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Items: 26


P-TEFb Activation by RBM7 Shapes a Pro-survival Transcriptional Response to Genotoxic Stress.

Bugai A, Quaresma AJC, Friedel CC, Lenasi T, Düster R, Sibley CR, Fujinaga K, Kukanja P, Hennig T, Blasius M, Geyer M, Ule J, Dölken L, Barborič M.

Mol Cell. 2019 Apr 18;74(2):254-267.e10. doi: 10.1016/j.molcel.2019.01.033. Epub 2019 Feb 26.


Exon Junction Complex Shapes the Transcriptome by Repressing Recursive Splicing.

Blazquez L, Emmett W, Faraway R, Pineda JMB, Bajew S, Gohr A, Haberman N, Sibley CR, Bradley RK, Irimia M, Ule J.

Mol Cell. 2018 Nov 1;72(3):496-509.e9. doi: 10.1016/j.molcel.2018.09.033.


Identification of expression quantitative trait loci associated with schizophrenia and affective disorders in normal brain tissue.

Bhalala OG, Nath AP; UK Brain Expression Consortium, Inouye M, Sibley CR.

PLoS Genet. 2018 Aug 24;14(8):e1007607. doi: 10.1371/journal.pgen.1007607. eCollection 2018 Aug.


Individual Nucleotide Resolution UV Cross-Linking and Immunoprecipitation (iCLIP) to Determine Protein-RNA Interactions.

Sibley CR.

Methods Mol Biol. 2018;1649:427-454. doi: 10.1007/978-1-4939-7213-5_29.


A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models.

Tyzack GE, Hall CE, Sibley CR, Cymes T, Forostyak S, Carlino G, Meyer IF, Schiavo G, Zhang SC, Gibbons GM, Newcombe J, Patani R, Lakatos A.

Nat Commun. 2017 Oct 27;8(1):1164. doi: 10.1038/s41467-017-01283-z.


Erratum to: Insights into the design and interpretation of iCLIP experiments.

Haberman N, Huppertz I, Attig J, König J, Wang Z, Hauer C, Hentze MW, Kulozik AE, Le Hir H, Curk T, Sibley CR, Zarnack K, Ule J.

Genome Biol. 2017 Aug 15;18(1):154. doi: 10.1186/s13059-017-1294-z. No abstract available.


Progressive Motor Neuron Pathology and the Role of Astrocytes in a Human Stem Cell Model of VCP-Related ALS.

Hall CE, Yao Z, Choi M, Tyzack GE, Serio A, Luisier R, Harley J, Preza E, Arber C, Crisp SJ, Watson PMD, Kullmann DM, Abramov AY, Wray S, Burley R, Loh SHY, Martins LM, Stevens MM, Luscombe NM, Sibley CR, Lakatos A, Ule J, Gandhi S, Patani R.

Cell Rep. 2017 May 30;19(9):1739-1749. doi: 10.1016/j.celrep.2017.05.024.


Transcript-specific characteristics determine the contribution of endo- and exonucleolytic decay pathways during the degradation of nonsense-mediated decay substrates.

Ottens F, Boehm V, Sibley CR, Ule J, Gehring NH.

RNA. 2017 Aug;23(8):1224-1236. doi: 10.1261/rna.059659.116. Epub 2017 May 1.


Insights into the design and interpretation of iCLIP experiments.

Haberman N, Huppertz I, Attig J, König J, Wang Z, Hauer C, Hentze MW, Kulozik AE, Le Hir H, Curk T, Sibley CR, Zarnack K, Ule J.

Genome Biol. 2017 Jan 16;18(1):7. doi: 10.1186/s13059-016-1130-x. Erratum in: Genome Biol. 2017 Aug 15;18(1):154.


Lessons from non-canonical splicing.

Sibley CR, Blazquez L, Ule J.

Nat Rev Genet. 2016 Jul;17(7):407-421. doi: 10.1038/nrg.2016.46. Epub 2016 May 31. Review.


The interaction of PRC2 with RNA or chromatin is mutually antagonistic.

Beltran M, Yates CM, Skalska L, Dawson M, Reis FP, Viiri K, Fisher CL, Sibley CR, Foster BM, Bartke T, Ule J, Jenner RG.

Genome Res. 2016 Jul;26(7):896-907. doi: 10.1101/gr.197632.115. Epub 2016 May 9.


Regulation of constitutive and alternative mRNA splicing across the human transcriptome by PRPF8 is determined by 5' splice site strength.

Wickramasinghe VO, Gonzàlez-Porta M, Perera D, Bartolozzi AR, Sibley CR, Hallegger M, Ule J, Marioni JC, Venkitaraman AR.

Genome Biol. 2015 Sep 21;16:201. doi: 10.1186/s13059-015-0749-3.


Recursive splicing in long vertebrate genes.

Sibley CR, Emmett W, Blazquez L, Faro A, Haberman N, Briese M, Trabzuni D, Ryten M, Weale ME, Hardy J, Modic M, Curk T, Wilson SW, Plagnol V, Ule J.

Nature. 2015 May 21;521(7552):371-375. doi: 10.1038/nature14466. Epub 2015 May 13.


Regulation of gene expression through production of unstable mRNA isoforms.

Sibley CR.

Biochem Soc Trans. 2014 Aug;42(4):1196-205. doi: 10.1042/BST20140102. Review.


iCLIP: protein-RNA interactions at nucleotide resolution.

Huppertz I, Attig J, D'Ambrogio A, Easton LE, Sibley CR, Sugimoto Y, Tajnik M, König J, Ule J.

Methods. 2014 Feb;65(3):274-87. doi: 10.1016/j.ymeth.2013.10.011. Epub 2013 Oct 25.


CLIPing the brain: studies of protein-RNA interactions important for neurodegenerative disorders.

Modic M, Ule J, Sibley CR.

Mol Cell Neurosci. 2013 Sep;56:429-35. doi: 10.1016/j.mcn.2013.04.002. Epub 2013 Apr 10. Review.


Silencing of Parkinson's disease-associated genes with artificial mirtron mimics of miR-1224.

Sibley CR, Seow Y, Curtis H, Weinberg MS, Wood MJ.

Nucleic Acids Res. 2012 Oct;40(19):9863-75. doi: 10.1093/nar/gks712. Epub 2012 Jul 30.


The greatest catch: big game fishing for mRNA-bound proteins.

Sibley CR, Attig J, Ule J.

Genome Biol. 2012 Jul 17;13(7):163. doi: 10.1186/gb4030.


Mirtrons, an emerging class of atypical miRNA.

Curtis HJ, Sibley CR, Wood MJ.

Wiley Interdiscip Rev RNA. 2012 Sep-Oct;3(5):617-32. doi: 10.1002/wrna.1122. Epub 2012 Jun 25. Review.


Artificial mirtron-mediated gene knockdown: functional DMPK silencing in mammalian cells.

Seow Y, Sibley CR, Wood MJ.

RNA. 2012 Jul;18(7):1328-37. doi: 10.1261/rna.030601.111. Epub 2012 May 30.


Using human pluripotent stem cells to study post-transcriptional mechanisms of neurodegenerative diseases.

Patani R, Sibley CR, Chandran S, Ule J.

Brain Res. 2012 Jun 26;1462:129-38. doi: 10.1016/j.brainres.2011.12.057. Epub 2012 Jan 5. Review.


Identification of allele-specific RNAi effectors targeting genetic forms of Parkinson's disease.

Sibley CR, Wood MJ.

PLoS One. 2011;6(10):e26194. doi: 10.1371/journal.pone.0026194. Epub 2011 Oct 21.


The biogenesis and characterization of mammalian microRNAs of mirtron origin.

Sibley CR, Seow Y, Saayman S, Dijkstra KK, El Andaloussi S, Weinberg MS, Wood MJ.

Nucleic Acids Res. 2012 Jan;40(1):438-48. doi: 10.1093/nar/gkr722. Epub 2011 Sep 13.


The miRNA pathway in neurological and skeletal muscle disease: implications for pathogenesis and therapy.

Sibley CR, Wood MJ.

J Mol Med (Berl). 2011 Nov;89(11):1065-77. doi: 10.1007/s00109-011-0781-z. Epub 2011 Jul 13. Review.


Novel RNA-based strategies for therapeutic gene silencing.

Sibley CR, Seow Y, Wood MJ.

Mol Ther. 2010 Mar;18(3):466-76. doi: 10.1038/mt.2009.306. Epub 2010 Jan 19. Review.


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