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Items: 1 to 50 of 51

1.

Inhibition of NF-κB in astrocytes is sufficient to delay neurodegeneration induced by proteotoxicity in neurons.

Li YX, Sibon OCM, Dijkers PF.

J Neuroinflammation. 2018 Sep 11;15(1):261. doi: 10.1186/s12974-018-1278-2.

2.

Mutations in PPCS, Encoding Phosphopantothenoylcysteine Synthetase, Cause Autosomal-Recessive Dilated Cardiomyopathy.

Iuso A, Wiersma M, Schüller HJ, Pode-Shakked B, Marek-Yagel D, Grigat M, Schwarzmayr T, Berutti R, Alhaddad B, Kanon B, Grzeschik NA, Okun JG, Perles Z, Salem Y, Barel O, Vardi A, Rubinshtein M, Tirosh T, Dubnov-Raz G, Messias AC, Terrile C, Barshack I, Volkov A, Avivi C, Eyal E, Mastantuono E, Kumbar M, Abudi S, Braunisch M, Strom TM, Meitinger T, Hoffmann GF, Prokisch H, Haack TB, Brundel BJJM, Haas D, Sibon OCM, Anikster Y.

Am J Hum Genet. 2018 Jun 7;102(6):1018-1030. doi: 10.1016/j.ajhg.2018.03.022. Epub 2018 May 10.

PMID:
29754768
3.

Thermosensory perception regulates speed of movement in response to temperature changes in Drosophila melanogaster.

Soto-Padilla A, Ruijsink R, Sibon OCM, van Rijn H, Billeter JC.

J Exp Biol. 2018 May 22;221(Pt 10). pii: jeb174151. doi: 10.1242/jeb.174151.

PMID:
29650755
4.

Endoplasmic Reticulum Stress Is Associated With Autophagy and Cardiomyocyte Remodeling in Experimental and Human Atrial Fibrillation.

Wiersma M, Meijering RAM, Qi XY, Zhang D, Liu T, Hoogstra-Berends F, Sibon OCM, Henning RH, Nattel S, Brundel BJJM.

J Am Heart Assoc. 2017 Oct 24;6(10). pii: e006458. doi: 10.1161/JAHA.117.006458.

5.

Acetyl-4'-phosphopantetheine is stable in serum and prevents phenotypes induced by pantothenate kinase deficiency.

Di Meo I, Colombelli C, Srinivasan B, de Villiers M, Hamada J, Jeong SY, Fox R, Woltjer RL, Tepper PG, Lahaye LL, Rizzetto E, Harrs CH, de Boer T, van der Zwaag M, Jenko B, Čusak A, Pahor J, Kosec G, Grzeschik NA, Hayflick SJ, Tiranti V, Sibon OCM.

Sci Rep. 2017 Sep 12;7(1):11260. doi: 10.1038/s41598-017-11564-8.

6.

Guanine quadruplex structures localize to heterochromatin.

Hoffmann RF, Moshkin YM, Mouton S, Grzeschik NA, Kalicharan RD, Kuipers J, Wolters AHG, Nishida K, Romashchenko AV, Postberg J, Lipps H, Berezikov E, Sibon OCM, Giepmans BNG, Lansdorp PM.

Nucleic Acids Res. 2017 Jun 2;45(10):6253. doi: 10.1093/nar/gkx301. No abstract available.

7.

Drosophila Vps13 Is Required for Protein Homeostasis in the Brain.

Vonk JJ, Yeshaw WM, Pinto F, Faber AI, Lahaye LL, Kanon B, van der Zwaag M, Velayos-Baeza A, Freire R, van IJzendoorn SC, Grzeschik NA, Sibon OC.

PLoS One. 2017 Jan 20;12(1):e0170106. doi: 10.1371/journal.pone.0170106. eCollection 2017.

8.

Coenzyme A: to make it or uptake it?

Sibon OC, Strauss E.

Nat Rev Mol Cell Biol. 2016 Oct;17(10):605-6. doi: 10.1038/nrm.2016.110. Epub 2016 Aug 24.

PMID:
27552973
9.

Specific protein homeostatic functions of small heat-shock proteins increase lifespan.

Vos MJ, Carra S, Kanon B, Bosveld F, Klauke K, Sibon OC, Kampinga HH.

Aging Cell. 2016 Apr;15(2):217-26. doi: 10.1111/acel.12422. Epub 2015 Dec 25.

10.

Overexpression of Cystathionine γ-Lyase Suppresses Detrimental Effects of Spinocerebellar Ataxia Type 3.

Snijder PM, Baratashvili M, Grzeschik NA, Leuvenink HGD, Kuijpers L, Huitema S, Schaap O, Giepmans BNG, Kuipers J, Miljkovic JL, Mitrovic A, Bos EM, Szabó C, Kampinga HH, Dijkers PF, Bos EM, Szabó C, Kampinga HH, Dijkers PF, Dunnen WFAD, Filipovic MR, Goor HV, Sibon OCM.

Mol Med. 2016 Jan;21(1):758-768. doi: 10.2119/molmed.2015.00221. Epub 2015 Oct 13.

11.

Guanine quadruplex structures localize to heterochromatin.

Hoffmann RF, Moshkin YM, Mouton S, Grzeschik NA, Kalicharan RD, Kuipers J, Wolters AH, Nishida K, Romashchenko AV, Postberg J, Lipps H, Berezikov E, Sibon OC, Giepmans BN, Lansdorp PM.

Nucleic Acids Res. 2016 Jan 8;44(1):152-63. doi: 10.1093/nar/gkv900. Epub 2015 Sep 17.

12.

Extracellular 4'-phosphopantetheine is a source for intracellular coenzyme A synthesis.

Srinivasan B, Baratashvili M, van der Zwaag M, Kanon B, Colombelli C, Lambrechts RA, Schaap O, Nollen EA, Podgoršek A, Kosec G, Petković H, Hayflick S, Tiranti V, Reijngoud DJ, Grzeschik NA, Sibon OC.

Nat Chem Biol. 2015 Oct;11(10):784-92. doi: 10.1038/nchembio.1906. Epub 2015 Aug 31.

PMID:
26322826
13.

Coenzyme A, more than 'just' a metabolic cofactor.

Srinivasan B, Sibon OC.

Biochem Soc Trans. 2014 Aug;42(4):1075-9. doi: 10.1042/BST20140125. Review.

PMID:
25110005
14.

Coenzyme A and its derivatives: renaissance of a textbook classic.

Theodoulou FL, Sibon OC, Jackowski S, Gout I.

Biochem Soc Trans. 2014 Aug;42(4):1025-32. doi: 10.1042/BST20140176. Review.

PMID:
25109997
15.

Impairment of Drosophila orthologs of the human orphan protein C19orf12 induces bang sensitivity and neurodegeneration.

Iuso A, Sibon OC, Gorza M, Heim K, Organisti C, Meitinger T, Prokisch H.

PLoS One. 2014 Feb 21;9(2):e89439. doi: 10.1371/journal.pone.0089439. eCollection 2014.

16.

Activation of histone deacetylase-6 induces contractile dysfunction through derailment of α-tubulin proteostasis in experimental and human atrial fibrillation.

Zhang D, Wu CT, Qi X, Meijering RA, Hoogstra-Berends F, Tadevosyan A, Cubukcuoglu Deniz G, Durdu S, Akar AR, Sibon OC, Nattel S, Henning RH, Brundel BJ.

Circulation. 2014 Jan 21;129(3):346-58. doi: 10.1161/CIRCULATIONAHA.113.005300. Epub 2013 Oct 21.

PMID:
24146251
17.

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.

den Hoed M, Eijgelsheim M, Esko T, Brundel BJ, Peal DS, Evans DM, Nolte IM, Segrè AV, Holm H, Handsaker RE, Westra HJ, Johnson T, Isaacs A, Yang J, Lundby A, Zhao JH, Kim YJ, Go MJ, Almgren P, Bochud M, Boucher G, Cornelis MC, Gudbjartsson D, Hadley D, van der Harst P, Hayward C, den Heijer M, Igl W, Jackson AU, Kutalik Z, Luan J, Kemp JP, Kristiansson K, Ladenvall C, Lorentzon M, Montasser ME, Njajou OT, O'Reilly PF, Padmanabhan S, St Pourcain B, Rankinen T, Salo P, Tanaka T, Timpson NJ, Vitart V, Waite L, Wheeler W, Zhang W, Draisma HH, Feitosa MF, Kerr KF, Lind PA, Mihailov E, Onland-Moret NC, Song C, Weedon MN, Xie W, Yengo L, Absher D, Albert CM, Alonso A, Arking DE, de Bakker PI, Balkau B, Barlassina C, Benaglio P, Bis JC, Bouatia-Naji N, Brage S, Chanock SJ, Chines PS, Chung M, Darbar D, Dina C, Dörr M, Elliott P, Felix SB, Fischer K, Fuchsberger C, de Geus EJ, Goyette P, Gudnason V, Harris TB, Hartikainen AL, Havulinna AS, Heckbert SR, Hicks AA, Hofman A, Holewijn S, Hoogstra-Berends F, Hottenga JJ, Jensen MK, Johansson A, Junttila J, Kääb S, Kanon B, Ketkar S, Khaw KT, Knowles JW, Kooner AS, Kors JA, Kumari M, Milani L, Laiho P, Lakatta EG, Langenberg C, Leusink M, Liu Y, Luben RN, Lunetta KL, Lynch SN, Markus MR, Marques-Vidal P, Mateo Leach I, McArdle WL, McCarroll SA, Medland SE, Miller KA, Montgomery GW, Morrison AC, Müller-Nurasyid M, Navarro P, Nelis M, O'Connell JR, O'Donnell CJ, Ong KK, Newman AB, Peters A, Polasek O, Pouta A, Pramstaller PP, Psaty BM, Rao DC, Ring SM, Rossin EJ, Rudan D, Sanna S, Scott RA, Sehmi JS, Sharp S, Shin JT, Singleton AB, Smith AV, Soranzo N, Spector TD, Stewart C, Stringham HM, Tarasov KV, Uitterlinden AG, Vandenput L, Hwang SJ, Whitfield JB, Wijmenga C, Wild SH, Willemsen G, Wilson JF, Witteman JC, Wong A, Wong Q, Jamshidi Y, Zitting P, Boer JM, Boomsma DI, Borecki IB, van Duijn CM, Ekelund U, Forouhi NG, Froguel P, Hingorani A, Ingelsson E, Kivimaki M, Kronmal RA, Kuh D, Lind L, Martin NG, Oostra BA, Pedersen NL, Quertermous T, Rotter JI, van der Schouw YT, Verschuren WM, Walker M, Albanes D, Arnar DO, Assimes TL, Bandinelli S, Boehnke M, de Boer RA, Bouchard C, Caulfield WL, Chambers JC, Curhan G, Cusi D, Eriksson J, Ferrucci L, van Gilst WH, Glorioso N, de Graaf J, Groop L, Gyllensten U, Hsueh WC, Hu FB, Huikuri HV, Hunter DJ, Iribarren C, Isomaa B, Jarvelin MR, Jula A, Kähönen M, Kiemeney LA, van der Klauw MM, Kooner JS, Kraft P, Iacoviello L, Lehtimäki T, Lokki ML, Mitchell BD, Navis G, Nieminen MS, Ohlsson C, Poulter NR, Qi L, Raitakari OT, Rimm EB, Rioux JD, Rizzi F, Rudan I, Salomaa V, Sever PS, Shields DC, Shuldiner AR, Sinisalo J, Stanton AV, Stolk RP, Strachan DP, Tardif JC, Thorsteinsdottir U, Tuomilehto J, van Veldhuisen DJ, Virtamo J, Viikari J, Vollenweider P, Waeber G, Widen E, Cho YS, Olsen JV, Visscher PM, Willer C, Franke L; Global BPgen Consortium; CARDIoGRAM Consortium, Erdmann J, Thompson JR; PR GWAS Consortium, Pfeufer A; QRS GWAS Consortium, Sotoodehnia N; QT-IGC Consortium, Newton-Cheh C; CHARGE-AF Consortium, Ellinor PT, Stricker BH, Metspalu A, Perola M, Beckmann JS, Smith GD, Stefansson K, Wareham NJ, Munroe PB, Sibon OC, Milan DJ, Snieder H, Samani NJ, Loos RJ.

Nat Genet. 2013 Jun;45(6):621-31. doi: 10.1038/ng.2610. Epub 2013 Apr 14.

18.

Cofilin/Twinstar phosphorylation levels increase in response to impaired coenzyme a metabolism.

Siudeja K, Grzeschik NA, Rana A, de Jong J, Sibon OC.

PLoS One. 2012;7(8):e43145. doi: 10.1371/journal.pone.0043145. Epub 2012 Aug 17.

19.

Brain, blood, and iron: perspectives on the roles of erythrocytes and iron in neurodegeneration.

Prohaska R, Sibon OC, Rudnicki DD, Danek A, Hayflick SJ, Verhaag EM, Vonk JJ, Margolis RL, Walker RH.

Neurobiol Dis. 2012 Jun;46(3):607-24. doi: 10.1016/j.nbd.2012.03.006. Epub 2012 Mar 9. Review.

20.

Impaired Coenzyme A metabolism affects histone and tubulin acetylation in Drosophila and human cell models of pantothenate kinase associated neurodegeneration.

Siudeja K, Srinivasan B, Xu L, Rana A, de Jong J, Nollen EA, Jackowski S, Sanford L, Hayflick S, Sibon OC.

EMBO Mol Med. 2011 Dec;3(12):755-66. doi: 10.1002/emmm.201100180. Epub 2011 Oct 14.

21.

Studying cell cycle checkpoints using Drosophila cultured cells.

Siudeja K, de Jong J, Sibon OC.

Methods Mol Biol. 2011;782:59-73. doi: 10.1007/978-1-61779-273-1_6.

PMID:
21870285
22.

Effects of different small HSPB members on contractile dysfunction and structural changes in a Drosophila melanogaster model for Atrial Fibrillation.

Zhang D, Ke L, Mackovicova K, Van Der Want JJ, Sibon OC, Tanguay RM, Morrow G, Henning RH, Kampinga HH, Brundel BJ.

J Mol Cell Cardiol. 2011 Sep;51(3):381-9. doi: 10.1016/j.yjmcc.2011.06.008. Epub 2011 Jul 13.

PMID:
21745477
23.

RNAi-induced off-target effects in Drosophila melanogaster: frequencies and solutions.

Seinen E, Burgerhof JG, Jansen RC, Sibon OC.

Brief Funct Genomics. 2011 Jul;10(4):206-14. doi: 10.1093/bfgp/elr017. Epub 2011 May 19.

PMID:
21596801
24.

Small heat shock proteins, protein degradation and protein aggregation diseases.

Vos MJ, Zijlstra MP, Carra S, Sibon OC, Kampinga HH.

Autophagy. 2011 Jan;7(1):101-3. Epub 2011 Jan 1.

PMID:
21045566
25.

RNAi experiments in D. melanogaster: solutions to the overlooked problem of off-targets shared by independent dsRNAs.

Seinen E, Burgerhof JG, Jansen RC, Sibon OC.

PLoS One. 2010 Oct 1;5(10). pii: e13119. doi: 10.1371/journal.pone.0013119.

26.

Identification of the Drosophila ortholog of HSPB8: implication of HSPB8 loss of function in protein folding diseases.

Carra S, Boncoraglio A, Kanon B, Brunsting JF, Minoia M, Rana A, Vos MJ, Seidel K, Sibon OC, Kampinga HH.

J Biol Chem. 2010 Nov 26;285(48):37811-22. doi: 10.1074/jbc.M110.127498. Epub 2010 Sep 21.

27.

HSPB7 is the most potent polyQ aggregation suppressor within the HSPB family of molecular chaperones.

Vos MJ, Zijlstra MP, Kanon B, van Waarde-Verhagen MA, Brunt ER, Oosterveld-Hut HM, Carra S, Sibon OC, Kampinga HH.

Hum Mol Genet. 2010 Dec 1;19(23):4677-93. doi: 10.1093/hmg/ddq398. Epub 2010 Sep 15.

PMID:
20843828
28.

Pantethine rescues a Drosophila model for pantothenate kinase-associated neurodegeneration.

Rana A, Seinen E, Siudeja K, Muntendam R, Srinivasan B, van der Want JJ, Hayflick S, Reijngoud DJ, Kayser O, Sibon OC.

Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):6988-93. doi: 10.1073/pnas.0912105107. Epub 2010 Mar 29.

29.

A high throughput experimental approach to identify miRNA targets in human cells.

Tan LP, Seinen E, Duns G, de Jong D, Sibon OC, Poppema S, Kroesen BJ, Kok K, van den Berg A.

Nucleic Acids Res. 2009 Nov;37(20):e137. doi: 10.1093/nar/gkp715. Epub 2009 Sep 4.

30.

Stwl modifies chromatin compaction and is required to maintain DNA integrity in the presence of perturbed DNA replication.

Yi X, de Vries HI, Siudeja K, Rana A, Lemstra W, Brunsting JF, Kok RM, Smulders YM, Schaefer M, Dijk F, Shang Y, Eggen BJ, Kampinga HH, Sibon OC.

Mol Biol Cell. 2009 Feb;20(3):983-94. doi: 10.1091/mbc.E08-06-0639. Epub 2008 Dec 3.

31.

Drosophila phosphopantothenoylcysteine synthetase is required for tissue morphogenesis during oogenesis.

Bosveld F, Rana A, Lemstra W, Kampinga HH, Sibon OC.

BMC Res Notes. 2008 Aug 29;1:75. doi: 10.1186/1756-0500-1-75.

32.

A long-term flow cytometry assay to analyze the role of specific genes of Drosophila melanogaster S2 cells in surviving genotoxic stress.

Yi X, Lemstra W, Vos MJ, Shang Y, Kampinga HH, Su TT, Sibon OC.

Cytometry A. 2008 Jul;73(7):637-42. doi: 10.1002/cyto.a.20579.

33.

De novo CoA biosynthesis is required to maintain DNA integrity during development of the Drosophila nervous system.

Bosveld F, Rana A, van der Wouden PE, Lemstra W, Ritsema M, Kampinga HH, Sibon OC.

Hum Mol Genet. 2008 Jul 1;17(13):2058-69. doi: 10.1093/hmg/ddn105. Epub 2008 Apr 10.

PMID:
18407920
34.

Establishment of cell fate during early Drosophila embryogenesis requires transcriptional Mediator subunit dMED31.

Bosveld F, van Hoek S, Sibon OC.

Dev Biol. 2008 Jan 15;313(2):802-13. Epub 2007 Nov 28.

35.

Polarised asymmetric inheritance of accumulated protein damage in higher eukaryotes.

Rujano MA, Bosveld F, Salomons FA, Dijk F, van Waarde MA, van der Want JJ, de Vos RA, Brunt ER, Sibon OC, Kampinga HH.

PLoS Biol. 2006 Dec;4(12):e417.

36.

Dysfunctional BRCA1 is only indirectly linked to multiple centrosomes.

Hut HM, Rembacz KP, van Waarde MA, Lemstra W, van Cappellen WA, Kampinga HH, Sibon OC.

Oncogene. 2005 Nov 17;24(51):7619-23.

PMID:
16205648
37.

Hsp70 protects mitotic cells against heat-induced centrosome damage and division abnormalities.

Hut HM, Kampinga HH, Sibon OC.

Mol Biol Cell. 2005 Aug;16(8):3776-85. Epub 2005 Jun 1.

38.

Grp/DChk1 is required for G2-M checkpoint activation in Drosophila S2 cells, whereas Dmnk/DChk2 is dispensable.

de Vries HI, Uyetake L, Lemstra W, Brunsting JF, Su TT, Kampinga HH, Sibon OC.

J Cell Sci. 2005 May 1;118(Pt 9):1833-42.

39.

Centrosomes split in the presence of impaired DNA integrity during mitosis.

Hut HM, Lemstra W, Blaauw EH, Van Cappellen GW, Kampinga HH, Sibon OC.

Mol Biol Cell. 2003 May;14(5):1993-2004. Epub 2003 Feb 6.

40.

Centrosomes as DNA damage regulators.

Sibon OC.

Nat Genet. 2003 May;34(1):6-7. No abstract available.

PMID:
12721543
41.

Dynamic changes in the localization of thermally unfolded nuclear proteins associated with chaperone-dependent protection.

Nollen EA, Salomons FA, Brunsting JF, van der Want JJ, Sibon OC, Kampinga HH.

Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12038-43. Epub 2001 Sep 25.

42.

DNA-replication/DNA-damage-dependent centrosome inactivation in Drosophila embryos.

Sibon OC, Kelkar A, Lemstra W, Theurkauf WE.

Nat Cell Biol. 2000 Feb;2(2):90-5.

PMID:
10655588
43.

The Drosophila ATM homologue Mei-41 has an essential checkpoint function at the midblastula transition.

Sibon OC, Laurençon A, Hawley R, Theurkauf WE.

Curr Biol. 1999 Mar 25;9(6):302-12.

44.

DNA-replication checkpoint control at the Drosophila midblastula transition.

Sibon OC, Stevenson VA, Theurkauf WE.

Nature. 1997 Jul 3;388(6637):93-7.

PMID:
9214509
45.

Structure, subnuclear distribution, and nuclear matrix association of the mammalian telomeric complex.

Ludérus ME, van Steensel B, Chong L, Sibon OC, Cremers FF, de Lange T.

J Cell Biol. 1996 Nov;135(4):867-81.

46.

EGF-receptor RNA metabolism in the nucleus of A431 cells.

Sibon OC, Wansink DG, Boonstra J, Humbel BM, Verkleij AJ, Cremers FF.

Eur J Cell Biol. 1996 Sep;71(1):45-52.

PMID:
8884177
47.

Ultrastructural localization of active genes in nuclei of A431 cells.

Wansink DG, Sibon OC, Cremers FF, van Driel R, de Jong L.

J Cell Biochem. 1996 Jul;62(1):10-8.

PMID:
8836871
48.

Ultra-small gold particles and silver enhancement as a detection system in immunolabeling and in situ hybridization experiments.

Humbel BM, Sibon OC, Stierhof YD, Schwarz H.

J Histochem Cytochem. 1995 Jul;43(7):735-7. No abstract available.

PMID:
7608530
49.

Localization of nuclear RNA by pre- and post-embedding in situ hybridization using different gold probes.

Sibon OC, Cremers FF, Humbel BM, Boonstra J, Verkleij AJ.

Histochem J. 1995 Jan;27(1):35-45.

PMID:
7536186

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