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Items: 1 to 50 of 242

1.

Multiorgan microfluidic platform with breathable lung chamber for inhalation or intravenous drug screening and development.

Miller PG, Chen CY, Wang YI, Gao E, Shuler ML.

Biotechnol Bioeng. 2019 Oct 14. doi: 10.1002/bit.27188. [Epub ahead of print]

PMID:
31608985
2.

Application of chemical reaction engineering principles to 'body-on-a-chip' systems.

Sung JH, Wang YI, Kim JH, Lee JM, Shuler ML.

AIChE J. 2018 Dec;64(12):4351-4360. doi: 10.1002/aic.16448. Epub 2018 Oct 12.

3.

On the potential of in vitro organ-chip models to define temporal pharmacokinetic-pharmacodynamic relationships.

McAleer CW, Pointon A, Long CJ, Brighton RL, Wilkin BD, Bridges LR, Narasimhan Sriram N, Fabre K, McDougall R, Muse VP, Mettetal JT, Srivastava A, Williams D, Schnepper MT, Roles JL, Shuler ML, Hickman JJ, Ewart L.

Sci Rep. 2019 Jul 3;9(1):9619. doi: 10.1038/s41598-019-45656-4.

4.

Correction: UniChip enables long-term recirculating unidirectional perfusion with gravity-driven flow for microphysiological systems.

Wang YI, Shuler ML.

Lab Chip. 2019 Aug 7;19(15):2619. doi: 10.1039/c9lc90073j. Epub 2019 Jul 2.

PMID:
31264674
5.

Strategies for using mathematical modeling approaches to design and interpret multi-organ microphysiological systems (MPS).

Sung JH, Wang Y, Shuler ML.

APL Bioeng. 2019 Jun 20;3(2):021501. doi: 10.1063/1.5097675. eCollection 2019 Jun. Review.

6.

Multi-organ system for the evaluation of efficacy and off-target toxicity of anticancer therapeutics.

McAleer CW, Long CJ, Elbrecht D, Sasserath T, Bridges LR, Rumsey JW, Martin C, Schnepper M, Wang Y, Schuler F, Roth AB, Funk C, Shuler ML, Hickman JJ.

Sci Transl Med. 2019 Jun 19;11(497). pii: eaav1386. doi: 10.1126/scitranslmed.aav1386.

PMID:
31217335
7.

Author Correction: A recellularized human colon model identifies cancer driver genes.

Chen HJ, Wei Z, Sun J, Bhattacharya A, Savage DJ, Serda R, Mackeyev Y, Curley SA, Bu P, Wang L, Chen S, Cohen-Gould L, Huang E, Shen X, Lipkin SM, Copeland NG, Jenkins NA, Shuler ML.

Nat Biotechnol. 2019 Jul;37(7):820. doi: 10.1038/s41587-019-0163-6.

PMID:
31160724
8.

A SIMPLE ASPECT RATIO DEPENDENT METHOD OF PATTERNING MICROWELLS FOR SELECTIVE CELL ATTACHMENT.

Zavrel EA, Shuler ML, Shen X.

2018 Des Med Devices Conf (2018). 2018 Apr;2018. pii: V001T05A001. doi: 10.1115/DMD2018-6811. No abstract available.

9.

Engineering a Bioartificial Human Colon Model Through Decellularization and Recellularization.

Chen HJ, Shuler ML.

Methods Mol Biol. 2019;1907:91-102. doi: 10.1007/978-1-4939-8967-6_7.

PMID:
30542993
10.

Recent Advances in Body-on-a-Chip Systems.

Sung JH, Wang YI, Narasimhan Sriram N, Jackson M, Long C, Hickman JJ, Shuler ML.

Anal Chem. 2019 Jan 2;91(1):330-351. doi: 10.1021/acs.analchem.8b05293. Epub 2018 Dec 11. No abstract available.

11.

Circulating MIR148A associates with sensitivity to adiponectin levels in human metabolic surgery for weight loss

Ariza-Nieto M, Alley JB, Samy S, Fitzgerald L, Vermeylen F, Shuler ML, Alemán JO.

Endocr Connect. 2018 Sep 1;7(9):975-982. doi: 10.1530/EC-18-0205.

12.

Advances in organ-, body-, and disease-on-a-chip systems.

Shuler ML.

Lab Chip. 2018 Dec 18;19(1):9-10. doi: 10.1039/c8lc90089b. No abstract available.

PMID:
30284573
13.

Circulating miR-148a associates with sensitivity to adiponectin levels in human metabolic surgery for weight loss.

Ariza-Nieto M, Alley JB, Samy S, Fitzgerald L, Vermeylen F, Shuler ML, Aleman JO.

Endocr Connect. 2018 Aug 2. pii: EC-18-0205. doi: 10.1530/EC-18-0205. [Epub ahead of print]

14.
15.

A pumpless body-on-a-chip model using a primary culture of human intestinal cells and a 3D culture of liver cells.

Chen HJ, Miller P, Shuler ML.

Lab Chip. 2018 Jul 10;18(14):2036-2046. doi: 10.1039/c8lc00111a.

16.

Microfluidic-Based Cell-Embedded Microgels Using Nonfluorinated Oil as a Model for the Gastrointestinal Niche.

Pajoumshariati SR, Azizi M, Wesner D, Miller PG, Shuler ML, Abbaspourrad A.

ACS Appl Mater Interfaces. 2018 Mar 21;10(11):9235-9246. doi: 10.1021/acsami.7b16916. Epub 2018 Mar 6.

PMID:
29474057
17.

Multiorgan Microphysiological Systems for Drug Development: Strategies, Advances, and Challenges.

Wang YI, Carmona C, Hickman JJ, Shuler ML.

Adv Healthc Mater. 2018 Jan;7(2). doi: 10.1002/adhm.201701000. Epub 2017 Dec 4. Review.

18.

Self-contained, low-cost Body-on-a-Chip systems for drug development.

Wang YI, Oleaga C, Long CJ, Esch MB, McAleer CW, Miller PG, Hickman JJ, Shuler ML.

Exp Biol Med (Maywood). 2017 Nov;242(17):1701-1713. doi: 10.1177/1535370217694101. Epub 2017 Feb 17. Review.

19.

Organ-, body- and disease-on-a-chip systems.

Shuler ML.

Lab Chip. 2017 Jul 11;17(14):2345-2346. doi: 10.1039/c7lc90068f. No abstract available.

PMID:
28671705
20.

A simple cell transport device keeps culture alive and functional during shipping.

Miller PG, Wang YI, Swan G, Shuler ML.

Biotechnol Prog. 2017 Sep;33(5):1257-1266. doi: 10.1002/btpr.2512. Epub 2017 Jun 21.

21.

Body-on-a-chip systems for animal-free toxicity testing.

Mahler GJ, Esch MB, Stokol T, Hickman JJ, Shuler ML.

Altern Lab Anim. 2016 Oct;44(5):469-478. Review.

PMID:
27805830
22.

Microfluidic blood-brain barrier model provides in vivo-like barrier properties for drug permeability screening.

Wang YI, Abaci HE, Shuler ML.

Biotechnol Bioeng. 2017 Jan;114(1):184-194. doi: 10.1002/bit.26045. Epub 2016 Jul 21.

23.

A recellularized human colon model identifies cancer driver genes.

Chen HJ, Wei Z, Sun J, Bhattacharya A, Savage DJ, Serda R, Mackeyev Y, Curley SA, Bu P, Wang L, Chen S, Cohen-Gould L, Huang E, Shen X, Lipkin SM, Copeland NG, Jenkins NA, Shuler ML.

Nat Biotechnol. 2016 Aug;34(8):845-51. doi: 10.1038/nbt.3586. Epub 2016 Jul 11. Erratum in: Nat Biotechnol. 2019 Jul;37(7):820.

24.

Modular, pumpless body-on-a-chip platform for the co-culture of GI tract epithelium and 3D primary liver tissue.

Esch MB, Ueno H, Applegate DR, Shuler ML.

Lab Chip. 2016 Jul 5;16(14):2719-29. doi: 10.1039/c6lc00461j.

PMID:
27332143
25.

Modeling Barrier Tissues In Vitro: Methods, Achievements, and Challenges.

Sakolish CM, Esch MB, Hickman JJ, Shuler ML, Mahler GJ.

EBioMedicine. 2016 Feb 13;5:30-9. doi: 10.1016/j.ebiom.2016.02.023. eCollection 2016 Mar. Review.

26.

Design and demonstration of a pumpless 14 compartment microphysiological system.

Miller PG, Shuler ML.

Biotechnol Bioeng. 2016 Oct;113(10):2213-27. doi: 10.1002/bit.25989. Epub 2016 Apr 29.

PMID:
27070809
27.

Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs.

Oleaga C, Bernabini C, Smith AS, Srinivasan B, Jackson M, McLamb W, Platt V, Bridges R, Cai Y, Santhanam N, Berry B, Najjar S, Akanda N, Guo X, Martin C, Ekman G, Esch MB, Langer J, Ouedraogo G, Cotovio J, Breton L, Shuler ML, Hickman JJ.

Sci Rep. 2016 Feb 3;6:20030. doi: 10.1038/srep20030.

28.

Multi-cellular 3D human primary liver cell culture elevates metabolic activity under fluidic flow.

Esch MB, Prot JM, Wang YI, Miller P, Llamas-Vidales JR, Naughton BA, Applegate DR, Shuler ML.

Lab Chip. 2015 May 21;15(10):2269-77. doi: 10.1039/c5lc00237k.

29.

Tissue factor-expressing tumor cells can bind to immobilized recombinant tissue factor pathway inhibitor under static and shear conditions in vitro.

Che SP, DeLeonardis C, Shuler ML, Stokol T.

PLoS One. 2015 Apr 7;10(4):e0123717. doi: 10.1371/journal.pone.0123717. eCollection 2015.

30.

Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling.

Abaci HE, Shuler ML.

Integr Biol (Camb). 2015 Apr;7(4):383-91. doi: 10.1039/c4ib00292j. Review.

31.

TEER measurement techniques for in vitro barrier model systems.

Srinivasan B, Kolli AR, Esch MB, Abaci HE, Shuler ML, Hickman JJ.

J Lab Autom. 2015 Apr;20(2):107-26. doi: 10.1177/2211068214561025. Epub 2015 Jan 13. Review.

32.

Pumpless microfluidic platform for drug testing on human skin equivalents.

Abaci HE, Gledhill K, Guo Z, Christiano AM, Shuler ML.

Lab Chip. 2015 Feb 7;15(3):882-8. doi: 10.1039/c4lc00999a.

33.

Toward in vitro models of brain structure and function.

Shuler ML, Hickman JJ.

Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13682-3. doi: 10.1073/pnas.1414484111. Epub 2014 Sep 5. No abstract available.

34.

Development of a genetic system for a model manganese-oxidizing proteobacterium, Leptothrix discophora SS1.

Bocioaga D, El Gheriany IA, Lion LW, Ghiorse WC, Shuler ML, Hay AG.

Microbiology. 2014 Nov;160(Pt 11):2396-405. doi: 10.1099/mic.0.079459-0. Epub 2014 Aug 22.

PMID:
25149187
35.
36.

Using physiologically-based pharmacokinetic-guided "body-on-a-chip" systems to predict mammalian response to drug and chemical exposure.

Sung JH, Srinivasan B, Esch MB, McLamb WT, Bernabini C, Shuler ML, Hickman JJ.

Exp Biol Med (Maywood). 2014 Sep;239(9):1225-39. doi: 10.1177/1535370214529397. Epub 2014 Jun 20. Review.

37.

Microphysiological systems and low-cost microfluidic platform with analytics.

Smith AS, Long CJ, Berry BJ, McAleer C, Stancescu M, Molnar P, Miller PG, Esch MB, Prot JM, Hickman JJ, Shuler ML.

Stem Cell Res Ther. 2013;4 Suppl 1:S9. doi: 10.1186/scrt370. Epub 2013 Dec 20. Review.

38.

How multi-organ microdevices can help foster drug development.

Esch MB, Smith AS, Prot JM, Oleaga C, Hickman JJ, Shuler ML.

Adv Drug Deliv Rev. 2014 Apr;69-70:158-69. doi: 10.1016/j.addr.2013.12.003. Epub 2014 Jan 9. Review.

39.

A physical sciences network characterization of non-tumorigenic and metastatic cells.

Physical Sciences - Oncology Centers Network, Agus DB, Alexander JF, Arap W, Ashili S, Aslan JE, Austin RH, Backman V, Bethel KJ, Bonneau R, Chen WC, Chen-Tanyolac C, Choi NC, Curley SA, Dallas M, Damania D, Davies PC, Decuzzi P, Dickinson L, Estevez-Salmeron L, Estrella V, Ferrari M, Fischbach C, Foo J, Fraley SI, Frantz C, Fuhrmann A, Gascard P, Gatenby RA, Geng Y, Gerecht S, Gillies RJ, Godin B, Grady WM, Greenfield A, Hemphill C, Hempstead BL, Hielscher A, Hillis WD, Holland EC, Ibrahim-Hashim A, Jacks T, Johnson RH, Joo A, Katz JE, Kelbauskas L, Kesselman C, King MR, Konstantopoulos K, Kraning-Rush CM, Kuhn P, Kung K, Kwee B, Lakins JN, Lambert G, Liao D, Licht JD, Liphardt JT, Liu L, Lloyd MC, Lyubimova A, Mallick P, Marko J, McCarty OJ, Meldrum DR, Michor F, Mumenthaler SM, Nandakumar V, O'Halloran TV, Oh S, Pasqualini R, Paszek MJ, Philips KG, Poultney CS, Rana K, Reinhart-King CA, Ros R, Semenza GL, Senechal P, Shuler ML, Srinivasan S, Staunton JR, Stypula Y, Subramanian H, Tlsty TD, Tormoen GW, Tseng Y, van Oudenaarden A, Verbridge SS, Wan JC, Weaver VM, Widom J, Will C, Wirtz D, Wojtkowiak J, Wu PH.

Sci Rep. 2013;3:1449. doi: 10.1038/srep01449.

40.

Microfabricated mammalian organ systems and their integration into models of whole animals and humans.

Sung JH, Esch MB, Prot JM, Long CJ, Smith A, Hickman JJ, Shuler ML.

Lab Chip. 2013 Apr 7;13(7):1201-12. doi: 10.1039/c3lc41017j. Review.

41.

Elmer L. Gaden, Jr. Tribute.

Clark DS, Blanch HW, Wang DI, Demain AL, Wandrey C, Hu WS, Schultz JS, Shuler ML, Hoare M, Lightfoot EN, Humphrey AE, Dordick JS, Asenjo JA.

Biotechnol Bioeng. 2012 Oct;109(10):2417-21. doi: 10.1002/bit.24610. No abstract available.

PMID:
22910882
42.

On chip porous polymer membranes for integration of gastrointestinal tract epithelium with microfluidic 'body-on-a-chip' devices.

Esch MB, Sung JH, Yang J, Yu C, Yu J, March JC, Shuler ML.

Biomed Microdevices. 2012 Oct;14(5):895-906. doi: 10.1007/s10544-012-9669-0.

PMID:
22847474
43.

Modeling a minimal cell.

Shuler ML, Foley P, Atlas J.

Methods Mol Biol. 2012;881:573-610. doi: 10.1007/978-1-61779-827-6_20.

PMID:
22639227
44.

Introduction to the special issue on micro- and nanofabrication techniques.

Shuler ML, Sung JH.

Ann Biomed Eng. 2012 Jun;40(6):1209-10. doi: 10.1007/s10439-012-0589-1. No abstract available.

PMID:
22588511
45.

Modeling life.

Shuler ML.

Ann Biomed Eng. 2012 Jul;40(7):1399-407. doi: 10.1007/s10439-012-0567-7. Epub 2012 Apr 17. Review.

PMID:
22527010
46.

Mini-scale bioprocessing systems for highly parallel animal cell cultures.

Kim BJ, Diao J, Shuler ML.

Biotechnol Prog. 2012 May-Jun;28(3):595-607. doi: 10.1002/btpr.1554. Epub 2012 May 21. Review.

PMID:
22522970
47.

Synthesis and characterization of high-throughput nanofabricated poly(4-hydroxy styrene) membranes for in vitro models of barrier tissue.

Shayan G, Felix N, Cho Y, Chatzichristidi M, Shuler ML, Ober CK, Lee KH.

Tissue Eng Part C Methods. 2012 Sep;18(9):667-76. doi: 10.1089/ten.TEC.2011.0598. Epub 2012 May 21.

PMID:
22435738
48.

Oral exposure to polystyrene nanoparticles affects iron absorption.

Mahler GJ, Esch MB, Tako E, Southard TL, Archer SD, Glahn RP, Shuler ML.

Nat Nanotechnol. 2012 Feb 12;7(4):264-71. doi: 10.1038/nnano.2012.3.

PMID:
22327877
49.

Metacridamides A and B, macrocycles from conidia of the entomopathogenic fungus Metarhizium acridum.

Krasnoff SB, Englich U, Miller PG, Shuler ML, Glahn RP, Donzelli BG, Gibson DM.

J Nat Prod. 2012 Feb 24;75(2):175-80. doi: 10.1021/np2007044. Epub 2012 Jan 31.

50.

Microtechnology for mimicking in vivo tissue environment.

Sung JH, Shuler ML.

Ann Biomed Eng. 2012 Jun;40(6):1289-300. doi: 10.1007/s10439-011-0491-2. Epub 2012 Jan 4. Review.

PMID:
22215276

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