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Corrigendum to "Targeting HIF-1α to Prevent Renal Ischemia-Reperfusion Injury: Does It Work?"

Sethi K, Rao K, Shulkes A, Baldwin G, Bolton D, Patel O, Ischia J.

Int J Cell Biol. 2019 Apr 10;2019:9598038. doi: 10.1155/2019/9598038. eCollection 2019.


Metformin may offer no protective effect in men undergoing external beam radiation therapy for prostate cancer.

Ranasinghe WKB, Williams S, Ischia J, Wetherell D, Baldwin G, Shulkes A, Sengupta S, Bolton D, Patel O.

BJU Int. 2019 May;123 Suppl 5:36-42. doi: 10.1111/bju.14709. Epub 2019 Apr 23.


Zinc preconditioning protects against renal ischaemia reperfusion injury in a preclinical sheep large animal model.

O'Kane D, Gibson L, May CN, du Plessis J, Shulkes A, Baldwin GS, Bolton D, Ischia J, Patel O.

Biometals. 2018 Oct;31(5):821-834. doi: 10.1007/s10534-018-0125-3. Epub 2018 Jul 4.


Zinc ion dyshomeostasis increases resistance of prostate cancer cells to oxidative stress via upregulation of HIF1α.

Wetherell D, Baldwin GS, Shulkes A, Bolton D, Ischia J, Patel O.

Oncotarget. 2018 Jan 3;9(9):8463-8477. doi: 10.18632/oncotarget.23893. eCollection 2018 Feb 2.


Protective effect of zinc preconditioning against renal ischemia reperfusion injury is dose dependent.

Rao K, Sethi K, Ischia J, Gibson L, Galea L, Xiao L, Yim M, Chang M, Papa N, Bolton D, Shulkes A, Baldwin GS, Patel O.

PLoS One. 2017 Jul 7;12(7):e0180028. doi: 10.1371/journal.pone.0180028. eCollection 2017.


Progastrin: a potential predictive marker of liver metastasis in colorectal cancer.

Westwood DA, Patel O, Christophi C, Shulkes A, Baldwin GS.

Int J Colorectal Dis. 2017 Jul;32(7):1061-1064. doi: 10.1007/s00384-017-2822-8. Epub 2017 Apr 21.


Distribution and characterisation of CCK containing enteroendocrine cells of the mouse small and large intestine.

Fakhry J, Wang J, Martins P, Fothergill LJ, Hunne B, Prieur P, Shulkes A, Rehfeld JF, Callaghan B, Furness JB.

Cell Tissue Res. 2017 Aug;369(2):245-253. doi: 10.1007/s00441-017-2612-1. Epub 2017 Apr 17.


Zinc Ions Mediate Gastrin Expression, Proliferation, and Migration Downstream of the Cholecystokinin-2 Receptor.

Chang M, Xiao L, Shulkes A, Baldwin GS, Patel O.

Endocrinology. 2016 Dec;157(12):4706-4719. Epub 2016 Oct 31.


Up-regulation of stem cell markers by P21-activated kinase 1 contributes to 5-fluorouracil resistance of colorectal cancer.

Huynh N, Shulkes A, Baldwin G, He H.

Cancer Biol Ther. 2016 Aug 2;17(8):813-23. doi: 10.1080/15384047.2016.1195045. Epub 2016 Jun 3.


Retro-inverso forms of gastrin5-12 are as biologically active as glycine-extended gastrin in vitro but not in vivo.

Marshall KM, Laval M, Sims I, Shulkes A, Baldwin GS.

Peptides. 2015 Dec;74:16-22. doi: 10.1016/j.peptides.2015.09.012. Epub 2015 Oct 22.


Activation by zinc of the human gastrin gene promoter in colon cancer cells in vitro and in vivo.

Marshall KM, Laval M, Estacio O, Hudson DF, Kalitsis P, Shulkes A, Baldwin GS, Patel O.

Metallomics. 2015 Oct;7(10):1390-8. doi: 10.1039/c5mt00147a. Epub 2015 Sep 25.


HIF1α expression under normoxia in prostate cancer--which pathways to target?

Ranasinghe WK, Baldwin GS, Bolton D, Shulkes A, Ischia J, Patel O.

J Urol. 2015 Mar;193(3):763-70. doi: 10.1016/j.juro.2014.10.085. Epub 2014 Oct 19. Review.


Glaucarubinone inhibits colorectal cancer growth by suppression of hypoxia-inducible factor 1α and β-catenin via a p-21 activated kinase 1-dependent pathway.

Huynh N, Beutler JA, Shulkes A, Baldwin GS, He H.

Biochim Biophys Acta. 2015 Jan;1853(1):157-65. doi: 10.1016/j.bbamcr.2014.10.013. Epub 2014 Oct 22.


Increased gastrin gene expression provides a physiological advantage to mice under hypoxic conditions.

Laval M, Baldwin GS, Shulkes A, Marshall KM.

Am J Physiol Gastrointest Liver Physiol. 2015 Jan 15;308(2):G76-84. doi: 10.1152/ajpgi.00344.2014. Epub 2014 Nov 13.


Identification of binding sites for C-terminal pro-gastrin-releasing peptide (GRP)-derived peptides in renal cell carcinoma: a potential target for future therapy.

Ischia J, Patel O, Sethi K, Nordlund MS, Bolton D, Shulkes A, Baldwin GS.

BJU Int. 2015 May;115(5):829-38. doi: 10.1111/bju.12886. Epub 2015 Jan 26.


Normoxic regulation of HIF-1α in prostate cancer.

Ranasinghe WK, Baldwin GS, Shulkes A, Bolton D, Patel O.

Nat Rev Urol. 2014 Jul;11(7):419. doi: 10.1038/nrurol.2013.110-c2. Epub 2014 Jul 1. No abstract available.


Demonstration and biological significance of a gastrin-P21-activated kinase 1 feedback loop in colorectal cancer cells.

Huynh N, Liu KH, Yim M, Shulkes A, Baldwin GS, He H.

Physiol Rep. 2014 Jun 24;2(6). pii: e12048. doi: 10.14814/phy2.12048. Print 2014 Jun 1.


CCK2R identifies and regulates gastric antral stem cell states and carcinogenesis.

Hayakawa Y, Jin G, Wang H, Chen X, Westphalen CB, Asfaha S, Renz BW, Ariyama H, Dubeykovskaya ZA, Takemoto Y, Lee Y, Muley A, Tailor Y, Chen D, Muthupalani S, Fox JG, Shulkes A, Worthley DL, Takaishi S, Wang TC.

Gut. 2015 Apr;64(4):544-53. doi: 10.1136/gutjnl-2014-307190. Epub 2014 Jun 20.


Expression and function of gastrin-releasing peptide (GRP) in normal and cancerous urological tissues.

Ischia J, Patel O, Bolton D, Shulkes A, Baldwin GS.

BJU Int. 2014 Mar;113 Suppl 2:40-7. doi: 10.1111/bju.12594. Review.


Circulating gastrin concentrations in patients at increased risk of developing colorectal carcinoma.

Paterson AC, Macrae FA, Pizzey C, Baldwin GS, Shulkes A.

J Gastroenterol Hepatol. 2014 Mar;29(3):480-6.


Glaucarubinone and gemcitabine synergistically reduce pancreatic cancer growth via down-regulation of P21-activated kinases.

Yeo D, Huynh N, Beutler JA, Christophi C, Shulkes A, Baldwin GS, Nikfarjam M, He H.

Cancer Lett. 2014 May 1;346(2):264-72. doi: 10.1016/j.canlet.2014.01.001. Epub 2014 Jan 31.


The effects of nonspecific HIF1α inhibitors on development of castrate resistance and metastases in prostate cancer.

Ranasinghe WK, Sengupta S, Williams S, Chang M, Shulkes A, Bolton DM, Baldwin G, Patel O.

Cancer Med. 2014 Apr;3(2):245-51. doi: 10.1002/cam4.189. Epub 2014 Jan 27.


Zinc ions upregulate the hormone gastrin via an E-box motif in the proximal gastrin promoter.

Xiao L, Kovac S, Chang M, Shulkes A, Baldwin GS, Patel O.

J Mol Endocrinol. 2013 Dec 20;52(1):29-42. doi: 10.1530/JME-13-0162. Print 2014 Feb.


P21-activated kinase 1 promotes colorectal cancer survival by up-regulation of hypoxia-inducible factor-1α.

Liu KH, Huynh N, Patel O, Shulkes A, Baldwin G, He H.

Cancer Lett. 2013 Oct 28;340(1):22-9. doi: 10.1016/j.canlet.2013.06.024. Epub 2013 Jun 26.


The C-terminal flanking peptide of progastrin induces gastric cell apoptosis and stimulates colonic cell division in vivo.

Marshall KM, Patel O, Bramante G, Laval M, Yim M, Baldwin GS, Shulkes A.

Peptides. 2013 Aug;46:83-93. doi: 10.1016/j.peptides.2013.05.009. Epub 2013 Jun 3.


Ketosis and appetite-mediating nutrients and hormones after weight loss.

Sumithran P, Prendergast LA, Delbridge E, Purcell K, Shulkes A, Kriketos A, Proietto J.

Eur J Clin Nutr. 2013 Jul;67(7):759-64. doi: 10.1038/ejcn.2013.90. Epub 2013 May 1.


The role of hypoxia-inducible factor 1α in determining the properties of castrate-resistant prostate cancers.

Ranasinghe WK, Xiao L, Kovac S, Chang M, Michiels C, Bolton D, Shulkes A, Baldwin GS, Patel O.

PLoS One. 2013;8(1):e54251. doi: 10.1371/journal.pone.0054251. Epub 2013 Jan 16.


p-21-Activated kinase 1 mediates gastrin-stimulated proliferation in the colorectal mucosa via multiple signaling pathways.

Huynh N, Yim M, Chernoff J, Shulkes A, Baldwin GS, He H.

Am J Physiol Gastrointest Liver Physiol. 2013 Mar 15;304(6):G561-7. doi: 10.1152/ajpgi.00218.2012. Epub 2013 Jan 10.


Induction of gastrin expression in gastrointestinal cells by hypoxia or cobalt is independent of hypoxia-inducible factor (HIF).

Xiao L, Kovac S, Chang M, Shulkes A, Baldwin GS, Patel O.

Endocrinology. 2012 Jul;153(7):3006-16. doi: 10.1210/en.2011-2069. Epub 2012 May 16.


The role of liver fructose-1,6-bisphosphatase in regulating appetite and adiposity.

Visinoni S, Khalid NF, Joannides CN, Shulkes A, Yim M, Whitehead J, Tiganis T, Lamont BJ, Favaloro JM, Proietto J, Andrikopoulos S, Fam BC.

Diabetes. 2012 May;61(5):1122-32. doi: 10.2337/db11-1511.


A new biomarker that predicts colonic neoplasia outcome in patients with hyperplastic colonic polyps.

Do C, Bertrand C, Palasse J, Delisle MB, Shulkes A, Cohen-Jonathan-Moyal E, Ferrand A, Seva C.

Cancer Prev Res (Phila). 2012 Apr;5(4):675-84. doi: 10.1158/1940-6207.CAPR-11-0408. Epub 2012 Feb 24.


Pro-GRP-derived peptides are expressed in colorectal cancer cells and tumors and are biologically active in vivo.

Patel O, Clyde D, Chang M, Nordlund MS, Steel R, Kemp BE, Pritchard DM, Shulkes A, Baldwin GS.

Endocrinology. 2012 Mar;153(3):1082-92. doi: 10.1210/en.2011-1875. Epub 2011 Dec 27.


Bismuth ions inhibit the biological activity of non-amidated gastrins in vivo.

Kovac S, Loh SW, Lachal S, Shulkes A, Baldwin GS.

Biochem Pharmacol. 2012 Feb 15;83(4):524-30. doi: 10.1016/j.bcp.2011.11.030. Epub 2011 Dec 8.


P-21 activated kinase 1 knockdown inhibits β-catenin signalling and blocks colorectal cancer growth.

He H, Huynh N, Liu KH, Malcontenti-Wilson C, Zhu J, Christophi C, Shulkes A, Baldwin GS.

Cancer Lett. 2012 Apr 1;317(1):65-71. doi: 10.1016/j.canlet.2011.11.014. Epub 2011 Nov 15.


Long-term persistence of hormonal adaptations to weight loss.

Sumithran P, Prendergast LA, Delbridge E, Purcell K, Shulkes A, Kriketos A, Proietto J.

N Engl J Med. 2011 Oct 27;365(17):1597-604. doi: 10.1056/NEJMoa1105816.


Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS): a new autosomal dominant syndrome.

Worthley DL, Phillips KD, Wayte N, Schrader KA, Healey S, Kaurah P, Shulkes A, Grimpen F, Clouston A, Moore D, Cullen D, Ormonde D, Mounkley D, Wen X, Lindor N, Carneiro F, Huntsman DG, Chenevix-Trench G, Suthers GK.

Gut. 2012 May;61(5):774-9. doi: 10.1136/gutjnl-2011-300348. Epub 2011 Aug 3. Erratum in: Gut. 2012 Sep;61(9):1305.


Gastrin-deficient mice have disturbed hematopoiesis in response to iron deficiency.

Kovac S, Anderson GJ, Alexander WS, Shulkes A, Baldwin GS.

Endocrinology. 2011 Aug;152(8):3062-73. doi: 10.1210/en.2010-1474. Epub 2011 Jun 7.


Histamine 3 receptor activation mediates inhibition of acid secretion during Helicobacter-induced gastritis.

Zavros Y, Mesiwala N, Waghray M, Todisco A, Shulkes A, Merchant JL.

World J Gastrointest Pathophysiol. 2010 Dec 15;1(5):154-65. doi: 10.4291/wjgp.v1.i5.154.


Ferric ions inhibit proteolytic processing of progastrin.

Bramante G, Patel O, Shulkes A, Baldwin GS.

Biochem Biophys Res Commun. 2011 Jan 28;404(4):1083-7. doi: 10.1016/j.bbrc.2010.12.117. Epub 2010 Dec 30.


In vivo analysis of mouse gastrin gene regulation in enhanced GFP-BAC transgenic mice.

Takaishi S, Shibata W, Tomita H, Jin G, Yang X, Ericksen R, Dubeykovskaya Z, Asfaha S, Quante M, Betz KS, Shulkes A, Wang TC.

Am J Physiol Gastrointest Liver Physiol. 2011 Feb;300(2):G334-44. doi: 10.1152/ajpgi.00134.2010. Epub 2010 Nov 4.


Gastrin increases its own synthesis in gastrointestinal cancer cells via the CCK2 receptor.

Kovac S, Xiao L, Shulkes A, Patel O, Baldwin GS.

FEBS Lett. 2010 Nov 5;584(21):4413-8. doi: 10.1016/j.febslet.2010.09.046. Epub 2010 Oct 8.


Pancreatic stellate cells produce acetylcholine and may play a role in pancreatic exocrine secretion.

Phillips PA, Yang L, Shulkes A, Vonlaufen A, Poljak A, Bustamante S, Warren A, Xu Z, Guilhaus M, Pirola R, Apte MV, Wilson JS.

Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17397-402. doi: 10.1073/pnas.1000359107. Epub 2010 Sep 17.


The C-terminal flanking peptide (CTFP) of progastrin inhibits apoptosis via a PI3-kinase-dependent pathway.

Patel O, Marshall KM, Bramante G, Baldwin GS, Shulkes A.

Regul Pept. 2010 Dec 10;165(2-3):224-31. doi: 10.1016/j.regpep.2010.08.005. Epub 2010 Aug 19.


Stimulation of proliferation in the colorectal mucosa by gastrin precursors is blocked by desferrioxamine.

Ferrand A, Lachal S, Bramante G, Kovac S, Shulkes A, Baldwin GS.

Am J Physiol Gastrointest Liver Physiol. 2010 Jul;299(1):G220-7. doi: 10.1152/ajpgi.00046.2010. Epub 2010 Apr 15.


Evolution of gastrointestinal hormones: the cholecystokinin/gastrin family.

Baldwin GS, Patel O, Shulkes A.

Curr Opin Endocrinol Diabetes Obes. 2010 Feb;17(1):77-88. doi: 10.1097/MED.0b013e328334e535. Review.


Isolation, identification and biological activity of gastrin-releasing peptide 1-46 (oGRP 1-46), the primary GRP gene-derived peptide product of the pregnant ovine endometrium.

Giraud AS, Dumesny C, Whitley JC, Parker LM, Jennings I, Kemp B, Moody TW, Sancho V, Jensen RT, Shulkes A.

Peptides. 2010 Feb;31(2):284-90. doi: 10.1016/j.peptides.2009.11.013. Epub 2009 Nov 26.


Inactivating cholecystokinin-2 receptor inhibits progastrin-dependent colonic crypt fission, proliferation, and colorectal cancer in mice.

Jin G, Ramanathan V, Quante M, Baik GH, Yang X, Wang SS, Tu S, Gordon SA, Pritchard DM, Varro A, Shulkes A, Wang TC.

J Clin Invest. 2009 Sep;119(9):2691-701. doi: 10.1172/JCI38918. Epub 2009 Aug 3.


Expression of gastrin precursors by CD133-positive colorectal cancer cells is crucial for tumour growth.

Ferrand A, Sandrin MS, Shulkes A, Baldwin GS.

Biochim Biophys Acta. 2009 Mar;1793(3):477-88. doi: 10.1016/j.bbamcr.2009.01.004. Epub 2009 Jan 15.


Gastrin-releasing peptide: different forms, different functions.

Ischia J, Patel O, Shulkes A, Baldwin GS.

Biofactors. 2009 Jan-Feb;35(1):69-75. doi: 10.1002/biof.10. Review.


Peptide processing and biology in human disease.

Kovac S, Shulkes A, Baldwin GS.

Curr Opin Endocrinol Diabetes Obes. 2009 Feb;16(1):79-85. doi: 10.1097/MED.0b013e3283202555. Review.

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