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Items: 1 to 50 of 484

1.

Author Correction: Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo.

Madiraju AK, Qiu Y, Perry RJ, Rahimi Y, Zhang XM, Zhang D, Camporez JG, Cline GW, Butrico GM, Kemp BE, Casals G, Steinberg GR, Vatner DF, Petersen KF, Shulman GI.

Nat Med. 2019 Mar;25(3):526-528. doi: 10.1038/s41591-018-0220-6.

PMID:
30733621
2.

Dehydration and insulinopenia are necessary and sufficient for euglycemic ketoacidosis in SGLT2 inhibitor-treated rats.

Perry RJ, Rabin-Court A, Song JD, Cardone RL, Wang Y, Kibbey RG, Shulman GI.

Nat Commun. 2019 Feb 1;10(1):548. doi: 10.1038/s41467-019-08466-w.

3.

Emerging Pharmacological Targets for the Treatment of Nonalcoholic Fatty Liver Disease, Insulin Resistance, and Type 2 Diabetes.

Goedeke L, Perry RJ, Shulman GI.

Annu Rev Pharmacol Toxicol. 2019 Jan 6;59:65-87. doi: 10.1146/annurev-pharmtox-010716-104727.

PMID:
30625285
4.

Ectopic lipid deposition mediates insulin resistance in adipose specific 11β-hydroxysteroid dehydrogenase type 1 transgenic mice.

Abulizi A, Camporez JP, Zhang D, Samuel VT, Shulman GI, Vatner DF.

Metabolism. 2019 Apr;93:1-9. doi: 10.1016/j.metabol.2018.12.003. Epub 2018 Dec 19.

PMID:
30576689
5.

PKCε contributes to lipid-induced insulin resistance through cross talk with p70S6K and through previously unknown regulators of insulin signaling.

Gassaway BM, Petersen MC, Surovtseva YV, Barber KW, Sheetz JB, Aerni HR, Merkel JS, Samuel VT, Shulman GI, Rinehart J.

Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):E8996-E9005. doi: 10.1073/pnas.1804379115. Epub 2018 Sep 4.

6.

The circulating metabolome of human starvation.

Steinhauser ML, Olenchock BA, O'Keefe J, Lun M, Pierce KA, Lee H, Pantano L, Klibanski A, Shulman GI, Clish CB, Fazeli PK.

JCI Insight. 2018 Aug 23;3(16). pii: 121434. doi: 10.1172/jci.insight.121434. eCollection 2018 Aug 23.

7.

Lacteal junction zippering protects against diet-induced obesity.

Zhang F, Zarkada G, Han J, Li J, Dubrac A, Ola R, Genet G, Boyé K, Michon P, Künzel SE, Camporez JP, Singh AK, Fong GH, Simons M, Tso P, Fernández-Hernando C, Shulman GI, Sessa WC, Eichmann A.

Science. 2018 Aug 10;361(6402):599-603. doi: 10.1126/science.aap9331.

8.

Loss of Nucleobindin-2 Causes Insulin Resistance in Obesity without Impacting Satiety or Adiposity.

Ravussin A, Youm YH, Sander J, Ryu S, Nguyen K, Varela L, Shulman GI, Sidorov S, Horvath TL, Schultze JL, Dixit VD.

Cell Rep. 2018 Jul 31;24(5):1085-1092.e6. doi: 10.1016/j.celrep.2018.06.112.

9.

Mechanisms of Insulin Action and Insulin Resistance.

Petersen MC, Shulman GI.

Physiol Rev. 2018 Oct 1;98(4):2133-2223. doi: 10.1152/physrev.00063.2017. Review.

PMID:
30067154
10.

Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo.

Madiraju AK, Qiu Y, Perry RJ, Rahimi Y, Zhang XM, Zhang D, Camporez JG, Cline GW, Butrico GM, Kemp BE, Casals G, Steinberg GR, Vatner DF, Petersen KF, Shulman GI.

Nat Med. 2018 Sep;24(9):1384-1394. doi: 10.1038/s41591-018-0125-4. Epub 2018 Jul 23. Erratum in: Nat Med. 2019 Mar;25(3):526-528.

11.

Deciphering the Role of Lipid Droplets in Cardiovascular Disease: A Report From the 2017 National Heart, Lung, and Blood Institute Workshop.

Goldberg IJ, Reue K, Abumrad NA, Bickel PE, Cohen S, Fisher EA, Galis ZS, Granneman JG, Lewandowski ED, Murphy R, Olive M, Schaffer JE, Schwartz-Longacre L, Shulman GI, Walther TC, Chen J.

Circulation. 2018 Jul 17;138(3):305-315. doi: 10.1161/CIRCULATIONAHA.118.033704. Review.

PMID:
30012703
12.

Uncoupling Hepatic Oxidative Phosphorylation Reduces Tumor Growth in Two Murine Models of Colon Cancer.

Wang Y, Nasiri AR, Damsky WE, Perry CJ, Zhang XM, Rabin-Court A, Pollak MN, Shulman GI, Perry RJ.

Cell Rep. 2018 Jul 3;24(1):47-55. doi: 10.1016/j.celrep.2018.06.008.

13.

Acetyl-CoA Carboxylase Inhibition Reverses NAFLD and Hepatic Insulin Resistance but Promotes Hypertriglyceridemia in Rodents.

Goedeke L, Bates J, Vatner DF, Perry RJ, Wang T, Ramirez R, Li L, Ellis MW, Zhang D, Wong KE, Beysen C, Cline GW, Ray AS, Shulman GI.

Hepatology. 2018 Dec;68(6):2197-2211. doi: 10.1002/hep.30097.

PMID:
29790582
14.

Elevated hepatic expression of H19 long noncoding RNA contributes to diabetic hyperglycemia.

Zhang N, Geng T, Wang Z, Zhang R, Cao T, Camporez JP, Cai SY, Liu Y, Dandolo L, Shulman GI, Carmichael GG, Taylor HS, Huang Y.

JCI Insight. 2018 May 17;3(10). pii: 120304. doi: 10.1172/jci.insight.120304. eCollection 2018 May 17.

15.

The Role of Leptin in Maintaining Plasma Glucose During Starvation.

Perry RJ, Shulman GI.

Postdoc J. 2018 Mar;6(3):3-19. doi: 10.14304/surya.jpr.v6n3.2.

16.

Absence of ANGPTL4 in adipose tissue improves glucose tolerance and attenuates atherogenesis.

Aryal B, Singh AK, Zhang X, Varela L, Rotllan N, Goedeke L, Chaube B, Camporez JP, Vatner DF, Horvath TL, Shulman GI, Suárez Y, Fernández-Hernando C.

JCI Insight. 2018 Mar 22;3(6). pii: 97918. doi: 10.1172/jci.insight.97918.

17.

Angptl8 antisense oligonucleotide improves adipose lipid metabolism and prevents diet-induced NAFLD and hepatic insulin resistance in rodents.

Vatner DF, Goedeke L, Camporez JG, Lyu K, Nasiri AR, Zhang D, Bhanot S, Murray SF, Still CD, Gerhard GS, Shulman GI, Samuel VT.

Diabetologia. 2018 Jun;61(6):1435-1446. doi: 10.1007/s00125-018-4579-1. Epub 2018 Mar 1.

PMID:
29497783
18.

In vivo studies on the mechanism of methylene cyclopropyl acetic acid and methylene cyclopropyl glycine-induced hypoglycemia.

Qiu Y, Perry RJ, Camporez JG, Zhang XM, Kahn M, Cline GW, Shulman GI, Vatner DF.

Biochem J. 2018 Mar 20;475(6):1063-1074. doi: 10.1042/BCJ20180063.

PMID:
29483297
19.

Genetic Ablation of miR-33 Increases Food Intake, Enhances Adipose Tissue Expansion, and Promotes Obesity and Insulin Resistance.

Price NL, Singh AK, Rotllan N, Goedeke L, Wing A, Canfrán-Duque A, Diaz-Ruiz A, Araldi E, Baldán Á, Camporez JP, Suárez Y, Rodeheffer MS, Shulman GI, de Cabo R, Fernández-Hernando C.

Cell Rep. 2018 Feb 20;22(8):2133-2145. doi: 10.1016/j.celrep.2018.01.074.

20.

Publisher Correction: Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA).

Perry RJ, Peng L, Cline GW, Butrico GM, Wang Y, Zhang XM, Rothman DL, Petersen KF, Shulman GI.

Nat Commun. 2018 Jan 31;9(1):498. doi: 10.1038/s41467-018-03023-3.

21.

Skeletal Muscle-Specific Deletion of MKP-1 Reveals a p38 MAPK/JNK/Akt Signaling Node That Regulates Obesity-Induced Insulin Resistance.

Lawan A, Min K, Zhang L, Canfran-Duque A, Jurczak MJ, Camporez JPG, Nie Y, Gavin TP, Shulman GI, Fernandez-Hernando C, Bennett AM.

Diabetes. 2018 Apr;67(4):624-635. doi: 10.2337/db17-0826. Epub 2018 Jan 9.

22.

Leptin Mediates a Glucose-Fatty Acid Cycle to Maintain Glucose Homeostasis in Starvation.

Perry RJ, Wang Y, Cline GW, Rabin-Court A, Song JD, Dufour S, Zhang XM, Petersen KF, Shulman GI.

Cell. 2018 Jan 11;172(1-2):234-248.e17. doi: 10.1016/j.cell.2017.12.001. Epub 2018 Jan 4.

23.

Mechanism by which arylamine N-acetyltransferase 1 ablation causes insulin resistance in mice.

Camporez JP, Wang Y, Faarkrog K, Chukijrungroat N, Petersen KF, Shulman GI.

Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11285-E11292. doi: 10.1073/pnas.1716990115. Epub 2017 Dec 13.

24.

Adipocyte JAK2 Regulates Hepatic Insulin Sensitivity Independently of Body Composition, Liver Lipid Content, and Hepatic Insulin Signaling.

Corbit KC, Camporez JPG, Edmunds LR, Tran JL, Vera NB, Erion DM, Deo RC, Perry RJ, Shulman GI, Jurczak MJ, Weiss EJ.

Diabetes. 2018 Feb;67(2):208-221. doi: 10.2337/db17-0524. Epub 2017 Dec 4.

25.

Mechanisms by which a Very-Low-Calorie Diet Reverses Hyperglycemia in a Rat Model of Type 2 Diabetes.

Perry RJ, Peng L, Cline GW, Wang Y, Rabin-Court A, Song JD, Zhang D, Zhang XM, Nozaki Y, Dufour S, Petersen KF, Shulman GI.

Cell Metab. 2018 Jan 9;27(1):210-217.e3. doi: 10.1016/j.cmet.2017.10.004. Epub 2017 Nov 9.

26.

Pathogenesis of hypothyroidism-induced NAFLD is driven by intra- and extrahepatic mechanisms.

Ferrandino G, Kaspari RR, Spadaro O, Reyna-Neyra A, Perry RJ, Cardone R, Kibbey RG, Shulman GI, Dixit VD, Carrasco N.

Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E9172-E9180. doi: 10.1073/pnas.1707797114. Epub 2017 Oct 10.

27.

Absence of Carbohydrate Response Element Binding Protein in Adipocytes Causes Systemic Insulin Resistance and Impairs Glucose Transport.

Vijayakumar A, Aryal P, Wen J, Syed I, Vazirani RP, Moraes-Vieira PM, Camporez JP, Gallop MR, Perry RJ, Peroni OD, Shulman GI, Saghatelian A, McGraw TE, Kahn BB.

Cell Rep. 2017 Oct 24;21(4):1021-1035. doi: 10.1016/j.celrep.2017.09.091.

28.

Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA).

Perry RJ, Peng L, Cline GW, Butrico GM, Wang Y, Zhang XM, Rothman DL, Petersen KF, Shulman GI.

Nat Commun. 2017 Oct 6;8(1):798. doi: 10.1038/s41467-017-01143-w. Erratum in: Nat Commun. 2018 Jan 31;9(1):498.

29.

Hepatic Inositol 1,4,5 Trisphosphate Receptor Type 1 Mediates Fatty Liver.

Feriod CN, Oliveira AG, Guerra MT, Nguyen L, Richards KM, Jurczak MJ, Ruan HB, Camporez JP, Yang X, Shulman GI, Bennett AM, Nathanson MH, Ehrlich BE.

Hepatol Commun. 2017 Feb;1(1):23-35. doi: 10.1002/hep4.1012. Epub 2016 Nov 11.

30.

Retinol saturase modulates lipid metabolism and the production of reactive oxygen species.

Pang XY, Wang S, Jurczak MJ, Shulman GI, Moise AR.

Arch Biochem Biophys. 2017 Nov 1;633:93-102. doi: 10.1016/j.abb.2017.09.009. Epub 2017 Sep 18.

31.

Nonalcoholic Fatty Liver Disease as a Nexus of Metabolic and Hepatic Diseases.

Samuel VT, Shulman GI.

Cell Metab. 2018 Jan 9;27(1):22-41. doi: 10.1016/j.cmet.2017.08.002. Epub 2017 Aug 31. Review.

32.

Regulation of hepatic glucose metabolism in health and disease.

Petersen MC, Vatner DF, Shulman GI.

Nat Rev Endocrinol. 2017 Oct;13(10):572-587. doi: 10.1038/nrendo.2017.80. Epub 2017 Jul 21. Review.

33.

Hepatic Diacylglycerol-Associated Protein Kinase Cε Translocation Links Hepatic Steatosis to Hepatic Insulin Resistance in Humans.

Ter Horst KW, Gilijamse PW, Versteeg RI, Ackermans MT, Nederveen AJ, la Fleur SE, Romijn JA, Nieuwdorp M, Zhang D, Samuel VT, Vatner DF, Petersen KF, Shulman GI, Serlie MJ.

Cell Rep. 2017 Jun 6;19(10):1997-2004. doi: 10.1016/j.celrep.2017.05.035.

34.

Roles of Diacylglycerols and Ceramides in Hepatic Insulin Resistance.

Petersen MC, Shulman GI.

Trends Pharmacol Sci. 2017 Jul;38(7):649-665. doi: 10.1016/j.tips.2017.04.004. Epub 2017 May 24. Review.

35.

Mechanisms of Insulin Resistance in Primary and Secondary Nonalcoholic Fatty Liver.

Jelenik T, Kaul K, Séquaris G, Flögel U, Phielix E, Kotzka J, Knebel B, Fahlbusch P, Hörbelt T, Lehr S, Reinbeck AL, Müller-Wieland D, Esposito I, Shulman GI, Szendroedi J, Roden M.

Diabetes. 2017 Aug;66(8):2241-2253. doi: 10.2337/db16-1147. Epub 2017 May 10.

36.

Mitochondrial-Targeted Catalase Protects Against High-Fat Diet-Induced Muscle Insulin Resistance by Decreasing Intramuscular Lipid Accumulation.

Lee HY, Lee JS, Alves T, Ladiges W, Rabinovitch PS, Jurczak MJ, Choi CS, Shulman GI, Samuel VT.

Diabetes. 2017 Aug;66(8):2072-2081. doi: 10.2337/db16-1334. Epub 2017 May 5.

37.

Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes.

Sharabi K, Lin H, Tavares CDJ, Dominy JE, Camporez JP, Perry RJ, Schilling R, Rines AK, Lee J, Hickey M, Bennion M, Palmer M, Nag PP, Bittker JA, Perez J, Jedrychowski MP, Ozcan U, Gygi SP, Kamenecka TM, Shulman GI, Schreiber SL, Griffin PR, Puigserver P.

Cell. 2017 Mar 23;169(1):148-160.e15. doi: 10.1016/j.cell.2017.03.001.

38.

A controlled-release mitochondrial protonophore reverses hypertriglyceridemia, nonalcoholic steatohepatitis, and diabetes in lipodystrophic mice.

Abulizi A, Perry RJ, Camporez JPG, Jurczak MJ, Petersen KF, Aspichueta P, Shulman GI.

FASEB J. 2017 Jul;31(7):2916-2924. doi: 10.1096/fj.201700001R. Epub 2017 Mar 22.

39.

Adipocyte JAK2 mediates growth hormone-induced hepatic insulin resistance.

Corbit KC, Camporez JPG, Tran JL, Wilson CG, Lowe DA, Nordstrom SM, Ganeshan K, Perry RJ, Shulman GI, Jurczak MJ, Weiss EJ.

JCI Insight. 2017 Feb 9;2(3):e91001. doi: 10.1172/jci.insight.91001.

40.

The human longevity gene homolog INDY and interleukin-6 interact in hepatic lipid metabolism.

von Loeffelholz C, Lieske S, Neuschäfer-Rube F, Willmes DM, Raschzok N, Sauer IM, König J, Fromm MF, Horn P, Chatzigeorgiou A, Pathe-Neuschäfer-Rube A, Jordan J, Pfeiffer AFH, Mingrone G, Bornstein SR, Stroehle P, Harms C, Wunderlich FT, Helfand SL, Bernier M, de Cabo R, Shulman GI, Chavakis T, Püschel GP, Birkenfeld AL.

Hepatology. 2017 Aug;66(2):616-630. doi: 10.1002/hep.29089. Epub 2017 Jun 26.

41.

Mechanism for leptin's acute insulin-independent effect to reverse diabetic ketoacidosis.

Perry RJ, Peng L, Abulizi A, Kennedy L, Cline GW, Shulman GI.

J Clin Invest. 2017 Feb 1;127(2):657-669. doi: 10.1172/JCI88477. Epub 2017 Jan 23.

42.

A Non-invasive Method to Assess Hepatic Acetyl-CoA In Vivo.

Perry RJ, Peng L, Cline GW, Petersen KF, Shulman GI.

Cell Metab. 2017 Mar 7;25(3):749-756. doi: 10.1016/j.cmet.2016.12.017. Epub 2017 Jan 19.

43.

Loss of astrocyte cholesterol synthesis disrupts neuronal function and alters whole-body metabolism.

Ferris HA, Perry RJ, Moreira GV, Shulman GI, Horton JD, Kahn CR.

Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):1189-1194. doi: 10.1073/pnas.1620506114. Epub 2017 Jan 17.

44.

Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance.

Petersen MC, Madiraju AK, Gassaway BM, Marcel M, Nasiri AR, Butrico G, Marcucci MJ, Zhang D, Abulizi A, Zhang XM, Philbrick W, Hubbard SR, Jurczak MJ, Samuel VT, Rinehart J, Shulman GI.

J Clin Invest. 2016 Nov 1;126(11):4361-4371. doi: 10.1172/JCI86013. Epub 2016 Oct 17.

45.

Resolution of non-alcoholic steatohepatitis after growth hormone replacement in a pediatric liver transplant patient with panhypopituitarism.

Gilliland T, Dufour S, Shulman GI, Petersen KF, Emre SH.

Pediatr Transplant. 2016 Dec;20(8):1157-1163. doi: 10.1111/petr.12819. Epub 2016 Oct 20.

PMID:
27762491
46.

MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels.

Nagarajan A, Petersen MC, Nasiri AR, Butrico G, Fung A, Ruan HB, Kursawe R, Caprio S, Thibodeau J, Bourgeois-Daigneault MC, Sun L, Gao G, Bhanot S, Jurczak MJ, Green MR, Shulman GI, Wajapeyee N.

Nat Commun. 2016 Aug 31;7:12639. doi: 10.1038/ncomms12639.

47.

CD301b(+) Mononuclear Phagocytes Maintain Positive Energy Balance through Secretion of Resistin-like Molecule Alpha.

Kumamoto Y, Camporez JPG, Jurczak MJ, Shanabrough M, Horvath T, Shulman GI, Iwasaki A.

Immunity. 2016 Sep 20;45(3):583-596. doi: 10.1016/j.immuni.2016.08.002. Epub 2016 Aug 23.

48.

Assessment of Hepatic Mitochondrial Oxidation and Pyruvate Cycling in NAFLD by (13)C Magnetic Resonance Spectroscopy.

Petersen KF, Befroy DE, Dufour S, Rothman DL, Shulman GI.

Cell Metab. 2016 Jul 12;24(1):167-71. doi: 10.1016/j.cmet.2016.06.005.

49.

Imeglimin lowers glucose primarily by amplifying glucose-stimulated insulin secretion in high-fat-fed rodents.

Perry RJ, Cardone RL, Petersen MC, Zhang D, Fouqueray P, Hallakou-Bozec S, Bolze S, Shulman GI, Petersen KF, Kibbey RG.

Am J Physiol Endocrinol Metab. 2016 Aug 1;311(2):E461-70. doi: 10.1152/ajpendo.00009.2016. Epub 2016 Jul 12.

50.

Hypophosphatemia promotes lower rates of muscle ATP synthesis.

Pesta DH, Tsirigotis DN, Befroy DE, Caballero D, Jurczak MJ, Rahimi Y, Cline GW, Dufour S, Birkenfeld AL, Rothman DL, Carpenter TO, Insogna K, Petersen KF, Bergwitz C, Shulman GI.

FASEB J. 2016 Oct;30(10):3378-3387. Epub 2016 Jun 23.

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