Bottley A, Bushell M, Willis AE, Siddle K.

Nucleic Acids Res. 2009 Sep;37(17):5881-93. doi: 10.1093/nar/gkp623. Epub 2009 Aug 4.

30.

The transcription factors Egr1 and Egr2 have opposing influences on adipocyte differentiation.

Boyle KB, Hadaschik D, Virtue S, Cawthorn WP, Ridley SH, O'Rahilly S, Siddle K.

Cell Death Differ. 2009 May;16(5):782-9. doi: 10.1038/cdd.2009.11. Epub 2009 Feb 20.

31.

An investigation of the ligand binding properties and negative cooperativity of soluble insulin-like growth factor receptors.

Surinya KH, Forbes BE, Occhiodoro F, Booker GW, Francis GL, Siddle K, Wallace JC, Cosgrove LJ.

J Biol Chem. 2008 Feb 29;283(9):5355-63. Epub 2007 Dec 3.

33.

Differential phosphorylation of IRS-1 and IRS-2 by insulin and IGF-I receptors.

Rakatzi I, Stosik M, Gromke T, Siddle K, Eckel J.

Arch Physiol Biochem. 2006 Feb;112(1):37-47.

PMID:
16754202
34.

Regulation of insulin receptor substrate 1 pleckstrin homology domain by protein kinase C: role of serine 24 phosphorylation.

Nawaratne R, Gray A, Jørgensen CH, Downes CP, Siddle K, Sethi JK.

Mol Endocrinol. 2006 Aug;20(8):1838-52. Epub 2006 Mar 30.

35.

Glycomics investigation into insulin action.

Parry S, Hadaschik D, Blancher C, Kumaran MK, Bochkina N, Morris HR, Richardson S, Aitman TJ, Gauguier D, Siddle K, Scott J, Dell A.

Biochim Biophys Acta. 2006 Apr;1760(4):652-68. Epub 2006 Jan 10.

PMID:
16473469
36.

Assessing psychosocial risk in pregnant/postpartum women using the Contextual Assessment of Maternity Experience (CAME)--recent life adversity, social support and maternal feelings.

Bernazzani O, Marks MN, Bifulco A, Siddle K, Asten P, Conroy S.

Soc Psychiatry Psychiatr Epidemiol. 2005 Jun;40(6):497-508.

PMID:
16003600
37.

Grb10 and Grb14: enigmatic regulators of insulin action--and more?

Holt LJ, Siddle K.

Biochem J. 2005 Jun 1;388(Pt 2):393-406. Review.

38.

Contextual Assessment of the Maternity Experience: development of an instrument for cross-cultural research.

Bernazzani O, Conroy S, Marks MN, Siddle KA, Guedeney N, Bifulco A, Asten P, Figueiredo B, Gorman LL, Bellini S, Glatigny-Dallay E, Hayes S, Klier CM, Kammerer MH, Henshaw CA; TCS-PND Group.

Br J Psychiatry Suppl. 2004 Feb;46:s24-30.

PMID:
14754815
39.

Cell proliferation activities on skin fibroblasts from a short child with absence of one copy of the type 1 insulin-like growth factor receptor (IGF1R) gene and a tall child with three copies of the IGF1R gene.

Okubo Y, Siddle K, Firth H, O'Rahilly S, Wilson LC, Willatt L, Fukushima T, Takahashi S, Petry CJ, Saukkonen T, Stanhope R, Dunger DB.

J Clin Endocrinol Metab. 2003 Dec;88(12):5981-8.

PMID:
14671200
40.

Attractin' more attention - new pieces in the obesity puzzle?

Yeo GS, Siddle K.

Biochem J. 2003 Dec 15;376(Pt 3):e7-8.

42.

Deletion of V335 from the L2 domain of the insulin receptor results in a conformationally abnormal receptor that is unable to bind insulin and causes Donohue's syndrome in a human subject.

George S, Johansen A, Soos MA, Mortensen H, Gammeltoft S, Saudek V, Siddle K, Hansen L, O'Rahilly S.

Endocrinology. 2003 Feb;144(2):631-7.

PMID:
12538626
43.

Microarray analysis of insulin and insulin-like growth factor-1 (IGF-1) receptor signaling reveals the selective up-regulation of the mitogen heparin-binding EGF-like growth factor by IGF-1.

Mulligan C, Rochford J, Denyer G, Stephens R, Yeo G, Freeman T, Siddle K, O'Rahilly S.

J Biol Chem. 2002 Nov 8;277(45):42480-7. Epub 2002 Sep 3.

44.

Role of insulin receptor dimerization domains in ligand binding, cooperativity, and modulation by anti-receptor antibodies.

Surinya KH, Molina L, Soos MA, Brandt J, Kristensen C, Siddle K.

J Biol Chem. 2002 May 10;277(19):16718-25. Epub 2002 Mar 1.

45.

Specificity in ligand binding and intracellular signalling by insulin and insulin-like growth factor receptors.

Siddle K, Ursø B, Niesler CA, Cope DL, Molina L, Surinya KH, Soos MA.

Biochem Soc Trans. 2001 Aug;29(Pt 4):513-25. Review.

PMID:
11498020
46.

Adipose depot-specific expression of cIAP2 in human preadipocytes and modulation of expression by serum factors and TNFalpha.

Niesler CU, Prins JB, O'Rahilly S, Siddle K, Montague CT.

Int J Obes Relat Metab Disord. 2001 Jul;25(7):1027-33.

PMID:
11443502
47.

Defect in insulin-like growth factor-1 survival mechanism in atherosclerotic plaque-derived vascular smooth muscle cells is mediated by reduced surface binding and signaling.

Patel VA, Zhang QJ, Siddle K, Soos MA, Goddard M, Weissberg PL, Bennett MR.

Circ Res. 2001 May 11;88(9):895-902.

PMID:
11348998
48.

Comparison of anti-apoptotic signalling by the insulin receptor and IGF-I receptor in preadipocytes and adipocytes.

Ursø B, Niesler CU, O'Rahilly S, Siddle K.

Cell Signal. 2001 Apr;13(4):279-85.

PMID:
11306245
49.

The role of insulin dissociation from its endosomal receptor in insulin degradation.

Bevan AP, Seabright PJ, Tikerpae J, Posner BI, Smith GD, Siddle K.

Mol Cell Endocrinol. 2000 Jun;164(1-2):145-57.

PMID:
11026566
50.

IGF-I inhibits apoptosis induced by serum withdrawal, but potentiates TNF-alpha-induced apoptosis, in 3T3-L1 preadipocytes.

Niesler CU, Ursø B, Prins JB, Siddle K.

J Endocrinol. 2000 Oct;167(1):165-74.

PMID:
11018764

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