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Items: 1 to 50 of 418

1.

Identification of a tumor-specific allo-HLA-restricted γδTCR.

Kierkels GJJ, Scheper W, Meringa AD, Johanna I, Beringer DX, Janssen A, Schiffler M, Aarts-Riemens T, Kramer L, Straetemans T, Heijhuurs S, Leusen JHW, San José E, Fuchs K, Griffioen M, Falkenburg JH, Bongiovanni L, de Bruin A, Vargas-Diaz D, Altelaar M, Heck AJR, Shultz LD, Ishikawa F, Nishimura MI, Sebestyén Z, Kuball J.

Blood Adv. 2019 Oct 8;3(19):2870-2882. doi: 10.1182/bloodadvances.2019032409.

2.

Genome-wide Analysis of Salmonella enterica serovar Typhi in Humanized Mice Reveals Key Virulence Features.

Karlinsey JE, Stepien TA, Mayho M, Singletary LA, Bingham-Ramos LK, Brehm MA, Greiner DL, Shultz LD, Gallagher LA, Bawn M, Kingsley RA, Libby SJ, Fang FC.

Cell Host Microbe. 2019 Sep 11;26(3):426-434.e6. doi: 10.1016/j.chom.2019.08.001. Epub 2019 Aug 22.

PMID:
31447308
3.

AK002, a Humanized Sialic Acid-Binding Immunoglobulin-Like Lectin-8 Antibody that Induces Antibody-Dependent Cell-Mediated Cytotoxicity against Human Eosinophils and Inhibits Mast Cell-Mediated Anaphylaxis in Mice.

Youngblood BA, Brock EC, Leung J, Falahati R, Bryce PJ, Bright J, Williams J, Shultz LD, Greiner DL, Brehm MA, Bebbington C, Tomasevic N.

Int Arch Allergy Immunol. 2019;180(2):91-102. doi: 10.1159/000501637. Epub 2019 Aug 9.

4.

Correction to: Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop.

Bedognetti D, Ceccarelli M, Galluzzi L, Lu R, Palucka K, Samayoa J, Spranger S, Warren S, Wong KK, Ziv E, Chowell D, Coussens LM, De Carvalho DD, DeNardo DG, Galon J, Kaufman HL, Kirchhoff T, Lotze MT, Luke JJ, Minn AJ, Politi K, Shultz LD, Simon R, Thórsson V, Weidhaas JB, Ascierto ML, Ascierto PA, Barnes JM, Barsan V, Bommareddy PK, Bot A, Church SE, Ciliberto G, De Maria A, Draganov D, Ho WS, McGee HM, Monette A, Murphy JF, Nisticò P, Park W, Patel M, Quigley M, Radvanyi L, Raftopoulos H, Rudqvist NP, Snyder A, Sweis RF, Valpione S, Zappasodi R, Butterfield LH, Disis ML, Fox BA, Cesano A, Marincola FM; Society for Immunotherapy of Cancer (SITC) Cancer Immune Responsiveness Task Force and Working Groups.

J Immunother Cancer. 2019 Jul 4;7(1):167. doi: 10.1186/s40425-019-0640-y.

5.

Humanized immune system mouse models: progress, challenges and opportunities.

Allen TM, Brehm MA, Bridges S, Ferguson S, Kumar P, Mirochnitchenko O, Palucka K, Pelanda R, Sanders-Beer B, Shultz LD, Su L, PrabhuDas M.

Nat Immunol. 2019 Jul;20(7):770-774. doi: 10.1038/s41590-019-0416-z. No abstract available.

PMID:
31160798
6.

Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop.

Bedognetti D, Ceccarelli M, Galluzzi L, Lu R, Palucka K, Samayoa J, Spranger S, Warren S, Wong KK, Ziv E, Chowell D, Coussens LM, De Carvalho DD, DeNardo DG, Galon J, Kaufman HL, Kirchhoff T, Lotze MT, Luke JJ, Minn AJ, Politi K, Shultz LD, Simon R, Thórsson V, Weidhaas JB, Ascierto ML, Ascierto PA, Barnes JM, Barsan V, Bommareddy PK, Bot A, Church SE, Ciliberto G, De Maria A, Draganov D, Ho WS, McGee HM, Monette A, Murphy JF, Nisticò P, Park W, Patel M, Quigley M, Radvanyi L, Raftopoulos H, Rudqvist NP, Snyder A, Sweis RF, Valpione S, Zappasodi R, Butterfield LH, Disis ML, Fox BA, Cesano A, Marincola FM; Society for Immunotherapy of Cancer (SITC) Cancer Immune Responsiveness Task Force and Working Groups.

J Immunother Cancer. 2019 May 22;7(1):131. doi: 10.1186/s40425-019-0602-4. Review. Erratum in: J Immunother Cancer. 2019 Jul 4;7(1):167.

7.

Mesenchymal stem cells: From regeneration to cancer.

Li P, Gong Z, Shultz LD, Ren G.

Pharmacol Ther. 2019 Aug;200:42-54. doi: 10.1016/j.pharmthera.2019.04.005. Epub 2019 Apr 16. Review.

PMID:
30998940
8.

Human NK cell development in hIL-7 and hIL-15 knockin NOD/SCID/IL2rgKO mice.

Matsuda M, Ono R, Iyoda T, Endo T, Iwasaki M, Tomizawa-Murasawa M, Saito Y, Kaneko A, Shimizu K, Yamada D, Ogonuki N, Watanabe T, Nakayama M, Koseki Y, Kezuka-Shiotani F, Hasegawa T, Yabe H, Kato S, Ogura A, Shultz LD, Ohara O, Taniguchi M, Koseki H, Fujii SI, Ishikawa F.

Life Sci Alliance. 2019 Apr 1;2(2). pii: e201800195. doi: 10.26508/lsa.201800195. Print 2019 Apr.

9.

Humanized mouse models of immunological diseases and precision medicine.

Shultz LD, Keck J, Burzenski L, Jangalwe S, Vaidya S, Greiner DL, Brehm MA.

Mamm Genome. 2019 Jun;30(5-6):123-142. doi: 10.1007/s00335-019-09796-2. Epub 2019 Mar 7. Review.

PMID:
30847553
10.

Co-activation of macrophages and T cells contribute to chronic GVHD in human IL-6 transgenic humanised mouse model.

Ono R, Watanabe T, Kawakami E, Iwasaki M, Tomizawa-Murasawa M, Matsuda M, Najima Y, Takagi S, Fujiki S, Sato R, Mochizuki Y, Yoshida H, Sato K, Yabe H, Kato S, Saito Y, Taniguchi S, Shultz LD, Ohara O, Amagai M, Koseki H, Ishikawa F.

EBioMedicine. 2019 Mar;41:584-596. doi: 10.1016/j.ebiom.2019.02.001. Epub 2019 Feb 13.

11.

Human Anti-HIV-1 gp120 Monoclonal Antibodies with Neutralizing Activity Cloned from Humanized Mice Infected with HIV-1.

Gawron MA, Duval M, Carbone C, Jaiswal S, Wallace A, Martin JC 3rd, Dauphin A, Brehm MA, Greiner DL, Shultz LD, Luban J, Cavacini LA.

J Immunol. 2019 Feb 1;202(3):799-804. doi: 10.4049/jimmunol.1801085. Epub 2018 Dec 28.

PMID:
30593536
12.

Ectopic high endothelial venules in pancreatic ductal adenocarcinoma: A unique site for targeted delivery.

Bahmani B, Uehara M, Ordikhani F, Li X, Jiang L, Banouni N, Ichimura T, Kasinath V, Eskandari SK, Annabi N, Bromberg JS, Shultz LD, Greiner DL, Abdi R.

EBioMedicine. 2018 Dec;38:79-88. doi: 10.1016/j.ebiom.2018.11.030. Epub 2018 Nov 27.

13.

Ectonucleoside Triphosphate Diphosphohydrolase-3 Antibody Targets Adult Human Pancreatic β Cells for In Vitro and In Vivo Analysis.

Saunders DC, Brissova M, Phillips N, Shrestha S, Walker JT, Aramandla R, Poffenberger G, Flaherty DK, Weller KP, Pelletier J, Cooper T, Goff MT, Virostko J, Shostak A, Dean ED, Greiner DL, Shultz LD, Prasad N, Levy SE, Carnahan RH, Dai C, Sévigny J, Powers AC.

Cell Metab. 2019 Mar 5;29(3):745-754.e4. doi: 10.1016/j.cmet.2018.10.007. Epub 2018 Nov 15.

PMID:
30449685
14.

Lack of acute xenogeneic graft- versus-host disease, but retention of T-cell function following engraftment of human peripheral blood mononuclear cells in NSG mice deficient in MHC class I and II expression.

Brehm MA, Kenney LL, Wiles MV, Low BE, Tisch RM, Burzenski L, Mueller C, Greiner DL, Shultz LD.

FASEB J. 2019 Mar;33(3):3137-3151. doi: 10.1096/fj.201800636R. Epub 2018 Nov 1.

PMID:
30383447
15.

RHBDF2-Regulated Growth Factor Signaling in a Rare Human Disease, Tylosis With Esophageal Cancer: What Can We Learn From Murine Models?

Hosur V, Farley ML, Low BE, Burzenski LM, Shultz LD, Wiles MV.

Front Genet. 2018 Jul 4;9:233. doi: 10.3389/fgene.2018.00233. eCollection 2018.

16.

Genetic Models of Macrophage Depletion.

Hua L, Shi J, Shultz LD, Ren G.

Methods Mol Biol. 2018;1784:243-258. doi: 10.1007/978-1-4939-7837-3_22. Review.

17.

ADAM17 is essential for ectodomain shedding of the EGF-receptor ligand amphiregulin.

Hosur V, Farley ML, Burzenski LM, Shultz LD, Wiles MV.

FEBS Open Bio. 2018 Mar 12;8(4):702-710. doi: 10.1002/2211-5463.12407. eCollection 2018 Apr.

18.

α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes.

Brissova M, Haliyur R, Saunders D, Shrestha S, Dai C, Blodgett DM, Bottino R, Campbell-Thompson M, Aramandla R, Poffenberger G, Lindner J, Pan FC, von Herrath MG, Greiner DL, Shultz LD, Sanyoura M, Philipson LH, Atkinson M, Harlan DM, Levy SE, Prasad N, Stein R, Powers AC.

Cell Rep. 2018 Mar 6;22(10):2667-2676. doi: 10.1016/j.celrep.2018.02.032.

19.

Patient-derived xenografts of low-grade B-cell lymphomas demonstrate roles of the tumor microenvironment.

Burack WR, Spence JM, Spence JP, Spence SA, Rock PJ, Shenoy GN, Shultz LD, Bankert RB, Bernstein SH.

Blood Adv. 2017 Jul 7;1(16):1263-1273. doi: 10.1182/bloodadvances.2017005892. eCollection 2017 Jul 11.

20.

Humanized mice in studying efficacy and mechanisms of PD-1-targeted cancer immunotherapy.

Wang M, Yao LC, Cheng M, Cai D, Martinek J, Pan CX, Shi W, Ma AH, De Vere White RW, Airhart S, Liu ET, Banchereau J, Brehm MA, Greiner DL, Shultz LD, Palucka K, Keck JG.

FASEB J. 2018 Mar;32(3):1537-1549. doi: 10.1096/fj.201700740R. Epub 2018 Jan 3.

21.

Tissue-specific role of RHBDF2 in cutaneous wound healing and hyperproliferative skin disease.

Hosur V, Lyons BL, Burzenski LM, Shultz LD.

BMC Res Notes. 2017 Nov 7;10(1):573. doi: 10.1186/s13104-017-2899-8.

22.

Overcoming mutational complexity in acute myeloid leukemia by inhibition of critical pathways.

Saito Y, Mochizuki Y, Ogahara I, Watanabe T, Hogdal L, Takagi S, Sato K, Kaneko A, Kajita H, Uchida N, Fukami T, Shultz LD, Taniguchi S, Ohara O, Letai AG, Ishikawa F.

Sci Transl Med. 2017 Oct 25;9(413). pii: eaao1214. doi: 10.1126/scitranslmed.aao1214.

23.

Survival Advantage of Both Human Hepatocyte Xenografts and Genome-Edited Hepatocytes for Treatment of α-1 Antitrypsin Deficiency.

Borel F, Tang Q, Gernoux G, Greer C, Wang Z, Barzel A, Kay MA, Shultz LD, Greiner DL, Flotte TR, Brehm MA, Mueller C.

Mol Ther. 2017 Nov 1;25(11):2477-2489. doi: 10.1016/j.ymthe.2017.09.020. Epub 2017 Sep 25.

24.

Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling.

Dai C, Hang Y, Shostak A, Poffenberger G, Hart N, Prasad N, Phillips N, Levy SE, Greiner DL, Shultz LD, Bottino R, Kim SK, Powers AC.

J Clin Invest. 2017 Oct 2;127(10):3835-3844. doi: 10.1172/JCI91761. Epub 2017 Sep 18.

25.

Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics.

Kooreman NG, de Almeida PE, Stack JP, Nelakanti RV, Diecke S, Shao NY, Swijnenburg RJ, Sanchez-Freire V, Matsa E, Liu C, Connolly AJ, Hamming JF, Quax PHA, Brehm MA, Greiner DL, Shultz LD, Wu JC.

Cell Rep. 2017 Aug 22;20(8):1978-1990. doi: 10.1016/j.celrep.2017.08.003.

26.

Gene Therapy with an Adeno-Associated Viral Vector Expressing Human Interleukin-2 Alters Immune System Homeostasis in Humanized Mice.

Durost PA, Aryee KE, Manzoor F, Tisch RM, Mueller C, Jurczyk A, Shultz LD, Brehm MA.

Hum Gene Ther. 2018 Mar;29(3):352-365. doi: 10.1089/hum.2017.072. Epub 2017 Oct 3.

27.

Genetic deletion of amphiregulin restores the normal skin phenotype in a mouse model of the human skin disease tylosis.

Hosur V, Low BE, Shultz LD, Wiles MV.

Biol Open. 2017 Aug 15;6(8):1174-1179. doi: 10.1242/bio.026260.

28.

mRNA-mediated glycoengineering ameliorates deficient homing of human stem cell-derived hematopoietic progenitors.

Lee J, Dykstra B, Spencer JA, Kenney LL, Greiner DL, Shultz LD, Brehm MA, Lin CP, Sackstein R, Rossi DJ.

J Clin Invest. 2017 Jun 1;127(6):2433-2437. doi: 10.1172/JCI92030. Epub 2017 May 8.

29.

A novel hemolytic complement-sufficient NSG mouse model supports studies of complement-mediated antitumor activity in vivo.

Verma MK, Clemens J, Burzenski L, Sampson SB, Brehm MA, Greiner DL, Shultz LD.

J Immunol Methods. 2017 Jul;446:47-53. doi: 10.1016/j.jim.2017.03.021. Epub 2017 Apr 6.

30.

Development of Humanized Mice in the Age of Genome Editing.

Hosur V, Low BE, Avery C, Shultz LD, Wiles MV.

J Cell Biochem. 2017 Oct;118(10):3043-3048. doi: 10.1002/jcb.26002. Epub 2017 May 15.

31.

Early induction of NRF2 antioxidant pathway by RHBDF2 mediates rapid cutaneous wound healing.

Hosur V, Burzenski LM, Stearns TM, Farley ML, Sundberg JP, Wiles MV, Shultz LD.

Exp Mol Pathol. 2017 Apr;102(2):337-346. doi: 10.1016/j.yexmp.2017.03.003. Epub 2017 Mar 6.

32.

Analysis of parameters that affect human hematopoietic cell outputs in mutant c-kit-immunodeficient mice.

Miller PH, Rabu G, MacAldaz M, Knapp DJ, Cheung AM, Dhillon K, Nakamichi N, Beer PA, Shultz LD, Humphries RK, Eaves CJ.

Exp Hematol. 2017 Apr;48:41-49. doi: 10.1016/j.exphem.2016.12.012. Epub 2017 Jan 11.

33.
34.

Humanized Mouse Models of Clinical Disease.

Walsh NC, Kenney LL, Jangalwe S, Aryee KE, Greiner DL, Brehm MA, Shultz LD.

Annu Rev Pathol. 2017 Jan 24;12:187-215. doi: 10.1146/annurev-pathol-052016-100332. Epub 2016 Dec 5. Review.

35.

Distinct Differences on Neointima Formation in Immunodeficient and Humanized Mice after Carotid or Femoral Arterial Injury.

Moser J, van Ark J, van Dijk MC, Greiner DL, Shultz LD, van Goor H, Hillebrands JL.

Sci Rep. 2016 Oct 19;6:35387. doi: 10.1038/srep35387.

36.

Combined B, T and NK Cell Deficiency Accelerates Atherosclerosis in BALB/c Mice.

Cheng F, Twardowski L, Reifenberg K, Winter K, Canisius A, Pross E, Fan J, Schmitt E, Shultz LD, Lackner KJ, Torzewski M.

PLoS One. 2016 Aug 26;11(8):e0157311. doi: 10.1371/journal.pone.0157311. eCollection 2016.

37.

Cell-Extrinsic MHC Class I Molecule Engagement Augments Human NK Cell Education Programmed by Cell-Intrinsic MHC Class I.

Boudreau JE, Liu XR, Zhao Z, Zhang A, Shultz LD, Greiner DL, Dupont B, Hsu KC.

Immunity. 2016 Aug 16;45(2):280-91. doi: 10.1016/j.immuni.2016.07.005. Epub 2016 Aug 2.

38.

A Salmonella nanoparticle mimic overcomes multidrug resistance in tumours.

Mercado-Lubo R, Zhang Y, Zhao L, Rossi K, Wu X, Zou Y, Castillo A, Leonard J, Bortell R, Greiner DL, Shultz LD, Han G, McCormick BA.

Nat Commun. 2016 Jul 25;7:12225. doi: 10.1038/ncomms12225.

39.

Generation of Immunodeficient Mice Bearing Human Immune Systems by the Engraftment of Hematopoietic Stem Cells.

Hasgur S, Aryee KE, Shultz LD, Greiner DL, Brehm MA.

Methods Mol Biol. 2016;1438:67-78. doi: 10.1007/978-1-4939-3661-8_4.

40.

Humanized mouse model of mast cell-mediated passive cutaneous anaphylaxis and passive systemic anaphylaxis.

Bryce PJ, Falahati R, Kenney LL, Leung J, Bebbington C, Tomasevic N, Krier RA, Hsu CL, Shultz LD, Greiner DL, Brehm MA.

J Allergy Clin Immunol. 2016 Sep;138(3):769-779. doi: 10.1016/j.jaci.2016.01.049. Epub 2016 Apr 6.

41.

Genetically modified human CD4(+) T cells can be evaluated in vivo without lethal graft-versus-host disease.

Ali R, Babad J, Follenzi A, Gebe JA, Brehm MA, Nepom GT, Shultz LD, Greiner DL, DiLorenzo TP.

Immunology. 2016 Aug;148(4):339-51. doi: 10.1111/imm.12613.

42.

Stress-impaired transcription factor expression and insulin secretion in transplanted human islets.

Dai C, Kayton NS, Shostak A, Poffenberger G, Cyphert HA, Aramandla R, Thompson C, Papagiannis IG, Emfinger C, Shiota M, Stafford JM, Greiner DL, Herrera PL, Shultz LD, Stein R, Powers AC.

J Clin Invest. 2016 May 2;126(5):1857-70. doi: 10.1172/JCI83657. Epub 2016 Apr 11.

43.

Patient-Derived Tumor Xenografts: Why Now?

Liu ET, Bult CJ, Shultz LD.

JAMA Oncol. 2016 May 1;2(5):567-568. doi: 10.1001/jamaoncol.2016.0193. No abstract available.

PMID:
27055176
44.

P-Rex1 Promotes Resistance to VEGF/VEGFR-Targeted Therapy in Prostate Cancer.

Goel HL, Pursell B, Shultz LD, Greiner DL, Brekken RA, Vander Kooi CW, Mercurio AM.

Cell Rep. 2016 Mar 8;14(9):2193-2208. doi: 10.1016/j.celrep.2016.02.016. Epub 2016 Feb 25.

45.

Induction of WT1-specific human CD8+ T cells from human HSCs in HLA class I Tg NOD/SCID/IL2rgKO mice.

Najima Y, Tomizawa-Murasawa M, Saito Y, Watanabe T, Ono R, Ochi T, Suzuki N, Fujiwara H, Ohara O, Shultz LD, Yasukawa M, Ishikawa F.

Blood. 2016 Feb 11;127(6):722-34. doi: 10.1182/blood-2014-10-604777. Epub 2015 Dec 23.

46.

Improvements and Limitations of Humanized Mouse Models for HIV Research: NIH/NIAID "Meet the Experts" 2015 Workshop Summary.

Akkina R, Allam A, Balazs AB, Blankson JN, Burnett JC, Casares S, Garcia JV, Hasenkrug KJ, Kashanchi F, Kitchen SG, Klein F, Kumar P, Luster AD, Poluektova LY, Rao M, Sanders-Beer BE, Shultz LD, Zack JA.

AIDS Res Hum Retroviruses. 2016 Feb;32(2):109-19. doi: 10.1089/AID.2015.0258.

47.

Genetic ablation of lymphocytes and cytokine signaling in nonobese diabetic mice prevents diet-induced obesity and insulin resistance.

Friedline RH, Ko HJ, Jung DY, Lee Y, Bortell R, Dagdeviren S, Patel PR, Hu X, Inashima K, Kearns C, Tsitsilianos N, Shafiq U, Shultz LD, Lee KW, Greiner DL, Kim JK.

FASEB J. 2016 Mar;30(3):1328-38. doi: 10.1096/fj.15-280610. Epub 2015 Dec 7.

48.

Humanized Mouse Models for Transplant Immunology.

Kenney LL, Shultz LD, Greiner DL, Brehm MA.

Am J Transplant. 2016 Feb;16(2):389-97. doi: 10.1111/ajt.13520. Epub 2015 Nov 20. Review.

49.

Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection.

Sewald X, Ladinsky MS, Uchil PD, Beloor J, Pi R, Herrmann C, Motamedi N, Murooka TT, Brehm MA, Greiner DL, Shultz LD, Mempel TR, Bjorkman PJ, Kumar P, Mothes W.

Science. 2015 Oct 30;350(6260):563-567. doi: 10.1126/science.aab2749. Epub 2015 Oct 1.

50.

Efficient and Targeted Transduction of Nonhuman Primate Liver With Systemically Delivered Optimized AAV3B Vectors.

Li S, Ling C, Zhong L, Li M, Su Q, He R, Tang Q, Greiner DL, Shultz LD, Brehm MA, Flotte TR, Mueller C, Srivastava A, Gao G.

Mol Ther. 2015 Dec;23(12):1867-76. doi: 10.1038/mt.2015.174. Epub 2015 Sep 25.

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