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Items: 1 to 50 of 131

1.

Comprehensive analysis of all evolutionary paths between two divergent PDZ domain specificities.

Teyra J, Ernst A, Singer A, Sicheri F, Sidhu SS.

Protein Sci. 2019 Oct 25. doi: 10.1002/pro.3759. [Epub ahead of print]

PMID:
31654425
2.

Structural and Functional Analysis of Ubiquitin-based Inhibitors That Target the Backsides of E2 Enzymes.

Garg P, Ceccarelli DF, Keszei AFA, Kurinov I, Sicheri F, Sidhu SS.

J Mol Biol. 2019 Oct 19. pii: S0022-2836(18)30280-8. doi: 10.1016/j.jmb.2019.09.024. [Epub ahead of print]

PMID:
31634471
3.

Rigidification Dramatically Improves Inhibitor Selectivity for RAF Kinases.

Assadieskandar A, Yu C, Maisonneuve P, Kurinov I, Sicheri F, Zhang C.

ACS Med Chem Lett. 2019 Jun 4;10(7):1074-1080. doi: 10.1021/acsmedchemlett.9b00194. eCollection 2019 Jul 11.

PMID:
31312411
4.

FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.

Ceccarelli DF, Ivantsiv S, Mullin AA, Coyaud E, Manczyk N, Maisonneuve P, Kurinov I, Zhao L, Go C, Gingras AC, Raught B, Cordes S, Sicheri F.

Structure. 2019 Jun 4;27(6):1000-1012.e6. doi: 10.1016/j.str.2019.03.022. Epub 2019 May 2.

PMID:
31056421
5.

The ubiquitin interacting motifs of USP37 act on the proximal Ub of a di-Ub chain to enhance catalytic efficiency.

Manczyk N, Veggiani G, Teyra J, Strilchuk AW, Sidhu SS, Sicheri F.

Sci Rep. 2019 Mar 11;9(1):4119. doi: 10.1038/s41598-019-40815-z.

6.

OAS-RNase L innate immune pathway mediates the cytotoxicity of a DNA-demethylating drug.

Banerjee S, Gusho E, Gaughan C, Dong B, Gu X, Holvey-Bates E, Talukdar M, Li Y, Weiss SR, Sicheri F, Saunthararajah Y, Stark GR, Silverman RH.

Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):5071-5076. doi: 10.1073/pnas.1815071116. Epub 2019 Feb 27.

7.

Dimerization of a ubiquitin variant leads to high affinity interactions with a ubiquitin interacting motif.

Manczyk N, Veggiani G, Gish GD, Yates BP, Ernst A, Sidhu SS, Sicheri F.

Protein Sci. 2019 May;28(5):848-856. doi: 10.1002/pro.3593. Epub 2019 Mar 12.

PMID:
30793400
8.

Yeast Two-Hybrid Analysis for Ubiquitin Variant Inhibitors of Human Deubiquitinases.

Pascoe N, Seetharaman A, Teyra J, Manczyk N, Satori MA, Tjandra D, Makhnevych T, Schwerdtfeger C, Brasher BB, Moffat J, Costanzo M, Boone C, Sicheri F, Sidhu SS.

J Mol Biol. 2019 Mar 15;431(6):1160-1171. doi: 10.1016/j.jmb.2019.02.007. Epub 2019 Feb 11.

PMID:
30763569
9.

Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15.

Teyra J, Singer AU, Schmitges FW, Jaynes P, Kit Leng Lui S, Polyak MJ, Fodil N, Krieger JR, Tong J, Schwerdtfeger C, Brasher BB, Ceccarelli DFJ, Moffat J, Sicheri F, Moran MF, Gros P, Eichhorn PJA, Lenter M, Boehmelt G, Sidhu SS.

Structure. 2019 Apr 2;27(4):590-605.e5. doi: 10.1016/j.str.2019.01.002. Epub 2019 Jan 31.

PMID:
30713027
10.

Author Correction: Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome.

Gayden T, Sepulveda FE, Khuong-Quang DA, Pratt J, Valera ET, Garrigue A, Kelso S, Sicheri F, Mikael LG, Hamel N, Bajic A, Dali R, Deshmukh S, Dervovic D, Schramek D, Guerin F, Taipale M, Nikbakht H, Majewski J, Moshous D, Charlebois J, Abish S, Bole-Feysot C, Nitschke P, Bader-Meunier B, Mitchell D, Thieblemont C, Battistella M, Gravel S, Nguyen VH, Conyers R, Diana JS, McCormack C, Prince HM, Besnard M, Blanche S, Ekert PG, Fraitag S, Foulkes WD, Fischer A, Neven B, Michonneau D, de Saint Basile G, Jabado N.

Nat Genet. 2019 Jan;51(1):196. doi: 10.1038/s41588-018-0304-8.

PMID:
30429576
11.

Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome.

Gayden T, Sepulveda FE, Khuong-Quang DA, Pratt J, Valera ET, Garrigue A, Kelso S, Sicheri F, Mikael LG, Hamel N, Bajic A, Dali R, Deshmukh S, Dervovic D, Schramek D, Guerin F, Taipale M, Nikbakht H, Majewski J, Moshous D, Charlebois J, Abish S, Bole-Feysot C, Nitschke P, Bader-Meunier B, Mitchell D, Thieblemont C, Battistella M, Gravel S, Nguyen VH, Conyers R, Diana JS, McCormack C, Prince HM, Besnard M, Blanche S, Ekert PG, Fraitag S, Foulkes WD, Fischer A, Neven B, Michonneau D, de Saint Basile G, Jabado N.

Nat Genet. 2018 Dec;50(12):1650-1657. doi: 10.1038/s41588-018-0251-4. Epub 2018 Oct 29. Erratum in: Nat Genet. 2018 Nov 14;:.

PMID:
30374066
12.

Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1.

Daou S, Barbour H, Ahmed O, Masclef L, Baril C, Sen Nkwe N, Tchelougou D, Uriarte M, Bonneil E, Ceccarelli D, Mashtalir N, Tanji M, Masson JY, Thibault P, Sicheri F, Yang H, Carbone M, Therrien M, Affar EB.

Nat Commun. 2018 Oct 22;9(1):4385. doi: 10.1038/s41467-018-06854-2.

13.

A feed forward loop enforces YAP/TAZ signaling during tumorigenesis.

Gill MK, Christova T, Zhang YY, Gregorieff A, Zhang L, Narimatsu M, Song S, Xiong S, Couzens AL, Tong J, Krieger JR, Moran MF, Zlotta AR, van der Kwast TH, Gingras AC, Sicheri F, Wrana JL, Attisano L.

Nat Commun. 2018 Aug 29;9(1):3510. doi: 10.1038/s41467-018-05939-2.

14.

Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase.

Hunter RW, Hughey CC, Lantier L, Sundelin EI, Peggie M, Zeqiraj E, Sicheri F, Jessen N, Wasserman DH, Sakamoto K.

Nat Med. 2018 Sep;24(9):1395-1406. doi: 10.1038/s41591-018-0159-7. Epub 2018 Aug 27.

15.

Real-time tracking of complex ubiquitination cascades using a fluorescent confocal on-bead assay.

Koszela J, Pham NT, Evans D, Mann S, Perez-Pi I, Shave S, Ceccarelli DFJ, Sicheri F, Tyers M, Auer M.

BMC Biol. 2018 Aug 10;16(1):88. doi: 10.1186/s12915-018-0554-z.

16.

A Structure-Based Strategy for Engineering Selective Ubiquitin Variant Inhibitors of Skp1-Cul1-F-Box Ubiquitin Ligases.

Gorelik M, Manczyk N, Pavlenco A, Kurinov I, Sidhu SS, Sicheri F.

Structure. 2018 Sep 4;26(9):1226-1236.e3. doi: 10.1016/j.str.2018.06.004. Epub 2018 Jul 19.

17.

Structural Basis for Auto-Inhibition of the NDR1 Kinase Domain by an Atypically Long Activation Segment.

Xiong S, Lorenzen K, Couzens AL, Templeton CM, Rajendran D, Mao DYL, Juang YC, Chiovitti D, Kurinov I, Guettler S, Gingras AC, Sicheri F.

Structure. 2018 Aug 7;26(8):1101-1115.e6. doi: 10.1016/j.str.2018.05.014. Epub 2018 Jul 5.

18.

Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer.

Zhao N, Cao J, Xu L, Tang Q, Dobrolecki LE, Lv X, Talukdar M, Lu Y, Wang X, Hu DZ, Shi Q, Xiang Y, Wang Y, Liu X, Bu W, Jiang Y, Li M, Gong Y, Sun Z, Ying H, Yuan B, Lin X, Feng XH, Hartig SM, Li F, Shen H, Chen Y, Han L, Zeng Q, Patterson JB, Kaipparettu BA, Putluri N, Sicheri F, Rosen JM, Lewis MT, Chen X.

J Clin Invest. 2018 Apr 2;128(4):1283-1299. doi: 10.1172/JCI95873. Epub 2018 Feb 26.

19.

MEK drives BRAF activation through allosteric control of KSR proteins.

Lavoie H, Sahmi M, Maisonneuve P, Marullo SA, Thevakumaran N, Jin T, Kurinov I, Sicheri F, Therrien M.

Nature. 2018 Feb 22;554(7693):549-553. doi: 10.1038/nature25478. Epub 2018 Feb 12.

20.

Effects of rigidity on the selectivity of protein kinase inhibitors.

Assadieskandar A, Yu C, Maisonneuve P, Liu X, Chen YC, Prakash GKS, Kurinov I, Sicheri F, Zhang C.

Eur J Med Chem. 2018 Feb 25;146:519-528. doi: 10.1016/j.ejmech.2018.01.053. Epub 2018 Jan 31.

21.

Vivid views of the PINK1 protein.

Daou S, Sicheri F.

Nature. 2017 Dec 7;552(7683):38-39. doi: 10.1038/d41586-017-07691-x. No abstract available.

PMID:
29219973
22.

Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR-Cas9 genome-editing efficiency.

Canny MD, Moatti N, Wan LCK, Fradet-Turcotte A, Krasner D, Mateos-Gomez PA, Zimmermann M, Orthwein A, Juang YC, Zhang W, Noordermeer SM, Seclen E, Wilson MD, Vorobyov A, Munro M, Ernst A, Ng TF, Cho T, Cannon PM, Sidhu SS, Sicheri F, Durocher D.

Nat Biotechnol. 2018 Jan;36(1):95-102. doi: 10.1038/nbt.4021. Epub 2017 Nov 27.

23.

MOB1 Mediated Phospho-recognition in the Core Mammalian Hippo Pathway.

Couzens AL, Xiong S, Knight JDR, Mao DY, Guettler S, Picaud S, Kurinov I, Filippakopoulos P, Sicheri F, Gingras AC.

Mol Cell Proteomics. 2017 Jun;16(6):1098-1110. doi: 10.1074/mcp.M116.065490. Epub 2017 Apr 3.

24.

Regulation of Protein Interactions by Mps One Binder (MOB1) Phosphorylation.

Xiong S, Couzens AL, Kean MJ, Mao DY, Guettler S, Kurinov I, Gingras AC, Sicheri F.

Mol Cell Proteomics. 2017 Jun;16(6):1111-1125. doi: 10.1074/mcp.M117.068130. Epub 2017 Apr 3.

25.

Structural and functional characterization of a ubiquitin variant engineered for tight and specific binding to an alpha-helical ubiquitin interacting motif.

Manczyk N, Yates BP, Veggiani G, Ernst A, Sicheri F, Sidhu SS.

Protein Sci. 2017 May;26(5):1060-1069. doi: 10.1002/pro.3155. Epub 2017 Mar 24.

26.

Mechanism of catalysis, E2 recognition, and autoinhibition for the IpaH family of bacterial E3 ubiquitin ligases.

Keszei AF, Sicheri F.

Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):1311-1316. doi: 10.1073/pnas.1611595114. Epub 2017 Jan 23.

27.

An allosteric conduit facilitates dynamic multisite substrate recognition by the SCFCdc4 ubiquitin ligase.

Csizmok V, Orlicky S, Cheng J, Song J, Bah A, Delgoshaie N, Lin H, Mittag T, Sicheri F, Chan HS, Tyers M, Forman-Kay JD.

Nat Commun. 2017 Jan 3;8:13943. doi: 10.1038/ncomms13943.

28.

Proteomic analysis of the human KEOPS complex identifies C14ORF142 as a core subunit homologous to yeast Gon7.

Wan LC, Maisonneuve P, Szilard RK, Lambert JP, Ng TF, Manczyk N, Huang H, Laister R, Caudy AA, Gingras AC, Durocher D, Sicheri F.

Nucleic Acids Res. 2017 Jan 25;45(2):805-817. doi: 10.1093/nar/gkw1181. Epub 2016 Nov 29.

29.

Inhibition of RAS function through targeting an allosteric regulatory site.

Spencer-Smith R, Koide A, Zhou Y, Eguchi RR, Sha F, Gajwani P, Santana D, Gupta A, Jacobs M, Herrero-Garcia E, Cobbert J, Lavoie H, Smith M, Rajakulendran T, Dowdell E, Okur MN, Dementieva I, Sicheri F, Therrien M, Hancock JF, Ikura M, Koide S, O'Bryan JP.

Nat Chem Biol. 2017 Jan;13(1):62-68. doi: 10.1038/nchembio.2231. Epub 2016 Nov 7.

30.

The structural basis of modified nucleosome recognition by 53BP1.

Wilson MD, Benlekbir S, Fradet-Turcotte A, Sherker A, Julien JP, McEwan A, Noordermeer SM, Sicheri F, Rubinstein JL, Durocher D.

Nature. 2016 Aug 4;536(7614):100-3. Epub 2016 Jul 27.

PMID:
27462807
31.

Structural and functional characterization of KEOPS dimerization by Pcc1 and its role in t6A biosynthesis.

Wan LC, Pillon MC, Thevakumaran N, Sun Y, Chakrabartty A, Guarné A, Kurinov I, Durocher D, Sicheri F.

Nucleic Acids Res. 2016 Aug 19;44(14):6971-80. doi: 10.1093/nar/gkw542. Epub 2016 Jun 14.

32.

Inhibition of SCF ubiquitin ligases by engineered ubiquitin variants that target the Cul1 binding site on the Skp1-F-box interface.

Gorelik M, Orlicky S, Sartori MA, Tang X, Marcon E, Kurinov I, Greenblatt JF, Tyers M, Moffat J, Sicheri F, Sidhu SS.

Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3527-32. doi: 10.1073/pnas.1519389113. Epub 2016 Mar 14.

33.

Higher-Order Assembly of BRCC36-KIAA0157 Is Required for DUB Activity and Biological Function.

Zeqiraj E, Tian L, Piggott CA, Pillon MC, Duffy NM, Ceccarelli DF, Keszei AF, Lorenzen K, Kurinov I, Orlicky S, Gish GD, Heck AJ, Guarné A, Greenberg RA, Sicheri F.

Mol Cell. 2015 Sep 17;59(6):970-83. doi: 10.1016/j.molcel.2015.07.028. Epub 2015 Sep 3.

34.

Getting a handle on glycogen synthase - Its interaction with glycogenin.

Zeqiraj E, Sicheri F.

Mol Aspects Med. 2015 Dec;46:63-9. doi: 10.1016/j.mam.2015.08.004. Epub 2015 Aug 13. Review.

35.

Baculovirus protein PK2 subverts eIF2α kinase function by mimicry of its kinase domain C-lobe.

Li JJ, Cao C, Fixsen SM, Young JM, Ono C, Bando H, Elde NC, Katsuma S, Dever TE, Sicheri F.

Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):E4364-73. doi: 10.1073/pnas.1505481112. Epub 2015 Jul 27.

36.

Expression and purification of functional human glycogen synthase-1:glycogenin-1 complex in insect cells.

Hunter RW, Zeqiraj E, Morrice N, Sicheri F, Sakamoto K.

Protein Expr Purif. 2015 Apr;108:23-29. doi: 10.1016/j.pep.2014.12.007. Epub 2014 Dec 17.

37.

Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation.

Thevakumaran N, Lavoie H, Critton DA, Tebben A, Marinier A, Sicheri F, Therrien M.

Nat Struct Mol Biol. 2015 Jan;22(1):37-43. doi: 10.1038/nsmb.2924. Epub 2014 Dec 1.

PMID:
25437913
38.

Dimerization-induced allostery in protein kinase regulation.

Lavoie H, Li JJ, Thevakumaran N, Therrien M, Sicheri F.

Trends Biochem Sci. 2014 Oct;39(10):475-86. doi: 10.1016/j.tibs.2014.08.004. Epub 2014 Sep 11. Review.

PMID:
25220378
39.

Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors.

Sanches M, Duffy NM, Talukdar M, Thevakumaran N, Chiovitti D, Canny MD, Lee K, Kurinov I, Uehling D, Al-awar R, Poda G, Prakesch M, Wilson B, Tam V, Schweitzer C, Toro A, Lucas JL, Vuga D, Lehmann L, Durocher D, Zeng Q, Patterson JB, Sicheri F.

Nat Commun. 2014 Aug 28;5:4202. doi: 10.1038/ncomms5202.

40.

Structural basis for the recruitment of glycogen synthase by glycogenin.

Zeqiraj E, Tang X, Hunter RW, García-Rocha M, Judd A, Deak M, von Wilamowitz-Moellendorff A, Kurinov I, Guinovart JJ, Tyers M, Sakamoto K, Sicheri F.

Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):E2831-40. doi: 10.1073/pnas.1402926111. Epub 2014 Jun 30.

41.

Structural basis of Rad53 kinase activation by dimerization and activation segment exchange.

Wybenga-Groot LE, Ho CS, Sweeney FD, Ceccarelli DF, McGlade CJ, Durocher D, Sicheri F.

Cell Signal. 2014 Sep;26(9):1825-36. doi: 10.1016/j.cellsig.2014.05.004. Epub 2014 May 9.

PMID:
24815189
42.

Dimeric structure of pseudokinase RNase L bound to 2-5A reveals a basis for interferon-induced antiviral activity.

Huang H, Zeqiraj E, Dong B, Jha BK, Duffy NM, Orlicky S, Thevakumaran N, Talukdar M, Pillon MC, Ceccarelli DF, Wan LC, Juang YC, Mao DY, Gaughan C, Brinton MA, Perelygin AA, Kourinov I, Guarné A, Silverman RH, Sicheri F.

Mol Cell. 2014 Jan 23;53(2):221-34. doi: 10.1016/j.molcel.2013.12.025.

43.

E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin.

Huang H, Ceccarelli DF, Orlicky S, St-Cyr DJ, Ziemba A, Garg P, Plamondon S, Auer M, Sidhu S, Marinier A, Kleiger G, Tyers M, Sicheri F.

Nat Chem Biol. 2014 Feb;10(2):156-163. doi: 10.1038/nchembio.1412. Epub 2013 Dec 15.

44.

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

Couzens AL, Knight JD, Kean MJ, Teo G, Weiss A, Dunham WH, Lin ZY, Bagshaw RD, Sicheri F, Pawson T, Wrana JL, Choi H, Gingras AC.

Sci Signal. 2013 Nov 19;6(302):rs15. doi: 10.1126/scisignal.2004712.

PMID:
24255178
45.

Structure of an SspH1-PKN1 complex reveals the basis for host substrate recognition and mechanism of activation for a bacterial E3 ubiquitin ligase.

Keszei AF, Tang X, McCormick C, Zeqiraj E, Rohde JR, Tyers M, Sicheri F.

Mol Cell Biol. 2014 Feb;34(3):362-73. doi: 10.1128/MCB.01360-13. Epub 2013 Nov 18.

46.

53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark.

Fradet-Turcotte A, Canny MD, Escribano-Díaz C, Orthwein A, Leung CC, Huang H, Landry MC, Kitevski-LeBlanc J, Noordermeer SM, Sicheri F, Durocher D.

Nature. 2013 Jul 4;499(7456):50-4. doi: 10.1038/nature12318. Epub 2013 Jun 12.

47.

The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis.

Rivkin E, Almeida SM, Ceccarelli DF, Juang YC, MacLean TA, Srikumar T, Huang H, Dunham WH, Fukumura R, Xie G, Gondo Y, Raught B, Gingras AC, Sicheri F, Cordes SP.

Nature. 2013 Jun 20;498(7454):318-24. doi: 10.1038/nature12296. Epub 2013 May 24.

48.

Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization.

Lavoie H, Thevakumaran N, Gavory G, Li JJ, Padeganeh A, Guiral S, Duchaine J, Mao DY, Bouvier M, Sicheri F, Therrien M.

Nat Chem Biol. 2013 Jul;9(7):428-36. doi: 10.1038/nchembio.1257. Epub 2013 May 19.

49.

Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system.

Wan LC, Mao DY, Neculai D, Strecker J, Chiovitti D, Kurinov I, Poda G, Thevakumaran N, Yuan F, Szilard RK, Lissina E, Nislow C, Caudy AA, Durocher D, Sicheri F.

Nucleic Acids Res. 2013 Jul;41(12):6332-46. doi: 10.1093/nar/gkt322. Epub 2013 Apr 25.

50.

A strategy for modulation of enzymes in the ubiquitin system.

Ernst A, Avvakumov G, Tong J, Fan Y, Zhao Y, Alberts P, Persaud A, Walker JR, Neculai AM, Neculai D, Vorobyov A, Garg P, Beatty L, Chan PK, Juang YC, Landry MC, Yeh C, Zeqiraj E, Karamboulas K, Allali-Hassani A, Vedadi M, Tyers M, Moffat J, Sicheri F, Pelletier L, Durocher D, Raught B, Rotin D, Yang J, Moran MF, Dhe-Paganon S, Sidhu SS.

Science. 2013 Feb 1;339(6119):590-5. doi: 10.1126/science.1230161. Epub 2013 Jan 3.

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