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Items: 1 to 50 of 320

1.

A Non-cognitive Behavioral Model for Interpreting Functional Neuroimaging Studies.

Shulman RG, Rothman DL.

Front Hum Neurosci. 2019 Mar 11;13:28. doi: 10.3389/fnhum.2019.00028. eCollection 2019.

2.

The Glycogen Shunt Maintains Glycolytic Homeostasis and the Warburg Effect in Cancer.

Shulman RG, Rothman DL.

Trends Cancer. 2017 Nov;3(11):761-767. doi: 10.1016/j.trecan.2017.09.007. Epub 2017 Nov 6. Review.

PMID:
29120752
3.

Homeostasis and the glycogen shunt explains aerobic ethanol production in yeast.

Shulman RG, Rothman DL.

Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):10902-7. doi: 10.1073/pnas.1510730112. Epub 2015 Aug 17.

4.

Insights from neuroenergetics into the interpretation of functional neuroimaging: an alternative empirical model for studying the brain's support of behavior.

Shulman RG, Hyder F, Rothman DL.

J Cereb Blood Flow Metab. 2014 Nov;34(11):1721-35. doi: 10.1038/jcbfm.2014.145. Epub 2014 Aug 27. Review.

5.

Direct evidence for activity-dependent glucose phosphorylation in neurons with implications for the astrocyte-to-neuron lactate shuttle.

Patel AB, Lai JC, Chowdhury GM, Hyder F, Rothman DL, Shulman RG, Behar KL.

Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5385-90. doi: 10.1073/pnas.1403576111. Epub 2014 Mar 26.

6.

Glutamatergic function in the resting awake human brain is supported by uniformly high oxidative energy.

Hyder F, Fulbright RK, Shulman RG, Rothman DL.

J Cereb Blood Flow Metab. 2013 Mar;33(3):339-47. doi: 10.1038/jcbfm.2012.207. Epub 2013 Jan 9. Review. Erratum in: J Cereb Blood Flow Metab. 2014 Feb;34(2):368.

7.

A philosophical analysis of neuroenergetics.

Shulman RG.

Front Neuroenergetics. 2011 Nov 18;3:6. doi: 10.3389/fnene.2011.00006. eCollection 2011. No abstract available.

8.

Baseline brain energy supports the state of consciousness.

Shulman RG, Hyder F, Rothman DL.

Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11096-101. doi: 10.1073/pnas.0903941106. Epub 2009 Jun 19.

9.

Neurophysiology of functional imaging.

van Eijsden P, Hyder F, Rothman DL, Shulman RG.

Neuroimage. 2009 May 1;45(4):1047-54. doi: 10.1016/j.neuroimage.2008.08.026. Epub 2008 Aug 30. Review.

10.

Energetics of neuronal signaling and fMRI activity.

Maandag NJ, Coman D, Sanganahalli BG, Herman P, Smith AJ, Blumenfeld H, Shulman RG, Hyder F.

Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20546-51. Epub 2007 Dec 13.

11.

A BOLD search for baseline.

Shulman RG, Rothman DL, Hyder F.

Neuroimage. 2007 Jun;36(2):277-81. Epub 2007 Jan 16.

12.

Neuronal-glial glucose oxidation and glutamatergic-GABAergic function.

Hyder F, Patel AB, Gjedde A, Rothman DL, Behar KL, Shulman RG.

J Cereb Blood Flow Metab. 2006 Jul;26(7):865-77. Epub 2006 Jan 11. Review.

PMID:
16407855
13.

Glycogen turnover forms lactate during exercise.

Shulman RG.

Exerc Sport Sci Rev. 2005 Oct;33(4):157-62. Review.

PMID:
16239831
14.

The contribution of GABA to glutamate/glutamine cycling and energy metabolism in the rat cortex in vivo.

Patel AB, de Graaf RA, Mason GF, Rothman DL, Shulman RG, Behar KL.

Proc Natl Acad Sci U S A. 2005 Apr 12;102(15):5588-93. Epub 2005 Apr 4.

15.

Cerebral pyruvate carboxylase flux is unaltered during bicuculline-seizures.

Patel AB, Chowdhury GM, de Graaf RA, Rothman DL, Shulman RG, Behar KL.

J Neurosci Res. 2005 Jan 1-15;79(1-2):128-38. Erratum in: J Neurosci Res. 2005 Jun 1;80(5):738.

PMID:
15562501
16.

Glutamatergic neurotransmission and neuronal glucose oxidation are coupled during intense neuronal activation.

Patel AB, de Graaf RA, Mason GF, Kanamatsu T, Rothman DL, Shulman RG, Behar KL.

J Cereb Blood Flow Metab. 2004 Sep;24(9):972-85.

PMID:
15356418
17.

Energetic basis of brain activity: implications for neuroimaging.

Shulman RG, Rothman DL, Behar KL, Hyder F.

Trends Neurosci. 2004 Aug;27(8):489-95. Review.

PMID:
15271497
18.

Protein phosphorylation can regulate metabolite concentrations rather than control flux: the example of glycogen synthase.

Schafer JR, Fell DA, Rothman D, Shulman RG.

Proc Natl Acad Sci U S A. 2004 Feb 10;101(6):1485-90. Epub 2004 Jan 26.

19.

Coupling of glutamatergic neurotransmission and neuronal glucose oxidation over the entire range of cerebral cortex activity.

Patel AB, De Graaf RA, Mason GF, Rothman DL, Shulman RG, Behar KL.

Ann N Y Acad Sci. 2003 Nov;1003:452-3. No abstract available.

PMID:
14684486
20.

Cerebral metabolism and consciousness.

Shulman RG, Hyder F, Rothman DL.

C R Biol. 2003 Mar;326(3):253-73. Review.

PMID:
12806834
21.

Biophysical basis of brain activity: implications for neuroimaging.

Shulman RG, Hyder F, Rothman DL.

Q Rev Biophys. 2002 Aug;35(3):287-325. Review.

PMID:
12599751
22.

In vivo NMR studies of the glutamate neurotransmitter flux and neuroenergetics: implications for brain function.

Rothman DL, Behar KL, Hyder F, Shulman RG.

Annu Rev Physiol. 2003;65:401-27. Epub 2002 May 1. Review.

PMID:
12524459
23.

Mapping at glomerular resolution: fMRI of rat olfactory bulb.

Kida I, Xu F, Shulman RG, Hyder F.

Magn Reson Med. 2002 Sep;48(3):570-6.

24.

Total neuroenergetics support localized brain activity: implications for the interpretation of fMRI.

Hyder F, Rothman DL, Shulman RG.

Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10771-6. Epub 2002 Jul 19.

25.

Cerebral energetics and spiking frequency: the neurophysiological basis of fMRI.

Smith AJ, Blumenfeld H, Behar KL, Rothman DL, Shulman RG, Hyder F.

Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10765-70. Epub 2002 Jul 19.

27.

Lactate efflux and the neuroenergetic basis of brain function.

Shulman RG, Hyder F, Rothman DL.

NMR Biomed. 2001 Nov-Dec;14(7-8):389-96.

PMID:
11746930
28.

Cerebral energetics and the glycogen shunt: neurochemical basis of functional imaging.

Shulman RG, Hyder F, Rothman DL.

Proc Natl Acad Sci U S A. 2001 May 22;98(11):6417-22. Epub 2001 May 8.

29.

Flux control in the rat gastrocnemius glycogen synthesis pathway by in vivo 13C/31P NMR spectroscopy.

Chase JR, Rothman DL, Shulman RG.

Am J Physiol Endocrinol Metab. 2001 Apr;280(4):E598-607.

30.

The "glycogen shunt" in exercising muscle: A role for glycogen in muscle energetics and fatigue.

Shulman RG, Rothman DL.

Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):457-61.

31.

13C NMR of intermediary metabolism: implications for systemic physiology.

Shulman RG, Rothman DL.

Annu Rev Physiol. 2001;63:15-48. Review.

PMID:
11181947
32.

In vivo (13)C NMR measurement of neurotransmitter glutamate cycling, anaplerosis and TCA cycle flux in rat brain during.

Sibson NR, Mason GF, Shen J, Cline GW, Herskovits AZ, Wall JE, Behar KL, Rothman DL, Shulman RG.

J Neurochem. 2001 Feb;76(4):975-89.

33.

Functional imaging studies: linking mind and basic neuroscience.

Shulman RG.

Am J Psychiatry. 2001 Jan;158(1):11-20. Review.

PMID:
11136626
34.

Assessment and discrimination of odor stimuli in rat olfactory bulb by dynamic functional MRI.

Xu F, Kida I, Hyder F, Shulman RG.

Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10601-6.

35.

NMR of glycogen in exercise.

Price TB, Rothman DL, Shulman RG.

Proc Nutr Soc. 1999 Nov;58(4):851-9. Review.

PMID:
10817152
36.

Regulation of cerebral oxygen delivery.

Hyder F, Shulman RG, Rothman DL.

Adv Exp Med Biol. 1999;471:99-110. No abstract available.

PMID:
10659136
37.

In vivo nuclear magnetic resonance spectroscopy studies of the relationship between the glutamate-glutamine neurotransmitter cycle and functional neuroenergetics.

Rothman DL, Sibson NR, Hyder F, Shen J, Behar KL, Shulman RG.

Philos Trans R Soc Lond B Biol Sci. 1999 Jul 29;354(1387):1165-77. Review.

38.

Determination of the rate of the glutamate/glutamine cycle in the human brain by in vivo 13C NMR.

Shen J, Petersen KF, Behar KL, Brown P, Nixon TW, Mason GF, Petroff OA, Shulman GI, Shulman RG, Rothman DL.

Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):8235-40.

39.

Stimulated changes in localized cerebral energy consumption under anesthesia.

Shulman RG, Rothman DL, Hyder F.

Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):3245-50.

40.

Energy on demand.

Magistretti PJ, Pellerin L, Rothman DL, Shulman RG.

Science. 1999 Jan 22;283(5401):496-7. No abstract available.

PMID:
9988650
41.

15N-NMR spectroscopy studies of ammonia transport and glutamine synthesis in the hyperammonemic rat brain.

Shen J, Sibson NR, Cline G, Behar KL, Rothman DL, Shulman RG.

Dev Neurosci. 1998;20(4-5):434-43.

PMID:
9778582
42.

Functional energy metabolism: in vivo 13C-NMR spectroscopy evidence for coupling of cerebral glucose consumption and glutamatergic neuronalactivity.

Sibson NR, Shen J, Mason GF, Rothman DL, Behar KL, Shulman RG.

Dev Neurosci. 1998;20(4-5):321-30. Review.

PMID:
9778568
43.

Interpreting functional imaging studies in terms of neurotransmitter cycling.

Shulman RG, Rothman DL.

Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11993-8. Review.

44.

A model for the regulation of cerebral oxygen delivery.

Hyder F, Shulman RG, Rothman DL.

J Appl Physiol (1985). 1998 Aug;85(2):554-64.

45.

Dynamic mapping at the laminar level of odor-elicited responses in rat olfactory bulb by functional MRI.

Yang X, Renken R, Hyder F, Siddeek M, Greer CA, Shepherd GM, Shulman RG.

Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7715-20.

46.

In vivo 13C NMR measurements of hepatocellular tricarboxylic acid cycle flux.

Jucker BM, Lee JY, Shulman RG.

J Biol Chem. 1998 May 15;273(20):12187-94.

47.

Hard days in the trenches.

Shulman RG.

FASEB J. 1998 Mar;12(3):255-8. No abstract available.

PMID:
9506465
48.

Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity.

Sibson NR, Dhankhar A, Mason GF, Rothman DL, Behar KL, Shulman RG.

Proc Natl Acad Sci U S A. 1998 Jan 6;95(1):316-21.

49.

Functional MRI BOLD signal coincides with electrical activity in the rat whisker barrels.

Yang X, Hyder F, Shulman RG.

Magn Reson Med. 1997 Dec;38(6):874-7.

PMID:
9402186
50.

Oxidative glucose metabolism in rat brain during single forepaw stimulation: a spatially localized 1H[13C] nuclear magnetic resonance study.

Hyder F, Rothman DL, Mason GF, Rangarajan A, Behar KL, Shulman RG.

J Cereb Blood Flow Metab. 1997 Oct;17(10):1040-7.

PMID:
9346428

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