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Items: 1 to 50 of 496

1.

Controlled-release mitochondrial protonophore (CRMP) reverses dyslipidemia and hepatic steatosis in dysmetabolic nonhuman primates.

Goedeke L, Peng L, Montalvo-Romeral V, Butrico GM, Dufour S, Zhang XM, Perry RJ, Cline GW, Kievit P, Chng K, Petersen KF, Shulman GI.

Sci Transl Med. 2019 Oct 2;11(512). pii: eaay0284. doi: 10.1126/scitranslmed.aay0284.

PMID:
31578240
2.

Regulation of hepatic mitochondrial oxidation by glucose-alanine cycling during starvation in humans.

Petersen KF, Dufour S, Cline GW, Shulman GI.

J Clin Invest. 2019 Sep 23. pii: 129913. doi: 10.1172/JCI129913. [Epub ahead of print]

3.

GS-0976 (Firsocostat): an investigational liver-directed acetyl-CoA carboxylase (ACC) inhibitor for the treatment of non-alcoholic steatohepatitis (NASH).

Alkhouri N, Lawitz E, Noureddin M, DeFronzo R, Shulman GI.

Expert Opin Investig Drugs. 2019 Sep 19:1-7. doi: 10.1080/13543784.2020.1668374. [Epub ahead of print]

PMID:
31519114
4.

The effects of increased acetate turnover on glucose-induced insulin secretion in lean and obese humans.

Petersen KF, Impellizeri A, Cline GW, Shulman GI.

J Clin Transl Sci. 2019 Feb;3(1):18-20. doi: 10.1017/cts.2018.342.

5.

Considering the Links Between Nonalcoholic Fatty Liver Disease and Insulin Resistance: Revisiting the Role of Protein Kinase C ε.

Samuel VT, Petersen MC, Gassaway BM, Vatner DF, Rinehart J, Shulman GI.

Hepatology. 2019 Jun 20. doi: 10.1002/hep.30829. [Epub ahead of print] No abstract available.

PMID:
31220350
6.

Leptin's hunger-suppressing effects are mediated by the hypothalamic-pituitary-adrenocortical axis in rodents.

Perry RJ, Resch JM, Douglass AM, Madara JC, Rabin-Court A, Kucukdereli H, Wu C, Song JD, Lowell BB, Shulman GI.

Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13670-13679. doi: 10.1073/pnas.1901795116. Epub 2019 Jun 18.

7.

Anti-inflammatory effects of oestrogen mediate the sexual dimorphic response to lipid-induced insulin resistance.

Camporez JP, Lyu K, Goldberg EL, Zhang D, Cline GW, Jurczak MJ, Dixit VD, Petersen KF, Shulman GI.

J Physiol. 2019 Aug;597(15):3885-3903. doi: 10.1113/JP277270. Epub 2019 Jul 4.

PMID:
31206703
8.

TFAM Enhances Fat Oxidation and Attenuates High-Fat Diet-Induced Insulin Resistance in Skeletal Muscle.

Koh JH, Johnson ML, Dasari S, LeBrasseur NK, Vuckovic I, Henderson GC, Cooper SA, Manjunatha S, Ruegsegger GN, Shulman GI, Lanza IR, Nair KS.

Diabetes. 2019 Aug;68(8):1552-1564. doi: 10.2337/db19-0088. Epub 2019 May 14.

PMID:
31088855
9.

Cardiac myocyte KLF5 regulates body weight via alteration of cardiac FGF21.

Pol CJ, Pollak NM, Jurczak MJ, Zacharia E, Karagiannides I, Kyriazis ID, Ntziachristos P, Scerbo DA, Brown BR, Aifantis I, Shulman GI, Goldberg IJ, Drosatos K.

Biochim Biophys Acta Mol Basis Dis. 2019 Sep 1;1865(9):2125-2137. doi: 10.1016/j.bbadis.2019.04.010. Epub 2019 Apr 26.

PMID:
31029826
10.

Defective fatty acid oxidation in mice with muscle-specific acyl-CoA synthetase 1 deficiency increases amino acid use and impairs muscle function.

Zhao L, Pascual F, Bacudio L, Suchanek AL, Young PA, Li LO, Martin SA, Camporez JP, Perry RJ, Shulman GI, Klett EL, Coleman RA.

J Biol Chem. 2019 May 31;294(22):8819-8833. doi: 10.1074/jbc.RA118.006790. Epub 2019 Apr 11.

PMID:
30975900
11.

Altered In Vivo Lipid Fluxes and Cell Dynamics in Subcutaneous Adipose Tissues Are Associated With the Unfavorable Pattern of Fat Distribution in Obese Adolescent Girls.

Nouws J, Fitch M, Mata M, Santoro N, Galuppo B, Kursawe R, Narayan D, Vash-Margita A, Pierpont B, Shulman GI, Hellerstein M, Caprio S.

Diabetes. 2019 Jun;68(6):1168-1177. doi: 10.2337/db18-1162. Epub 2019 Apr 1.

PMID:
30936147
12.

Adipose glucocorticoid action influences whole-body metabolism via modulation of hepatic insulin action.

Abulizi A, Camporez JP, Jurczak MJ, Høyer KF, Zhang D, Cline GW, Samuel VT, Shulman GI, Vatner DF.

FASEB J. 2019 Jul;33(7):8174-8185. doi: 10.1096/fj.201802706R. Epub 2019 Mar 28.

PMID:
30922125
13.

Author Correction: Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo.

Madiraju AK, Qiu Y, Perry RJ, Rahimi Y, Zhang XM, Zhang D, Camporez JG, Cline GW, Butrico GM, Kemp BE, Casals G, Steinberg GR, Vatner DF, Petersen KF, Shulman GI.

Nat Med. 2019 Mar;25(3):526-528. doi: 10.1038/s41591-018-0220-6.

PMID:
30733621
14.

Dehydration and insulinopenia are necessary and sufficient for euglycemic ketoacidosis in SGLT2 inhibitor-treated rats.

Perry RJ, Rabin-Court A, Song JD, Cardone RL, Wang Y, Kibbey RG, Shulman GI.

Nat Commun. 2019 Feb 1;10(1):548. doi: 10.1038/s41467-019-08466-w.

15.

Emerging Pharmacological Targets for the Treatment of Nonalcoholic Fatty Liver Disease, Insulin Resistance, and Type 2 Diabetes.

Goedeke L, Perry RJ, Shulman GI.

Annu Rev Pharmacol Toxicol. 2019 Jan 6;59:65-87. doi: 10.1146/annurev-pharmtox-010716-104727.

PMID:
30625285
16.

Ectopic lipid deposition mediates insulin resistance in adipose specific 11β-hydroxysteroid dehydrogenase type 1 transgenic mice.

Abulizi A, Camporez JP, Zhang D, Samuel VT, Shulman GI, Vatner DF.

Metabolism. 2019 Apr;93:1-9. doi: 10.1016/j.metabol.2018.12.003. Epub 2018 Dec 19.

PMID:
30576689
17.

PKCε contributes to lipid-induced insulin resistance through cross talk with p70S6K and through previously unknown regulators of insulin signaling.

Gassaway BM, Petersen MC, Surovtseva YV, Barber KW, Sheetz JB, Aerni HR, Merkel JS, Samuel VT, Shulman GI, Rinehart J.

Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):E8996-E9005. doi: 10.1073/pnas.1804379115. Epub 2018 Sep 4.

18.

The circulating metabolome of human starvation.

Steinhauser ML, Olenchock BA, O'Keefe J, Lun M, Pierce KA, Lee H, Pantano L, Klibanski A, Shulman GI, Clish CB, Fazeli PK.

JCI Insight. 2018 Aug 23;3(16). pii: 121434. doi: 10.1172/jci.insight.121434. eCollection 2018 Aug 23.

19.

Lacteal junction zippering protects against diet-induced obesity.

Zhang F, Zarkada G, Han J, Li J, Dubrac A, Ola R, Genet G, Boyé K, Michon P, Künzel SE, Camporez JP, Singh AK, Fong GH, Simons M, Tso P, Fernández-Hernando C, Shulman GI, Sessa WC, Eichmann A.

Science. 2018 Aug 10;361(6402):599-603. doi: 10.1126/science.aap9331.

20.

Loss of Nucleobindin-2 Causes Insulin Resistance in Obesity without Impacting Satiety or Adiposity.

Ravussin A, Youm YH, Sander J, Ryu S, Nguyen K, Varela L, Shulman GI, Sidorov S, Horvath TL, Schultze JL, Dixit VD.

Cell Rep. 2018 Jul 31;24(5):1085-1092.e6. doi: 10.1016/j.celrep.2018.06.112.

21.

Mechanisms of Insulin Action and Insulin Resistance.

Petersen MC, Shulman GI.

Physiol Rev. 2018 Oct 1;98(4):2133-2223. doi: 10.1152/physrev.00063.2017. Review.

22.

Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo.

Madiraju AK, Qiu Y, Perry RJ, Rahimi Y, Zhang XM, Zhang D, Camporez JG, Cline GW, Butrico GM, Kemp BE, Casals G, Steinberg GR, Vatner DF, Petersen KF, Shulman GI.

Nat Med. 2018 Sep;24(9):1384-1394. doi: 10.1038/s41591-018-0125-4. Epub 2018 Jul 23. Erratum in: Nat Med. 2019 Mar;25(3):526-528.

23.

Deciphering the Role of Lipid Droplets in Cardiovascular Disease: A Report From the 2017 National Heart, Lung, and Blood Institute Workshop.

Goldberg IJ, Reue K, Abumrad NA, Bickel PE, Cohen S, Fisher EA, Galis ZS, Granneman JG, Lewandowski ED, Murphy R, Olive M, Schaffer JE, Schwartz-Longacre L, Shulman GI, Walther TC, Chen J.

Circulation. 2018 Jul 17;138(3):305-315. doi: 10.1161/CIRCULATIONAHA.118.033704. Review.

24.

Uncoupling Hepatic Oxidative Phosphorylation Reduces Tumor Growth in Two Murine Models of Colon Cancer.

Wang Y, Nasiri AR, Damsky WE, Perry CJ, Zhang XM, Rabin-Court A, Pollak MN, Shulman GI, Perry RJ.

Cell Rep. 2018 Jul 3;24(1):47-55. doi: 10.1016/j.celrep.2018.06.008.

25.

Acetyl-CoA Carboxylase Inhibition Reverses NAFLD and Hepatic Insulin Resistance but Promotes Hypertriglyceridemia in Rodents.

Goedeke L, Bates J, Vatner DF, Perry RJ, Wang T, Ramirez R, Li L, Ellis MW, Zhang D, Wong KE, Beysen C, Cline GW, Ray AS, Shulman GI.

Hepatology. 2018 Dec;68(6):2197-2211. doi: 10.1002/hep.30097.

PMID:
29790582
26.

Elevated hepatic expression of H19 long noncoding RNA contributes to diabetic hyperglycemia.

Zhang N, Geng T, Wang Z, Zhang R, Cao T, Camporez JP, Cai SY, Liu Y, Dandolo L, Shulman GI, Carmichael GG, Taylor HS, Huang Y.

JCI Insight. 2018 May 17;3(10). pii: 120304. doi: 10.1172/jci.insight.120304. eCollection 2018 May 17.

27.

The Role of Leptin in Maintaining Plasma Glucose During Starvation.

Perry RJ, Shulman GI.

Postdoc J. 2018 Mar;6(3):3-19. doi: 10.14304/surya.jpr.v6n3.2.

28.

Absence of ANGPTL4 in adipose tissue improves glucose tolerance and attenuates atherogenesis.

Aryal B, Singh AK, Zhang X, Varela L, Rotllan N, Goedeke L, Chaube B, Camporez JP, Vatner DF, Horvath TL, Shulman GI, Suárez Y, Fernández-Hernando C.

JCI Insight. 2018 Mar 22;3(6). pii: 97918. doi: 10.1172/jci.insight.97918.

29.

Angptl8 antisense oligonucleotide improves adipose lipid metabolism and prevents diet-induced NAFLD and hepatic insulin resistance in rodents.

Vatner DF, Goedeke L, Camporez JG, Lyu K, Nasiri AR, Zhang D, Bhanot S, Murray SF, Still CD, Gerhard GS, Shulman GI, Samuel VT.

Diabetologia. 2018 Jun;61(6):1435-1446. doi: 10.1007/s00125-018-4579-1. Epub 2018 Mar 1.

30.

In vivo studies on the mechanism of methylene cyclopropyl acetic acid and methylene cyclopropyl glycine-induced hypoglycemia.

Qiu Y, Perry RJ, Camporez JG, Zhang XM, Kahn M, Cline GW, Shulman GI, Vatner DF.

Biochem J. 2018 Mar 20;475(6):1063-1074. doi: 10.1042/BCJ20180063.

31.

Genetic Ablation of miR-33 Increases Food Intake, Enhances Adipose Tissue Expansion, and Promotes Obesity and Insulin Resistance.

Price NL, Singh AK, Rotllan N, Goedeke L, Wing A, Canfrán-Duque A, Diaz-Ruiz A, Araldi E, Baldán Á, Camporez JP, Suárez Y, Rodeheffer MS, Shulman GI, de Cabo R, Fernández-Hernando C.

Cell Rep. 2018 Feb 20;22(8):2133-2145. doi: 10.1016/j.celrep.2018.01.074.

32.

Publisher Correction: Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA).

Perry RJ, Peng L, Cline GW, Butrico GM, Wang Y, Zhang XM, Rothman DL, Petersen KF, Shulman GI.

Nat Commun. 2018 Jan 31;9(1):498. doi: 10.1038/s41467-018-03023-3.

33.

Skeletal Muscle-Specific Deletion of MKP-1 Reveals a p38 MAPK/JNK/Akt Signaling Node That Regulates Obesity-Induced Insulin Resistance.

Lawan A, Min K, Zhang L, Canfran-Duque A, Jurczak MJ, Camporez JPG, Nie Y, Gavin TP, Shulman GI, Fernandez-Hernando C, Bennett AM.

Diabetes. 2018 Apr;67(4):624-635. doi: 10.2337/db17-0826. Epub 2018 Jan 9.

34.

Leptin Mediates a Glucose-Fatty Acid Cycle to Maintain Glucose Homeostasis in Starvation.

Perry RJ, Wang Y, Cline GW, Rabin-Court A, Song JD, Dufour S, Zhang XM, Petersen KF, Shulman GI.

Cell. 2018 Jan 11;172(1-2):234-248.e17. doi: 10.1016/j.cell.2017.12.001. Epub 2018 Jan 4.

35.

Mechanism by which arylamine N-acetyltransferase 1 ablation causes insulin resistance in mice.

Camporez JP, Wang Y, Faarkrog K, Chukijrungroat N, Petersen KF, Shulman GI.

Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11285-E11292. doi: 10.1073/pnas.1716990115. Epub 2017 Dec 13.

36.

Adipocyte JAK2 Regulates Hepatic Insulin Sensitivity Independently of Body Composition, Liver Lipid Content, and Hepatic Insulin Signaling.

Corbit KC, Camporez JPG, Edmunds LR, Tran JL, Vera NB, Erion DM, Deo RC, Perry RJ, Shulman GI, Jurczak MJ, Weiss EJ.

Diabetes. 2018 Feb;67(2):208-221. doi: 10.2337/db17-0524. Epub 2017 Dec 4.

37.

Mechanisms by which a Very-Low-Calorie Diet Reverses Hyperglycemia in a Rat Model of Type 2 Diabetes.

Perry RJ, Peng L, Cline GW, Wang Y, Rabin-Court A, Song JD, Zhang D, Zhang XM, Nozaki Y, Dufour S, Petersen KF, Shulman GI.

Cell Metab. 2018 Jan 9;27(1):210-217.e3. doi: 10.1016/j.cmet.2017.10.004. Epub 2017 Nov 9.

38.

Pathogenesis of hypothyroidism-induced NAFLD is driven by intra- and extrahepatic mechanisms.

Ferrandino G, Kaspari RR, Spadaro O, Reyna-Neyra A, Perry RJ, Cardone R, Kibbey RG, Shulman GI, Dixit VD, Carrasco N.

Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E9172-E9180. doi: 10.1073/pnas.1707797114. Epub 2017 Oct 10.

39.

Absence of Carbohydrate Response Element Binding Protein in Adipocytes Causes Systemic Insulin Resistance and Impairs Glucose Transport.

Vijayakumar A, Aryal P, Wen J, Syed I, Vazirani RP, Moraes-Vieira PM, Camporez JP, Gallop MR, Perry RJ, Peroni OD, Shulman GI, Saghatelian A, McGraw TE, Kahn BB.

Cell Rep. 2017 Oct 24;21(4):1021-1035. doi: 10.1016/j.celrep.2017.09.091.

40.

Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA).

Perry RJ, Peng L, Cline GW, Butrico GM, Wang Y, Zhang XM, Rothman DL, Petersen KF, Shulman GI.

Nat Commun. 2017 Oct 6;8(1):798. doi: 10.1038/s41467-017-01143-w. Erratum in: Nat Commun. 2018 Jan 31;9(1):498.

41.

Hepatic Inositol 1,4,5 Trisphosphate Receptor Type 1 Mediates Fatty Liver.

Feriod CN, Oliveira AG, Guerra MT, Nguyen L, Richards KM, Jurczak MJ, Ruan HB, Camporez JP, Yang X, Shulman GI, Bennett AM, Nathanson MH, Ehrlich BE.

Hepatol Commun. 2017 Feb;1(1):23-35. doi: 10.1002/hep4.1012. Epub 2016 Nov 11.

42.

Retinol saturase modulates lipid metabolism and the production of reactive oxygen species.

Pang XY, Wang S, Jurczak MJ, Shulman GI, Moise AR.

Arch Biochem Biophys. 2017 Nov 1;633:93-102. doi: 10.1016/j.abb.2017.09.009. Epub 2017 Sep 18.

43.

Nonalcoholic Fatty Liver Disease as a Nexus of Metabolic and Hepatic Diseases.

Samuel VT, Shulman GI.

Cell Metab. 2018 Jan 9;27(1):22-41. doi: 10.1016/j.cmet.2017.08.002. Epub 2017 Aug 31. Review.

44.

Regulation of hepatic glucose metabolism in health and disease.

Petersen MC, Vatner DF, Shulman GI.

Nat Rev Endocrinol. 2017 Oct;13(10):572-587. doi: 10.1038/nrendo.2017.80. Epub 2017 Jul 21. Review.

45.

Hepatic Diacylglycerol-Associated Protein Kinase Cε Translocation Links Hepatic Steatosis to Hepatic Insulin Resistance in Humans.

Ter Horst KW, Gilijamse PW, Versteeg RI, Ackermans MT, Nederveen AJ, la Fleur SE, Romijn JA, Nieuwdorp M, Zhang D, Samuel VT, Vatner DF, Petersen KF, Shulman GI, Serlie MJ.

Cell Rep. 2017 Jun 6;19(10):1997-2004. doi: 10.1016/j.celrep.2017.05.035.

46.

Roles of Diacylglycerols and Ceramides in Hepatic Insulin Resistance.

Petersen MC, Shulman GI.

Trends Pharmacol Sci. 2017 Jul;38(7):649-665. doi: 10.1016/j.tips.2017.04.004. Epub 2017 May 24. Review.

47.

Mechanisms of Insulin Resistance in Primary and Secondary Nonalcoholic Fatty Liver.

Jelenik T, Kaul K, Séquaris G, Flögel U, Phielix E, Kotzka J, Knebel B, Fahlbusch P, Hörbelt T, Lehr S, Reinbeck AL, Müller-Wieland D, Esposito I, Shulman GI, Szendroedi J, Roden M.

Diabetes. 2017 Aug;66(8):2241-2253. doi: 10.2337/db16-1147. Epub 2017 May 10.

48.

Mitochondrial-Targeted Catalase Protects Against High-Fat Diet-Induced Muscle Insulin Resistance by Decreasing Intramuscular Lipid Accumulation.

Lee HY, Lee JS, Alves T, Ladiges W, Rabinovitch PS, Jurczak MJ, Choi CS, Shulman GI, Samuel VT.

Diabetes. 2017 Aug;66(8):2072-2081. doi: 10.2337/db16-1334. Epub 2017 May 5.

49.

Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes.

Sharabi K, Lin H, Tavares CDJ, Dominy JE, Camporez JP, Perry RJ, Schilling R, Rines AK, Lee J, Hickey M, Bennion M, Palmer M, Nag PP, Bittker JA, Perez J, Jedrychowski MP, Ozcan U, Gygi SP, Kamenecka TM, Shulman GI, Schreiber SL, Griffin PR, Puigserver P.

Cell. 2017 Mar 23;169(1):148-160.e15. doi: 10.1016/j.cell.2017.03.001.

50.

A controlled-release mitochondrial protonophore reverses hypertriglyceridemia, nonalcoholic steatohepatitis, and diabetes in lipodystrophic mice.

Abulizi A, Perry RJ, Camporez JPG, Jurczak MJ, Petersen KF, Aspichueta P, Shulman GI.

FASEB J. 2017 Jul;31(7):2916-2924. doi: 10.1096/fj.201700001R. Epub 2017 Mar 22.

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