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Items: 1 to 50 of 113

1.

Gallium disrupts bacterial iron metabolism and has therapeutic effects in mice and humans with lung infections.

Goss CH, Kaneko Y, Khuu L, Anderson GD, Ravishankar S, Aitken ML, Lechtzin N, Zhou G, Czyz DM, McLean K, Olakanmi O, Shuman HA, Teresi M, Wilhelm E, Caldwell E, Salipante SJ, Hornick DB, Siehnel RJ, Becker L, Britigan BE, Singh PK.

Sci Transl Med. 2018 Sep 26;10(460). pii: eaat7520. doi: 10.1126/scitranslmed.aat7520.

PMID:
30257953
2.

GigA and GigB are Master Regulators of Antibiotic Resistance, Stress Responses, and Virulence in Acinetobacter baumannii.

Gebhardt MJ, Shuman HA.

J Bacteriol. 2017 Apr 25;199(10). pii: e00066-17. doi: 10.1128/JB.00066-17. Print 2017 May 15.

3.

Seeing red; the development of pON.mCherry, a broad-host range constitutive expression plasmid for Gram-negative bacteria.

Gebhardt MJ, Jacobson RK, Shuman HA.

PLoS One. 2017 Mar 3;12(3):e0173116. doi: 10.1371/journal.pone.0173116. eCollection 2017.

4.

A dual-targeting approach to inhibit Brucella abortus replication in human cells.

Czyż DM, Jain-Gupta N, Shuman HA, Crosson S.

Sci Rep. 2016 Oct 21;6:35835. doi: 10.1038/srep35835.

5.

Direct targeting of membrane fusion by SNARE mimicry: Convergent evolution of Legionella effectors.

Shi X, Halder P, Yavuz H, Jahn R, Shuman HA.

Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):8807-12. doi: 10.1073/pnas.1608755113. Epub 2016 Jul 19.

6.

Genomic analysis of 38 Legionella species identifies large and diverse effector repertoires.

Burstein D, Amaro F, Zusman T, Lifshitz Z, Cohen O, Gilbert JA, Pupko T, Shuman HA, Segal G.

Nat Genet. 2016 Feb;48(2):167-75. doi: 10.1038/ng.3481. Epub 2016 Jan 11.

7.

Joint Transcriptional Control of Virulence and Resistance to Antibiotic and Environmental Stress in Acinetobacter baumannii.

Gebhardt MJ, Gallagher LA, Jacobson RK, Usacheva EA, Peterson LR, Zurawski DV, Shuman HA.

MBio. 2015 Nov 10;6(6):e01660-15. doi: 10.1128/mBio.01660-15.

8.

Diverse protist grazers select for virulence-related traits in Legionella.

Amaro F, Wang W, Gilbert JA, Anderson OR, Shuman HA.

ISME J. 2015 Jul;9(7):1607-18. doi: 10.1038/ismej.2014.248. Epub 2015 Jan 9.

9.

Genetic Manipulation of Acinetobacter baumannii.

Jacobs AC, Thompson MG, Gebhardt M, Corey BW, Yildirim S, Shuman HA, Zurawski DV.

Curr Protoc Microbiol. 2014 Nov 3;35:6G.2.1-11. doi: 10.1002/9780471729259.mc06g02s35.

PMID:
25367274
10.

Host-directed antimicrobial drugs with broad-spectrum efficacy against intracellular bacterial pathogens.

Czyż DM, Potluri LP, Jain-Gupta N, Riley SP, Martinez JJ, Steck TL, Crosson S, Shuman HA, Gabay JE.

MBio. 2014 Jul 29;5(4):e01534-14. doi: 10.1128/mBio.01534-14.

11.

Identification of novel Coxiella burnetii Icm/Dot effectors and genetic analysis of their involvement in modulating a mitogen-activated protein kinase pathway.

Lifshitz Z, Burstein D, Schwartz K, Shuman HA, Pupko T, Segal G.

Infect Immun. 2014 Sep;82(9):3740-52. doi: 10.1128/IAI.01729-14. Epub 2014 Jun 23.

12.

Analysis of the transcriptome of Legionella pneumophila hfq mutant reveals a new mobile genetic element.

Trigui H, Dudyk P, Sum J, Shuman HA, Faucher SP.

Microbiology. 2013 Aug;159(Pt 8):1649-60. doi: 10.1099/mic.0.067983-0. Epub 2013 May 31.

13.

Legionella pneumophila transcriptional response following exposure to CuO nanoparticles.

Lu J, Struewing I, Buse HY, Kou J, Shuman HA, Faucher SP, Ashbolt NJ.

Appl Environ Microbiol. 2013 Apr;79(8):2713-20. doi: 10.1128/AEM.03462-12. Epub 2013 Feb 15.

14.

Computational modeling and experimental validation of the Legionella and Coxiella virulence-related type-IVB secretion signal.

Lifshitz Z, Burstein D, Peeri M, Zusman T, Schwartz K, Shuman HA, Pupko T, Segal G.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):E707-15. doi: 10.1073/pnas.1215278110. Epub 2013 Feb 4.

15.

In vitro derivation of macrophage from guinea pig bone marrow with human M-CSF.

Yu KO, Porcelli SA, Shuman HA.

J Immunol Methods. 2013 Mar 29;389(1-2):88-94. doi: 10.1016/j.jim.2013.01.005. Epub 2013 Jan 16.

PMID:
23333710
16.

Methods to study legionella transcriptome in vitro and in vivo.

Faucher SP, Shuman HA.

Methods Mol Biol. 2013;954:567-82. doi: 10.1007/978-1-62703-161-5_35.

PMID:
23150421
17.

A pathogen's journey in the host cell: Bridges between actin and traffic.

Franco IS, Shuman HA.

Bioarchitecture. 2012 Feb 1;2(2):38-42.

18.

The Legionella pneumophila effector VipA is an actin nucleator that alters host cell organelle trafficking.

Franco IS, Shohdy N, Shuman HA.

PLoS Pathog. 2012 Feb;8(2):e1002546. doi: 10.1371/journal.ppat.1002546. Epub 2012 Feb 23.

19.

Whole-genome sequence of the human pathogen Legionella pneumophila serogroup 12 strain 570-CO-H.

Amaro F, Gilbert JA, Owens S, Trimble W, Shuman HA.

J Bacteriol. 2012 Mar;194(6):1613-4. doi: 10.1128/JB.06626-11.

20.

Small Regulatory RNA and Legionella pneumophila.

Faucher SP, Shuman HA.

Front Microbiol. 2011 May 6;2:98. doi: 10.3389/fmicb.2011.00098. eCollection 2011.

21.

Legionella Pneumophila Transcriptome during Intracellular Multiplication in Human Macrophages.

Faucher SP, Mueller CA, Shuman HA.

Front Microbiol. 2011 Apr 4;2:60. doi: 10.3389/fmicb.2011.00060. eCollection 2011.

22.

Chemical synthesis enables biochemical and antibacterial evaluation of streptolydigin antibiotics.

Pronin SV, Martinez A, Kuznedelov K, Severinov K, Shuman HA, Kozmin SA.

J Am Chem Soc. 2011 Aug 10;133(31):12172-84. doi: 10.1021/ja2041964. Epub 2011 Jul 20.

23.

Cyclic diguanylate signaling proteins control intracellular growth of Legionella pneumophila.

Levi A, Folcher M, Jenal U, Shuman HA.

MBio. 2011 Jan 11;2(1):e00316-10. doi: 10.1128/mBio.00316-10.

24.

A new heterolobosean amoeba Solumitrus palustris n. g., n. sp. isolated from freshwater marsh soil.

Anderson OR, Wang W, Faucher SP, Bi K, Shuman HA.

J Eukaryot Microbiol. 2011 Jan-Feb;58(1):60-7. doi: 10.1111/j.1550-7408.2010.00520.x.

PMID:
21182560
25.

Antibiotics and UV radiation induce competence for natural transformation in Legionella pneumophila.

Charpentier X, Kay E, Schneider D, Shuman HA.

J Bacteriol. 2011 Mar;193(5):1114-21. doi: 10.1128/JB.01146-10. Epub 2010 Dec 17.

26.

ArgR-regulated genes are derepressed in the Legionella-containing vacuole.

Hovel-Miner G, Faucher SP, Charpentier X, Shuman HA.

J Bacteriol. 2010 Sep;192(17):4504-16. doi: 10.1128/JB.00465-10. Epub 2010 Jul 9.

27.

Legionella pneumophila 6S RNA optimizes intracellular multiplication.

Faucher SP, Friedlander G, Livny J, Margalit H, Shuman HA.

Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7533-8. doi: 10.1073/pnas.0911764107. Epub 2010 Apr 5.

28.

Intracellular bacteria encode inhibitory SNARE-like proteins.

Paumet F, Wesolowski J, Garcia-Diaz A, Delevoye C, Aulner N, Shuman HA, Subtil A, Rothman JE.

PLoS One. 2009 Oct 12;4(10):e7375. doi: 10.1371/journal.pone.0007375.

29.

Interferons direct an effective innate response to Legionella pneumophila infection.

Plumlee CR, Lee C, Beg AA, Decker T, Shuman HA, Schindler C.

J Biol Chem. 2009 Oct 30;284(44):30058-66. doi: 10.1074/jbc.M109.018283. Epub 2009 Aug 31.

30.

Chemical genetics reveals bacterial and host cell functions critical for type IV effector translocation by Legionella pneumophila.

Charpentier X, Gabay JE, Reyes M, Zhu JW, Weiss A, Shuman HA.

PLoS Pathog. 2009 Jul;5(7):e1000501. doi: 10.1371/journal.ppat.1000501. Epub 2009 Jul 3.

31.

The perplexing functions and surprising origins of Legionella pneumophila type IV secretion effectors.

Franco IS, Shuman HA, Charpentier X.

Cell Microbiol. 2009 Oct;11(10):1435-43. doi: 10.1111/j.1462-5822.2009.01351.x. Epub 2009 Jun 26. Review.

PMID:
19563462
32.

Gemfibrozil inhibits Legionella pneumophila and Mycobacterium tuberculosis enoyl coenzyme A reductases and blocks intracellular growth of these bacteria in macrophages.

Reich-Slotky R, Kabbash CA, Della-Latta P, Blanchard JS, Feinmark SJ, Freeman S, Kaplan G, Shuman HA, Silverstein SC.

J Bacteriol. 2009 Aug;191(16):5262-71. doi: 10.1128/JB.00175-09. Epub 2009 May 8.

33.

SigmaS controls multiple pathways associated with intracellular multiplication of Legionella pneumophila.

Hovel-Miner G, Pampou S, Faucher SP, Clarke M, Morozova I, Morozov P, Russo JJ, Shuman HA, Kalachikov S.

J Bacteriol. 2009 Apr;191(8):2461-73. doi: 10.1128/JB.01578-08. Epub 2009 Feb 13.

34.

Loss of RNase R induces competence development in Legionella pneumophila.

Charpentier X, Faucher SP, Kalachikov S, Shuman HA.

J Bacteriol. 2008 Dec;190(24):8126-36. doi: 10.1128/JB.01035-08. Epub 2008 Oct 10.

35.

Legionella eukaryotic-like type IV substrates interfere with organelle trafficking.

de Felipe KS, Glover RT, Charpentier X, Anderson OR, Reyes M, Pericone CD, Shuman HA.

PLoS Pathog. 2008 Aug 1;4(8):e1000117. doi: 10.1371/journal.ppat.1000117. Erratum in: PLoS Pathog. 2010;6(3). doi: 10.1371/annotation/f079872b-7bce-41fe-bc16-c2e45d44b19e. PLoS Pathog. 2010;6(3). doi: 10.1371/annotation/c7438c1b-5b65-4f4c-aaa3-062909e89525.

36.

Host cell-dependent secretion and translocation of the LepA and LepB effectors of Legionella pneumophila.

Chen J, Reyes M, Clarke M, Shuman HA.

Cell Microbiol. 2007 Jul;9(7):1660-71. Epub 2007 Feb 16.

PMID:
17371403
37.

Evidence for acquisition of Legionella type IV secretion substrates via interdomain horizontal gene transfer.

de Felipe KS, Pampou S, Jovanovic OS, Pericone CD, Ye SF, Kalachikov S, Shuman HA.

J Bacteriol. 2005 Nov;187(22):7716-26.

38.

Pathogen effector protein screening in yeast identifies Legionella factors that interfere with membrane trafficking.

Shohdy N, Efe JA, Emr SD, Shuman HA.

Proc Natl Acad Sci U S A. 2005 Mar 29;102(13):4866-71. Epub 2005 Mar 21.

39.
40.

The genomic sequence of the accidental pathogen Legionella pneumophila.

Chien M, Morozova I, Shi S, Sheng H, Chen J, Gomez SM, Asamani G, Hill K, Nuara J, Feder M, Rineer J, Greenberg JJ, Steshenko V, Park SH, Zhao B, Teplitskaya E, Edwards JR, Pampou S, Georghiou A, Chou IC, Iannuccilli W, Ulz ME, Kim DH, Geringer-Sameth A, Goldsberry C, Morozov P, Fischer SG, Segal G, Qu X, Rzhetsky A, Zhang P, Cayanis E, De Jong PJ, Ju J, Kalachikov S, Shuman HA, Russo JJ.

Science. 2004 Sep 24;305(5692):1966-8.

41.

Comparative sequence analysis of the icm/dot genes in Legionella.

Morozova I, Qu X, Shi S, Asamani G, Greenberg JE, Shuman HA, Russo JJ.

Plasmid. 2004 Mar;51(2):127-47.

PMID:
15003709
42.

Legionella effectors that promote nonlytic release from protozoa.

Chen J, de Felipe KS, Clarke M, Lu H, Anderson OR, Segal G, Shuman HA.

Science. 2004 Feb 27;303(5662):1358-61.

43.

Macroautophagy is dispensable for intracellular replication of Legionella pneumophila in Dictyostelium discoideum.

Otto GP, Wu MY, Clarke M, Lu H, Anderson OR, Hilbi H, Shuman HA, Kessin RH.

Mol Microbiol. 2004 Jan;51(1):63-72.

44.

Virulence conversion of Legionella pneumophila by conjugal transfer of chromosomal DNA.

Miyamoto H, Yoshida S, Taniguchi H, Shuman HA.

J Bacteriol. 2003 Nov;185(22):6712-8.

45.

Amphipols: polymeric surfactants for membrane biology research.

Popot JL, Berry EA, Charvolin D, Creuzenet C, Ebel C, Engelman DM, Flötenmeyer M, Giusti F, Gohon Y, Hong Q, Lakey JH, Leonard K, Shuman HA, Timmins P, Warschawski DE, Zito F, Zoonens M, Pucci B, Tribet C.

Cell Mol Life Sci. 2003 Aug;60(8):1559-74. Review.

PMID:
14513831
46.

Disulfide cross-linking reveals a site of stable interaction between C-terminal regulatory domains of the two MalK subunits in the maltose transport complex.

Samanta S, Ayvaz T, Reyes M, Shuman HA, Chen J, Davidson AL.

J Biol Chem. 2003 Sep 12;278(37):35265-71. Epub 2003 Jun 17.

47.

The art and design of genetic screens: Escherichia coli.

Shuman HA, Silhavy TJ.

Nat Rev Genet. 2003 Jun;4(6):419-31. Review.

PMID:
12776212
48.

Just toothpicks and logic: how some labs succeed at solving complex problems.

Shuman HA.

J Bacteriol. 2003 Jan;185(2):387-90. No abstract available.

49.

Cryptococcus neoformans interactions with amoebae suggest an explanation for its virulence and intracellular pathogenic strategy in macrophages.

Steenbergen JN, Shuman HA, Casadevall A.

Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15245-50. Epub 2001 Dec 11.

50.

Icm/dot-dependent upregulation of phagocytosis by Legionella pneumophila.

Hilbi H, Segal G, Shuman HA.

Mol Microbiol. 2001 Nov;42(3):603-17.

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