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Items: 1 to 50 of 84

1.

Pharmacological chaperones of ATP-sensitive potassium channels: Mechanistic insight from cryoEM structures.

Martin GM, Sung MW, Shyng SL.

Mol Cell Endocrinol. 2020 Feb 15;502:110667. doi: 10.1016/j.mce.2019.110667. Epub 2019 Dec 9. Review.

PMID:
31821855
2.

Ion Channels of the Islets in Type 2 Diabetes.

Jacobson DA, Shyng SL.

J Mol Biol. 2019 Aug 30. pii: S0022-2836(19)30523-6. doi: 10.1016/j.jmb.2019.08.014. [Epub ahead of print] Review.

PMID:
31473158
3.

Novel dominant KATP channel mutations in infants with congenital hyperinsulinism: Validation by in vitro expression studies and in vivo carrier phenotyping.

Boodhansingh KE, Kandasamy B, Mitteer L, Givler S, De Leon DD, Shyng SL, Ganguly A, Stanley CA.

Am J Med Genet A. 2019 Nov;179(11):2214-2227. doi: 10.1002/ajmg.a.61335. Epub 2019 Aug 28.

4.

Mechanism of pharmacochaperoning in a mammalian KATP channel revealed by cryo-EM.

Martin GM, Sung MW, Yang Z, Innes LM, Kandasamy B, David LL, Yoshioka C, Shyng SL.

Elife. 2019 Jul 25;8. pii: e46417. doi: 10.7554/eLife.46417.

5.

Leptin-induced Trafficking of KATP Channels: A Mechanism to Regulate Pancreatic β-cell Excitability and Insulin Secretion.

Cochrane V, Shyng SL.

Int J Mol Sci. 2019 May 30;20(11). pii: E2660. doi: 10.3390/ijms20112660. Review.

6.

Functional characterization of activating mutations in the sulfonylurea receptor 1 (ABCC8) causing neonatal diabetes mellitus in Asian Indian children.

Balamurugan K, Kavitha B, Yang Z, Mohan V, Radha V, Shyng SL.

Pediatr Diabetes. 2019 Jun;20(4):397-407. doi: 10.1111/pedi.12843. Epub 2019 Apr 2.

PMID:
30861254
7.

Outbreak of Escherichia coli O157:H7 Infections Linked to Aged Raw Milk Gouda Cheese, Canada, 2013.

Currie A, Galanis E, Chacon PA, Murray R, Wilcott L, Kirkby P, Honish L, Franklin K, Farber J, Parker R, Shyng S, Sharma D, Tschetter L, Hoang L, Chui L, Pacagnella A, Wong J, Pritchard J, Kerr A, Taylor M, Mah V, Flint J; Investigative Team.

J Food Prot. 2018 Feb;81(2):325-331. doi: 10.4315/0362-028X.JFP-17-283.

PMID:
29369688
8.

Methods for Characterizing Disease-Associated ATP-Sensitive Potassium Channel Mutations.

Kandasamy B, Shyng SL.

Methods Mol Biol. 2018;1684:85-104. doi: 10.1007/978-1-4939-7362-0_8.

PMID:
29058186
9.

Probing Subunits Interactions in KATP Channels Using Photo-Crosslinking via Genetically Encoded p-Azido-L-phenylalanine.

Devaraneni P, Rex EA, Shyng SL.

Methods Mol Biol. 2018;1684:51-61. doi: 10.1007/978-1-4939-7362-0_5.

PMID:
29058183
10.

Anti-diabetic drug binding site in a mammalian KATP channel revealed by Cryo-EM.

Martin GM, Kandasamy B, DiMaio F, Yoshioka C, Shyng SL.

Elife. 2017 Oct 24;6. pii: e31054. doi: 10.7554/eLife.31054.

11.

NMDA receptors mediate leptin signaling and regulate potassium channel trafficking in pancreatic β-cells.

Wu Y, Fortin DA, Cochrane VA, Chen PC, Shyng SL.

J Biol Chem. 2017 Sep 15;292(37):15512-15524. doi: 10.1074/jbc.M117.802249. Epub 2017 Aug 2.

12.

Targeting the Gut Microbiota-FXR Signaling Axis for Glycemic Control: Does a Dietary Supplement Work Magic?

Shyng SL.

Diabetes. 2017 Mar;66(3):571-573. doi: 10.2337/dbi16-0066. No abstract available.

13.

Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating.

Martin GM, Yoshioka C, Rex EA, Fay JF, Xie Q, Whorton MR, Chen JZ, Shyng SL.

Elife. 2017 Jan 16;6. pii: e24149. doi: 10.7554/eLife.24149.

14.

Pharmacological Correction of Trafficking Defects in ATP-sensitive Potassium Channels Caused by Sulfonylurea Receptor 1 Mutations.

Martin GM, Rex EA, Devaraneni P, Denton JS, Boodhansingh KE, DeLeon DD, Stanley CA, Shyng SL.

J Biol Chem. 2016 Oct 14;291(42):21971-21983. Epub 2016 Aug 29.

15.

Concerted Trafficking Regulation of Kv2.1 and KATP Channels by Leptin in Pancreatic β-Cells.

Wu Y, Shyng SL, Chen PC.

J Biol Chem. 2015 Dec 11;290(50):29676-90. doi: 10.1074/jbc.M115.670877. Epub 2015 Oct 9.

16.

Multi-Province Listeriosis Outbreak Linked to Contaminated Deli Meat Consumed Primarily in Institutional Settings, Canada, 2008.

Currie A, Farber JM, Nadon C, Sharma D, Whitfield Y, Gaulin C, Galanis E, Bekal S, Flint J, Tschetter L, Pagotto F, Lee B, Jamieson F, Badiani T, MacDonald D, Ellis A, May-Hadford J, McCormick R, Savelli C, Middleton D, Allen V, Tremblay FW, MacDougall L, Hoang L, Shyng S, Everett D, Chui L, Louie M, Bangura H, Levett PN, Wilkinson K, Wylie J, Reid J, Major B, Engel D, Douey D, Huszczynski G, Di Lecci J, Strazds J, Rousseau J, Ma K, Isaac L, Sierpinska U.

Foodborne Pathog Dis. 2015 Aug;12(8):645-52. doi: 10.1089/fpd.2015.1939. Epub 2015 Jun 3.

PMID:
26258258
17.

Structurally distinct ligands rescue biogenesis defects of the KATP channel complex via a converging mechanism.

Devaraneni PK, Martin GM, Olson EM, Zhou Q, Shyng SL.

J Biol Chem. 2015 Mar 20;290(12):7980-91. doi: 10.1074/jbc.M114.634576. Epub 2015 Jan 30.

18.

Phosphatidylinositol 4,5-biphosphate (PIP2) modulates syntaxin-1A binding to sulfonylurea receptor 2A to regulate cardiac ATP-sensitive potassium (KATP) channels.

Xie L, Liang T, Kang Y, Lin X, Sobbi R, Xie H, Chao C, Backx P, Feng ZP, Shyng SL, Gaisano HY.

J Mol Cell Cardiol. 2014 Oct;75:100-10. doi: 10.1016/j.yjmcc.2014.07.012. Epub 2014 Jul 26.

PMID:
25073062
19.

Carbamazepine inhibits ATP-sensitive potassium channel activity by disrupting channel response to MgADP.

Zhou Q, Chen PC, Devaraneni PK, Martin GM, Olson EM, Shyng SL.

Channels (Austin). 2014;8(4):376-82.

20.

Monoallelic ABCC8 mutations are a common cause of diazoxide-unresponsive diffuse form of congenital hyperinsulinism.

Saint-Martin C, Zhou Q, Martin GM, Vaury C, Leroy G, Arnoux JB, de Lonlay P, Shyng SL, Bellanné-Chantelot C.

Clin Genet. 2015 May;87(5):448-54. doi: 10.1111/cge.12428. Epub 2014 Jun 6.

21.

Pharmacological rescue of trafficking-impaired ATP-sensitive potassium channels.

Martin GM, Chen PC, Devaraneni P, Shyng SL.

Front Physiol. 2013 Dec 24;4:386. doi: 10.3389/fphys.2013.00386. Review.

22.
23.

Carbamazepine as a novel small molecule corrector of trafficking-impaired ATP-sensitive potassium channels identified in congenital hyperinsulinism.

Chen PC, Olson EM, Zhou Q, Kryukova Y, Sampson HM, Thomas DY, Shyng SL.

J Biol Chem. 2013 Jul 19;288(29):20942-54. doi: 10.1074/jbc.M113.470948. Epub 2013 Jun 6.

24.

A Kir6.2 pore mutation causes inactivation of ATP-sensitive potassium channels by disrupting PIP2-dependent gating.

Bushman JD, Zhou Q, Shyng SL.

PLoS One. 2013 May 20;8(5):e63733. doi: 10.1371/journal.pone.0063733. Print 2013.

25.

Engineered Kir6.2 mutations that correct the trafficking defect of K(ATP) channels caused by specific SUR1 mutations.

Zhou Q, Pratt EB, Shyng SL.

Channels (Austin). 2013 Jul-Aug;7(4):313-7. Epub 2013 May 21.

26.

Compounds that correct F508del-CFTR trafficking can also correct other protein trafficking diseases: an in vitro study using cell lines.

Sampson HM, Lam H, Chen PC, Zhang D, Mottillo C, Mirza M, Qasim K, Shrier A, Shyng SL, Hanrahan JW, Thomas DY.

Orphanet J Rare Dis. 2013 Jan 14;8:11. doi: 10.1186/1750-1172-8-11.

27.

Genotype and phenotype correlations in 417 children with congenital hyperinsulinism.

Snider KE, Becker S, Boyajian L, Shyng SL, MacMullen C, Hughes N, Ganapathy K, Bhatti T, Stanley CA, Ganguly A.

J Clin Endocrinol Metab. 2013 Feb;98(2):E355-63. doi: 10.1210/jc.2012-2169. Epub 2012 Dec 28.

28.

Co-inheritance of two ABCC8 mutations causing an unresponsive congenital hyperinsulinism: clinical and functional characterization of two novel ABCC8 mutations.

Faletra F, Snider K, Shyng SL, Bruno I, Athanasakis E, Gasparini P, Dionisi-Vici C, Ventura A, Zhou Q, Stanley CA, Burlina A.

Gene. 2013 Mar 1;516(1):122-5. doi: 10.1016/j.gene.2012.12.055. Epub 2012 Dec 22.

29.

Engineered interaction between SUR1 and Kir6.2 that enhances ATP sensitivity in KATP channels.

Pratt EB, Zhou Q, Gay JW, Shyng SL.

J Gen Physiol. 2012 Aug;140(2):175-87. doi: 10.1085/jgp.201210803. Epub 2012 Jul 16.

30.

Role of Derlin-1 protein in proteostasis regulation of ATP-sensitive potassium channels.

Wang F, Olson EM, Shyng SL.

J Biol Chem. 2012 Mar 23;287(13):10482-93. doi: 10.1074/jbc.M111.312223. Epub 2012 Feb 6.

31.

Some cannabinoid receptor ligands and their distomers are direct-acting openers of SUR1 K(ATP) channels.

Lynch CJ, Zhou Q, Shyng SL, Heal DJ, Cheetham SC, Dickinson K, Gregory P, Firnges M, Nordheim U, Goshorn S, Reiche D, Turski L, Antel J.

Am J Physiol Endocrinol Metab. 2012 Mar 1;302(5):E540-51. doi: 10.1152/ajpendo.00258.2011. Epub 2011 Dec 13.

32.

Relative expression of a dominant mutated ABCC8 allele determines the clinical manifestation of congenital hyperinsulinism.

Shemer R, Avnon Ziv C, Laiba E, Zhou Q, Gay J, Tunovsky-Babaey S, Shyng SL, Glaser B, Zangen DH.

Diabetes. 2012 Jan;61(1):258-63. doi: 10.2337/db11-0984. Epub 2011 Nov 21.

33.

ATP activates ATP-sensitive potassium channels composed of mutant sulfonylurea receptor 1 and Kir6.2 with diminished PIP2 sensitivity.

Pratt EB, Shyng SL.

Channels (Austin). 2011 Jul-Aug;5(4):314-9. doi: 10.4161/chan.5.4.16510. Epub 2011 Jul 1.

34.

A role of the sulfonylurea receptor 1 in endocytic trafficking of ATP-sensitive potassium channels.

Bruederle CE, Gay J, Shyng SL.

Traffic. 2011 Sep;12(9):1242-56. doi: 10.1111/j.1600-0854.2011.01227.x. Epub 2011 Jul 3.

35.

Diazoxide-unresponsive congenital hyperinsulinism in children with dominant mutations of the β-cell sulfonylurea receptor SUR1.

Macmullen CM, Zhou Q, Snider KE, Tewson PH, Becker SA, Aziz AR, Ganguly A, Shyng SL, Stanley CA.

Diabetes. 2011 Jun;60(6):1797-804. doi: 10.2337/db10-1631. Epub 2011 May 2. Erratum in: Diabetes. 2011 Nov;60(11):3097.

36.

N-terminal transmembrane domain of SUR1 controls gating of Kir6.2 by modulating channel sensitivity to PIP2.

Pratt EB, Tewson P, Bruederle CE, Skach WR, Shyng SL.

J Gen Physiol. 2011 Mar;137(3):299-314. doi: 10.1085/jgp.201010557. Epub 2011 Feb 14.

37.

Syntaxin 1A regulates surface expression of beta-cell ATP-sensitive potassium channels.

Chen PC, Bruederle CE, Gaisano HY, Shyng SL.

Am J Physiol Cell Physiol. 2011 Mar;300(3):C506-16. doi: 10.1152/ajpcell.00429.2010. Epub 2011 Jan 5.

38.

ATP modulates interaction of syntaxin-1A with sulfonylurea receptor 1 to regulate pancreatic beta-cell KATP channels.

Kang Y, Zhang Y, Liang T, Leung YM, Ng B, Xie H, Chang N, Chan J, Shyng SL, Tsushima RG, Gaisano HY.

J Biol Chem. 2011 Feb 18;286(7):5876-83. doi: 10.1074/jbc.M109.089607. Epub 2010 Dec 20.

39.

Neonatal diabetes caused by mutations in sulfonylurea receptor 1: interplay between expression and Mg-nucleotide gating defects of ATP-sensitive potassium channels.

Zhou Q, Garin I, Castaño L, Argente J, Muñoz-Calvo MT, Perez de Nanclares G, Shyng SL.

J Clin Endocrinol Metab. 2010 Dec;95(12):E473-8. doi: 10.1210/jc.2010-1231. Epub 2010 Sep 1.

40.

Role of Hsp90 in biogenesis of the beta-cell ATP-sensitive potassium channel complex.

Yan FF, Pratt EB, Chen PC, Wang F, Skach WR, David LL, Shyng SL.

Mol Biol Cell. 2010 Jun 15;21(12):1945-54. doi: 10.1091/mbc.E10-02-0116. Epub 2010 Apr 28.

41.

Characterization and functional restoration of a potassium channel Kir6.2 pore mutation identified in congenital hyperinsulinism.

Bushman JD, Gay JW, Tewson P, Stanley CA, Shyng SL.

J Biol Chem. 2010 Feb 26;285(9):6012-23. doi: 10.1074/jbc.M109.085860. Epub 2009 Dec 23.

42.

Challenges of investigating community outbreaks of cyclosporiasis, British Columbia, Canada.

Shah L, MacDougall L, Ellis A, Ong C, Shyng S, LeBlanc L; British Columbia Cyclospora Investigation Team.

Emerg Infect Dis. 2009 Aug;15(8):1286-8. doi: 10.3201/eid1508.081585.

43.

Down-regulation of ZnT8 expression in INS-1 rat pancreatic beta cells reduces insulin content and glucose-inducible insulin secretion.

Fu Y, Tian W, Pratt EB, Dirling LB, Shyng SL, Meshul CK, Cohen DM.

PLoS One. 2009 May 25;4(5):e5679. doi: 10.1371/journal.pone.0005679.

44.

Sulfonylurea receptor 1 mutations that cause opposite insulin secretion defects with chemical chaperone exposure.

Pratt EB, Yan FF, Gay JW, Stanley CA, Shyng SL.

J Biol Chem. 2009 Mar 20;284(12):7951-9. doi: 10.1074/jbc.M807012200. Epub 2009 Jan 16.

45.

Clinical characteristics and biochemical mechanisms of congenital hyperinsulinism associated with dominant KATP channel mutations.

Pinney SE, MacMullen C, Becker S, Lin YW, Hanna C, Thornton P, Ganguly A, Shyng SL, Stanley CA.

J Clin Invest. 2008 Aug;118(8):2877-86. doi: 10.1172/JCI35414.

46.

Novel de novo mutation in sulfonylurea receptor 1 presenting as hyperinsulinism in infancy followed by overt diabetes in early adolescence.

Abdulhadi-Atwan M, Bushman J, Tornovsky-Babaey S, Perry A, Abu-Libdeh A, Glaser B, Shyng SL, Zangen DH.

Diabetes. 2008 Jul;57(7):1935-40. doi: 10.2337/db08-0159. Epub 2008 Apr 4. Erratum in: Diabetes. 2008 Sep;57(9):2552. Bushmann, Jeremy [corrected to Bushman, Jeremy].

47.

Destabilization of ATP-sensitive potassium channel activity by novel KCNJ11 mutations identified in congenital hyperinsulinism.

Lin YW, Bushman JD, Yan FF, Haidar S, MacMullen C, Ganguly A, Stanley CA, Shyng SL.

J Biol Chem. 2008 Apr 4;283(14):9146-56. doi: 10.1074/jbc.M708798200. Epub 2008 Feb 4.

48.

Congenital hyperinsulinism associated ABCC8 mutations that cause defective trafficking of ATP-sensitive K+ channels: identification and rescue.

Yan FF, Lin YW, MacMullen C, Ganguly A, Stanley CA, Shyng SL.

Diabetes. 2007 Sep;56(9):2339-48. Epub 2007 Jun 15.

49.
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