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Items: 1 to 50 of 66

1.

Deletion of Cdkn1b in ACI rats leads to increased proliferation and pregnancy-associated changes in the mammary gland due to perturbed systemic endocrine environment.

Ding L, Shunkwiler LB, Harper NW, Zhao Y, Hinohara K, Huh SJ, Ekram MB, Guz J, Kern MJ, Awgulewitsch A, Shull JD, Smits BMG, Polyak K.

PLoS Genet. 2019 Mar 20;15(3):e1008002. doi: 10.1371/journal.pgen.1008002. eCollection 2019 Mar.

2.
3.

Genetic variation in sensitivity to estrogens and breast cancer risk.

Jerry DJ, Shull JD, Hadsell DL, Rijnkels M, Dunphy KA, Schneider SS, Vandenberg LN, Majhi PD, Byrne C, Trentham-Dietz A.

Mamm Genome. 2018 Feb;29(1-2):24-37. doi: 10.1007/s00335-018-9741-z. Epub 2018 Feb 27. Review.

4.

Rat models of 17β-estradiol-induced mammary cancer reveal novel insights into breast cancer etiology and prevention.

Shull JD, Dennison KL, Chack AC, Trentham-Dietz A.

Physiol Genomics. 2018 Mar 1;50(3):215-234. doi: 10.1152/physiolgenomics.00105.2017. Epub 2018 Jan 26. Review.

5.

Dietary γ-Tocopherol-Rich Mixture Inhibits Estrogen-Induced Mammary Tumorigenesis by Modulating Estrogen Metabolism, Antioxidant Response, and PPARγ.

Das Gupta S, Sae-tan S, Wahler J, So JY, Bak MJ, Cheng LC, Lee MJ, Lin Y, Shih WJ, Shull JD, Safe S, Yang CS, Suh N.

Cancer Prev Res (Phila). 2015 Sep;8(9):807-16. doi: 10.1158/1940-6207.CAPR-15-0154. Epub 2015 Jun 30.

6.

Development and characterization of a novel rat model of estrogen-induced mammary cancer.

Dennison KL, Samanas NB, Harenda QE, Hickman MP, Seiler NL, Ding L, Shull JD.

Endocr Relat Cancer. 2015 Apr;22(2):239-48. doi: 10.1530/ERC-14-0539.

7.

Genetic etiology of renal agenesis: fine mapping of Renag1 and identification of Kit as the candidate functional gene.

Samanas NB, Commers TW, Dennison KL, Harenda QE, Kurz SG, Lachel CM, Wavrin KL, Bowler M, Nijman IJ, Guryev V, Cuppen E, Hubner N, Sullivan R, Vezina CM, Shull JD.

PLoS One. 2015 Feb 18;10(2):e0118147. doi: 10.1371/journal.pone.0118147. eCollection 2015.

8.

CXM: a new tool for mapping breast cancer risk in the tumor microenvironment.

Flister MJ, Endres BT, Rudemiller N, Sarkis AB, Santarriaga S, Roy I, Lemke A, Geurts AM, Moreno C, Ran S, Tsaih SW, De Pons J, Carlson DF, Tan W, Fahrenkrug SC, Lazarova Z, Lazar J, North PE, LaViolette PS, Dwinell MB, Shull JD, Jacob HJ.

Cancer Res. 2014 Nov 15;74(22):6419-29. doi: 10.1158/0008-5472.CAN-13-3212. Epub 2014 Aug 29.

9.

Validation of six genetic determinants of susceptibility to estrogen-induced mammary cancer in the rat and assessment of their relevance to breast cancer risk in humans.

Colletti JA 2nd, Leland-Wavrin KM, Kurz SG, Hickman MP, Seiler NL, Samanas NB, Eckert QA, Dennison KL, Ding L, Schaffer BS, Shull JD.

G3 (Bethesda). 2014 May 28;4(8):1385-94. doi: 10.1534/g3.114.011163.

10.

Ept7 influences estrogen action in the pituitary gland and body weight of rats.

Kurz SG, Dennison KL, Samanas NB, Hickman MP, Eckert QA, Walker TL, Cupp AS, Shull JD.

Mamm Genome. 2014 Jun;25(5-6):244-52. doi: 10.1007/s00335-014-9504-4. Epub 2014 Jan 22.

11.

Association of cellular and molecular responses in the rat mammary gland to 17β-estradiol with susceptibility to mammary cancer.

Ding L, Zhao Y, Warren CL, Sullivan R, Eliceiri KW, Shull JD.

BMC Cancer. 2013 Dec 5;13:573. doi: 10.1186/1471-2407-13-573.

12.

Systematic biases in DNA copy number originate from isolation procedures.

van Heesch S, Mokry M, Boskova V, Junker W, Mehon R, Toonen P, de Bruijn E, Shull JD, Aitman TJ, Cuppen E, Guryev V.

Genome Biol. 2013 Apr 24;14(4):R33. doi: 10.1186/gb-2013-14-4-r33.

13.

Mapping of three genetic determinants of susceptibility to estrogen-induced mammary cancer within the Emca8 locus on rat chromosome 5.

Schaffer BS, Leland-Wavrin KM, Kurz SG, Colletti JA, Seiler NL, Warren CL, Shull JD.

Cancer Prev Res (Phila). 2013 Jan;6(1):59-69. doi: 10.1158/1940-6207.CAPR-12-0346-T. Epub 2012 Nov 14.

14.

Tamoxifen induces regression of estradiol-induced mammary cancer in the ACI.COP-Ept2 rat model.

Ruhlen RL, Willbrand DM, Besch-Williford CL, Ma L, Shull JD, Sauter ER.

Breast Cancer Res Treat. 2009 Oct;117(3):517-24. doi: 10.1007/s10549-008-0169-0. Epub 2008 Sep 9.

15.

Distribution and functional impact of DNA copy number variation in the rat.

Guryev V, Saar K, Adamovic T, Verheul M, van Heesch SA, Cook S, Pravenec M, Aitman T, Jacob H, Shull JD, Hubner N, Cuppen E.

Nat Genet. 2008 May;40(5):538-45. doi: 10.1038/ng.141.

PMID:
18443591
16.

Progress and prospects in rat genetics: a community view.

Aitman TJ, Critser JK, Cuppen E, Dominiczak A, Fernandez-Suarez XM, Flint J, Gauguier D, Geurts AM, Gould M, Harris PC, Holmdahl R, Hubner N, Izsvák Z, Jacob HJ, Kuramoto T, Kwitek AE, Marrone A, Mashimo T, Moreno C, Mullins J, Mullins L, Olsson T, Pravenec M, Riley L, Saar K, Serikawa T, Shull JD, Szpirer C, Twigger SN, Voigt B, Worley K.

Nat Genet. 2008 May;40(5):516-22. doi: 10.1038/ng.147. Review.

PMID:
18443588
17.

Tissue-specific actions of the Ept1, Ept2, Ept6, and Ept9 genetic determinants of responsiveness to estrogens in the female rat.

Kurz SG, Hansen KK, McLaughlin MT, Shivaswamy V, Schaffer BS, Gould KA, McComb RD, Meza JL, Shull JD.

Endocrinology. 2008 Aug;149(8):3850-9. doi: 10.1210/en.2008-0173. Epub 2008 Apr 17.

18.
19.

Genetic control of estrogen action in the rat: mapping of QTLs that impact pituitary lactotroph hyperplasia in a BN x ACI intercross.

Shull JD, Lachel CM, Murrin CR, Pennington KL, Schaffer BS, Strecker TE, Gould KA.

Mamm Genome. 2007 Sep;18(9):657-69. Epub 2007 Sep 18.

PMID:
17876666
20.

Nonrandom pattern of chromosome aberrations in 17beta-estradiol-induced rat mammary tumors: indications of distinct pathways for tumor development.

Adamovic T, Roshani L, Chen L, Schaffer BS, Helou K, Levan G, Olsson B, Shull JD.

Genes Chromosomes Cancer. 2007 May;46(5):459-69.

PMID:
17285573
21.

Genetic bases of estrogen-induced tumorigenesis in the rat: mapping of loci controlling susceptibility to mammary cancer in a Brown Norway x ACI intercross.

Schaffer BS, Lachel CM, Pennington KL, Murrin CR, Strecker TE, Tochacek M, Gould KA, Meza JL, McComb RD, Shull JD.

Cancer Res. 2006 Aug 1;66(15):7793-800.

22.

Genetic bases of renal agenesis in the ACI rat: mapping of Renag1 to chromosome 14.

Shull JD, Lachel CM, Strecker TE, Spady TJ, Tochacek M, Pennington KL, Murrin CR, Meza JL, Schaffer BS, Flood LA, Gould KA.

Mamm Genome. 2006 Jul;17(7):751-9. Epub 2006 Jul 14.

PMID:
16845468
23.

Genetic mapping of loci controlling diethylstilbestrol-induced thymic atrophy in the Brown Norway rat.

Gould KA, Strecker TE, Hansen KK, Bynoté KK, Peterson KA, Shull JD.

Mamm Genome. 2006 May;17(5):451-64.

PMID:
16688534
24.

Localization of Eutr2, a locus controlling susceptibility to DES-induced uterine inflammation and pyometritis, to RNO5 using a congenic rat strain.

Pandey J, Gould KA, McComb RD, Shull JD, Wendell DL.

Mamm Genome. 2005 Nov;16(11):865-72. Epub 2005 Nov 11.

PMID:
16284802
25.

Genetic mapping of Eutr1, a locus controlling E2-induced pyometritis in the Brown Norway rat, to RNO5.

Gould KA, Pandey J, Lachel CM, Murrin CR, Flood LA, Pennington KL, Schaffer BS, Tochacek M, McComb RD, Meza JL, Wendell DL, Shull JD.

Mamm Genome. 2005 Nov;16(11):854-64. Epub 2005 Nov 11.

PMID:
16284801
26.

Genetic bases of estrogen-induced pituitary tumorigenesis: identification of genetic loci determining estrogen-induced pituitary growth in reciprocal crosses between the ACI and Copenhagen rat strains.

Strecker TE, Spady TJ, Schaffer BS, Gould KA, Kaufman AE, Shen F, McLaughlin MT, Pennington KL, Meza JL, Shull JD.

Genetics. 2005 Apr;169(4):2189-97. Epub 2005 Jan 31.

27.

Genetic determination of susceptibility to estrogen-induced mammary cancer in the ACI rat: mapping of Emca1 and Emca2 to chromosomes 5 and 18.

Gould KA, Tochacek M, Schaffer BS, Reindl TM, Murrin CR, Lachel CM, VanderWoude EA, Pennington KL, Flood LA, Bynote KK, Meza JL, Newton MA, Shull JD.

Genetics. 2004 Dec;168(4):2113-25.

28.

Rat strain specific attenuation of estrogen action in the anterior pituitary gland by dietary energy restriction.

Harvell DM, Buckles LK, Gould KA, Pennington KL, McComb RD, Shull JD.

Endocrine. 2003 Jul;21(2):175-83.

PMID:
12897383
29.

Dietary energy restriction inhibits estrogen-induced mammary, but not pituitary, tumorigenesis in the ACI rat.

Harvell DM, Strecker TE, Xie B, Pennington KL, McComb RD, Shull JD.

Carcinogenesis. 2002 Jan;23(1):161-9.

PMID:
11756237
30.

Susceptibility to estrogen-induced mammary cancer segregates as an incompletely dominant phenotype in reciprocal crosses between the ACI and Copenhagen rat strains.

Shull JD, Pennington KL, Reindl TM, Snyder MC, Strecker TE, Spady TJ, Tochacek M, McComb RD.

Endocrinology. 2001 Dec;142(12):5124-30.

PMID:
11713205
31.

Diet-gene interactions in estrogen-induced mammary carcinogenesis in the ACI rat.

Harvell DM, Strecker TE, Xie B, Buckles LK, Tochacek M, McComb RD, Shull JD.

J Nutr. 2001 Nov;131(11 Suppl):3087S-91S. doi: 10.1093/jn/131.11.3087S.

PMID:
11694653
32.

DES action in the thymus: inhibition of cell proliferation and genetic variation.

Gould KA, Shull JD, Gorski J.

Mol Cell Endocrinol. 2000 Dec 22;170(1-2):31-9.

PMID:
11162888
33.
34.

Rat strain-specific actions of 17beta-estradiol in the mammary gland: correlation between estrogen-induced lobuloalveolar hyperplasia and susceptibility to estrogen-induced mammary cancers.

Harvell DM, Strecker TE, Tochacek M, Xie B, Pennington KL, McComb RD, Roy SK, Shull JD.

Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2779-84.

35.

Estrogen-induced pituitary tumor development in the ACI rat not inhibited by dietary energy restriction.

Spady TJ, Pennington KL, McComb RD, Birt DF, Shull JD.

Mol Carcinog. 1999 Dec;26(4):239-53.

PMID:
10569801
36.
37.

Modulation of estrogen action in the rat pituitary and mammary glands by dietary energy consumption.

Spady TJ, Harvell DM, Lemus-Wilson A, Strecker TE, Pennington KL, Vander Woude EA, Birt DF, McComb RD, Shull JD.

J Nutr. 1999 Feb;129(2S Suppl):587S-590S. doi: 10.1093/jn/129.2.587S.

PMID:
10064338
38.

Estrogen induction of prolactin-producing pituitary tumors in the Fischer 344 rat: modulation by dietary-energy but not protein consumption.

Shull JD, Birt DF, McComb RD, Spady TJ, Pennington KL, Shaw-Bruha CM.

Mol Carcinog. 1998 Oct;23(2):96-105.

PMID:
9808163
39.

Dietary energy restriction abolishes development of prolactin-producing pituitary tumors in Fischer 344 rats treated with 17beta-estradiol.

Spady TJ, Lemus-Wilson AM, Pennington KL, Blackwood DJ, Paschall TM, Birt DF, McComb RD, Shull JD.

Mol Carcinog. 1998 Oct;23(2):86-95.

PMID:
9808162
40.

Identification in the rat prolactin gene of sequences homologous to the distal promoter of the human prolactin gene.

Shaw-Bruha CM, Pennington KL, Shull JD.

Biochim Biophys Acta. 1998 Nov 8;1442(2-3):304-13.

PMID:
9804978
41.

Dietary lignin, and insoluble fiber, enhance uterine cancer but did not influence mammary cancer induced by N-methyl-N-nitrosourea in rats.

Birt DF, Markin RS, Blackwood D, Harvell DM, Shull JD, Pennington KL.

Nutr Cancer. 1998;31(1):24-30.

PMID:
9682245
42.

Estrogen-induced tumorigenesis in the Copenhagen rat: disparate susceptibilities to development of prolactin-producing pituitary tumors and mammary carcinomas.

Spady TJ, Harvell DM, Snyder MC, Pennington KL, McComb RD, Shull JD.

Cancer Lett. 1998 Feb 13;124(1):95-103.

PMID:
9500197
43.

Ovary-intact, but not ovariectomized female ACI rats treated with 17beta-estradiol rapidly develop mammary carcinoma.

Shull JD, Spady TJ, Snyder MC, Johansson SL, Pennington KL.

Carcinogenesis. 1997 Aug;18(8):1595-601.

PMID:
9276635
44.
45.

17 beta-Estradiol inhibits the production of dopamine by the tuberoinfundibular dopaminergic neurons of the male rat.

Shaw-Bruha CM, Happe HK, Murrin LC, Rodriguez-Sierra JF, Shull JD.

Brain Res Bull. 1996;40(1):33-6.

PMID:
8722750
47.

Sequence of the promoter region of the mouse gene encoding ornithine aminotransferase.

Shull JD, Esumi N, Colwell AS, Pennington KL, Jendoubi M.

Gene. 1995 Sep 11;162(2):275-7.

PMID:
7557443
48.
49.

Epidermal growth factor induces prolactin mRNA in GH4C1 cells via a protein synthesis-dependent pathway.

Gilchrist CA, Shull JD.

Mol Cell Endocrinol. 1993 Apr;92(2):201-6.

PMID:
8391491
50.

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