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Human PAH is characterized by a pattern of lipid-related insulin resistance.

Hemnes AR, Luther JM, Rhodes CJ, Burgess JP, Carlson J, Fan R, Fessel JP, Fortune N, Gerszten RE, Halliday SJ, Hekmat R, Howard L, Newman JH, Niswender KD, Pugh ME, Robbins IM, Sheng Q, Shibao CA, Shyr Y, Sumner S, Talati M, Wharton J, Wilkins MR, Ye F, Yu C, West J, Brittain EL.

JCI Insight. 2019 Jan 10;4(1). pii: 123611. doi: 10.1172/jci.insight.123611. [Epub ahead of print]


beRBP: binding estimation for human RNA-binding proteins.

Yu H, Wang J, Sheng Q, Liu Q, Shyr Y.

Nucleic Acids Res. 2018 Dec 27. doi: 10.1093/nar/gky1294. [Epub ahead of print]


Periampullary Gangliocytic Paraganglioma.

Chiang CS, Shyr BU, Chen SC, Shyr YM, Wang SE.

J Gastrointest Surg. 2018 Dec 18. doi: 10.1007/s11605-018-4019-z. [Epub ahead of print]


Learning curves for robotic pancreatic surgery-from distal pancreatectomy to pancreaticoduodenectomy.

Shyr BU, Chen SC, Shyr YM, Wang SE.

Medicine (Baltimore). 2018 Nov;97(45):e13000. doi: 10.1097/MD.0000000000013000.


Quantitative assessment of cell population diversity in single-cell landscapes.

Liu Q, Herring CA, Sheng Q, Ping J, Simmons AJ, Chen B, Banerjee A, Li W, Gu G, Coffey RJ, Shyr Y, Lau KS.

PLoS Biol. 2018 Oct 22;16(10):e2006687. doi: 10.1371/journal.pbio.2006687. eCollection 2018 Oct.


LNK deficiency promotes acute aortic dissection and rupture.

Laroumanie F, Korneva A, Bersi MR, Alexander MR, Xiao L, Zhong X, Van Beusecum JP, Chen Y, Saleh MA, McMaster WG, Gavulic KA, Dale BL, Zhao S, Guo Y, Shyr Y, Perrien DS, Cox NJ, Curci JA, Humphrey JD, Madhur MS.

JCI Insight. 2018 Oct 18;3(20). pii: 122558. doi: 10.1172/jci.insight.122558. [Epub ahead of print]


HACER: an atlas of human active enhancers to interpret regulatory variants.

Wang J, Dai X, Berry LD, Cogan JD, Liu Q, Shyr Y.

Nucleic Acids Res. 2019 Jan 8;47(D1):D106-D112. doi: 10.1093/nar/gky864.


First-line Chemotherapy Responsiveness and Patterns of Metastatic Spread Identify Clinical Syndromes Present Within Advanced KRAS Mutant Non-Small-cell Lung Cancer With Different Prognostic Significance.

Iams WT, Yu H, Shyr Y, Patil T, Horn L, McCoach C, Kelly K, Doebele RC, Camidge DR.

Clin Lung Cancer. 2018 Nov;19(6):531-543. doi: 10.1016/j.cllc.2018.08.011. Epub 2018 Aug 22.


Nascent RNA sequencing analysis provides insights into enhancer-mediated gene regulation.

Wang J, Zhao Y, Zhou X, Hiebert SW, Liu Q, Shyr Y.

BMC Genomics. 2018 Aug 23;19(1):633. doi: 10.1186/s12864-018-5016-z.


Bioinformatic analysis of endogenous and exogenous small RNAs on lipoproteins.

Allen RM, Zhao S, Ramirez Solano MA, Zhu W, Michell DL, Wang Y, Shyr Y, Sethupathy P, Linton MF, Graf GA, Sheng Q, Vickers KC.

J Extracell Vesicles. 2018 Aug 13;7(1):1506198. doi: 10.1080/20013078.2018.1506198. eCollection 2018.


Comparison between robotic and open pancreaticoduodenectomy with modified Blumgart pancreaticojejunostomy: A propensity score-matched study.

Wang SE, Shyr BU, Chen SC, Shyr YM.

Surgery. 2018 Dec;164(6):1162-1167. doi: 10.1016/j.surg.2018.06.031. Epub 2018 Aug 6.


Genomic Profiling of T-Cell Neoplasms Reveals Frequent JAK1 and JAK3 Mutations With Clonal Evasion From Targeted Therapies.

Greenplate A, Wang K, Tripathi RM, Palma N, Ali SM, Stephens PJ, Miller VA, Shyr Y, Guo Y, Reddy NM, Kozhaya L, Unutmaz D, Chen X, Irish JM, Davé UP.

JCO Precis Oncol. 2018;2018. doi: 10.1200/PO.17.00019. Epub 2018 Feb 13.


Clinicopathological differences in signet ring cell adenocarcinoma between early and advanced gastric cancer.

Kao YC, Fang WL, Wang RF, Li AF, Yang MH, Wu CW, Shyr YM, Huang KH.

Gastric Cancer. 2018 Aug 1. doi: 10.1007/s10120-018-0860-8. [Epub ahead of print]


RnaSeqSampleSize: real data based sample size estimation for RNA sequencing.

Zhao S, Li CI, Guo Y, Sheng Q, Shyr Y.

BMC Bioinformatics. 2018 May 30;19(1):191. doi: 10.1186/s12859-018-2191-5.


Correlation between HGF/c-Met and Notch1 signaling pathways in human gastric cancer cells.

Huang KH, Sung IC, Fang WL, Chi CW, Yeh TS, Lee HC, Yin PH, Li AF, Wu CW, Shyr YM, Yang MH.

Oncol Rep. 2018 Jul;40(1):294-302. doi: 10.3892/or.2018.6447. Epub 2018 May 16.


Robotic distal pancreatectomy: Comparison of spleen-preservation by the Warshaw technique and splenectomy.

Wang SE, Shyr BU, Chen SC, Shyr YM.

Int J Med Robot. 2018 Oct;14(5):e1922. doi: 10.1002/rcs.1922. Epub 2018 May 10.


Myeloid-derived macrophages and secreted HSP90α induce pancreatic ductal adenocarcinoma development.

Chen CC, Chen LL, Li CP, Hsu YT, Jiang SS, Fan CS, Chua KV, Huang SX, Shyr YM, Chen LT, Huang TS.

Oncoimmunology. 2018 Feb 1;7(5):e1424612. doi: 10.1080/2162402X.2018.1424612. eCollection 2018.


Directed solutions to address differences in access to liver transplantation.

Ye F, Sheng Q, Feurer ID, Zhao Z, Fan R, Teng J, Ping J, Rega SA, Hanto DW, Shyr Y, Karp SJ.

Am J Transplant. 2018 Nov;18(11):2670-2678. doi: 10.1111/ajt.14889. Epub 2018 May 24.


Treatment options in idiopathic subglottic stenosis: protocol for a prospective international multicentre pragmatic trial.

Gelbard A, Shyr Y, Berry L, Hillel AT, Ekbom DC, Edell ES, Kasperbauer JL, Lott DG, Donovan DT, Garrett CG, Sandhu G, Daniero JJ, Netterville JL, Schindler JS, Smith ME, Bryson PC, Lorenz RR, Francis DO.

BMJ Open. 2018 Apr 10;8(4):e022243. doi: 10.1136/bmjopen-2018-022243.


Caspase-3, a key apoptotic protein, as a prognostic marker in gastric cancer after curative surgery.

Huang KH, Fang WL, Li AF, Liang PH, Wu CW, Shyr YM, Yang MH.

Int J Surg. 2018 Apr;52:258-263. doi: 10.1016/j.ijsu.2018.02.055. Epub 2018 Mar 1.


Feasibility trial for primary stroke prevention in children with sickle cell anemia in Nigeria (SPIN trial).

Galadanci NA, Umar Abdullahi S, Vance LD, Musa Tabari A, Ali S, Belonwu R, Salihu A, Amal Galadanci A, Wudil Jibir B, Bello-Manga H, Neville K, Kirkham FJ, Shyr Y, Phillips S, Covert BV, Kassim AA, Jordan LC, Aliyu MH, DeBaun MR.

Am J Hematol. 2018 Mar;93(3):E83. doi: 10.1002/ajh.25012. Epub 2018 Feb 2. No abstract available.


Dynamics of Zebrafish Heart Regeneration Using an HPLC-ESI-MS/MS Approach.

Ma D, Tu C, Sheng Q, Yang Y, Kan Z, Guo Y, Shyr Y, Scott IC, Lou X.

J Proteome Res. 2018 Mar 2;17(3):1300-1308. doi: 10.1021/acs.jproteome.7b00915. Epub 2018 Feb 5.


Robotic assisted excision of type I choledochal cyst with Roux-en-y hepaticojejunostomy reconstruction.

Wang SE, Chen SC, Shyr BU, Shyr YM.

Hepatobiliary Surg Nutr. 2017 Dec;6(6):397-400. doi: 10.21037/hbsn.2017.01.15.


Toxicities, safeties and clinical response of dacarbazine-based chemotherapy on neuroendocrine tumors in Taiwan population.

Chiu HY, Lin LY, Chou WC, Fang WL, Shyr YM, Yeh YC, Mu-Hsin Chang P, Chen MH, Hung YP, Chao Y, Chien SH, Chen MH.

J Chin Med Assoc. 2018 May;81(5):423-428. doi: 10.1016/j.jcma.2017.08.020. Epub 2017 Dec 26.


The Impact of Smoking and TP53 Mutations in Lung Adenocarcinoma Patients with Targetable Mutations-The Lung Cancer Mutation Consortium (LCMC2).

Aisner DL, Sholl LM, Berry LD, Rossi MR, Chen H, Fujimoto J, Moreira AL, Ramalingam SS, Villaruz LC, Otterson GA, Haura E, Politi K, Glisson B, Cetnar J, Garon EB, Schiller J, Waqar SN, Sequist LV, Brahmer J, Shyr Y, Kugler K, Wistuba II, Johnson BE, Minna JD, Kris MG, Bunn PA, Kwiatkowski DJ; LCMC2 investigators.

Clin Cancer Res. 2018 Mar 1;24(5):1038-1047. doi: 10.1158/1078-0432.CCR-17-2289. Epub 2017 Dec 7.


Shanghai Score: A Prognostic and Adjuvant Treatment-evaluating System Constructed for Chinese Patients with Hepatocellular Carcinoma after Curative Resection.

Sun HC, Xie L, Yang XR, Li W, Yu J, Zhu XD, Xia Y, Zhang T, Xu Y, Hu B, Du LP, Zeng LY, Ouyang J, Zhang W, Song TQ, Li Q, Shi YH, Zhou J, Qiu SJ, Liu Q, Li YX, Tang ZY, Shyr Y, Shen F, Fan J.

Chin Med J (Engl). 2017 Nov 20;130(22):2650-2660. doi: 10.4103/0366-6999.218019. Erratum in: Chin Med J (Engl). 2017 Dec 20;130(24):3020.


Comparative study of the 7th and 8th AJCC editions for gastric cancer patients after curative surgery.

Fang WL, Huang KH, Chen MH, Liu CA, Hung YP, Chao Y, Tai LC, Lo SS, Li AF, Wu CW, Shyr YM.

PLoS One. 2017 Nov 13;12(11):e0187626. doi: 10.1371/journal.pone.0187626. eCollection 2017.


Endocan expression is correlated with poor progression-free survival in patients with pancreatic neuroendocrine tumors.

Lin LY, Yeh YC, Chu CH, Won JGS, Shyr YM, Chao Y, Li CP, Wang SE, Chen MH.

Medicine (Baltimore). 2017 Oct;96(41):e8262. doi: 10.1097/MD.0000000000008262.


The discrepancy among single nucleotide variants detected by DNA and RNA high throughput sequencing data.

Guo Y, Zhao S, Sheng Q, Samuels DC, Shyr Y.

BMC Genomics. 2017 Oct 3;18(Suppl 6):690. doi: 10.1186/s12864-017-4022-x.


Longitudinal Cell-Free DNA Analysis in Patients with Small Cell Lung Cancer Reveals Dynamic Insights into Treatment Efficacy and Disease Relapse.

Almodovar K, Iams WT, Meador CB, Zhao Z, York S, Horn L, Yan Y, Hernandez J, Chen H, Shyr Y, Lim LP, Raymond CK, Lovly CM.

J Thorac Oncol. 2018 Jan;13(1):112-123. doi: 10.1016/j.jtho.2017.09.1951. Epub 2017 Sep 23.


A pilot study of lymph node mapping with indocyanine green in robotic gastrectomy for gastric cancer.

Lan YT, Huang KH, Chen PH, Liu CA, Lo SS, Wu CW, Shyr YM, Fang WL.

SAGE Open Med. 2017 Aug 21;5:2050312117727444. doi: 10.1177/2050312117727444. eCollection 2017.


Corrigendum to "Comparative Study of Exome Copy Number Variation Estimation Tools Using Array Comparative Genomic Hybridization as Control".

Guo Y, Sheng Q, Samuels DC, Lehmann B, Bauer JA, Pietenpol J, Shyr Y.

Biomed Res Int. 2017;2017:7409598. doi: 10.1155/2017/7409598. Epub 2017 Jul 18.


Effects of Chinese medicinal herbs on expression of brain-derived Neurotrophic factor (BDNF) and its interaction with human breast cancer MDA-MB-231 cells and endothelial HUVECs.

Chiu JH, Chen FP, Tsai YF, Lin MT, Tseng LM, Shyr YM.

BMC Complement Altern Med. 2017 Aug 12;17(1):401. doi: 10.1186/s12906-017-1909-7.


Genomic profiling of ER+ breast cancers after short-term estrogen suppression reveals alterations associated with endocrine resistance.

Giltnane JM, Hutchinson KE, Stricker TP, Formisano L, Young CD, Estrada MV, Nixon MJ, Du L, Sanchez V, Ericsson PG, Kuba MG, Sanders ME, Mu XJ, Van Allen EM, Wagle N, Mayer IA, Abramson V, Gόmez H, Rizzo M, Toy W, Chandarlapaty S, Mayer EL, Christiansen J, Murphy D, Fitzgerald K, Wang K, Ross JS, Miller VA, Stephens PJ, Yelensky R, Garraway L, Shyr Y, Meszoely I, Balko JM, Arteaga CL.

Sci Transl Med. 2017 Aug 9;9(402). pii: eaai7993. doi: 10.1126/scitranslmed.aai7993.


Estimating relative mitochondrial DNA copy number using high throughput sequencing data.

Zhang P, Lehmann BD, Samuels DC, Zhao S, Zhao YY, Shyr Y, Guo Y.

Genomics. 2017 Oct;109(5-6):457-462. doi: 10.1016/j.ygeno.2017.07.002. Epub 2017 Jul 19.


Comparison of the surgical outcomes of minimally invasive and open surgery for octogenarian and older compared to younger gastric cancer patients: a retrospective cohort study.

Liu CA, Huang KH, Chen MH, Lo SS, Li AF, Wu CW, Shyr YM, Fang WL.

BMC Surg. 2017 Jun 12;17(1):68. doi: 10.1186/s12893-017-0265-3.


Power and sample size calculations for high-throughput sequencing-based experiments.

Li CI, Samuels DC, Zhao YY, Shyr Y, Guo Y.

Brief Bioinform. 2018 Nov 27;19(6):1247-1255. doi: 10.1093/bib/bbx061.


Brain-derived neurotrophic factor (BDNF) -TrKB signaling modulates cancer-endothelial cells interaction and affects the outcomes of triple negative breast cancer.

Tsai YF, Tseng LM, Hsu CY, Yang MH, Chiu JH, Shyr YM.

PLoS One. 2017 Jun 12;12(6):e0178173. doi: 10.1371/journal.pone.0178173. eCollection 2017.


Multisite external validation of a risk prediction model for the diagnosis of blood stream infections in febrile pediatric oncology patients without severe neutropenia.

Esbenshade AJ, Zhao Z, Aftandilian C, Saab R, Wattier RL, Beauchemin M, Miller TP, Wilkes JJ, Kelly MJ, Fernbach A, Jeng M, Schwartz CL, Dvorak CC, Shyr Y, Moons KGM, Sulis ML, Friedman DL.

Cancer. 2017 Oct 1;123(19):3781-3790. doi: 10.1002/cncr.30792. Epub 2017 May 23. Erratum in: Cancer. 2018 Apr 15;124(8):1841-1844.


Role of estrogen receptors and Src signaling in mechanisms of bone metastasis by estrogen receptor positive breast cancers.

Chiu JH, Wen CS, Wang JY, Hsu CY, Tsai YF, Hung SC, Tseng LM, Shyr YM.

J Transl Med. 2017 May 4;15(1):97. doi: 10.1186/s12967-017-1192-x.


Identification of active miRNA promoters from nuclear run-on RNA sequencing.

Liu Q, Wang J, Zhao Y, Li CI, Stengel KR, Acharya P, Johnston G, Hiebert SW, Shyr Y.

Nucleic Acids Res. 2017 Jul 27;45(13):e121. doi: 10.1093/nar/gkx318.


Feasibility trial for primary stroke prevention in children with sickle cell anemia in Nigeria (SPIN trial).

Galadanci NA, Umar Abdullahi S, Vance LD, Musa Tabari A, Ali S, Belonwu R, Salihu A, Amal Galadanci A, Wudil Jibir B, Bello-Manga H, Neville K, Kirkham FJ, Shyr Y, Phillips S, Covert BV, Kassim AA, Jordan LC, Aliyu MH, DeBaun MR.

Am J Hematol. 2017 Aug;92(8):780-788. doi: 10.1002/ajh.24770. Epub 2017 Jun 15. Erratum in: Am J Hematol. 2018 Mar;93(3):E83.


StrandScript: evaluation of Illumina genotyping array design and strand correction.

Wang J, Samuels DC, Shyr Y, Guo Y.

Bioinformatics. 2017 Aug 1;33(15):2399-2401. doi: 10.1093/bioinformatics/btx186.


Metastatic polyp of the gallbladder from renal cell carcinoma.

Shyr BU, Chen SC, Shyr YM, Lee RC, Wang SE.

BMC Cancer. 2017 Apr 4;17(1):244. doi: 10.1186/s12885-017-3243-3.


Strategies for processing and quality control of Illumina genotyping arrays.

Zhao S, Jing W, Samuels DC, Sheng Q, Shyr Y, Guo Y.

Brief Bioinform. 2018 Sep 28;19(5):765-775. doi: 10.1093/bib/bbx012.


IGFBP3 Modulates Lung Tumorigenesis and Cell Growth through IGF1 Signaling.

Wang YA, Sun Y, Palmer J, Solomides C, Huang LC, Shyr Y, Dicker AP, Lu B.

Mol Cancer Res. 2017 Jul;15(7):896-904. doi: 10.1158/1541-7786.MCR-16-0390. Epub 2017 Mar 22.


Acute macular edema and peripapillary soft exudate after pancreas transplantation with accelerated progression of diabetic retinopathy.

Tsai FY, Lau LI, Li AF, Chen SJ, Wang SE, Lee FL, Liu CJ, Shyr YM.

J Chin Med Assoc. 2017 May;80(5):319-325. doi: 10.1016/j.jcma.2017.01.004. Epub 2017 Mar 18.


A comparison of the molecular subtypes of triple-negative breast cancer among non-Asian and Taiwanese women.

Tseng LM, Chiu JH, Liu CY, Tsai YF, Wang YL, Yang CW, Shyr YM.

Breast Cancer Res Treat. 2017 Jun;163(2):241-254. doi: 10.1007/s10549-017-4195-7. Epub 2017 Mar 15.


Integrated expression analysis identifies transcription networks in mouse and human gastric neoplasia.

Chen Z, Soutto M, Rahman B, Fazili MW, Peng D, Blanca Piazuelo M, Chen H, Kay Washington M, Shyr Y, El-Rifai W.

Genes Chromosomes Cancer. 2017 Jul;56(7):535-547. doi: 10.1002/gcc.22456. Epub 2017 Apr 4.


A Randomized Phase II Neoadjuvant Study of Cisplatin, Paclitaxel With or Without Everolimus in Patients with Stage II/III Triple-Negative Breast Cancer (TNBC): Responses and Long-term Outcome Correlated with Increased Frequency of DNA Damage Response Gene Mutations, TNBC Subtype, AR Status, and Ki67.

Jovanović B, Mayer IA, Mayer EL, Abramson VG, Bardia A, Sanders ME, Kuba MG, Estrada MV, Beeler JS, Shaver TM, Johnson KC, Sanchez V, Rosenbluth JM, Dillon PM, Forero-Torres A, Chang JC, Meszoely IM, Grau AM, Lehmann BD, Shyr Y, Sheng Q, Chen SC, Arteaga CL, Pietenpol JA.

Clin Cancer Res. 2017 Aug 1;23(15):4035-4045. doi: 10.1158/1078-0432.CCR-16-3055. Epub 2017 Mar 7.

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