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Items: 4


Regenerative proliferation of differentiated cells by mTORC1-dependent paligenosis.

Willet SG, Lewis MA, Miao ZF, Liu D, Radyk MD, Cunningham RL, Burclaff J, Sibbel G, Lo HG, Blanc V, Davidson NO, Wang ZN, Mills JC.

EMBO J. 2018 Apr 3;37(7). pii: e98311. doi: 10.15252/embj.201798311. Epub 2018 Feb 21.


A single transcription factor is sufficient to induce and maintain secretory cell architecture.

Lo HG, Jin RU, Sibbel G, Liu D, Karki A, Joens MS, Madison BB, Zhang B, Blanc V, Fitzpatrick JA, Davidson NO, Konieczny SF, Mills JC.

Genes Dev. 2017 Jan 15;31(2):154-171. doi: 10.1101/gad.285684.116. Epub 2017 Feb 7.


Osteopetrorickets due to Snx10 deficiency in mice results from both failed osteoclast activity and loss of gastric acid-dependent calcium absorption.

Ye L, Morse LR, Zhang L, Sasaki H, Mills JC, Odgren PR, Sibbel G, Stanley JR, Wong G, Zamarioli A, Battaglino RA.

PLoS Genet. 2015 Mar 26;11(3):e1005057. doi: 10.1371/journal.pgen.1005057. eCollection 2015 Mar.


Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium.

Stange DE, Koo BK, Huch M, Sibbel G, Basak O, Lyubimova A, Kujala P, Bartfeld S, Koster J, Geahlen JH, Peters PJ, van Es JH, van de Wetering M, Mills JC, Clevers H.

Cell. 2013 Oct 10;155(2):357-68. doi: 10.1016/j.cell.2013.09.008.

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