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Inhibition of the Dead Box RNA Helicase 3 Prevents HIV-1 Tat and Cocaine-Induced Neurotoxicity by Targeting Microglia Activation.

Aksenova M, Sybrandt J, Cui B, Sikirzhytski V, Ji H, Odhiambo D, Lucius MD, Turner JR, Broude E, Peña E, Lizarraga S, Zhu J, Safro I, Wyatt MD, Shtutman M.

J Neuroimmune Pharmacol. 2019 Dec 4. doi: 10.1007/s11481-019-09885-8. [Epub ahead of print]


Identifying Cancers Impacted by CDK8/19.

Roninson IB, Győrffy B, Mack ZT, Shtil AA, Shtutman MS, Chen M, Broude EV.

Cells. 2019 Aug 3;8(8). pii: E821. doi: 10.3390/cells8080821.


Coordination Analysis of Gene Expression Points to the Relative Impact of Different Regulators During Endoplasmic Reticulum Stress.

Zhang Y, Lucius MD, Altomare D, Havighorst A, Farmaki E, Chatzistamou I, Shtutman M, Kiaris H.

DNA Cell Biol. 2019 Sep;38(9):969-981. doi: 10.1089/dna.2019.4910. Epub 2019 Aug 6.


hnRNPs Interacting with mRNA Localization Motifs Define Axonal RNA Regulons.

Lee SJ, Oses-Prieto JA, Kawaguchi R, Sahoo PK, Kar AN, Rozenbaum M, Oliver D, Chand S, Ji H, Shtutman M, Miller-Randolph S, Taylor RJ, Fainzilber M, Coppola G, Burlingame AL, Twiss JL.

Mol Cell Proteomics. 2018 Nov;17(11):2091-2106. doi: 10.1074/mcp.RA118.000603. Epub 2018 Jul 23.


MOLIERE: Automatic Biomedical Hypothesis Generation System.

Sybrandt J, Shtutman M, Safro I.

KDD. 2017 Aug;2017:1633-1642. doi: 10.1145/3097983.3098057.


CDK8/19 Mediator kinases potentiate induction of transcription by NFκB.

Chen M, Liang J, Ji H, Yang Z, Altilia S, Hu B, Schronce A, McDermott MSJ, Schools GP, Lim CU, Oliver D, Shtutman MS, Lu T, Stark GR, Porter DC, Broude EV, Roninson IB.

Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10208-10213. doi: 10.1073/pnas.1710467114. Epub 2017 Aug 30.


Impact of Pharmacogenetics on Efficacy and Safety of Statin Therapy for Dyslipidemia.

Maxwell WD, Ramsey LB, Johnson SG, Moore KG, Shtutman M, Schoonover JH, Kawaguchi-Suzuki M.

Pharmacotherapy. 2017 Sep;37(9):1172-1190. doi: 10.1002/phar.1981. Epub 2017 Aug 23. Review.


Identification of novel cancer therapeutic targets using a designed and pooled shRNA library screen.

Oliver D, Ji H, Liu P, Gasparian A, Gardiner E, Lee S, Zenteno A, Perinskaya LO, Chen M, Buckhaults P, Broude E, Wyatt MD, Valafar H, Peña E, Shtutman M.

Sci Rep. 2017 Feb 22;7:43023. doi: 10.1038/srep43023.


Inhibition of CDK8 mediator kinase suppresses estrogen dependent transcription and the growth of estrogen receptor positive breast cancer.

McDermott MS, Chumanevich AA, Lim CU, Liang J, Chen M, Altilia S, Oliver D, Rae JM, Shtutman M, Kiaris H, Győrffy B, Roninson IB, Broude EV.

Oncotarget. 2017 Feb 21;8(8):12558-12575. doi: 10.18632/oncotarget.14894.


Crystal structure of truncated human coatomer protein complex subunit ζ1 (Copζ1).

Lunev S, Semmelink MF, Xian JL, Ma KY, Leenders AJ, Dömling AS, Shtutman M, Groves MR.

Acta Crystallogr F Struct Biol Commun. 2017 Jan 1;73(Pt 1):1-8. doi: 10.1107/S2053230X16018896. Epub 2017 Jan 1.


Cellular Model of p21-Induced Senescence.

Shtutman M, Chang BD, Schools GP, Broude EV.

Methods Mol Biol. 2017;1534:31-39.


Transgenerational attenuation of opioid self-administration as a consequence of adolescent morphine exposure.

Vassoler FM, Oliver DJ, Wyse C, Blau A, Shtutman M, Turner JR, Byrnes EM.

Neuropharmacology. 2017 Feb;113(Pt A):271-280. doi: 10.1016/j.neuropharm.2016.10.006. Epub 2016 Oct 8.


PDE11A regulates social behaviors and is a key mechanism by which social experience sculpts the brain.

Hegde S, Ji H, Oliver D, Patel NS, Poupore N, Shtutman M, Kelly MP.

Neuroscience. 2016 Oct 29;335:151-69. doi: 10.1016/j.neuroscience.2016.08.019. Epub 2016 Aug 17.


Arginyltransferase suppresses cell tumorigenic potential and inversely correlates with metastases in human cancers.

Rai R, Zhang F, Colavita K, Leu NA, Kurosaka S, Kumar A, Birnbaum MD, Győrffy B, Dong DW, Shtutman M, Kashina A.

Oncogene. 2016 Aug 4;35(31):4058-68. doi: 10.1038/onc.2015.473. Epub 2015 Dec 21.


Expression of CDK8 and CDK8-interacting Genes as Potential Biomarkers in Breast Cancer.

Broude EV, Győrffy B, Chumanevich AA, Chen M, McDermott MS, Shtutman M, Catroppo JF, Roninson IB.

Curr Cancer Drug Targets. 2015;15(8):739-49. Review.


Prefrontal microRNA-221 Mediates Environmental Enrichment-Induced Increase of Locomotor Sensitivity to Nicotine.

Gomez AM, Altomare D, Sun WL, Midde NM, Ji H, Shtutman M, Turner JR, Creek KE, Zhu J.

Int J Neuropsychopharmacol. 2015 Aug 1;19(1). pii: pyv090. doi: 10.1093/ijnp/pyv090.


Identification of novel genes that regulate androgen receptor signaling and growth of androgen-deprived prostate cancer cells.

Levina E, Ji H, Chen M, Baig M, Oliver D, Ohouo P, Lim CU, Schools G, Carmack S, Ding Y, Broude EV, Roninson IB, Buttyan R, Shtutman M.

Oncotarget. 2015 May 30;6(15):13088-104.


Purification of high-quality RNA from synthetic polyethylene glycol-based hydrogels.

Gasparian A, Daneshian L, Ji H, Jabbari E, Shtutman M.

Anal Biochem. 2015 Sep 1;484:1-3. doi: 10.1016/j.ab.2015.05.002. Epub 2015 May 8.


Transcriptomes and shRNA suppressors in a TP53 allele-specific model of early-onset colon cancer in African Americans.

Weige CC, Birtwistle MR, Mallick H, Yi N, Berrong Z, Cloessner E, Duff K, Tidwell J, Clendenning M, Wilkerson B, Farrell C, Bunz F, Ji H, Shtutman M, Creek KE, Banister CE, Buckhaults PJ.

Mol Cancer Res. 2014 Jul;12(7):1029-41. doi: 10.1158/1541-7786.MCR-13-0286-T. Epub 2014 Apr 17.


Paracrine Hedgehog increases the steroidogenic potential of prostate stromal cells in a Gli-dependent manner.

Levina E, Chen M, Carkner R, Shtutman M, Buttyan R.

Prostate. 2012 Jun 1;72(8):817-24. doi: 10.1002/pros.21500. Epub 2011 Oct 24.


Tumor-specific silencing of COPZ2 gene encoding coatomer protein complex subunit ζ 2 renders tumor cells dependent on its paralogous gene COPZ1.

Shtutman M, Baig M, Levina E, Hurteau G, Lim CU, Broude E, Nikiforov M, Harkins TT, Carmack CS, Ding Y, Wieland F, Buttyan R, Roninson IB.

Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12449-54. doi: 10.1073/pnas.1103842108. Epub 2011 Jul 11.


Antifungal testing and high-throughput screening of compound library against Geomyces destructans, the etiologic agent of geomycosis (WNS) in bats.

Chaturvedi S, Rajkumar SS, Li X, Hurteau GJ, Shtutman M, Chaturvedi V.

PLoS One. 2011 Mar 2;6(3):e17032. doi: 10.1371/journal.pone.0017032.


Effects of androgen receptor and androgen on gene expression in prostate stromal fibroblasts and paracrine signaling to prostate cancer cells.

Tanner MJ, Welliver RC Jr, Chen M, Shtutman M, Godoy A, Smith G, Mian BM, Buttyan R.

PLoS One. 2011 Jan 18;6(1):e16027. doi: 10.1371/journal.pone.0016027.


Hedgehog/Gli supports androgen signaling in androgen deprived and androgen independent prostate cancer cells.

Chen M, Feuerstein MA, Levina E, Baghel PS, Carkner RD, Tanner MJ, Shtutman M, Vacherot F, Terry S, de la Taille A, Buttyan R.

Mol Cancer. 2010 Apr 26;9:89. doi: 10.1186/1476-4598-9-89.


Function-based gene identification using enzymatically generated normalized shRNA library and massive parallel sequencing.

Shtutman M, Maliyekkel A, Shao Y, Carmack CS, Baig M, Warholic N, Cole K, Broude EV, Harkins TT, Ding Y, Roninson IB.

Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7377-82. doi: 10.1073/pnas.1003055107. Epub 2010 Apr 5.


Pharmacologic inhibition of MEK and PI-3K converges on the mTOR/S6 pathway to decelerate cellular senescence.

Demidenko ZN, Shtutman M, Blagosklonny MV.

Cell Cycle. 2009 Jun 15;8(12):1896-900. Epub 2009 Jun 21.


Signaling function of alpha-catenin in microtubule regulation.

Shtutman M, Chausovsky A, Prager-Khoutorsky M, Schiefermeier N, Boguslavsky S, Kam Z, Fuchs E, Geiger B, Borisy GG, Bershadsky AD.

Cell Cycle. 2008 Aug;7(15):2377-83. Epub 2008 May 30.


Repression of the SUMO-specific protease Senp1 induces p53-dependent premature senescence in normal human fibroblasts.

Yates KE, Korbel GA, Shtutman M, Roninson IB, DiMaio D.

Aging Cell. 2008 Oct;7(5):609-21. doi: 10.1111/j.1474-9726.2008.00411.x. Epub 2008 Jul 24.


Expression of L1-CAM and ADAM10 in human colon cancer cells induces metastasis.

Gavert N, Sheffer M, Raveh S, Spaderna S, Shtutman M, Brabletz T, Barany F, Paty P, Notterman D, Domany E, Ben-Ze'ev A.

Cancer Res. 2007 Aug 15;67(16):7703-12.


p120 catenin regulates lamellipodial dynamics and cell adhesion in cooperation with cortactin.

Boguslavsky S, Grosheva I, Landau E, Shtutman M, Cohen M, Arnold K, Feinstein E, Geiger B, Bershadsky A.

Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):10882-7. Epub 2007 Jun 18.


Targeted activation of beta-catenin signaling in basal mammary epithelial cells affects mammary development and leads to hyperplasia.

Teulière J, Faraldo MM, Deugnier MA, Shtutman M, Ben-Ze'ev A, Thiery JP, Glukhova MA.

Development. 2005 Jan;132(2):267-77. Epub 2004 Dec 8.


MicroRNA expression detected by oligonucleotide microarrays: system establishment and expression profiling in human tissues.

Barad O, Meiri E, Avniel A, Aharonov R, Barzilai A, Bentwich I, Einav U, Gilad S, Hurban P, Karov Y, Lobenhofer EK, Sharon E, Shiboleth YM, Shtutman M, Bentwich Z, Einat P.

Genome Res. 2004 Dec;14(12):2486-94.


beta-catenin-dependent and -independent effects of DeltaN-plakoglobin on epidermal growth and differentiation.

Teulière J, Faraldo MM, Shtutman M, Birchmeier W, Huelsken J, Thiery JP, Glukhova MA.

Mol Cell Biol. 2004 Oct;24(19):8649-61.


Identification and handling of artifactual gene expression profiles emerging in microarray hybridization experiments.

Brodsky L, Leontovich A, Shtutman M, Feinstein E.

Nucleic Acids Res. 2004 Mar 3;32(4):e46.


PKCeta associates with cyclin E/Cdk2 complex in serum-starved MCF-7 and NIH-3T3 cells.

Shtutman M, Hershko T, Maissel A, Fima E, Livneh E.

Exp Cell Res. 2003 May 15;286(1):22-9.


PML is a target gene of beta-catenin and plakoglobin, and coactivates beta-catenin-mediated transcription.

Shtutman M, Zhurinsky J, Oren M, Levina E, Ben-Ze'ev A.

Cancer Res. 2002 Oct 15;62(20):5947-54.


Nr-CAM is a target gene of the beta-catenin/LEF-1 pathway in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis.

Conacci-Sorrell ME, Ben-Yedidia T, Shtutman M, Feinstein E, Einat P, Ben-Ze'ev A.

Genes Dev. 2002 Aug 15;16(16):2058-72.


PKCeta enhances cell cycle progression, the expression of G1 cyclins and p21 in MCF-7 cells.

Fima E, Shtutman M, Libros P, Missel A, Shahaf G, Kahana G, Livneh E.

Oncogene. 2001 Oct 11;20(46):6794-804.


Deregulated beta-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation.

Damalas A, Kahan S, Shtutman M, Ben-Ze'ev A, Oren M.

EMBO J. 2001 Sep 3;20(17):4912-22.


Cadherin sequences that inhibit beta-catenin signaling: a study in yeast and mammalian cells.

Simcha I, Kirkpatrick C, Sadot E, Shtutman M, Polevoy G, Geiger B, Peifer M, Ben-Ze'ev A.

Mol Biol Cell. 2001 Apr;12(4):1177-88.


Recruitment of beta-catenin to cadherin-mediated intercellular adhesions is involved in myogenic induction.

Goichberg P, Shtutman M, Ben-Ze'ev A, Geiger B.

J Cell Sci. 2001 Apr;114(Pt 7):1309-19.


The integration of cell adhesion with gene expression: the role of beta-catenin.

Ben-Ze'ev A, Shtutman M, Zhurinsky J.

Exp Cell Res. 2000 Nov 25;261(1):75-82. Review. No abstract available.


[Vesicular transport gene bet1 is differentially transcribed in transformed cells with various metastatic potential].

Chepurnyh TV, Shtutman MS, Bykova AV, Ianushevich IuG, Tatosian AG.

Mol Biol (Mosk). 2000 Sep-Oct;34(5):907-10. Russian. No abstract available.


Plakoglobin and beta-catenin: protein interactions, regulation and biological roles.

Zhurinsky J, Shtutman M, Ben-Ze'ev A.

J Cell Sci. 2000 Sep;113 ( Pt 18):3127-39. Review.


The integrin-linked kinase regulates the cyclin D1 gene through glycogen synthase kinase 3beta and cAMP-responsive element-binding protein-dependent pathways.

D'Amico M, Hulit J, Amanatullah DF, Zafonte BT, Albanese C, Bouzahzah B, Fu M, Augenlicht LH, Donehower LA, Takemaru K, Moon RT, Davis R, Lisanti MP, Shtutman M, Zhurinsky J, Ben-Ze'ev A, Troussard AA, Dedhar S, Pestell RG.

J Biol Chem. 2000 Oct 20;275(42):32649-57.


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