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Items: 1 to 50 of 106

1.

Loss of Cyclin E1 attenuates hepatitis and hepatocarcinogenesis in a mouse model of chronic liver injury.

Ehedego H, Mohs A, Jansen B, Hiththetiya K, Sicinski P, Liedtke C, Trautwein C.

Oncogene. 2018 Jun;37(25):3329-3339. doi: 10.1038/s41388-018-0181-8. Epub 2018 Mar 19.

PMID:
29551768
2.

Kinase-independent function of E-type cyclins in liver cancer.

Geng Y, Michowski W, Chick JM, Wang YE, Jecrois ME, Sweeney KE, Liu L, Han RC, Ke N, Zagozdzon A, Sicinska E, Bronson RT, Gygi SP, Sicinski P.

Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):1015-1020. doi: 10.1073/pnas.1711477115. Epub 2018 Jan 16.

PMID:
29339491
3.

Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance.

Zhang J, Bu X, Wang H, Zhu Y, Geng Y, Nihira NT, Tan Y, Ci Y, Wu F, Dai X, Guo J, Huang YH, Fan C, Ren S, Sun Y, Freeman GJ, Sicinski P, Wei W.

Nature. 2018 Jan 4;553(7686):91-95. doi: 10.1038/nature25015. Epub 2017 Nov 16.

4.

Identification of cell cycle-targeting microRNAs through genome-wide screens.

Hydbring P, Wang Y, Bogorad RL, Yin H, Anderson DG, Li C, Sicinski P.

Cell Cycle. 2017;16(23):2241-2248. doi: 10.1080/15384101.2017.1380132. Epub 2017 Nov 14.

5.

Cell cycle-targeting microRNAs promote differentiation by enforcing cell-cycle exit.

Otto T, Candido SV, Pilarz MS, Sicinska E, Bronson RT, Bowden M, Lachowicz IA, Mulry K, Fassl A, Han RC, Jecrois ES, Sicinski P.

Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):10660-10665. doi: 10.1073/pnas.1702914114. Epub 2017 Sep 18.

6.

Cyclin A2 modulates kinetochore-microtubule attachment in meiosis II.

Zhang QH, Yuen WS, Adhikari D, Flegg JA, FitzHarris G, Conti M, Sicinski P, Nabti I, Marangos P, Carroll J.

J Cell Biol. 2017 Oct 2;216(10):3133-3143. doi: 10.1083/jcb.201607111. Epub 2017 Aug 17.

7.

Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells.

Johannessen L, Sundberg TB, O'Connell DJ, Kolde R, Berstler J, Billings KJ, Khor B, Seashore-Ludlow B, Fassl A, Russell CN, Latorre IJ, Jiang B, Graham DB, Perez JR, Sicinski P, Phillips AJ, Schreiber SL, Gray NS, Shamji AF, Xavier RJ.

Nat Chem Biol. 2017 Oct;13(10):1102-1108. doi: 10.1038/nchembio.2458. Epub 2017 Aug 14.

PMID:
28805801
8.

The metabolic function of cyclin D3-CDK6 kinase in cancer cell survival.

Wang H, Nicolay BN, Chick JM, Gao X, Geng Y, Ren H, Gao H, Yang G, Williams JA, Suski JM, Keibler MA, Sicinska E, Gerdemann U, Haining WN, Roberts TM, Polyak K, Gygi SP, Dyson NJ, Sicinski P.

Nature. 2017 Jun 15;546(7658):426-430. doi: 10.1038/nature22797. Epub 2017 Jun 7.

9.

Cell-Cycle-Targeting MicroRNAs as Therapeutic Tools against Refractory Cancers.

Hydbring P, Wang Y, Fassl A, Li X, Matia V, Otto T, Choi YJ, Sweeney KE, Suski JM, Yin H, Bogorad RL, Goel S, Yuzugullu H, Kauffman KJ, Yang J, Jin C, Li Y, Floris D, Swanson R, Ng K, Sicinska E, Anders L, Zhao JJ, Polyak K, Anderson DG, Li C, Sicinski P.

Cancer Cell. 2017 Apr 10;31(4):576-590.e8. doi: 10.1016/j.ccell.2017.03.004.

10.

A Sequentially Priming Phosphorylation Cascade Activates the Gliomagenic Transcription Factor Olig2.

Zhou J, Tien AC, Alberta JA, Ficarro SB, Griveau A, Sun Y, Deshpande JS, Card JD, Morgan-Smith M, Michowski W, Hashizume R, James CD, Ligon KL, Snider WD, Sicinski P, Marto JA, Rowitch DH, Stiles CD.

Cell Rep. 2017 Mar 28;18(13):3167-3177. doi: 10.1016/j.celrep.2017.03.003.

11.

G1 cyclins link proliferation, pluripotency and differentiation of embryonic stem cells.

Liu L, Michowski W, Inuzuka H, Shimizu K, Nihira NT, Chick JM, Li N, Geng Y, Meng AY, Ordureau A, Kołodziejczyk A, Ligon KL, Bronson RT, Polyak K, Harper JW, Gygi SP, Wei W, Sicinski P.

Nat Cell Biol. 2017 Mar;19(3):177-188. doi: 10.1038/ncb3474. Epub 2017 Feb 13.

12.

Cell cycle proteins as promising targets in cancer therapy.

Otto T, Sicinski P.

Nat Rev Cancer. 2017 Jan 27;17(2):93-115. doi: 10.1038/nrc.2016.138. Review.

13.

Proteomic Landscape of Tissue-Specific Cyclin E Functions in Vivo.

Odajima J, Saini S, Jung P, Ndassa-Colday Y, Ficaro S, Geng Y, Marco E, Michowski W, Wang YE, DeCaprio JA, Litovchick L, Marto J, Sicinski P.

PLoS Genet. 2016 Nov 9;12(11):e1006429. doi: 10.1371/journal.pgen.1006429. eCollection 2016 Nov.

14.

MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis.

Aranda-Orgilles B, Saldaña-Meyer R, Wang E, Trompouki E, Fassl A, Lau S, Mullenders J, Rocha PP, Raviram R, Guillamot M, Sánchez-Díaz M, Wang K, Kayembe C, Zhang N, Amoasii L, Choudhuri A, Skok JA, Schober M, Reinberg D, Sicinski P, Schrewe H, Tsirigos A, Zon LI, Aifantis I.

Cell Stem Cell. 2016 Dec 1;19(6):784-799. doi: 10.1016/j.stem.2016.08.004. Epub 2016 Aug 25.

15.

Cyclin A2 promotes DNA repair in the brain during both development and aging.

Gygli PE, Chang JC, Gokozan HN, Catacutan FP, Schmidt TA, Kaya B, Goksel M, Baig FS, Chen S, Griveau A, Michowski W, Wong M, Palanichamy K, Sicinski P, Nelson RJ, Czeisler C, Otero JJ.

Aging (Albany NY). 2016 Jul;8(7):1540-70. doi: 10.18632/aging.100990.

16.

Inhibition of Rb Phosphorylation Leads to mTORC2-Mediated Activation of Akt.

Zhang J, Xu K, Liu P, Geng Y, Wang B, Gan W, Guo J, Wu F, Chin YR, Berrios C, Lien EC, Toker A, DeCaprio JA, Sicinski P, Wei W.

Mol Cell. 2016 Jun 16;62(6):929-942. doi: 10.1016/j.molcel.2016.04.023. Epub 2016 May 26.

17.

Non-canonical functions of cell cycle cyclins and cyclin-dependent kinases.

Hydbring P, Malumbres M, Sicinski P.

Nat Rev Mol Cell Biol. 2016 May;17(5):280-92. doi: 10.1038/nrm.2016.27. Epub 2016 Apr 1. Review.

18.

Overcoming Therapeutic Resistance in HER2-Positive Breast Cancers with CDK4/6 Inhibitors.

Goel S, Wang Q, Watt AC, Tolaney SM, Dillon DA, Li W, Ramm S, Palmer AC, Yuzugullu H, Varadan V, Tuck D, Harris LN, Wong KK, Liu XS, Sicinski P, Winer EP, Krop IE, Zhao JJ.

Cancer Cell. 2016 Mar 14;29(3):255-269. doi: 10.1016/j.ccell.2016.02.006.

19.

E-type cyclins modulate telomere integrity in mammalian male meiosis.

Manterola M, Sicinski P, Wolgemuth DJ.

Chromosoma. 2016 Jun;125(2):253-64. doi: 10.1007/s00412-015-0564-3. Epub 2015 Dec 28.

20.

The cyclin D1-CDK4 oncogenic interactome enables identification of potential novel oncogenes and clinical prognosis.

Jirawatnotai S, Sharma S, Michowski W, Suktitipat B, Geng Y, Quackenbush J, Elias JE, Gygi SP, Wang YE, Sicinski P.

Cell Cycle. 2014;13(18):2889-900. doi: 10.4161/15384101.2014.946850.

21.

Cyclin C is a haploinsufficient tumour suppressor.

Li N, Fassl A, Chick J, Inuzuka H, Li X, Mansour MR, Liu L, Wang H, King B, Shaik S, Gutierrez A, Ordureau A, Otto T, Kreslavsky T, Baitsch L, Bury L, Meyer CA, Ke N, Mulry KA, Kluk MJ, Roy M, Kim S, Zhang X, Geng Y, Zagozdzon A, Jenkinson S, Gale RE, Linch DC, Zhao JJ, Mullighan CG, Harper JW, Aster JC, Aifantis I, von Boehmer H, Gygi SP, Wei W, Look AT, Sicinski P.

Nat Cell Biol. 2014 Nov;16(11):1080-91. doi: 10.1038/ncb3046. Epub 2014 Oct 26.

22.

D-cyclins repress apoptosis in hematopoietic cells by controlling death receptor Fas and its ligand FasL.

Choi YJ, Saez B, Anders L, Hydbring P, Stefano J, Bacon NA, Cook C, Kalaszczynska I, Signoretti S, Young RA, Scadden DT, Sicinski P.

Dev Cell. 2014 Aug 11;30(3):255-67. doi: 10.1016/j.devcel.2014.06.015. Epub 2014 Jul 31.

23.

Cyclin D1 represses gluconeogenesis via inhibition of the transcriptional coactivator PGC1α.

Bhalla K, Liu WJ, Thompson K, Anders L, Devarakonda S, Dewi R, Buckley S, Hwang BJ, Polster B, Dorsey SG, Sun Y, Sicinski P, Girnun GD.

Diabetes. 2014 Oct;63(10):3266-78. doi: 10.2337/db13-1283. Epub 2014 Jun 19.

24.

Cyclin D activates the Rb tumor suppressor by mono-phosphorylation.

Narasimha AM, Kaulich M, Shapiro GS, Choi YJ, Sicinski P, Dowdy SF.

Elife. 2014 Jun 4;3. doi: 10.7554/eLife.02872.

25.

Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression.

Lee Y, Dominy JE, Choi YJ, Jurczak M, Tolliday N, Camporez JP, Chim H, Lim JH, Ruan HB, Yang X, Vazquez F, Sicinski P, Shulman GI, Puigserver P.

Nature. 2014 Jun 26;510(7506):547-51. doi: 10.1038/nature13267. Epub 2014 May 25.

26.

PP2A-mediated regulation of Ras signaling in G2 is essential for stable quiescence and normal G1 length.

Naetar N, Soundarapandian V, Litovchick L, Goguen KL, Sablina AA, Bowman-Colin C, Sicinski P, Hahn WC, DeCaprio JA, Livingston DM.

Mol Cell. 2014 Jun 19;54(6):932-45. doi: 10.1016/j.molcel.2014.04.023. Epub 2014 May 22.

27.

Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus.

Liu P, Begley M, Michowski W, Inuzuka H, Ginzberg M, Gao D, Tsou P, Gan W, Papa A, Kim BM, Wan L, Singh A, Zhai B, Yuan M, Wang Z, Gygi SP, Lee TH, Lu KP, Toker A, Pandolfi PP, Asara JM, Kirschner MW, Sicinski P, Cantley L, Wei W.

Nature. 2014 Apr 24;508(7497):541-5. doi: 10.1038/nature13079. Epub 2014 Mar 9.

28.

Mammalian E-type cyclins control chromosome pairing, telomere stability and CDK2 localization in male meiosis.

Martinerie L, Manterola M, Chung SS, Panigrahi SK, Weisbach M, Vasileva A, Geng Y, Sicinski P, Wolgemuth DJ.

PLoS Genet. 2014 Feb 27;10(2):e1004165. doi: 10.1371/journal.pgen.1004165. eCollection 2014 Feb. Erratum in: PLoS Genet. 2014 Apr;10(4):e1004350.

29.

Postsynaptic GABAB receptor activity regulates excitatory neuronal architecture and spatial memory.

Terunuma M, Revilla-Sanchez R, Quadros IM, Deng Q, Deeb TZ, Lumb M, Sicinski P, Haydon PG, Pangalos MN, Moss SJ.

J Neurosci. 2014 Jan 15;34(3):804-16. doi: 10.1523/JNEUROSCI.3320-13.2013.

30.

Cerebellar cortical lamination and foliation require cyclin A2.

Otero JJ, Kalaszczynska I, Michowski W, Wong M, Gygli PE, Gokozan HN, Griveau A, Odajima J, Czeisler C, Catacutan FP, Murnen A, Schüller U, Sicinski P, Rowitch D.

Dev Biol. 2014 Jan 15;385(2):328-39. doi: 10.1016/j.ydbio.2013.10.019. Epub 2013 Oct 30.

31.

The kinase-independent, second life of CDK6 in transcription.

Otto T, Sicinski P.

Cancer Cell. 2013 Aug 12;24(2):141-3. doi: 10.1016/j.ccr.2013.07.019.

32.

p600 Plays Essential Roles in Fetal Development.

Nakaya T, Ishiguro K, Belzil C, Rietsch AM, Yu Q, Mizuno S, Bronson RT, Geng Y, Nguyen MD, Akashi K, Sicinski P, Nakatani Y.

PLoS One. 2013 Jun 18;8(6):e66269. doi: 10.1371/journal.pone.0066269. Print 2013.

33.

Concurrent deletion of cyclin E1 and cyclin-dependent kinase 2 in hepatocytes inhibits DNA replication and liver regeneration in mice.

Hu W, Nevzorova YA, Haas U, Moro N, Sicinski P, Geng Y, Barbacid M, Trautwein C, Liedtke C.

Hepatology. 2014 Feb;59(2):651-60. doi: 10.1002/hep.26584. Epub 2013 Dec 24.

34.

Unexpected outcomes of CDK4/6 inhibition.

Choi YJ, Sicinski P.

Oncotarget. 2013 Feb;4(2):176-7. No abstract available.

35.

Differences in regulation and function of E-cyclins in human cancer cells.

Geng Y, Sicinski P.

Cell Cycle. 2013 Apr 15;12(8):1165. doi: 10.4161/cc.24487. Epub 2013 Apr 2. No abstract available.

36.

β-Selection-induced proliferation is required for αβ T cell differentiation.

Kreslavsky T, Gleimer M, Miyazaki M, Choi Y, Gagnon E, Murre C, Sicinski P, von Boehmer H.

Immunity. 2012 Nov 16;37(5):840-53. doi: 10.1016/j.immuni.2012.08.020.

37.

The requirement for cyclin D function in tumor maintenance.

Choi YJ, Li X, Hydbring P, Sanda T, Stefano J, Christie AL, Signoretti S, Look AT, Kung AL, von Boehmer H, Sicinski P.

Cancer Cell. 2012 Oct 16;22(4):438-51. doi: 10.1016/j.ccr.2012.09.015.

38.

Canonical and atypical E2Fs regulate the mammalian endocycle.

Chen HZ, Ouseph MM, Li J, Pécot T, Chokshi V, Kent L, Bae S, Byrne M, Duran C, Comstock G, Trikha P, Mair M, Senapati S, Martin CK, Gandhi S, Wilson N, Liu B, Huang YW, Thompson JC, Raman S, Singh S, Leone M, Machiraju R, Huang K, Mo X, Fernandez S, Kalaszczynska I, Wolgemuth DJ, Sicinski P, Huang T, Jin V, Leone G.

Nat Cell Biol. 2012 Nov;14(11):1192-202. doi: 10.1038/ncb2595. Epub 2012 Oct 14.

39.

Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number.

Sankaran VG, Ludwig LS, Sicinska E, Xu J, Bauer DE, Eng JC, Patterson HC, Metcalf RA, Natkunam Y, Orkin SH, Sicinski P, Lander ES, Lodish HF.

Genes Dev. 2012 Sep 15;26(18):2075-87. doi: 10.1101/gad.197020.112. Epub 2012 Aug 28.

40.

Proteomic identification of a direct role for cyclin d1 in DNA damage repair.

Jirawatnotai S, Hu Y, Livingston DM, Sicinski P.

Cancer Res. 2012 Sep 1;72(17):4289-93. doi: 10.1158/0008-5472.CAN-11-3549. Epub 2012 Aug 22. Review.

41.

Cyclin E1 controls proliferation of hepatic stellate cells and is essential for liver fibrogenesis in mice.

Nevzorova YA, Bangen JM, Hu W, Haas U, Weiskirchen R, Gassler N, Huss S, Tacke F, Sicinski P, Trautwein C, Liedtke C.

Hepatology. 2012 Sep;56(3):1140-9. doi: 10.1002/hep.25736. Epub 2012 Jul 12.

42.

A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells.

Anders L, Ke N, Hydbring P, Choi YJ, Widlund HR, Chick JM, Zhai H, Vidal M, Gygi SP, Braun P, Sicinski P.

Cancer Cell. 2011 Nov 15;20(5):620-34. doi: 10.1016/j.ccr.2011.10.001.

43.

Cyclin E constrains Cdk5 activity to regulate synaptic plasticity and memory formation.

Odajima J, Wills ZP, Ndassa YM, Terunuma M, Kretschmannova K, Deeb TZ, Geng Y, Gawrzak S, Quadros IM, Newman J, Das M, Jecrois ME, Yu Q, Li N, Bienvenu F, Moss SJ, Greenberg ME, Marto JA, Sicinski P.

Dev Cell. 2011 Oct 18;21(4):655-68. doi: 10.1016/j.devcel.2011.08.009. Epub 2011 Sep 22.

44.

A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers.

Jirawatnotai S, Hu Y, Michowski W, Elias JE, Becks L, Bienvenu F, Zagozdzon A, Goswami T, Wang YE, Clark AB, Kunkel TA, van Harn T, Xia B, Correll M, Quackenbush J, Livingston DM, Gygi SP, Sicinski P.

Nature. 2011 Jun 8;474(7350):230-4. doi: 10.1038/nature10155.

45.

Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss.

Cole AM, Myant K, Reed KR, Ridgway RA, Athineos D, Van den Brink GR, Muncan V, Clevers H, Clarke AR, Sicinski P, Sansom OJ.

Cancer Res. 2010 Oct 15;70(20):8149-58. doi: 10.1158/0008-5472.CAN-10-0315. Epub 2010 Aug 24. Erratum in: Cancer Res. 2013 Jan 1;73(1):469.

46.

Requirement for cyclin D3 in germinal center formation and function.

Peled JU, Yu JJ, Venkatesh J, Bi E, Ding BB, Krupski-Downs M, Shaknovich R, Sicinski P, Diamond B, Scharff MD, Ye BH.

Cell Res. 2010 Jun;20(6):631-46. doi: 10.1038/cr.2010.55. Epub 2010 Apr 20.

47.

Cyclins A and E trigger DNA damage.

Odajima J, Kalaszczynska I, Sicinski P.

Cell Cycle. 2010 Apr 1;9(7):1231-2. Epub 2010 Apr 1. No abstract available.

PMID:
20404525
48.

Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen.

Bienvenu F, Jirawatnotai S, Elias JE, Meyer CA, Mizeracka K, Marson A, Frampton GM, Cole MF, Odom DT, Odajima J, Geng Y, Zagozdzon A, Jecrois M, Young RA, Liu XS, Cepko CL, Gygi SP, Sicinski P.

Nature. 2010 Jan 21;463(7279):374-8. doi: 10.1038/nature08684.

49.

Cyclin A is redundant in fibroblasts but essential in hematopoietic and embryonic stem cells.

Kalaszczynska I, Geng Y, Iino T, Mizuno S, Choi Y, Kondratiuk I, Silver DP, Wolgemuth DJ, Akashi K, Sicinski P.

Cell. 2009 Jul 23;138(2):352-65. doi: 10.1016/j.cell.2009.04.062. Epub 2009 Jul 9.

50.

FoxM1 is a downstream target and marker of HER2 overexpression in breast cancer.

Francis RE, Myatt SS, Krol J, Hartman J, Peck B, McGovern UB, Wang J, Guest SK, Filipovic A, Gojis O, Palmieri C, Peston D, Shousha S, Yu Q, Sicinski P, Coombes RC, Lam EW.

Int J Oncol. 2009 Jul;35(1):57-68.

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