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Items: 1 to 50 of 115

1.

Collagen VI, conformation of A-domain arrays and microfibril architecture.

Beecher N, Roseman AM, Jowitt TA, Berry R, Troilo H, Kammerer RA, Shuttleworth CA, Kielty CM, Baldock C.

J Biol Chem. 2011 Nov 18;286(46):40266-75. doi: 10.1074/jbc.M111.265595. Epub 2011 Sep 9.

2.

Density of human bone marrow stromal cells regulates commitment to vascular lineages.

Whyte JL, Ball SG, Shuttleworth CA, Brennan K, Kielty CM.

Stem Cell Res. 2011 May;6(3):238-50. doi: 10.1016/j.scr.2011.02.001. Epub 2011 Feb 17.

3.

Assembly of fibrillin microfibrils governs extracellular deposition of latent TGF beta.

Massam-Wu T, Chiu M, Choudhury R, Chaudhry SS, Baldwin AK, McGovern A, Baldock C, Shuttleworth CA, Kielty CM.

J Cell Sci. 2010 Sep 1;123(Pt 17):3006-18. doi: 10.1242/jcs.073437. Epub 2010 Aug 10.

4.

Neuropilin-1 regulates platelet-derived growth factor receptor signalling in mesenchymal stem cells.

Ball SG, Bayley C, Shuttleworth CA, Kielty CM.

Biochem J. 2010 Mar 15;427(1):29-40. doi: 10.1042/BJ20091512.

5.

Platelet-derived growth factor receptors regulate mesenchymal stem cell fate: implications for neovascularization.

Ball SG, Shuttleworth CA, Kielty CM.

Expert Opin Biol Ther. 2010 Jan;10(1):57-71. doi: 10.1517/14712590903379510. Review.

PMID:
20078229
6.

A mutation in the mouse Amelx tri-tyrosyl domain results in impaired secretion of amelogenin and phenocopies human X-linked amelogenesis imperfecta.

Barron MJ, Brookes SJ, Kirkham J, Shore RC, Hunt C, Mironov A, Kingswell NJ, Maycock J, Shuttleworth CA, Dixon MJ.

Hum Mol Genet. 2010 Apr 1;19(7):1230-47. doi: 10.1093/hmg/ddq001. Epub 2010 Jan 12.

7.

Heparan sulfate regulates fibrillin-1 N- and C-terminal interactions.

Cain SA, Baldwin AK, Mahalingam Y, Raynal B, Jowitt TA, Shuttleworth CA, Couchman JR, Kielty CM.

J Biol Chem. 2008 Oct 3;283(40):27017-27. doi: 10.1074/jbc.M803373200. Epub 2008 Jul 31.

8.

Fibrillin-1 microfibril deposition is dependent on fibronectin assembly.

Kinsey R, Williamson MR, Chaudhry S, Mellody KT, McGovern A, Takahashi S, Shuttleworth CA, Kielty CM.

J Cell Sci. 2008 Aug 15;121(Pt 16):2696-704. doi: 10.1242/jcs.029819. Epub 2008 Jul 24.

9.

Mesenchymal stem cells and neovascularization: role of platelet-derived growth factor receptors.

Ball SG, Shuttleworth CA, Kielty CM.

J Cell Mol Med. 2007 Sep-Oct;11(5):1012-30. Review.

10.

Applying elastic fibre biology in vascular tissue engineering.

Kielty CM, Stephan S, Sherratt MJ, Williamson M, Shuttleworth CA.

Philos Trans R Soc Lond B Biol Sci. 2007 Aug 29;362(1484):1293-312. Review.

11.

Fibulin-5 binds human smooth-muscle cells through alpha5beta1 and alpha4beta1 integrins, but does not support receptor activation.

Lomas AC, Mellody KT, Freeman LJ, Bax DV, Shuttleworth CA, Kielty CM.

Biochem J. 2007 Aug 1;405(3):417-28.

12.

Vascular endothelial growth factor can signal through platelet-derived growth factor receptors.

Ball SG, Shuttleworth CA, Kielty CM.

J Cell Biol. 2007 May 7;177(3):489-500. Epub 2007 Apr 30.

13.

Cell adhesion to fibrillin-1: identification of an Arg-Gly-Asp-dependent synergy region and a heparin-binding site that regulates focal adhesion formation.

Bax DV, Mahalingam Y, Cain S, Mellody K, Freeman L, Younger K, Shuttleworth CA, Humphries MJ, Couchman JR, Kielty CM.

J Cell Sci. 2007 Apr 15;120(Pt 8):1383-92. Epub 2007 Mar 20.

14.

Fibrillin-1 regulates the bioavailability of TGFbeta1.

Chaudhry SS, Cain SA, Morgan A, Dallas SL, Shuttleworth CA, Kielty CM.

J Cell Biol. 2007 Jan 29;176(3):355-67. Epub 2007 Jan 22.

15.

Platelet-derived growth factor receptor-alpha is a key determinant of smooth muscle alpha-actin filaments in bone marrow-derived mesenchymal stem cells.

Ball SG, Shuttleworth CA, Kielty CM.

Int J Biochem Cell Biol. 2007;39(2):379-91. Epub 2006 Sep 24.

PMID:
17070723
16.

Cell-matrix biology in vascular tissue engineering.

Stephan S, Ball SG, Williamson M, Bax DV, Lomas A, Shuttleworth CA, Kielty CM.

J Anat. 2006 Oct;209(4):495-502. Review.

17.

Alpha2(VIII) collagen substrata enhance endothelial cell retention under acute shear stress flow via an alpha2beta1 integrin-dependent mechanism: an in vitro and in vivo study.

Turner NJ, Murphy MO, Kielty CM, Shuttleworth CA, Black RA, Humphries MJ, Walker MG, Canfield AE.

Circulation. 2006 Aug 22;114(8):820-9. Epub 2006 Aug 14.

PMID:
16908762
18.

Marfan syndrome-causing mutations in fibrillin-1 result in gross morphological alterations and highlight the structural importance of the second hybrid domain.

Mellody KT, Freeman LJ, Baldock C, Jowitt TA, Siegler V, Raynal BD, Cain SA, Wess TJ, Shuttleworth CA, Kielty CM.

J Biol Chem. 2006 Oct 20;281(42):31854-62. Epub 2006 Aug 10.

19.

Proteomic analysis of fibrillin-rich microfibrils.

Cain SA, Morgan A, Sherratt MJ, Ball SG, Shuttleworth CA, Kielty CM.

Proteomics. 2006 Jan;6(1):111-22.

PMID:
16302274
20.

Fibrillin-1 interactions with heparin. Implications for microfibril and elastic fiber assembly.

Cain SA, Baldock C, Gallagher J, Morgan A, Bax DV, Weiss AS, Shuttleworth CA, Kielty CM.

J Biol Chem. 2005 Aug 26;280(34):30526-37. Epub 2005 Jun 24.

21.

Homotypic fibrillin-1 interactions in microfibril assembly.

Marson A, Rock MJ, Cain SA, Freeman LJ, Morgan A, Mellody K, Shuttleworth CA, Baldock C, Kielty CM.

J Biol Chem. 2005 Feb 11;280(6):5013-21. Epub 2004 Nov 29.

22.

Substrate-dependent morphology of supramolecular assemblies: fibrillin and type-VI collagen microfibrils.

Sherratt MJ, Holmes DF, Shuttleworth CA, Kielty CM.

Biophys J. 2004 May;86(5):3211-22.

23.

Molecular basis of elastic fiber formation. Critical interactions and a tropoelastin-fibrillin-1 cross-link.

Rock MJ, Cain SA, Freeman LJ, Morgan A, Mellody K, Marson A, Shuttleworth CA, Weiss AS, Kielty CM.

J Biol Chem. 2004 May 28;279(22):23748-58. Epub 2004 Mar 23.

24.

Expression and supramolecular assembly of recombinant alpha1(viii) and alpha2(viii) collagen homotrimers.

Stephan S, Sherratt MJ, Hodson N, Shuttleworth CA, Kielty CM.

J Biol Chem. 2004 May 14;279(20):21469-77. Epub 2004 Feb 27.

25.

Fibrillin microfibrils are stiff reinforcing fibres in compliant tissues.

Sherratt MJ, Baldock C, Haston JL, Holmes DF, Jones CJ, Shuttleworth CA, Wess TJ, Kielty CM.

J Mol Biol. 2003 Sep 5;332(1):183-93.

PMID:
12946356
26.

The supramolecular organization of collagen VI microfibrils.

Baldock C, Sherratt MJ, Shuttleworth CA, Kielty CM.

J Mol Biol. 2003 Jul 4;330(2):297-307.

PMID:
12823969
27.

Cell adhesion to fibrillin-1 molecules and microfibrils is mediated by alpha 5 beta 1 and alpha v beta 3 integrins.

Bax DV, Bernard SE, Lomas A, Morgan A, Humphries J, Shuttleworth CA, Humphries MJ, Kielty CM.

J Biol Chem. 2003 Sep 5;278(36):34605-16. Epub 2003 Jun 13.

28.

Fibrillin-rich microfibrils: elastic biopolymers of the extracellular matrix.

Kielty CM, Wess TJ, Haston L, Ashworth JL, Sherratt MJ, Shuttleworth CA.

J Muscle Res Cell Motil. 2002;23(5-6):581-96. Review.

PMID:
12785107
29.

Elastic fibres.

Kielty CM, Sherratt MJ, Shuttleworth CA.

J Cell Sci. 2002 Jul 15;115(Pt 14):2817-28. Review.

30.

Expression of latent TGF-beta binding proteins and association with TGF-beta 1 and fibrillin-1 following arterial injury.

Sinha S, Heagerty AM, Shuttleworth CA, Kielty CM.

Cardiovasc Res. 2002 Mar;53(4):971-83.

PMID:
11922907
31.

Fibrillin: from microfibril assembly to biomechanical function.

Kielty CM, Baldock C, Lee D, Rock MJ, Ashworth JL, Shuttleworth CA.

Philos Trans R Soc Lond B Biol Sci. 2002 Feb 28;357(1418):207-17. Review.

32.

Upregulation of collagen VIII following porcine coronary artery angioplasty is related to smooth muscle cell migration not angiogenesis.

Sinha S, Kielty CM, Heagerty AM, Canfield AE, Shuttleworth CA.

Int J Exp Pathol. 2001 Oct;82(5):295-302.

33.

Distribution and expression of type VI collagen in photoaged skin.

Watson RE, Ball SG, Craven NM, Boorsma J, East CL, Shuttleworth CA, Kielty CM, Griffiths CE.

Br J Dermatol. 2001 Apr;144(4):751-9.

PMID:
11298533
34.

The supramolecular organization of fibrillin-rich microfibrils.

Baldock C, Koster AJ, Ziese U, Rock MJ, Sherratt MJ, Kadler KE, Shuttleworth CA, Kielty CM.

J Cell Biol. 2001 Mar 5;152(5):1045-56.

35.

The role of the C1 and C2 a-domains in type VI collagen assembly.

Ball SG, Baldock C, Kielty CM, Shuttleworth CA.

J Biol Chem. 2001 Mar 9;276(10):7422-30. Epub 2000 Oct 17.

36.

Fibrillin-rich microfibrils of the extracellular matrix: ultrastructure and assembly.

Sherratt MJ, Wess TJ, Baldock C, Ashworth J, Purslow PP, Shuttleworth CA, Kielty CM.

Micron. 2001 Feb;32(2):185-200. Review.

PMID:
10936461
37.

Secondary structure of a fibrillin-1 eight-cysteine motif.

Dyer C, Shuttleworth CA, Wess T, Brass A, Kielty CM.

Biochem Soc Trans. 1998 Feb;26(1):S19. No abstract available.

PMID:
10909777
38.

Stability of type VIII collagen homotrimers: comparison with alpha1(X).

Illidge C, Kielty CM, Shuttleworth CA.

Biochem Soc Trans. 1998 Feb;26(1):S18. No abstract available.

PMID:
10909776
39.

Regulation of fibrillin carboxy-terminal furin processing by N-glycosylation, and association of amino- and carboxy-terminal sequences.

Ashworth JL, Kelly V, Rock MJ, Shuttleworth CA, Kielty CM.

J Cell Sci. 1999 Nov;112 ( Pt 22):4163-71.

40.

Fibrillin assembly: dimer formation mediated by amino-terminal sequences.

Ashworth JL, Kelly V, Wilson R, Shuttleworth CA, Kielty CM.

J Cell Sci. 1999 Oct;112 ( Pt 20):3549-58.

41.

Fibrillin degradation by matrix metalloproteinases: identification of amino- and carboxy-terminal cleavage sites.

Hindson VJ, Ashworth JL, Rock MJ, Cunliffe S, Shuttleworth CA, Kielty CM.

FEBS Lett. 1999 Jun 11;452(3):195-8.

42.

Fibrillin-rich microfibrils are reduced in photoaged skin. Distribution at the dermal-epidermal junction.

Watson RE, Griffiths CE, Craven NM, Shuttleworth CA, Kielty CM.

J Invest Dermatol. 1999 May;112(5):782-7.

43.

Fibrillin degradation by matrix metalloproteinases: implications for connective tissue remodelling.

Ashworth JL, Murphy G, Rock MJ, Sherratt MJ, Shapiro SD, Shuttleworth CA, Kielty CM.

Biochem J. 1999 May 15;340 ( Pt 1):171-81.

44.

Cellular and extracellular biology of the latent transforming growth factor-beta binding proteins.

Sinha S, Nevett C, Shuttleworth CA, Kielty CM.

Matrix Biol. 1998 Dec;17(8-9):529-45. Review.

PMID:
9923648
45.

Calcium determines the supramolecular organization of fibrillin-rich microfibrils.

Wess TJ, Purslow PP, Sherratt MJ, Ashworth J, Shuttleworth CA, Kielty CM.

J Cell Biol. 1998 May 4;141(3):829-37.

46.

The Tight skin mouse: demonstration of mutant fibrillin-1 production and assembly into abnormal microfibrils.

Kielty CM, Raghunath M, Siracusa LD, Sherratt MJ, Peters R, Shuttleworth CA, Jimenez SA.

J Cell Biol. 1998 Mar 9;140(5):1159-66.

47.

Clinical features of photodamaged human skin are associated with a reduction in collagen VII.

Craven NM, Watson RE, Jones CJ, Shuttleworth CA, Kielty CM, Griffiths CE.

Br J Dermatol. 1997 Sep;137(3):344-50.

PMID:
9349327
48.

Purification of fibrillin-containing microfibrils and collagen VI microfibrils by density gradient centrifugation.

Kielty CM, Hanssen E, Shuttleworth CA.

Anal Biochem. 1998 Jan 1;255(1):108-12.

PMID:
9448848
49.

Type VIII collagen.

Shuttleworth CA.

Int J Biochem Cell Biol. 1997 Oct;29(10):1145-8. Review.

PMID:
9438378
50.

Microfibrillar elements of the dermal matrix.

Kielty CM, Shuttleworth CA.

Microsc Res Tech. 1997 Aug 15;38(4):413-27. Review.

PMID:
9297691

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