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The novel application of cordycepin in maintaining stem cell pluripotency and increasing iPS cell generation efficiency.

Wang CH, Chang CH, Lin TL, Fu RH, Huang YC, Chen SY, Shyu WC, Liu SP.

Sci Rep. 2020 Feb 10;10(1):2187. doi: 10.1038/s41598-020-59154-5.


Biotransformation Pathways and Metabolite Profiles of Oral [14C]Alisertib (MLN8237), an Investigational Aurora A Kinase Inhibitor, in Patients with Advanced Solid Tumors.

Pusalkar S, Zhou X, Li Y, Cohen L, Yang JJ, Balani SK, Xia C, Shyu WC, Lu C, Venkatakrishnan K, Chowdhury SK.

Drug Metab Dispos. 2020 Mar;48(3):217-229. doi: 10.1124/dmd.119.087338. Epub 2020 Jan 7.


Mechanisms of ischaemic neural progenitor proliferation: a regulatory role of the HIF-1α-CBX7 pathway.

Chiu HY, Lee HT, Lee KH, Zhao Y, Hsu CY, Shyu WC.

Neuropathol Appl Neurobiol. 2019 Oct 19. doi: 10.1111/nan.12585. [Epub ahead of print]


Role of FOXC1 in regulating APSCs self-renewal via STI-1/PrPC signaling.

Lee YH, Lee HT, Chen CL, Chang CH, Hsu CY, Shyu WC.

Theranostics. 2019 Aug 15;9(22):6443-6465. doi: 10.7150/thno.35619. eCollection 2019.


Antiapoptotic and mitochondrial biogenetic effects of exercise training on ovariectomized hypertensive rat hearts.

Lin YY, Hong Y, Yu SH, Wu XB, Shyu WC, Chen JS, Ting H, Yang AL, Lee SD.

J Appl Physiol (1985). 2019 Jun 1;126(6):1661-1672. doi: 10.1152/japplphysiol.00038.2019. Epub 2019 Apr 18.


Combined effects of 17β-estradiol and exercise training on cardiac apoptosis in ovariectomized rats.

Lin YY, Chen JS, Wu XB, Shyu WC, Chaunchaiyakul R, Zhao XL, Kuo CH, Cheng YJ, Yang AL, Lee SD.

PLoS One. 2018 Dec 20;13(12):e0208633. doi: 10.1371/journal.pone.0208633. eCollection 2018.


A Next-Generation Sequencing-Based Platform for Quantitative Detection of Hepatitis B Virus Pre-S Mutants in Plasma of Hepatocellular Carcinoma Patients.

Teng CF, Huang HY, Li TC, Shyu WC, Wu HC, Lin CY, Su IJ, Jeng LB.

Sci Rep. 2018 Oct 4;8(1):14816. doi: 10.1038/s41598-018-33051-4.


RGS4 deficit in prefrontal cortex contributes to the behaviors related to schizophrenia via system xc--mediated glutamatergic dysfunction in mice.

Huang MW, Lin YJ, Chang CW, Lei FJ, Ho EP, Liu RS, Shyu WC, Hsieh CH.

Theranostics. 2018 Sep 9;8(17):4781-4794. doi: 10.7150/thno.25189. eCollection 2018.


Predictors of Response to Autologous Dendritic Cell Therapy in Glioblastoma Multiforme.

Jan CI, Tsai WC, Harn HJ, Shyu WC, Liu MC, Lu HM, Chiu SC, Cho DY.

Front Immunol. 2018 May 29;9:727. doi: 10.3389/fimmu.2018.00727. eCollection 2018.


Role of Insulin-like Growth Factor 1 Receptor Signaling in Stem Cell Stemness and Therapeutic Efficacy.

Teng CF, Jeng LB, Shyu WC.

Cell Transplant. 2018 Sep;27(9):1313-1319. doi: 10.1177/0963689718779777. Epub 2018 Jun 8. Review.


Combination of fucoidan-based magnetic nanoparticles and immunomodulators enhances tumour-localized immunotherapy.

Chiang CS, Lin YJ, Lee R, Lai YH, Cheng HW, Hsieh CH, Shyu WC, Chen SY.

Nat Nanotechnol. 2018 Aug;13(8):746-754. doi: 10.1038/s41565-018-0146-7. Epub 2018 May 14.


Potential role of CBX7 in regulating pluripotency of adult human pluripotent-like olfactory stem cells in stroke model.

Fan JR, Lee HT, Lee W, Lin CH, Hsu CY, Hsieh CH, Shyu WC.

Cell Death Dis. 2018 May 1;9(5):502. doi: 10.1038/s41419-018-0519-8.


Increase of Meningitis Risk in Stroke Patients in Taiwan.

Wang CH, Lin TL, Muo CH, Lin CH, Huang YC, Fu RH, Shyu WC, Liu SP.

Front Neurol. 2018 Mar 2;9:116. doi: 10.3389/fneur.2018.00116. eCollection 2018.


Generation of novel induced pluripotent stem cell (iPSC) line from a 16-year-old sialidosis patient with NEU-1 gene mutation.

Liu SP, Hsu YH, Huang CY, Ho MC, Cheng YC, Wen CH, Lu HE, Tsai CH, Shyu WC, Hsieh PCH.

Stem Cell Res. 2018 Apr;28:39-43. doi: 10.1016/j.scr.2018.01.024. Epub 2018 Jan 31.


Neuroprotective Effects of Betulin in Pharmacological and Transgenic Caenorhabditis elegans Models of Parkinson's Disease.

Tsai CW, Tsai RT, Liu SP, Chen CS, Tsai MC, Chien SH, Hung HS, Lin SZ, Shyu WC, Fu RH.

Cell Transplant. 2017 Dec;26(12):1903-1918. doi: 10.1177/0963689717738785.


CYP Suppression in Human Hepatocytes by Monomethyl Auristatin E, the Payload in Brentuximab Vedotin (Adcetris®), is Associated with Microtubule Disruption.

Wolenski FS, Xia CQ, Ma B, Han TH, Shyu WC, Balani SK.

Eur J Drug Metab Pharmacokinet. 2018 Jun;43(3):347-354. doi: 10.1007/s13318-017-0455-5.


Human Olfactory Ensheathing Cell Transplantation Improves Motor Function in a Mouse Model of Type 3 Spinocerebellar Ataxia.

Hsieh J, Liu JW, Harn HJ, Hsueh KW, Rajamani K, Deng YC, Chia CM, Shyu WC, Lin SZ, Chiou TW.

Cell Transplant. 2017 Oct;26(10):1611-1621. doi: 10.1177/0963689717732578.


Direct Reprogramming of Human Suspension Cells into Mesodermal Cell Lineages via Combined Magnetic Targeting and Photothermal Stimulation by Magnetic Graphene Oxide Complexes.

Chiang MY, Lin YZ, Chang SJ, Shyu WC, Lu HE, Chen SY.

Small. 2017 Aug;13(32). doi: 10.1002/smll.201700703. Epub 2017 Jun 30.


Tumor Hypoxia Regulates Forkhead Box C1 to Promote Lung Cancer Progression.

Lin YJ, Shyu WC, Chang CW, Wang CC, Wu CP, Lee HT, Chen LJ, Hsieh CH.

Theranostics. 2017 Mar 5;7(5):1177-1191. doi: 10.7150/thno.17895. eCollection 2017.


A Crucial Role of CXCL14 for Promoting Regulatory T Cells Activation in Stroke.

Lee HT, Liu SP, Lin CH, Lee SW, Hsu CY, Sytwu HK, Hsieh CH, Shyu WC.

Theranostics. 2017 Feb 8;7(4):855-875. doi: 10.7150/thno.17558. eCollection 2017.


Pre-S2 Mutant-Induced Mammalian Target of Rapamycin Signal Pathways as Potential Therapeutic Targets for Hepatitis B Virus-Associated Hepatocellular Carcinoma.

Teng CF, Wu HC, Shyu WC, Jeng LB, Su IJ.

Cell Transplant. 2017 Mar 13;26(3):429-438. doi: 10.3727/096368916X694382. Epub 2017 Feb 14. Review.


The Coexistence of Hypertension and Ovariectomy Additively Increases Cardiac Apoptosis.

Lin YY, Cheng YJ, Hu J, Chu LX, Shyu WC, Kao CL, Lin TB, Kuo CH, Yang AL, Lee SD.

Int J Mol Sci. 2016 Dec 6;17(12). pii: E2036.


IGF1R+ Dental Pulp Stem Cells Enhanced Neuroplasticity in Hypoxia-Ischemia Model.

Chiu HY, Lin CH, Hsu CY, Yu J, Hsieh CH, Shyu WC.

Mol Neurobiol. 2017 Dec;54(10):8225-8241. doi: 10.1007/s12035-016-0210-y. Epub 2016 Dec 2.


HIF-1α triggers long-lasting glutamate excitotoxicity via system xc- in cerebral ischaemia-reperfusion.

Hsieh CH, Lin YJ, Chen WL, Huang YC, Chang CW, Cheng FC, Liu RS, Shyu WC.

J Pathol. 2017 Feb;241(3):337-349. doi: 10.1002/path.4838. Epub 2016 Dec 29.


Role of IGF1R(+) MSCs in modulating neuroplasticity via CXCR4 cross-interaction.

Lee HT, Chang HT, Lee S, Lin CH, Fan JR, Lin SZ, Hsu CY, Hsieh CH, Shyu WC.

Sci Rep. 2016 Sep 2;6:32595. doi: 10.1038/srep32595.


Antiapoptotic effect of exercise training on ovariectomized rat hearts.

Huang CY, Lin YY, Hsu CC, Cheng SM, Shyu WC, Ting H, Yang AL, Ho TJ, Lee SD.

J Appl Physiol (1985). 2016 Aug 1;121(2):457-65. doi: 10.1152/japplphysiol.01042.2015. Epub 2016 Jun 23.


Synergistic Combination of Multistage Magnetic Guidance and Optimized Ligand Density in Targeting a Nanoplatform for Enhanced Cancer Therapy.

Chiang CS, Shen YS, Liu JJ, Shyu WC, Chen SY.

Adv Healthc Mater. 2016 Aug;5(16):2131-41. doi: 10.1002/adhm.201600479. Epub 2016 Jun 23.


Electrospun Polyacrylonitrile-Based Nanofibers Maintain Embryonic Stem Cell Stemness via TGF-Beta Signaling.

Liu SP, Lin CH, Lin SJ, Fu RH, Huang YC, Chen SY, Lin SZ, Hsu CY, Shyu WC.

J Biomed Nanotechnol. 2016 Apr;12(4):732-42.


Anti-apoptotic and Pro-survival Effects of Food Restriction on High-Fat Diet-Induced Obese Hearts.

Lin YY, Hsieh PS, Cheng YJ, Cheng SM, Chen CJ, Huang CY, Kuo CH, Kao CL, Shyu WC, Lee SD.

Cardiovasc Toxicol. 2017 Apr;17(2):163-174. doi: 10.1007/s12012-016-9370-2.


High mobility group box 1-induced epithelial mesenchymal transition in human airway epithelial cells.

Chen YC, Statt S, Wu R, Chang HT, Liao JW, Wang CN, Shyu WC, Lee CC.

Sci Rep. 2016 Jan 7;6:18815. doi: 10.1038/srep18815.


RANTES mediates kidney ischemia reperfusion injury through a possible role of HIF-1α and LncRNA PRINS.

Yu TM, Palanisamy K, Sun KT, Day YJ, Shu KH, Wang IK, Shyu WC, Chen P, Chen YL, Li CY.

Sci Rep. 2016 Jan 4;6:18424. doi: 10.1038/srep18424.


Plasma L5 levels are elevated in ischemic stroke patients and enhance platelet aggregation.

Shen MY, Chen FY, Hsu JF, Fu RH, Chang CM, Chang CT, Liu CH, Wu JR, Lee AS, Chan HC, Sheu JR, Lin SZ, Shyu WC, Sawamura T, Chang KC, Hsu CY, Chen CH.

Blood. 2016 Mar 10;127(10):1336-45. doi: 10.1182/blood-2015-05-646117. Epub 2015 Dec 17.


Multitheragnostic Multi-GNRs Crystal-Seeded Magnetic Nanoseaurchin for Enhanced In Vivo Mesenchymal-Stem-Cell Homing, Multimodal Imaging, and Stroke Therapy.

Chen PJ, Kang YD, Lin CH, Chen SY, Hsieh CH, Chen YY, Chiang CW, Lee W, Hsu CY, Liao LD, Fan CT, Li ML, Shyu WC.

Adv Mater. 2015 Nov 4;27(41):6488-95. doi: 10.1002/adma.201502784. Epub 2015 Sep 25.


Glucose Transporter Type 4 Redistribution on the Membrane Induced by Insulin through Akt in Hydrocortisone Treatment in Rat Skeletal Muscles.

Chen CM, Chiu L, Chen HC, Cheng CY, Shyu WC, Chou CW, Lu CY, Lin CT.

Chin J Physiol. 2015 Oct 31;58(5):294-301. doi: 10.4077/CJP.2015.BAD314.


Cardiac Fas-Dependent and Mitochondria-Dependent Apoptotic Pathways in a Transgenic Mouse Model of Huntington's Disease.

Wu BT, Chiang MC, Tasi CY, Kuo CH, Shyu WC, Kao CL, Huang CY, Lee SD.

Cardiovasc Toxicol. 2016 Apr;16(2):111-21. doi: 10.1007/s12012-015-9318-y.


Sambucus williamsii induced embryonic stem cells differentiated into neurons.

Liu SP, Hsu CY, Fu RH, Huang YC, Chen SY, Lin SZ, Shyu WC.

Biomedicine (Taipei). 2015;5(1):3. doi: 10.7603/s40681-015-0003-z. Epub 2015 Feb 2.


Differentiation of embryonic stem cells into cardiomyocytes used to investigate the cardioprotective effect of salvianolic acid B through BNIP3 involved pathway.

Huang CY, Chen SY, Fu RH, Huang YC, Chen SY, Shyu WC, Lin SZ, Liu SP.

Cell Transplant. 2015;24(3):561-71. doi: 10.3727/096368915X686995. Epub 2015 Feb 4.


Irisflorentin modifies properties of mouse bone marrow-derived dendritic cells and reduces the allergic contact hypersensitivity responses.

Fu RH, Tsai CW, Tsai RT, Liu SP, Chan TM, Ho YC, Lin HL, Chen YM, Hung HS, Chiu SC, Tsai CH, Wang YC, Shyu WC, Lin SZ.

Cell Transplant. 2015;24(3):573-88. doi: 10.3727/096368915X687002. Epub 2015 Feb 4.


The potential roles of EZH2 in regenerative medicine.

Chou RH, Chiu L, Yu YL, Shyu WC.

Cell Transplant. 2015;24(3):313-7. doi: 10.3727/096368915X686823. Epub 2015 Feb 2. Review.


Human umbilical cord mesenchymal stem cells: a new era for stem cell therapy.

Ding DC, Chang YH, Shyu WC, Lin SZ.

Cell Transplant. 2015;24(3):339-47. doi: 10.3727/096368915X686841. Epub 2015 Jan 23. Review.


Growth rate analysis and efficient experimental design for tumor xenograft studies.

Hather G, Liu R, Bandi S, Mettetal J, Manfredi M, Shyu WC, Donelan J, Chakravarty A.

Cancer Inform. 2014 Dec 9;13(Suppl 4):65-72. doi: 10.4137/CIN.S13974. eCollection 2014. Review.


PACAP38/PAC1 signaling induces bone marrow-derived cells homing to ischemic brain.

Lin CH, Chiu L, Lee HT, Chiang CW, Liu SP, Hsu YH, Lin SZ, Hsu CY, Hsieh CH, Shyu WC.

Stem Cells. 2015 Apr;33(4):1153-72. doi: 10.1002/stem.1915.


Livin contributes to tumor hypoxia-induced resistance to cytotoxic therapies in glioblastoma multiforme.

Hsieh CH, Lin YJ, Wu CP, Lee HT, Shyu WC, Wang CC.

Clin Cancer Res. 2015 Jan 15;21(2):460-70. doi: 10.1158/1078-0432.CCR-14-0618. Epub 2014 Nov 4.


Dose schedule optimization and the pharmacokinetic driver of neutropenia.

Patel M, Palani S, Chakravarty A, Yang J, Shyu WC, Mettetal JT.

PLoS One. 2014 Oct 31;9(10):e109892. doi: 10.1371/journal.pone.0109892. eCollection 2014.


Antagonistic interaction between cordyceps sinensis and exercise on protection in fulminant hepatic failure.

Cheng YJ, Shyu WC, Teng YH, Lan YH, Lee SD.

Am J Chin Med. 2014;42(5):1199-213. doi: 10.1142/S0192415X1450075X.


Translational exposure-efficacy modeling to optimize the dose and schedule of taxanes combined with the investigational Aurora A kinase inhibitor MLN8237 (alisertib).

Huck JJ, Zhang M, Mettetal J, Chakravarty A, Venkatakrishnan K, Zhou X, Kleinfield R, Hyer ML, Kannan K, Shinde V, Dorner A, Manfredi MG, Shyu WC, Ecsedy JA.

Mol Cancer Ther. 2014 Sep;13(9):2170-83. doi: 10.1158/1535-7163.MCT-14-0027. Epub 2014 Jun 30.


Down-regulation of MIF by NFκB under hypoxia accelerated neuronal loss during stroke.

Zhang S, Zis O, Ly PT, Wu Y, Zhang S, Zhang M, Cai F, Bucala R, Shyu WC, Song W.

FASEB J. 2014 Oct;28(10):4394-407. doi: 10.1096/fj.14-253625. Epub 2014 Jun 26.


Salvianolic acid B maintained stem cell pluripotency and increased proliferation rate by activating Jak2-Stat3 combined with EGFR-Erk1/2 pathways.

Liu CH, Shyu WC, Fu RH, Huang SJ, Chang CH, Huang YC, Chen SY, Lin SZ, Liu SP.

Cell Transplant. 2014;23(4-5):657-68. doi: 10.3727/096368914X678391.


Dryocrassin suppresses immunostimulatory function of dendritic cells and prolongs skin allograft survival.

Fu RH, Wang YC, Liu SP, Shih TR, Lin HL, Chen YM, Tsai RT, Tsai CH, Shyu WC, Lin SZ.

Cell Transplant. 2014;23(4-5):641-56. doi: 10.3727/096368914X678373. Erratum in: Cell Transplant. 2018 Jan 1;:963689718764947.


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