Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 114

1.

Shear stress regulation of miR-93 and miR-484 maturation through nucleolin.

Gongol B, Marin T, Zhang J, Wang SC, Sun W, He M, Chen S, Chen L, Li J, Liu JH, Martin M, Han Y, Kang J, Johnson DA, Lytle C, Li YS, Huang PH, Chien S, Shyy JY.

Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):12974-12979. doi: 10.1073/pnas.1902844116. Epub 2019 Jun 10.

PMID:
31182601
2.

Atheroprotective Flow Upregulates ITPR3 (Inositol 1,4,5-Trisphosphate Receptor 3) in Vascular Endothelium via KLF4 (Krüppel-Like Factor 4)-Mediated Histone Modifications.

He M, Huang TS, Li S, Hong HC, Chen Z, Martin M, Zhou X, Huang HY, Su SH, Zhang J, Wang WT, Kang J, Huang HD, Zhang J, Chien S, Shyy JY.

Arterioscler Thromb Vasc Biol. 2019 May;39(5):902-914. doi: 10.1161/ATVBAHA.118.312301.

PMID:
30917677
3.

Germline BMP9 mutation causes idiopathic pulmonary arterial hypertension.

Wang XJ, Lian TY, Jiang X, Liu SF, Li SQ, Jiang R, Wu WH, Ye J, Cheng CY, Du Y, Xu XQ, Wu Y, Peng FH, Sun K, Mao YM, Yu H, Liang C, Shyy JY, Zhang SY, Zhang X, Jing ZC.

Eur Respir J. 2019 Mar 14;53(3). pii: 1801609. doi: 10.1183/13993003.01609-2018. Print 2019 Mar.

PMID:
30578397
4.

Atheroprone flow enhances the endothelial-to-mesenchymal transition.

Lai B, Li Z, He M, Wang Y, Chen L, Zhang J, Yang Y, Shyy JY.

Am J Physiol Heart Circ Physiol. 2018 Nov 1;315(5):H1293-H1303. doi: 10.1152/ajpheart.00213.2018. Epub 2018 Jul 27.

PMID:
30052471
5.

Shear Stress Regulation of Endothelium: A Double-edged Sword.

Bai L, Shyy JY PhD.

J Transl Int Med. 2018 Jun 26;6(2):58-61. doi: 10.2478/jtim-2018-0019. eCollection 2018 Jun. No abstract available.

6.

AMP-activated Protein Kinase Phosphorylation of Angiotensin-Converting Enzyme 2 in Endothelium Mitigates Pulmonary Hypertension.

Zhang J, Dong J, Martin M, He M, Gongol B, Marin TL, Chen L, Shi X, Yin Y, Shang F, Wu Y, Huang HY, Zhang J, Zhang Y, Kang J, Moya EA, Huang HD, Powell FL, Chen Z, Thistlethwaite PA, Yuan ZY, Shyy JY.

Am J Respir Crit Care Med. 2018 Aug 15;198(4):509-520. doi: 10.1164/rccm.201712-2570OC.

7.

Bioinformatics Approach to Identify Novel AMPK Targets.

Gongol B, Marin T, Johnson DA, Shyy JY.

Methods Mol Biol. 2018;1732:99-109. doi: 10.1007/978-1-4939-7598-3_7.

PMID:
29480471
8.

Immediate Early Response Gene X-1 (IEX-1) Mediates Ischemic Preconditioning-Induced Cardioprotection in Rats.

Xu MJ, Cai Y, Qu A, Shyy JY, Li W, Wang X.

Oxid Med Cell Longev. 2017;2017:6109061. doi: 10.1155/2017/6109061. Epub 2017 Oct 29.

9.

A Special Report on the NHLBI Initiative to Study Cellular and Molecular Mechanisms of Arterial Stiffness and Its Association With Hypertension.

Oh YS, Berkowitz DE, Cohen RA, Figueroa CA, Harrison DG, Humphrey JD, Larson DF, Leopold JA, Mecham RP, Ruiz-Opazo N, Santhanam L, Seta F, Shyy JYJ, Sun Z, Tsao PS, Wagenseil JE, Galis ZS.

Circ Res. 2017 Nov 10;121(11):1216-1218. doi: 10.1161/CIRCRESAHA.117.311703. Review. No abstract available.

10.

Short-Term High-Salt Diet Increases Corin Level to Regulate the Salt-Water Balance in Humans and Rodents.

Zhang J, Yin Y, Chen L, Chu C, Wang Y, Lv Y, He M, Martin M, Huang PH, Mu JJ, Shyy JY, Yuan ZY.

Am J Hypertens. 2018 Jan 12;31(2):253-260. doi: 10.1093/ajh/hpx148.

11.

Systems biology analysis of longitudinal functional response of endothelial cells to shear stress.

Ajami NE, Gupta S, Maurya MR, Nguyen P, Li JY, Shyy JY, Chen Z, Chien S, Subramaniam S.

Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):10990-10995. doi: 10.1073/pnas.1707517114. Epub 2017 Sep 26.

12.

Krüppel-Like Factor 4 Regulation of Cholesterol-25-Hydroxylase and Liver X Receptor Mitigates Atherosclerosis Susceptibility.

Li Z, Martin M, Zhang J, Huang HY, Bai L, Zhang J, Kang J, He M, Li J, Maurya MR, Gupta S, Zhou G, Sangwung P, Xu YJ, Lei T, Huang HD, Jain M, Jain MK, Subramaniam S, Shyy JY.

Circulation. 2017 Oct 3;136(14):1315-1330. doi: 10.1161/CIRCULATIONAHA.117.027462. Epub 2017 Aug 9.

13.

MicroRNA-92a Mediates Endothelial Dysfunction in CKD.

Shang F, Wang SC, Hsu CY, Miao Y, Martin M, Yin Y, Wu CC, Wang YT, Wu G, Chien S, Huang HD, Tarng DC, Shiu YT, Cheung AK, Huang PH, Chen Z, Shyy JY.

J Am Soc Nephrol. 2017 Nov;28(11):3251-3261. doi: 10.1681/ASN.2016111215. Epub 2017 Jul 10.

14.

Mediator 1 Is Atherosclerosis Protective by Regulating Macrophage Polarization.

Bai L, Li Z, Li Q, Guan H, Zhao S, Liu R, Wang R, Zhang J, Jia Y, Fan J, Wang N, Reddy JK, Shyy JY, Liu E.

Arterioscler Thromb Vasc Biol. 2017 Aug;37(8):1470-1481. doi: 10.1161/ATVBAHA.117.309672. Epub 2017 Jun 22.

15.

Epigenetic Regulation: A New Frontier for Biomedical Engineers.

Chen Z, Li S, Subramaniam S, Shyy JY, Chien S.

Annu Rev Biomed Eng. 2017 Jun 21;19:195-219. doi: 10.1146/annurev-bioeng-071516-044720. Epub 2017 Mar 6. Review.

PMID:
28301736
16.

AMPK promotes mitochondrial biogenesis and function by phosphorylating the epigenetic factors DNMT1, RBBP7, and HAT1.

Marin TL, Gongol B, Zhang F, Martin M, Johnson DA, Xiao H, Wang Y, Subramaniam S, Chien S, Shyy JY.

Sci Signal. 2017 Jan 31;10(464). pii: eaaf7478. doi: 10.1126/scisignal.aaf7478.

17.

TIFA as a crucial mediator for NLRP3 inflammasome.

Lin TY, Wei TW, Li S, Wang SC, He M, Martin M, Zhang J, Shentu TP, Xiao H, Kang J, Wang KC, Chen Z, Chien S, Tsai MD, Shyy JY.

Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):15078-15083. doi: 10.1073/pnas.1618773114. Epub 2016 Dec 13.

18.

Context-Dependent Role of Oxidized Lipids and Lipoproteins in Inflammation.

Miller YI, Shyy JY.

Trends Endocrinol Metab. 2017 Feb;28(2):143-152. doi: 10.1016/j.tem.2016.11.002. Epub 2016 Dec 5. Review.

19.

miR-483 Targeting of CTGF Suppresses Endothelial-to-Mesenchymal Transition: Therapeutic Implications in Kawasaki Disease.

He M, Chen Z, Martin M, Zhang J, Sangwung P, Woo B, Tremoulet AH, Shimizu C, Jain MK, Burns JC, Shyy JY.

Circ Res. 2017 Jan 20;120(2):354-365. doi: 10.1161/CIRCRESAHA.116.310233. Epub 2016 Dec 6.

20.

AMP-Activated Protein Kinase and Sirtuin 1 Coregulation of Cortactin Contributes to Endothelial Function.

Shentu TP, He M, Sun X, Zhang J, Zhang F, Gongol B, Marin TL, Zhang J, Wen L, Wang Y, Geary GG, Zhu Y, Johnson DA, Shyy JY.

Arterioscler Thromb Vasc Biol. 2016 Dec;36(12):2358-2368. Epub 2016 Oct 6.

21.

Cardiovascular Protective Effect of Metformin and Telmisartan: Reduction of PARP1 Activity via the AMPK-PARP1 Cascade.

Shang F, Zhang J, Li Z, Zhang J, Yin Y, Wang Y, Marin TL, Gongol B, Xiao H, Zhang YY, Chen Z, Shyy JY, Lei T.

PLoS One. 2016 Mar 17;11(3):e0151845. doi: 10.1371/journal.pone.0151845. eCollection 2016.

22.

The nucleolar protein NIFK promotes cancer progression via CK1α/β-catenin in metastasis and Ki-67-dependent cell proliferation.

Lin TC, Su CY, Wu PY, Lai TC, Pan WA, Jan YH, Chang YC, Yeh CT, Chen CL, Ger LP, Chang HT, Yang CJ, Huang MS, Liu YP, Lin YF, Shyy JY, Tsai MD, Hsiao M.

Elife. 2016 Mar 17;5. pii: e11288. doi: 10.7554/eLife.11288.

23.

Activation of integrin α5 mediated by flow requires its translocation to membrane lipid rafts in vascular endothelial cells.

Sun X, Fu Y, Gu M, Zhang L, Li D, Li H, Chien S, Shyy JY, Zhu Y.

Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):769-74. doi: 10.1073/pnas.1524523113. Epub 2016 Jan 5.

24.

Identification of AMP-activated protein kinase targets by a consensus sequence search of the proteome.

Marin TL, Gongol B, Martin M, King SJ, Smith L, Johnson DA, Subramaniam S, Chien S, Shyy JY.

BMC Syst Biol. 2015 Mar 11;9:13. doi: 10.1186/s12918-015-0156-0.

25.

Oxidative stress activates endothelial innate immunity via sterol regulatory element binding protein 2 (SREBP2) transactivation of microRNA-92a.

Chen Z, Wen L, Martin M, Hsu CY, Fang L, Lin FM, Lin TY, Geary MJ, Geary GG, Zhao Y, Johnson DA, Chen JW, Lin SJ, Chien S, Huang HD, Miller YI, Huang PH, Shyy JY.

Circulation. 2015 Mar 3;131(9):805-14. doi: 10.1161/CIRCULATIONAHA.114.013675. Epub 2014 Dec 30.

26.
27.

Shear stress activation of nuclear receptor PXR in endothelial detoxification.

Wang X, Fang X, Zhou J, Chen Z, Zhao B, Xiao L, Liu A, Li YS, Shyy JY, Guan Y, Chien S, Wang N.

Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):13174-9. doi: 10.1073/pnas.1312065110. Epub 2013 Jul 22.

28.

Sterol regulatory element binding protein 2 activation of NLRP3 inflammasome in endothelium mediates hemodynamic-induced atherosclerosis susceptibility.

Xiao H, Lu M, Lin TY, Chen Z, Chen G, Wang WC, Marin T, Shentu TP, Wen L, Gongol B, Sun W, Liang X, Chen J, Huang HD, Pedra JH, Johnson DA, Shyy JY.

Circulation. 2013 Aug 6;128(6):632-42. doi: 10.1161/CIRCULATIONAHA.113.002714. Epub 2013 Jul 9.

29.

Ca2+/calmodulin-dependent protein kinase kinase β phosphorylation of Sirtuin 1 in endothelium is atheroprotective.

Wen L, Chen Z, Zhang F, Cui X, Sun W, Geary GG, Wang Y, Johnson DA, Zhu Y, Chien S, Shyy JY.

Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):E2420-7. doi: 10.1073/pnas.1309354110. Epub 2013 Jun 10.

30.

Mechanosensitive microRNAs-role in endothelial responses to shear stress and redox state.

Marin T, Gongol B, Chen Z, Woo B, Subramaniam S, Chien S, Shyy JY.

Free Radic Biol Med. 2013 Sep;64:61-8. doi: 10.1016/j.freeradbiomed.2013.05.034. Epub 2013 May 30. Review.

31.

Response to overexpression of 5-hydroxytryptamine 2B receptor gene in pulmonary hypertension: still a long way to understand its transcriptional regulation.

Liu Y, Tian XY, Mao G, Fang X, Fung ML, Shyy JY, Huang Y, Wang N.

Hypertension. 2013 Apr;61(4):e30. No abstract available.

PMID:
23607134
32.

Regulation of vascular smooth muscle cell turnover by endothelial cell-secreted microRNA-126: role of shear stress.

Zhou J, Li YS, Nguyen P, Wang KC, Weiss A, Kuo YC, Chiu JJ, Shyy JY, Chien S.

Circ Res. 2013 Jun 21;113(1):40-51. doi: 10.1161/CIRCRESAHA.113.280883. Epub 2013 Apr 19.

33.

Endothelial dysfunction in rheumatoid arthritis: the role of monocyte chemotactic protein-1-induced protein.

He M, Liang X, He L, Wen W, Zhao S, Wen L, Liu Y, Shyy JY, Yuan Z.

Arterioscler Thromb Vasc Biol. 2013 Jun;33(6):1384-91. doi: 10.1161/ATVBAHA.113.301490. Epub 2013 Apr 11.

PMID:
23580143
34.

Regulation of SIRT1 by oxidative stress-responsive miRNAs and a systematic approach to identify its role in the endothelium.

Chen Z, Shentu TP, Wen L, Johnson DA, Shyy JY.

Antioxid Redox Signal. 2013 Nov 1;19(13):1522-38. doi: 10.1089/ars.2012.4803. Epub 2013 Apr 25. Review.

35.

Hypoxia-responsive miRNAs target argonaute 1 to promote angiogenesis.

Chen Z, Lai TC, Jan YH, Lin FM, Wang WC, Xiao H, Wang YT, Sun W, Cui X, Li YS, Fang T, Zhao H, Padmanabhan C, Sun R, Wang DL, Jin H, Chau GY, Huang HD, Hsiao M, Shyy JY.

J Clin Invest. 2013 Mar;123(3):1057-67. doi: 10.1172/JCI65344. Epub 2013 Feb 15.

36.

AMPKα2 exerts its anti-inflammatory effects through PARP-1 and Bcl-6.

Gongol B, Marin T, Peng IC, Woo B, Martin M, King S, Sun W, Johnson DA, Chien S, Shyy JY.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3161-6. doi: 10.1073/pnas.1222051110. Epub 2013 Feb 4.

37.

Peroxisome proliferator-activated receptor-γ ameliorates pulmonary arterial hypertension by inhibiting 5-hydroxytryptamine 2B receptor.

Liu Y, Tian XY, Mao G, Fang X, Fung ML, Shyy JY, Huang Y, Wang N.

Hypertension. 2012 Dec;60(6):1471-8. doi: 10.1161/HYPERTENSIONAHA.112.198887. Epub 2012 Oct 29.

PMID:
23108648
38.

miR-103/107 promote metastasis of colorectal cancer by targeting the metastasis suppressors DAPK and KLF4.

Chen HY, Lin YM, Chung HC, Lang YD, Lin CJ, Huang J, Wang WC, Lin FM, Chen Z, Huang HD, Shyy JY, Liang JT, Chen RH.

Cancer Res. 2012 Jul 15;72(14):3631-41. doi: 10.1158/0008-5472.CAN-12-0667. Epub 2012 May 16. Erratum in: Cancer Res. 2017 Dec 1;77(23 ):6788.

39.

Intermolecular binding between TIFA-FHA and TIFA-pT mediates tumor necrosis factor alpha stimulation and NF-κB activation.

Huang CC, Weng JH, Wei TY, Wu PY, Hsu PH, Chen YH, Wang SC, Qin D, Hung CC, Chen ST, Wang AH, Shyy JY, Tsai MD.

Mol Cell Biol. 2012 Jul;32(14):2664-73. doi: 10.1128/MCB.00438-12. Epub 2012 May 7. Erratum in: Mol Cell Biol. 2012 Sep;32(18):3800.

40.

Flow-dependent mass transfer may trigger endothelial signaling cascades.

Vandrangi P, Sosa M, Shyy JY, Rodgers VG.

PLoS One. 2012;7(4):e35260. doi: 10.1371/journal.pone.0035260. Epub 2012 Apr 27.

41.

Glucagon regulates ACC activity in adipocytes through the CAMKKβ/AMPK pathway.

Peng IC, Chen Z, Sun W, Li YS, Marin TL, Hsu PH, Su MI, Cui X, Pan S, Lytle CY, Johnson DA, Blaeser F, Chatila T, Shyy JY.

Am J Physiol Endocrinol Metab. 2012 Jun 15;302(12):E1560-8. doi: 10.1152/ajpendo.00504.2011. Epub 2012 Mar 27.

42.

Flow-Dependent Regulation of Kruppel-Like Factor 2 Is Mediated by MicroRNA-92a.

Wu W, Xiao H, Laguna-Fernandez A, Villarreal G Jr, Wang KC, Geary GG, Zhang Y, Wang WC, Huang HD, Zhou J, Li YS, Chien S, Garcia-Cardena G, Shyy JY.

Circulation. 2011 Aug 2;124(5):633-41. doi: 10.1161/CIRCULATIONAHA.110.005108. Epub 2011 Jul 18.

43.

MicroRNA-21 targets peroxisome proliferators-activated receptor-alpha in an autoregulatory loop to modulate flow-induced endothelial inflammation.

Zhou J, Wang KC, Wu W, Subramaniam S, Shyy JY, Chiu JJ, Li JY, Chien S.

Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10355-60. doi: 10.1073/pnas.1107052108. Epub 2011 Jun 2.

44.

AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice.

Li Y, Xu S, Mihaylova MM, Zheng B, Hou X, Jiang B, Park O, Luo Z, Lefai E, Shyy JY, Gao B, Wierzbicki M, Verbeuren TJ, Shaw RJ, Cohen RA, Zang M.

Cell Metab. 2011 Apr 6;13(4):376-388. doi: 10.1016/j.cmet.2011.03.009.

45.

A novel mechanism of γ/δ T-lymphocyte and endothelial activation by shear stress: the role of ecto-ATP synthase β chain.

Fu Y, Hou Y, Fu C, Gu M, Li C, Kong W, Wang X, Shyy JY, Zhu Y.

Circ Res. 2011 Feb 18;108(4):410-7. doi: 10.1161/CIRCRESAHA.110.230151. Epub 2010 Dec 30.

46.

Calcitonin gene-related peptide promotes angiogenesis via AMP-activated protein kinase.

Zheng S, Li W, Xu M, Bai X, Zhou Z, Han J, Shyy JY, Wang X.

Am J Physiol Cell Physiol. 2010 Dec;299(6):C1485-92. doi: 10.1152/ajpcell.00173.2010. Epub 2010 Sep 29.

47.

Beta-arrestin inhibits CAMKKbeta-dependent AMPK activation downstream of protease-activated-receptor-2.

Wang P, Jiang Y, Wang Y, Shyy JY, DeFea KA.

BMC Biochem. 2010 Sep 21;11:36. doi: 10.1186/1471-2091-11-36.

48.

Shear stress, SIRT1, and vascular homeostasis.

Chen Z, Peng IC, Cui X, Li YS, Chien S, Shyy JY.

Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10268-73. doi: 10.1073/pnas.1003833107. Epub 2010 May 17.

49.

microRNA: a master regulator of cellular processes for bioengineering systems.

Sun W, Julie Li YS, Huang HD, Shyy JY, Chien S.

Annu Rev Biomed Eng. 2010 Aug 15;12:1-27. doi: 10.1146/annurev-bioeng-070909-105314. Review.

PMID:
20415587
50.

Cholesterol increases adhesion of monocytes to endothelium by moving adhesion molecules out of caveolae.

Fu C, He J, Li C, Shyy JY, Zhu Y.

Biochim Biophys Acta. 2010 Jul;1801(7):702-10. doi: 10.1016/j.bbalip.2010.04.001. Epub 2010 Apr 9.

PMID:
20382259

Supplemental Content

Support Center