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Items: 1 to 50 of 145


Microbiome-focused asthma management strategies.

Shukla SD, Shastri MD, Chong WC, Dua K, Budden KF, Mahmood MQ, Hansbro NG, Keely S, Eri R, Patel RP, Peterson GM, Hansbro PM.

Curr Opin Pharmacol. 2019 Jun;46:143-149. doi: 10.1016/j.coph.2019.06.003. Epub 2019 Jul 26. Review.


Binge Alcohol Is More Injurious to Liver in Female than in Male Rats: Histopathological, Pharmacologic, and Epigenetic Profiles.

Shukla SD, Restrepo R, Aroor AR, Liu X, Lim RW, Franke JD, Ford DA, Korthuis RJ.

J Pharmacol Exp Ther. 2019 Sep;370(3):390-398. doi: 10.1124/jpet.119.258871. Epub 2019 Jul 1.


Functional effects of the microbiota in chronic respiratory disease.

Budden KF, Shukla SD, Rehman SF, Bowerman KL, Keely S, Hugenholtz P, Armstrong-James DPH, Adcock IM, Chotirmall SH, Chung KF, Hansbro PM.

Lancet Respir Med. 2019 Oct;7(10):907-920. doi: 10.1016/S2213-2600(18)30510-1. Epub 2019 Apr 8. Review.


Binge Drinking.

White AM, Tapert S, Shukla SD.

Alcohol Res. 2018;39(1):1-3. No abstract available.


Increasing complexity and interactions of oxidative stress in chronic respiratory diseases: An emerging need for novel drug delivery systems.

Dua K, Malyla V, Singhvi G, Wadhwa R, Krishna RV, Shukla SD, Shastri MD, Chellappan DK, Maurya PK, Satija S, Mehta M, Gulati M, Hansbro N, Collet T, Awasthi R, Gupta G, Hsu A, Hansbro PM.

Chem Biol Interact. 2019 Feb 1;299:168-178. doi: 10.1016/j.cbi.2018.12.009. Epub 2018 Dec 13. Review.


The role of environmental exposure to non-cigarette smoke in lung disease.

Kc R, Shukla SD, Gautam SS, Hansbro PM, O'Toole RF.

Clin Transl Med. 2018 Dec 5;7(1):39. doi: 10.1186/s40169-018-0217-2. Review.


Role of Oxidative Stress in the Pathology and Management of Human Tuberculosis.

Shastri MD, Shukla SD, Chong WC, Dua K, Peterson GM, Patel RP, Hansbro PM, Eri R, O'Toole RF.

Oxid Med Cell Longev. 2018 Oct 11;2018:7695364. doi: 10.1155/2018/7695364. eCollection 2018. Review.


Multi-drug resistant Mycobacterium tuberculosis & oxidative stress complexity: Emerging need for novel drug delivery approaches.

Dua K, Rapalli VK, Shukla SD, Singhvi G, Shastri MD, Chellappan DK, Satija S, Mehta M, Gulati M, Pinto TJA, Gupta G, Hansbro PM.

Biomed Pharmacother. 2018 Nov;107:1218-1229. doi: 10.1016/j.biopha.2018.08.101. Epub 2018 Aug 29. Review.


Test for Non-Synergistic Interactions in Phytomedicine, Just as You Do for Isolated Compounds.

Patel A, Khan FA, Sikdar A, Mondal A, Shukla SD, Khurana S.

J Exp Neurosci. 2018 Apr 18;12:1179069518767654. doi: 10.1177/1179069518767654. eCollection 2018.


Gut Microbial Changes, Interactions, and Their Implications on Human Lifecycle: An Ageing Perspective.

Vemuri R, Gundamaraju R, Shastri MD, Shukla SD, Kalpurath K, Ball M, Tristram S, Shankar EM, Ahuja K, Eri R.

Biomed Res Int. 2018 Feb 26;2018:4178607. doi: 10.1155/2018/4178607. eCollection 2018. Review.


Upregulated pneumococcal adhesion molecule (platelet-activating factor receptor) may predispose COPD patients to community-acquired pneumonia.

Shukla SD, Hansbro PM, Walters EH.

Int J Chron Obstruct Pulmon Dis. 2017 Oct 24;12:3111-3113. doi: 10.2147/COPD.S151142. eCollection 2017. No abstract available.


Potential Mechanisms of Microbial Pathogens in Idiopathic Interstitial Lung Disease.

Sohal SS, Hansbro PM, Shukla SD, Eapen MS, Walters EH.

Chest. 2017 Oct;152(4):899-900. doi: 10.1016/j.chest.2017.05.024. No abstract available.


Nanotechnology: Advancing the translational respiratory research.

Dua K, Shukla SD, de Jesus Andreoli Pinto T, Hansbro PM.

Interv Med Appl Sci. 2017 Mar;9(1):39-41. doi: 10.1556/1646.9.2017.1.02.


╬▓-catenin, Twist and Snail: Transcriptional regulation of EMT in smokers and COPD, and relation to airflow obstruction.

Mahmood MQ, Walters EH, Shukla SD, Weston S, Muller HK, Ward C, Sohal SS.

Sci Rep. 2017 Sep 7;7(1):10832. doi: 10.1038/s41598-017-11375-x.


Aspiration techniques for bronchoalveolar lavage in translational respiratory research: Paving the way to develop novel therapeutic moieties.

Dua K, Shukla SD, Hansbro PM.

J Biol Methods. 2017 Jul 3;4(3):e73. doi: 10.14440/jbm.2017.174. eCollection 2017. Review.


Blocking rhinoviral adhesion molecule (ICAM-1): potential to prevent COPD exacerbations.

Shukla SD, Hansbro PM, Walters EH.

Int J Chron Obstruct Pulmon Dis. 2017 May 11;12:1413-1414. doi: 10.2147/COPD.S138612. eCollection 2017. No abstract available.


Microbiome effects on immunity, health and disease in the lung.

Shukla SD, Budden KF, Neal R, Hansbro PM.

Clin Transl Immunology. 2017 Mar 10;6(3):e133. doi: 10.1038/cti.2017.6. eCollection 2017 Mar. Review.


Binge alcohol alters PNPLA3 levels in liver through epigenetic mechanism involving histone H3 acetylation.

Restrepo RJ, Lim RW, Korthuis RJ, Shukla SD.

Alcohol. 2017 May;60:77-82. doi: 10.1016/j.alcohol.2017.01.009. Epub 2017 Mar 12.


An isolate of Haemophilus haemolyticus produces a bacteriocin-like substance that inhibits the growth of nontypeable Haemophilus influenzae.

Latham RD, Gell DA, Fairbairn RL, Lyons AB, Shukla SD, Cho KY, Jones DA, Harkness NM, Tristram SG.

Int J Antimicrob Agents. 2017 Apr;49(4):503-506. doi: 10.1016/j.ijantimicag.2016.12.010. Epub 2017 Feb 24.


The Role of Epidermal Growth Factor Receptor in the Management of Gastrointestinal Carcinomas: Present Status and Future Perspectives.

Mahmood MQ, Shukla SD, Dua K, Shastri MD.

Curr Pharm Des. 2017;23(16):2314-2320. doi: 10.2174/1381612823666170124115159. Review.


Temporal upregulation of host surface receptors provides a window of opportunity for bacterial adhesion and disease.

Kc R, Shukla SD, Walters EH, O'Toole RF.

Microbiology. 2017 Apr;163(4):421-430. doi: 10.1099/mic.0.000434. Epub 2017 Apr 6. Review.


Microbiomes in respiratory health and disease: An Asia-Pacific perspective.

Chotirmall SH, Gellatly SL, Budden KF, Mac Aogain M, Shukla SD, Wood DL, Hugenholtz P, Pethe K, Hansbro PM.

Respirology. 2017 Feb;22(2):240-250. doi: 10.1111/resp.12971. Review.


The main rhinovirus respiratory tract adhesion site (ICAM-1) is upregulated in smokers and patients with chronic airflow limitation (CAL).

Shukla SD, Mahmood MQ, Weston S, Latham R, Muller HK, Sohal SS, Walters EH.

Respir Res. 2017 Jan 5;18(1):6. doi: 10.1186/s12931-016-0483-8.


Whether a novel drug delivery system can overcome the problem of biofilms in respiratory diseases?

Dua K, Shukla SD, Tekade RK, Hansbro PM.

Drug Deliv Transl Res. 2017 Feb;7(1):179-187. doi: 10.1007/s13346-016-0349-0. Review.


Inhaled corticosteroid normalizes some but not all airway vascular remodeling in COPD.

Soltani A, Walters EH, Reid DW, Shukla SD, Nowrin K, Ward C, Muller HK, Sohal SS.

Int J Chron Obstruct Pulmon Dis. 2016 Sep 22;11:2359-2367. eCollection 2016.


An antagonist of the platelet-activating factor receptor inhibits adherence of both nontypeable Haemophilus influenzae and Streptococcus pneumoniae to cultured human bronchial epithelial cells exposed to cigarette smoke.

Shukla SD, Fairbairn RL, Gell DA, Latham RD, Sohal SS, Walters EH, O'Toole RF.

Int J Chron Obstruct Pulmon Dis. 2016 Jul 25;11:1647-55. doi: 10.2147/COPD.S108698. eCollection 2016.


Evaluation of Models of Parkinson's Disease.

Jagmag SA, Tripathi N, Shukla SD, Maiti S, Khurana S.

Front Neurosci. 2016 Jan 19;9:503. doi: 10.3389/fnins.2015.00503. eCollection 2015. Review.


Platelet-activating factor receptor (PAFr) is upregulated in small airways and alveoli of smokers and COPD patients.

Shukla SD, Muller HK, Latham R, Sohal SS, Walters EH.

Respirology. 2016 Apr;21(3):504-10. doi: 10.1111/resp.12709. Epub 2015 Dec 10.


High Intrinsic Aerobic Capacity Protects against Ethanol-Induced Hepatic Injury and Metabolic Dysfunction: Study Using High Capacity Runner Rat Model.

Szary N, Rector RS, Uptergrove GM, Ridenhour SE, Shukla SD, Thyfault JP, Koch LG, Britton SL, Ibdah JA.

Biomolecules. 2015 Nov 20;5(4):3295-308. doi: 10.3390/biom5043295.


In Vivo Acute on Chronic Ethanol Effects in Liver: A Mouse Model Exhibiting Exacerbated Injury, Altered Metabolic and Epigenetic Responses.

Shukla SD, Aroor AR, Restrepo R, Kharbanda KK, Ibdah JA.

Biomolecules. 2015 Nov 20;5(4):3280-94. doi: 10.3390/biom5043280.


TB meets COPD: An emerging global co-morbidity in human lung disease.

O'Toole RF, Shukla SD, Walters EH.

Tuberculosis (Edinb). 2015 Dec;95(6):659-663. doi: 10.1016/ Epub 2015 Sep 2. Review.


Epithelial mesenchymal transition in smokers: large versus small airways and relation to airflow obstruction.

Mahmood MQ, Sohal SS, Shukla SD, Ward C, Hardikar A, Noor WD, Muller HK, Knight DA, Walters EH.

Int J Chron Obstruct Pulmon Dis. 2015 Aug 4;10:1515-24. doi: 10.2147/COPD.S81032. eCollection 2015.


Platelet activating factor receptor: gateway for bacterial chronic airway infection in chronic obstructive pulmonary disease and potential therapeutic target.

Shukla SD, Sohal SS, O'Toole RF, Eapen MS, Walters EH.

Expert Rev Respir Med. 2015 Aug;9(4):473-85. doi: 10.1586/17476348.2015.1070673. Review.


Erratum to: Epigenetic histone modifications in a clinically relevant rat model of chronic ethanol-binge-mediated liver injury.

Aroor AR, Restrepo RJ, Kharbanda KK, Shukla SD.

Hepatol Int. 2014 Sep;8 Suppl 2:431. doi: 10.1007/s12072-014-9564-2. No abstract available.


Epigenetic histone modifications in a clinically relevant rat model of chronic ethanol-binge-mediated liver injury.

Aroor AR, Restrepo RJ, Kharbanda KK, Shukla SD.

Hepatol Int. 2014 Sep;8 Suppl 2:421-30. doi: 10.1007/s12072-014-9546-4. Epub 2014 Jun 18. Erratum in: Hepatol Int. 2014 Sep;8 Suppl 2:431.


Different mechanisms for histone acetylation by ethanol and its metabolite acetate in rat primary hepatocytes.

Shukla SD, Restrepo R, Fish P, Lim RW, Ibdah JA.

J Pharmacol Exp Ther. 2015 Jul;354(1):18-23. doi: 10.1124/jpet.115.223867. Epub 2015 Apr 17.


Airway epithelial platelet-activating factor receptor expression is markedly upregulated in chronic obstructive pulmonary disease.

Shukla SD, Sohal SS, Mahmood MQ, Reid D, Muller HK, Walters EH.

Int J Chron Obstruct Pulmon Dis. 2014 Aug 13;9:853-61. doi: 10.2147/COPD.S67044. eCollection 2014.


Epigenetic effects of ethanol on the liver and gastrointestinal system.

Shukla SD, Lim RW.

Alcohol Res. 2013;35(1):47-55. Review.


Epigenetics--new frontier for alcohol research.

Shukla SD, Zakhari S.

Alcohol Res. 2013;35(1):1-2. No abstract available.


Binge ethanol and liver: new molecular developments.

Shukla SD, Pruett SB, Szabo G, Arteel GE.

Alcohol Clin Exp Res. 2013 Apr;37(4):550-7. doi: 10.1111/acer.12011. Epub 2013 Jan 24. Review.


Critical evaluation of ayurvedic plants for stimulating intrinsic antioxidant response.

Shukla SD, Bhatnagar M, Khurana S.

Front Neurosci. 2012 Jul 26;6:112. doi: 10.3389/fnins.2012.00112. eCollection 2012.


A proteomic analysis of liver after ethanol binge in chronically ethanol treated rats.

Aroor AR, Roy LJ, Restrepo RJ, Mooney BP, Shukla SD.

Proteome Sci. 2012 Apr 30;10(1):29. doi: 10.1186/1477-5956-10-29.


Gene-selective histone H3 acetylation in the absence of increase in global histone acetylation in liver of rats chronically fed alcohol.

Park PH, Lim RW, Shukla SD.

Alcohol Alcohol. 2012 May-Jun;47(3):233-9. doi: 10.1093/alcalc/ags004. Epub 2012 Feb 2.


Dysregulated phosphorylation and nuclear translocation of cyclic AMP response element binding protein (CREB) in rat liver after chronic ethanol binge.

Aroor AR, Jackson DE, Shukla SD.

Eur J Pharmacol. 2012 Mar 15;679(1-3):101-8. doi: 10.1016/j.ejphar.2011.12.045. Epub 2012 Jan 15.


Histone H3 phosphorylation (Ser10, Ser28) and phosphoacetylation (K9S10) are differentially associated with gene expression in liver of rats treated in vivo with acute ethanol.

James TT, Aroor AR, Lim RW, Shukla SD.

J Pharmacol Exp Ther. 2012 Feb;340(2):237-47. doi: 10.1124/jpet.111.186775. Epub 2011 Oct 24.


Binge ethanol intake in chronically exposed rat liver decreases LDL-receptor and increases angiotensinogen gene expression.

Aroor AR, Shukla SD.

World J Hepatol. 2011 Sep 27;3(9):250-5. doi: 10.4254/wjh.v3.i9.250.


Elevated activation of ERK1 and ERK2 accompany enhanced liver injury following alcohol binge in chronically ethanol-fed rats.

Aroor AR, Jackson DE, Shukla SD.

Alcohol Clin Exp Res. 2011 Dec;35(12):2128-38. doi: 10.1111/j.1530-0277.2011.01577.x. Epub 2011 Jul 25.


Knock down of GCN5 histone acetyltransferase by siRNA decreases ethanol-induced histone acetylation and affects differential expression of genes in human hepatoma cells.

Choudhury M, Pandey RS, Clemens DL, Davis JW, Lim RW, Shukla SD.

Alcohol. 2011 Jun;45(4):311-24. doi: 10.1016/j.alcohol.2010.12.003. Epub 2011 Mar 2.

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