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Items: 1 to 50 of 102


The phosphatase activity of soluble epoxide hydrolase regulates ATP-binding cassette transporter-A1-dependent cholesterol efflux.

Lien CC, Chen CH, Lee YM, Guo BC, Cheng LC, Pan CC, Shyue SK, Lee TS.

J Cell Mol Med. 2019 Oct;23(10):6611-6621. doi: 10.1111/jcmm.14519. Epub 2019 Aug 22.


Activation of TrkB/Akt signaling by a TrkB receptor agonist improves long-term histological and functional outcomes in experimental intracerebral hemorrhage.

Wu CH, Chen CC, Hung TH, Chuang YC, Chao M, Shyue SK, Chen SF.

J Biomed Sci. 2019 Jul 15;26(1):53. doi: 10.1186/s12929-019-0543-8.


ZNF479 downregulates metallothionein-1 expression by regulating ASH2L and DNMT1 in hepatocellular carcinoma.

Wu YJ, Ko BS, Liang SM, Lu YJ, Jan YJ, Jiang SS, Shyue SK, Chen L, Liou JY.

Cell Death Dis. 2019 May 28;10(6):408. doi: 10.1038/s41419-019-1651-9.


Cordycepin Suppresses Endothelial Cell Proliferation, Migration, Angiogenesis, and Tumor Growth by Regulating Focal Adhesion Kinase and p53.

Lin YT, Liang SM, Wu YJ, Wu YJ, Lu YJ, Jan YJ, Ko BS, Chuang YJ, Shyue SK, Kuo CC, Liou JY.

Cancers (Basel). 2019 Feb 1;11(2). pii: E168. doi: 10.3390/cancers11020168.


Correction: Regulation of Aldo-keto-reductase family 1 B10 by 14-3-3ε and their prognostic impact of hepatocellular carcinoma.

Liu TA, Jan YJ, Ko BS, Wu YJ, Lu YJ, Liang SM, Liu CC, Chen SC, Wang J, Shyue SK, Liou JY.

Oncotarget. 2018 Oct 9;9(79):35026. doi: 10.18632/oncotarget.26226. eCollection 2018 Oct 9.


Atypical Antipsychotic Drug Olanzapine Deregulates Hepatic Lipid Metabolism and Aortic Inflammation and Aggravates Atherosclerosis.

Chen CH, Shyue SK, Hsu CP, Lee TS.

Cell Physiol Biochem. 2018;50(4):1216-1229. doi: 10.1159/000494573. Epub 2018 Oct 24.


Deletion of caveolin-1 attenuates LPS/GalN-induced acute liver injury in mice.

Tsai TH, Tam K, Chen SF, Liou JY, Tsai YC, Lee YM, Huang TY, Shyue SK.

J Cell Mol Med. 2018 Nov;22(11):5573-5582. doi: 10.1111/jcmm.13831. Epub 2018 Aug 22.


Deletion or inhibition of soluble epoxide hydrolase protects against brain damage and reduces microglia-mediated neuroinflammation in traumatic brain injury.

Hung TH, Shyue SK, Wu CH, Chen CC, Lin CC, Chang CF, Chen SF.

Oncotarget. 2017 Sep 21;8(61):103236-103260. doi: 10.18632/oncotarget.21139. eCollection 2017 Nov 28.


Genetic deletion or pharmacological inhibition of soluble epoxide hydrolase reduces brain damage and attenuates neuroinflammation after intracerebral hemorrhage.

Wu CH, Shyue SK, Hung TH, Wen S, Lin CC, Chang CF, Chen SF.

J Neuroinflammation. 2017 Nov 25;14(1):230. doi: 10.1186/s12974-017-1005-4.


Improving the regenerative potential of olfactory ensheathing cells by overexpressing prostacyclin synthetase and its application in spinal cord repair.

Tsai MJ, Huang CT, Huang YS, Weng CF, Shyue SK, Huang MC, Liou DY, Lin YR, Cheng CH, Kuo HS, Lin Y, Lee MJ, Huang WH, Huang WC, Cheng H.

J Biomed Sci. 2017 May 25;24(1):34. doi: 10.1186/s12929-017-0340-1.


Cordycepin disrupts leukemia association with mesenchymal stromal cells and eliminates leukemia stem cell activity.

Liang SM, Lu YJ, Ko BS, Jan YJ, Shyue SK, Yet SF, Liou JY.

Sci Rep. 2017 Mar 7;7:43930. doi: 10.1038/srep43930.


Pyrogallol abates VSMC migration via modulation of Caveolin-1, matrix metalloproteinase and intima hyperplasia in carotid ligation mouse.

Ma YD, Thiyagarajan V, Tsai MJ, Lue SI, Chia YC, Shyue SK, Weng CF.

Environ Toxicol Pharmacol. 2016 Dec;48:63-75. doi: 10.1016/j.etap.2016.10.005. Epub 2016 Oct 15.


Transient Receptor Potential Ankyrin 1 Channel Involved in Atherosclerosis and Macrophage-Foam Cell Formation.

Zhao JF, Shyue SK, Kou YR, Lu TM, Lee TS.

Int J Biol Sci. 2016 May 25;12(7):812-23. doi: 10.7150/ijbs.15229. eCollection 2016.


The GroEL protein of Porphyromonas gingivalis regulates atherogenic phenomena in endothelial cells mediated by upregulating toll-like receptor 4 expression.

Huang CY, Shih CM, Tsao NW, Lin YW, Shih CC, Chiang KH, Shyue SK, Chang YJ, Hsieh CK, Lin FY.

Am J Transl Res. 2016 Feb 15;8(2):384-404. eCollection 2016.


Role of transient receptor potential ankyrin 1 channels in Alzheimer's disease.

Lee KI, Lee HT, Lin HC, Tsay HJ, Tsai FC, Shyue SK, Lee TS.

J Neuroinflammation. 2016 Apr 27;13(1):92. doi: 10.1186/s12974-016-0557-z.


Asymmetric Dimethylarginine Limits the Efficacy of Simvastatin Activating Endothelial Nitric Oxide Synthase.

Hsu CP, Zhao JF, Lin SJ, Shyue SK, Guo BC, Lu TM, Lee TS.

J Am Heart Assoc. 2016 Apr 18;5(4):e003327. doi: 10.1161/JAHA.116.003327.


Excess Nitric Oxide Activates TRPV1-Ca(2+)-Calpain Signaling and Promotes PEST-dependent Degradation of Liver X Receptor α.

Zhao JF, Shyue SK, Lee TS.

Int J Biol Sci. 2016 Jan 1;12(1):18-29. doi: 10.7150/ijbs.13549. eCollection 2016.


Regulation of aldo-keto-reductase family 1 B10 by 14-3-3ε and their prognostic impact of hepatocellular carcinoma.

Liu TA, Jan YJ, Ko BS, Wu YJ, Lu YJ, Liang SM, Liu CC, Chen SC, Wang J, Shyue SK, Liou JY.

Oncotarget. 2015 Nov 17;6(36):38967-82. doi: 10.18632/oncotarget.5734. Erratum in: Oncotarget. 2018 Oct 9;9(79):35026.


TRC8 downregulation contributes to the development of non-alcoholic steatohepatitis by exacerbating hepatic endoplasmic reticulum stress.

Chang PC, Tsai HW, Chiang MT, Huang PL, Shyue SK, Chau LY.

Biochim Biophys Acta. 2015 Nov;1852(11):2339-51. doi: 10.1016/j.bbadis.2015.08.022. Epub 2015 Aug 28.


Rho-associated kinase inhibitors promote the cardiac differentiation of embryonic and induced pluripotent stem cells.

Cheng YT, Yeih DF, Liang SM, Chien CY, Yu YL, Ko BS, Jan YJ, Kuo CC, Sung LY, Shyue SK, Chen MF, Yet SF, Wu KK, Liou JY.

Int J Cardiol. 2015 Dec 15;201:441-8. doi: 10.1016/j.ijcard.2015.08.118. Epub 2015 Aug 15.


Role of phosphatase activity of soluble epoxide hydrolase in regulating simvastatin-activated endothelial nitric oxide synthase.

Hou HH, Liao YJ, Hsiao SH, Shyue SK, Lee TS.

Sci Rep. 2015 Aug 25;5:13524. doi: 10.1038/srep13524. Erratum in: Sci Rep. 2017 Jul 31;7:46877.


Growth arrest DNA damage-inducible gene 45 gamma expression as a prognostic and predictive biomarker in hepatocellular carcinoma.

Ou DL, Shyue SK, Lin LI, Feng ZR, Liou JY, Fan HH, Lee BS, Hsu C, Cheng AL.

Oncotarget. 2015 Sep 29;6(29):27953-65. doi: 10.18632/oncotarget.4446.


Maternal exposure to di-(2-ethylhexyl) phthalate exposure deregulates blood pressure, adiposity, cholesterol metabolism and social interaction in mouse offspring.

Lee KI, Chiang CW, Lin HC, Zhao JF, Li CT, Shyue SK, Lee TS.

Arch Toxicol. 2016 May;90(5):1211-24. doi: 10.1007/s00204-015-1539-0. Epub 2015 May 21.


Linear correlation between average fluorescence intensity of green fluorescent protein and the multiplicity of infection of recombinant adenovirus.

Tsai YC, Tsai TH, Chang CP, Chen SF, Lee YM, Shyue SK.

J Biomed Sci. 2015 May 14;22:31. doi: 10.1186/s12929-015-0137-z.


Transient receptor potential vanilloid type 1 is vital for (-)-epigallocatechin-3-gallate mediated activation of endothelial nitric oxide synthase.

Guo BC, Wei J, Su KH, Chiang AN, Zhao JF, Chen HY, Shyue SK, Lee TS.

Mol Nutr Food Res. 2015 Apr;59(4):646-57. doi: 10.1002/mnfr.201400699. Epub 2015 Feb 9.


Di-(2-ethylhexyl) phthalate accelerates atherosclerosis in apolipoprotein E-deficient mice.

Zhao JF, Hsiao SH, Hsu MH, Pao KC, Kou YR, Shyue SK, Lee TS.

Arch Toxicol. 2016 Jan;90(1):181-90. doi: 10.1007/s00204-014-1377-5. Epub 2014 Oct 2.


The GroEL protein of Porphyromonas gingivalis accelerates tumor growth by enhancing endothelial progenitor cell function and neovascularization.

Lin FY, Huang CY, Lu HY, Shih CM, Tsao NW, Shyue SK, Lin CY, Chang YJ, Tsai CS, Lin YW, Lin SJ.

Mol Oral Microbiol. 2015 Jun;30(3):198-216. doi: 10.1111/omi.12083. Epub 2014 Oct 28.


Implication of transient receptor potential vanilloid type 1 in 14,15-epoxyeicosatrienoic acid-induced angiogenesis.

Su KH, Lee KI, Shyue SK, Chen HY, Wei J, Lee TS.

Int J Biol Sci. 2014 Sep 6;10(9):990-6. doi: 10.7150/ijbs.9832. eCollection 2014.


The essential role of transient receptor potential vanilloid 1 in simvastatin-induced activation of endothelial nitric oxide synthase and angiogenesis.

Su KH, Lin SJ, Wei J, Lee KI, Zhao JF, Shyue SK, Lee TS.

Acta Physiol (Oxf). 2014 Nov;212(3):191-204. doi: 10.1111/apha.12378. Epub 2014 Sep 20.


14-3-3σ induces heat shock protein 70 expression in hepatocellular carcinoma.

Liu CC, Jan YJ, Ko BS, Wu YM, Liang SM, Chen SC, Lee YM, Liu TA, Chang TC, Wang J, Shyue SK, Sung LY, Liou JY.

BMC Cancer. 2014 Jun 12;14:425. doi: 10.1186/1471-2407-14-425.


Activation of soluble guanylyl cyclase prevents foam cell formation and atherosclerosis.

Tsou CY, Chen CY, Zhao JF, Su KH, Lee HT, Lin SJ, Shyue SK, Hsiao SH, Lee TS.

Acta Physiol (Oxf). 2014 Apr;210(4):799-810. doi: 10.1111/apha.12210. Epub 2013 Dec 27.


Role of glycine N-methyltransferase in experimental ulcerative colitis.

Chou WY, Zhao JF, Chen YM, Lee KI, Su KH, Shyue SK, Lee TS.

J Gastroenterol Hepatol. 2014 Mar;29(3):494-501. doi: 10.1111/jgh.12434.


Novel effect of paeonol on the formation of foam cells: promotion of LXRα-ABCA1-dependent cholesterol efflux in macrophages.

Zhao JF, Jim Leu SJ, Shyue SK, Su KH, Wei J, Lee TS.

Am J Chin Med. 2013;41(5):1079-96. doi: 10.1142/S0192415X13500730.


Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex.

Chen SF, Wu CH, Lee YM, Tam K, Tsai YC, Liou JY, Shyue SK.

J Biol Chem. 2013 Nov 15;288(46):33462-9. doi: 10.1074/jbc.M113.521799. Epub 2013 Oct 2.


Activation of transient receptor potential vanilloid 1 decreases endothelial nitric oxide synthase phosphorylation at Thr497 by protein phosphatase 2B-dependent dephosphorylation of protein kinase C.

Ching LC, Zhao JF, Su KH, Shyue SK, Hsu CP, Lu TM, Lin SJ, Lee TS.

Acta Physiol (Oxf). 2013 Oct;209(2):124-35. doi: 10.1111/apha.12157. Epub 2013 Aug 29.


Activation of TRPV1 prevents OxLDL-induced lipid accumulation and TNF-α-induced inflammation in macrophages: role of liver X receptor α.

Zhao JF, Ching LC, Kou YR, Lin SJ, Wei J, Shyue SK, Lee TS.

Mediators Inflamm. 2013;2013:925171. doi: 10.1155/2013/925171. Epub 2013 Jun 26.


Excess nitric oxide impairs LXR(α)-ABCA1-dependent cholesterol efflux in macrophage foam cells.

Zhao JF, Shyue SK, Lin SJ, Wei J, Lee TS.

J Cell Physiol. 2014 Jan;229(1):117-25. doi: 10.1002/jcp.24429.


Enhanced prostacyclin synthesis by adenoviral gene transfer reduced glial activation and ameliorated dopaminergic dysfunction in hemiparkinsonian rats.

Tsai MJ, Weng CF, Yu NC, Liou DY, Kuo FS, Huang MC, Huang WC, Tam K, Shyue SK, Cheng H.

Oxid Med Cell Longev. 2013;2013:649809. doi: 10.1155/2013/649809. Epub 2013 Apr 3.


Inflammatory role of AMP-activated protein kinase signaling in an experimental model of toxic smoke inhalation injury.

Perng DW, Chang TM, Wang JY, Lee CC, Lu SH, Shyue SK, Lee TS, Kou YR.

Crit Care Med. 2013 Jan;41(1):120-32. doi: 10.1097/CCM.0b013e318265f653.


Essential role of transient receptor potential vanilloid type 1 in evodiamine-mediated protection against atherosclerosis.

Wei J, Ching LC, Zhao JF, Shyue SK, Lee HF, Kou YR, Lee TS.

Acta Physiol (Oxf). 2013 Feb;207(2):299-307. doi: 10.1111/apha.12005. Epub 2012 Oct 1.


Molecular mechanism of curcumin on the suppression of cholesterol accumulation in macrophage foam cells and atherosclerosis.

Zhao JF, Ching LC, Huang YC, Chen CY, Chiang AN, Kou YR, Shyue SK, Lee TS.

Mol Nutr Food Res. 2012 May;56(5):691-701. doi: 10.1002/mnfr.201100735.


Implication of AMP-activated protein kinase in transient receptor potential vanilloid type 1-mediated activation of endothelial nitric oxide synthase.

Ching LC, Chen CY, Su KH, Hou HH, Shyue SK, Kou YR, Lee TS.

Mol Med. 2012;18:805-15. doi: 10.2119/molmed.2011.00461.


Prior exercise training alleviates the lung inflammation induced by subsequent exposure to environmental cigarette smoke.

Yu YB, Liao YW, Su KH, Chang TM, Shyue SK, Kou YR, Lee TS.

Acta Physiol (Oxf). 2012 Aug;205(4):532-40. doi: 10.1111/j.1748-1716.2012.02433.x. Epub 2012 Mar 26.


Deficiency of glycine N-methyltransferase aggravates atherosclerosis in apolipoprotein E-null mice.

Chen CY, Ching LC, Liao YJ, Yu YB, Tsou CY, Shyue SK, Chen YM, Lee TS.

Mol Med. 2012 Jul 18;18:744-52. doi: 10.2119/molmed.2011.00396.


Spatial and temporal distribution of Oct-4 and acetylated H4K5 in rabbit embryos.

Chen CH, Chang WF, Liu CC, Su HY, Shyue SK, Cheng WT, Chen YE, Wu SC, Du F, Sung LY, Xu J.

Reprod Biomed Online. 2012 Apr;24(4):433-42. doi: 10.1016/j.rbmo.2012.01.001. Epub 2012 Jan 10.


Cancer immunotherapy using a membrane-bound interleukin-12 with B7-1 transmembrane and cytoplasmic domains.

Pan WY, Lo CH, Chen CC, Wu PY, Roffler SR, Shyue SK, Tao MH.

Mol Ther. 2012 May;20(5):927-37. doi: 10.1038/mt.2012.10. Epub 2012 Feb 14.


N-terminal domain of soluble epoxide hydrolase negatively regulates the VEGF-mediated activation of endothelial nitric oxide synthase.

Hou HH, Hammock BD, Su KH, Morisseau C, Kou YR, Imaoka S, Oguro A, Shyue SK, Zhao JF, Lee TS.

Cardiovasc Res. 2012 Jan 1;93(1):120-9. doi: 10.1093/cvr/cvr267. Epub 2011 Nov 8.


AMP-activated protein kinase mediates erythropoietin-induced activation of endothelial nitric oxide synthase.

Su KH, Yu YB, Hou HH, Zhao JF, Kou YR, Cheng LC, Shyue SK, Lee TS.

J Cell Physiol. 2012 Aug;227(8):3053-62. doi: 10.1002/jcp.23052.


Increased expression of 14-3-3β promotes tumor progression and predicts extrahepatic metastasis and worse survival in hepatocellular carcinoma.

Liu TA, Jan YJ, Ko BS, Chen SC, Liang SM, Hung YL, Hsu C, Shen TL, Lee YM, Chen PF, Wang J, Shyue SK, Liou JY.

Am J Pathol. 2011 Dec;179(6):2698-708. doi: 10.1016/j.ajpath.2011.08.010. Epub 2011 Oct 1. Erratum in: Am J Pathol. 2012 Jan;180(1):429.

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