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Mycobacterial DNA polymerase I: activities and crystal structures of the POL domain as apoenzyme and in complex with a DNA primer-template and of the full-length FEN/EXO-POL enzyme.

Ghosh S, Goldgur Y, Shuman S.

Nucleic Acids Res. 2020 Feb 8. pii: gkaa075. doi: 10.1093/nar/gkaa075. [Epub ahead of print]


Substrate analogs that trap the 2'-phospho-ADP-ribosylated RNA intermediate of the Tpt1 (tRNA 2'-phosphotransferase) reaction pathway.

Dantuluri S, Abdullahu L, Munir A, Katolik A, Damha MJ, Shuman S.

RNA. 2020 Jan 13. pii: rna.074377.119. doi: 10.1261/rna.074377.119. [Epub ahead of print]


Structures and single-molecule analysis of bacterial motor nuclease AdnAB illuminate the mechanism of DNA double-strand break resection.

Jia N, Unciuleac MC, Xue C, Greene EC, Patel DJ, Shuman S.

Proc Natl Acad Sci U S A. 2019 Dec 3;116(49):24507-24516. doi: 10.1073/pnas.1913546116. Epub 2019 Nov 18.


RNA ligation precedes the retrotransposition of U6/LINE-1 chimeric RNA.

Moldovan JB, Wang Y, Shuman S, Mills RE, Moran JV.

Proc Natl Acad Sci U S A. 2019 Oct 8;116(41):20612-20622. doi: 10.1073/pnas.1805404116. Epub 2019 Sep 23.


Inositol pyrophosphates impact phosphate homeostasis via modulation of RNA 3' processing and transcription termination.

Sanchez AM, Garg A, Shuman S, Schwer B.

Nucleic Acids Res. 2019 Sep 19;47(16):8452-8469. doi: 10.1093/nar/gkz567.


Structure-Function Analysis of the Phosphoesterase Component of the Nucleic Acid End-Healing Enzyme Runella slithyformis HD-Pnk.

Munir A, Shuman S.

J Bacteriol. 2019 Jul 24;201(16). pii: e00292-19. doi: 10.1128/JB.00292-19. Print 2019 Aug 15.


A Pilot Study of E-Cigarette Naïve Cigarette Smokers and the Effects on Craving After Acute Exposure to E-Cigarettes in the Laboratory.

De La Garza R 2nd, Shuman SL, Yammine L, Yoon JH, Salas R, Holst M.

Am J Addict. 2019 Sep;28(5):361-366. doi: 10.1111/ajad.12895. Epub 2019 May 8.


NAD+-dependent RNA terminal 2' and 3' phosphomonoesterase activity of a subset of Tpt1 enzymes.

Munir A, Abdullahu L, Banerjee A, Damha MJ, Shuman S.

RNA. 2019 Jul;25(7):783-792. doi: 10.1261/rna.071142.119. Epub 2019 Apr 24.


Structure of Fission Yeast Transcription Factor Pho7 Bound to pho1 Promoter DNA and Effect of Pho7 Mutations on DNA Binding and Phosphate Homeostasis.

Garg A, Goldgur Y, Sanchez AM, Schwer B, Shuman S.

Mol Cell Biol. 2019 Jun 13;39(13). pii: e00132-19. doi: 10.1128/MCB.00132-19. Print 2019 Jul 1.


Activity and structure of Pseudomonas putida MPE, a manganese-dependent single-strand DNA endonuclease encoded in a nucleic acid repair gene cluster.

Ejaz A, Goldgur Y, Shuman S.

J Biol Chem. 2019 May 10;294(19):7931-7941. doi: 10.1074/jbc.RA119.008049. Epub 2019 Mar 20.


Structures of ATP-bound DNA ligase D in a closed domain conformation reveal a network of amino acid and metal contacts to the ATP phosphates.

Unciuleac MC, Goldgur Y, Shuman S.

J Biol Chem. 2019 Mar 29;294(13):5094-5104. doi: 10.1074/jbc.RA119.007445. Epub 2019 Feb 4.


Structure of tRNA splicing enzyme Tpt1 illuminates the mechanism of RNA 2'-PO4 recognition and ADP-ribosylation.

Banerjee A, Munir A, Abdullahu L, Damha MJ, Goldgur Y, Shuman S.

Nat Commun. 2019 Jan 15;10(1):218. doi: 10.1038/s41467-018-08211-9.


Structure and two-metal mechanism of fungal tRNA ligase.

Banerjee A, Ghosh S, Goldgur Y, Shuman S.

Nucleic Acids Res. 2019 Feb 20;47(3):1428-1439. doi: 10.1093/nar/gky1275.


Domain Requirements and Genetic Interactions of the Mud1 Subunit of the Saccharomyces cerevisiae U1 snRNP.

Agarwal R, Schwer B, Shuman S.

G3 (Bethesda). 2019 Jan 9;9(1):145-151. doi: 10.1534/g3.118.200781.


RNA polymerase II CTD interactome with 3' processing and termination factors in fission yeast and its impact on phosphate homeostasis.

Sanchez AM, Shuman S, Schwer B.

Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10652-E10661. doi: 10.1073/pnas.1810711115. Epub 2018 Oct 24.


Characterization of Lhr-Core DNA helicase and manganese- dependent DNA nuclease components of a bacterial gene cluster encoding nucleic acid repair enzymes.

Ejaz A, Shuman S.

J Biol Chem. 2018 Nov 9;293(45):17491-17504. doi: 10.1074/jbc.RA118.005296. Epub 2018 Sep 17.


Distinctive structural basis for DNA recognition by the fission yeast Zn2Cys6 transcription factor Pho7 and its role in phosphate homeostasis.

Garg A, Goldgur Y, Schwer B, Shuman S.

Nucleic Acids Res. 2018 Nov 30;46(21):11262-11273. doi: 10.1093/nar/gky827.


NAD+-dependent synthesis of a 5'-phospho-ADP-ribosylated RNA/DNA cap by RNA 2'-phosphotransferase Tpt1.

Munir A, Banerjee A, Shuman S.

Nucleic Acids Res. 2018 Oct 12;46(18):9617-9624. doi: 10.1093/nar/gky792.


Deinococcus radiodurans HD-Pnk, a Nucleic Acid End-Healing Enzyme, Abets Resistance to Killing by Ionizing Radiation and Mitomycin C.

Schmier BJ, Shuman S.

J Bacteriol. 2018 Aug 10;200(17). pii: e00151-18. doi: 10.1128/JB.00151-18. Print 2018 Sep 1.


Two-step mechanism and step-arrest mutants of Runella slithyformis NAD+-dependent tRNA 2'-phosphotransferase Tpt1.

Munir A, Abdullahu L, Damha MJ, Shuman S.

RNA. 2018 Sep;24(9):1144-1157. doi: 10.1261/rna.067165.118. Epub 2018 Jun 8.


A long noncoding (lnc)RNA governs expression of the phosphate transporter Pho84 in fission yeast and has cascading effects on the flanking prt lncRNA and pho1 genes.

Garg A, Sanchez AM, Shuman S, Schwer B.

J Biol Chem. 2018 Mar 23;293(12):4456-4467. doi: 10.1074/jbc.RA117.001352. Epub 2018 Feb 2.


Structural basis for the GTP specificity of the RNA kinase domain of fungal tRNA ligase.

Remus BS, Goldgur Y, Shuman S.

Nucleic Acids Res. 2017 Dec 15;45(22):12945-12953. doi: 10.1093/nar/gkx1159.


Structure of mycobacterial 3'-to-5' RNA:DNA helicase Lhr bound to a ssDNA tracking strand highlights distinctive features of a novel family of bacterial helicases.

Ejaz A, Ordonez H, Jacewicz A, Ferrao R, Shuman S.

Nucleic Acids Res. 2018 Jan 9;46(1):442-455. doi: 10.1093/nar/gkx1163.


Poly(A) site choice and Pol2 CTD Serine-5 status govern lncRNA control of phosphate-responsive tgp1 gene expression in fission yeast.

Sanchez AM, Shuman S, Schwer B.

RNA. 2018 Feb;24(2):237-250. doi: 10.1261/rna.063966.117. Epub 2017 Nov 9.


Race and Ethnicity Do Not Clinically Associate with Quality of Life Among Patients with Chronic Severe Pain in a Federally Qualified Health Center.

Dhingra L, Schiller R, Teets R, Nosal S, Rodriguez S, Cruciani G, Barrett M, Ginzburg R, Ahmed E, Wasser T, Chen J, Shuman S, Crump C, Portenoy R.

Pain Med. 2018 Jul 1;19(7):1408-1418. doi: 10.1093/pm/pnx040.


Defining the DNA Binding Site Recognized by the Fission Yeast Zn2Cys6 Transcription Factor Pho7 and Its Role in Phosphate Homeostasis.

Schwer B, Sanchez AM, Garg A, Chatterjee D, Shuman S.

mBio. 2017 Aug 15;8(4). pii: e01218-17. doi: 10.1128/mBio.01218-17.


Intratumoral delivery of inactivated modified vaccinia virus Ankara (iMVA) induces systemic antitumor immunity via STING and Batf3-dependent dendritic cells.

Dai P, Wang W, Yang N, Serna-Tamayo C, Ricca JM, Zamarin D, Shuman S, Merghoub T, Wolchok JD, Deng L.

Sci Immunol. 2017 May 19;2(11). pii: eaal1713. doi: 10.1126/sciimmunol.aal1713.


The t6A modification acts as a positive determinant for the anticodon nuclease PrrC, and is distinctively nonessential in Streptococcus mutans.

Bacusmo JM, Orsini SS, Hu J, DeMott M, Thiaville PC, Elfarash A, Paulines MJ, Rojas-Benítez D, Meineke B, Deutsch C, Iwata-Reuyl D, Limbach PA, Dedon PC, Rice KC, Shuman S, Crécy-Lagard V.

RNA Biol. 2018;15(4-5):508-517. doi: 10.1080/15476286.2017.1353861. Epub 2017 Sep 13.


The DNA Repair Repertoire of Mycobacterium smegmatis FenA Includes the Incision of DNA 5' Flaps and the Removal of 5' Adenylylated Products of Aborted Nick Ligation.

Uson ML, Ghosh S, Shuman S.

J Bacteriol. 2017 Aug 8;199(17). pii: e00304-17. doi: 10.1128/JB.00304-17. Print 2017 Sep 1.


Characterization of DNA Binding by the Isolated N-Terminal Domain of Vaccinia Virus DNA Topoisomerase IB.

Reed B, Yakovleva L, Shuman S, Ghose R.

Biochemistry. 2017 Jul 5;56(26):3307-3317. doi: 10.1021/acs.biochem.7b00042. Epub 2017 Jun 19.


Two-metal versus one-metal mechanisms of lysine adenylylation by ATP-dependent and NAD+-dependent polynucleotide ligases.

Unciuleac MC, Goldgur Y, Shuman S.

Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2592-2597. doi: 10.1073/pnas.1619220114. Epub 2017 Feb 21.


Deletion of the rnl gene encoding a nick-sealing RNA ligase sensitizes Deinococcus radiodurans to ionizing radiation.

Schmier BJ, Chen X, Wolin S, Shuman S.

Nucleic Acids Res. 2017 Apr 20;45(7):3812-3821. doi: 10.1093/nar/gkx038.


Will the circle be unbroken: specific mutations in the yeast Sm protein ring expose a requirement for assembly factor Brr1, a homolog of Gemin2.

Schwer B, Roth AJ, Shuman S.

RNA. 2017 Mar;23(3):420-430. doi: 10.1261/rna.059881.116. Epub 2016 Dec 14.


Homologous recombination mediated by the mycobacterial AdnAB helicase without end resection by the AdnAB nucleases.

Gupta R, Unciuleac MC, Shuman S, Glickman MS.

Nucleic Acids Res. 2017 Jan 25;45(2):762-774. doi: 10.1093/nar/gkw1130. Epub 2016 Nov 29.


Phospho-site mutants of the RNA Polymerase II C-terminal domain alter subtelomeric gene expression and chromatin modification state in fission yeast.

Inada M, Nichols RJ, Parsa JY, Homer CM, Benn RA, Hoxie RS, Madhani HD, Shuman S, Schwer B, Pleiss JA.

Nucleic Acids Res. 2016 Nov 2;44(19):9180-9189. Epub 2016 Jul 8.


Characterization of the tRNA ligases of pathogenic fungi Aspergillus fumigatus and Coccidioides immitis.

Remus BS, Schwer B, Shuman S.

RNA. 2016 Oct;22(10):1500-9. doi: 10.1261/rna.057455.116. Epub 2016 Aug 4.


Structure-function analysis and genetic interactions of the SmG, SmE, and SmF subunits of the yeast Sm protein ring.

Schwer B, Kruchten J, Shuman S.

RNA. 2016 Sep;22(9):1320-8. doi: 10.1261/rna.057448.116. Epub 2016 Jul 14.


Structure-function analysis and genetic interactions of the Luc7 subunit of the Saccharomyces cerevisiae U1 snRNP.

Agarwal R, Schwer B, Shuman S.

RNA. 2016 Sep;22(9):1302-10. doi: 10.1261/rna.056911.116. Epub 2016 Jun 27.


Perceptions and Experiences of Intimate Partner Violence in Abidjan, Côte d'Ivoire.

Shuman SJ, Falb KL, Cardoso LF, Cole H, Kpebo D, Gupta J.

PLoS One. 2016 Jun 16;11(6):e0157348. doi: 10.1371/journal.pone.0157348. eCollection 2016.


Parallel analysis of ribonucleotide-dependent deletions produced by yeast Top1 in vitro and in vivo.

Cho JE, Huang SY, Burgers PM, Shuman S, Pommier Y, Jinks-Robertson S.

Nucleic Acids Res. 2016 Sep 19;44(16):7714-21. doi: 10.1093/nar/gkw495. Epub 2016 Jun 1.


What Factors Contribute to Intimate Partner Violence Against Women in Urban, Conflict-Affected Settings? Qualitative Findings from Abidjan, Côte d'Ivoire.

Cardoso LF, Gupta J, Shuman S, Cole H, Kpebo D, Falb KL.

J Urban Health. 2016 Apr;93(2):364-78. doi: 10.1007/s11524-016-0029-x.


Crystal Structure and Biochemical Characterization of a Mycobacterium smegmatis AAA-Type Nucleoside Triphosphatase Phosphohydrolase (Msm0858).

Unciuleac MC, Smith PC, Shuman S.

J Bacteriol. 2016 Apr 28;198(10):1521-33. doi: 10.1128/JB.00905-15. Print 2016 May 15.


Nanomolar Inhibitors of Trypanosoma brucei RNA Triphosphatase.

Smith P, Ho CK, Takagi Y, Djaballah H, Shuman S.

mBio. 2016 Feb 23;7(1):e00058-16. doi: 10.1128/mBio.00058-16.

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