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Items: 24


Structural insights into non-covalent ubiquitin activation of the cIAP1-UbcH5B∼ubiquitin complex.

Patel A, Sibbet GJ, Huang DT.

J Biol Chem. 2019 Jan 25;294(4):1240-1249. doi: 10.1074/jbc.RA118.006045. Epub 2018 Dec 6.


A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants.

Gabrielsen M, Buetow L, Nakasone MA, Ahmed SF, Sibbet GJ, Smith BO, Zhang W, Sidhu SS, Huang DT.

Mol Cell. 2017 Oct 19;68(2):456-470.e10. doi: 10.1016/j.molcel.2017.09.027.


Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity.

Nomura K, Klejnot M, Kowalczyk D, Hock AK, Sibbet GJ, Vousden KH, Huang DT.

Nat Struct Mol Biol. 2017 Jul;24(7):578-587. doi: 10.1038/nsmb.3414. Epub 2017 May 29.


Mutational activation of BRAF confers sensitivity to transforming growth factor beta inhibitors in human cancer cells.

Spender LC, Ferguson GJ, Liu S, Cui C, Girotti MR, Sibbet G, Higgs EB, Shuttleworth MK, Hamilton T, Lorigan P, Weller M, Vincent DF, Sansom OJ, Frame M, Dijke PT, Marais R, Inman GJ.

Oncotarget. 2016 Dec 13;7(50):81995-82012. doi: 10.18632/oncotarget.13226.


Casitas B-lineage lymphoma linker helix mutations found in myeloproliferative neoplasms affect conformation.

Buetow L, Tria G, Ahmed SF, Hock A, Dou H, Sibbet GJ, Svergun DI, Huang DT.

BMC Biol. 2016 Sep 8;14:76. doi: 10.1186/s12915-016-0298-6.


Activation of a primed RING E3-E2-ubiquitin complex by non-covalent ubiquitin.

Buetow L, Gabrielsen M, Anthony NG, Dou H, Patel A, Aitkenhead H, Sibbet GJ, Smith BO, Huang DT.

Mol Cell. 2015 Apr 16;58(2):297-310. doi: 10.1016/j.molcel.2015.02.017. Epub 2015 Mar 19.


Essentiality of a non-RING element in priming donor ubiquitin for catalysis by a monomeric E3.

Dou H, Buetow L, Sibbet GJ, Cameron K, Huang DT.

Nat Struct Mol Biol. 2013 Aug;20(8):982-986. doi: 10.1038/nsmb.2621. Epub 2013 Jul 14.


BIRC7-E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer.

Dou H, Buetow L, Sibbet GJ, Cameron K, Huang DT.

Nat Struct Mol Biol. 2012 Sep;19(9):876-83. doi: 10.1038/nsmb.2379. Epub 2012 Aug 14.


Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl.

Dou H, Buetow L, Hock A, Sibbet GJ, Vousden KH, Huang DT.

Nat Struct Mol Biol. 2012 Jan 22;19(2):184-92. doi: 10.1038/nsmb.2231.


Deep evolutionary conservation of an intramolecular protein kinase activation mechanism.

Han J, Miranda-Saavedra D, Luebbering N, Singh A, Sibbet G, Ferguson MA, Cleghon V.

PLoS One. 2012;7(1):e29702. doi: 10.1371/journal.pone.0029702. Epub 2012 Jan 3.


Characterization of a domain that transiently converts class 2 DYRKs into intramolecular tyrosine kinases.

Kinstrie R, Luebbering N, Miranda-Saavedra D, Sibbet G, Han J, Lochhead PA, Cleghon V.

Sci Signal. 2010 Mar 2;3(111):ra16. doi: 10.1126/scisignal.2000579.


A chaperone-dependent GSK3beta transitional intermediate mediates activation-loop autophosphorylation.

Lochhead PA, Kinstrie R, Sibbet G, Rawjee T, Morrice N, Cleghon V.

Mol Cell. 2006 Nov 17;24(4):627-33.


dDYRK2 and Minibrain interact with the chromatin remodelling factors SNR1 and TRX.

Kinstrie R, Lochhead PA, Sibbet G, Morrice N, Cleghon V.

Biochem J. 2006 Aug 15;398(1):45-54.


Activation-loop autophosphorylation is mediated by a novel transitional intermediate form of DYRKs.

Lochhead PA, Sibbet G, Morrice N, Cleghon V.

Cell. 2005 Jun 17;121(6):925-36.


dDYRK2: a novel dual-specificity tyrosine-phosphorylation-regulated kinase in Drosophila.

Lochhead PA, Sibbet G, Kinstrie R, Cleghon T, Rylatt M, Morrison DK, Cleghon V.

Biochem J. 2003 Sep 1;374(Pt 2):381-91.


Down-regulation of MHC class I by bovine papillomavirus E5 oncoproteins.

Ashrafi GH, Tsirimonaki E, Marchetti B, O'Brien PM, Sibbet GJ, Andrew L, Campo MS.

Oncogene. 2002 Jan 10;21(2):248-59.


alpha6 integrin is not the obligatory cell receptor for bovine papillomavirus type 4

Sibbet G, Romero-Graillet C, Meneguzzi G, Saveria Campo M.

J Gen Virol. 2000 Jun;81 Pt 6:1629. No abstract available.


alpha6 integrin is not the obligatory cell receptor for bovine papillomavirus type 4.

Sibbet G, Romero-Graillet C, Meneguzzi G, Campo MS.

J Gen Virol. 2000 Feb;81(Pt 2):327-34. Erratum in: J Gen Virol 2000 Jun;81 Pt 6:1629.


Tissue specific transcription of the human epsilon-globin gene following transfection into the embryonic erythroid cell line K562.

Allan M, Montague P, Grindlay GJ, Sibbet G, Donovan-Peluso M, Bank A, Paul J.

Nucleic Acids Res. 1985 Sep 11;13(17):6125-36.


Selective depletion and reconstitution of nucleosome core particles.

Sibbet GJ, Carpenter BG.

Biochim Biophys Acta. 1983 Aug 2;740(3):331-8.


Neutron-scattering studies of accurately reconstituted nucleosome core particles and the effect of ionic strength on core particle structure.

Sibbet GJ, Carpenter BG, Ibel K, May RP, Kneale GG, Bradbury EM, Baldwin JP.

Eur J Biochem. 1983 Jun 15;133(2):393-8.

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