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Items: 1 to 50 of 72

1.

Differentiation of Human Pluripotent Stem Cells into Colonic Organoids via Transient Activation of BMP Signaling.

Múnera JO, Sundaram N, Rankin SA, Hill D, Watson C, Mahe M, Vallance JE, Shroyer NF, Sinagoga KL, Zarzoso-Lacoste A, Hudson JR, Howell JC, Chatuvedi P, Spence JR, Shannon JM, Zorn AM, Helmrath MA, Wells JM.

Cell Stem Cell. 2019 May 2;24(5):829. doi: 10.1016/j.stem.2019.04.002. No abstract available.

2.

Cellular Plasticity of Defa4Cre-Expressing Paneth Cells in Response to Notch Activation and Intestinal Injury.

Jones JC, Brindley CD, Elder NH, Myers MG Jr, Rajala MW, Dekaney CM, McNamee EN, Frey MR, Shroyer NF, Dempsey PJ.

Cell Mol Gastroenterol Hepatol. 2019;7(3):533-554. doi: 10.1016/j.jcmgh.2018.11.004. Epub 2018 Nov 27.

3.

Growth Factor-Independent 1 Is a Tumor Suppressor Gene in Colorectal Cancer.

Chen MS, Lo YH, Chen X, Williams CS, Donnelly JM, Criss ZK 2nd, Patel S, Butkus JM, Dubrulle J, Finegold MJ, Shroyer NF.

Mol Cancer Res. 2019 Mar;17(3):697-708. doi: 10.1158/1541-7786.MCR-18-0666. Epub 2019 Jan 3.

PMID:
30606770
4.

An Organoid-Based Preclinical Model of Human Gastric Cancer.

Steele NG, Chakrabarti J, Wang J, Biesiada J, Holokai L, Chang J, Nowacki LM, Hawkins J, Mahe M, Sundaram N, Shroyer N, Medvedovic M, Helmrath M, Ahmad S, Zavros Y.

Cell Mol Gastroenterol Hepatol. 2019;7(1):161-184. doi: 10.1016/j.jcmgh.2018.09.008. Epub 2018 Sep 20.

5.

A Method for Cryogenic Preservation of Human Biopsy Specimens and Subsequent Organoid Culture.

Tsai YH, Czerwinski M, Wu A, Dame MK, Attili D, Hill E, Colacino JA, Nowacki LM, Shroyer NF, Higgins PDR, Kao JY, Spence JR.

Cell Mol Gastroenterol Hepatol. 2018 May 30;6(2):218-222.e7. doi: 10.1016/j.jcmgh.2018.04.008. eCollection 2018. No abstract available.

6.

Sox4 Promotes Atoh1-Independent Intestinal Secretory Differentiation Toward Tuft and Enteroendocrine Fates.

Gracz AD, Samsa LA, Fordham MJ, Trotier DC, Zwarycz B, Lo YH, Bao K, Starmer J, Raab JR, Shroyer NF, Reinhardt RL, Magness ST.

Gastroenterology. 2018 Nov;155(5):1508-1523.e10. doi: 10.1053/j.gastro.2018.07.023. Epub 2018 Jul 25.

PMID:
30055169
7.

Novel Segment- and Host-Specific Patterns of Enteroaggregative Escherichia coli Adherence to Human Intestinal Enteroids.

Rajan A, Vela L, Zeng XL, Yu X, Shroyer N, Blutt SE, Poole NM, Carlin LG, Nataro JP, Estes MK, Okhuysen PC, Maresso AW.

MBio. 2018 Feb 20;9(1). pii: e02419-17. doi: 10.1128/mBio.02419-17.

8.

Epithelial WNT Ligands Are Essential Drivers of Intestinal Stem Cell Activation.

Zou WY, Blutt SE, Zeng XL, Chen MS, Lo YH, Castillo-Azofeifa D, Klein OD, Shroyer NF, Donowitz M, Estes MK.

Cell Rep. 2018 Jan 23;22(4):1003-1015. doi: 10.1016/j.celrep.2017.12.093. Epub 2018 Jan 28.

9.

Differentiation of Human Pluripotent Stem Cells into Colonic Organoids via Transient Activation of BMP Signaling.

Múnera JO, Sundaram N, Rankin SA, Hill D, Watson C, Mahe M, Vallance JE, Shroyer NF, Sinagoga KL, Zarzoso-Lacoste A, Hudson JR, Howell JC, Chatuvedi P, Spence JR, Shannon JM, Zorn AM, Helmrath MA, Wells JM.

Cell Stem Cell. 2017 Jul 6;21(1):51-64.e6. doi: 10.1016/j.stem.2017.05.020. Epub 2017 Jun 22. Erratum in: Cell Stem Cell. 2019 May 2;24(5):829.

10.

SPDEF Induces Quiescence of Colorectal Cancer Cells by Changing the Transcriptional Targets of β-catenin.

Lo YH, Noah TK, Chen MS, Zou W, Borras E, Vilar E, Shroyer NF.

Gastroenterology. 2017 Jul;153(1):205-218.e8. doi: 10.1053/j.gastro.2017.03.048. Epub 2017 Apr 5.

PMID:
28390865
11.

Engineering bacterial thiosulfate and tetrathionate sensors for detecting gut inflammation.

Daeffler KN, Galley JD, Sheth RU, Ortiz-Velez LC, Bibb CO, Shroyer NF, Britton RA, Tabor JJ.

Mol Syst Biol. 2017 Apr 3;13(4):923. doi: 10.15252/msb.20167416.

12.

The ErbB3 receptor tyrosine kinase negatively regulates Paneth cells by PI3K-dependent suppression of Atoh1.

Almohazey D, Lo YH, Vossler CV, Simmons AJ, Hsieh JJ, Bucar EB, Schumacher MA, Hamilton KE, Lau KS, Shroyer NF, Frey MR.

Cell Death Differ. 2017 May;24(5):855-865. doi: 10.1038/cdd.2017.27. Epub 2017 Mar 17.

13.

Transcriptional Regulation by ATOH1 and its Target SPDEF in the Intestine.

Lo YH, Chung E, Li Z, Wan YW, Mahe MM, Chen MS, Noah TK, Bell KN, Yalamanchili HK, Klisch TJ, Liu Z, Park JS, Shroyer NF.

Cell Mol Gastroenterol Hepatol. 2016 Oct 21;3(1):51-71. doi: 10.1016/j.jcmgh.2016.10.001. eCollection 2017 Jan.

14.

Using primary murine intestinal enteroids to study dietary TAG absorption, lipoprotein synthesis, and the role of apoC-III in the intestine.

Jattan J, Rodia C, Li D, Diakhate A, Dong H, Bataille A, Shroyer NF, Kohan AB.

J Lipid Res. 2017 May;58(5):853-865. doi: 10.1194/jlr.M071340. Epub 2017 Feb 3.

15.

Tumor Organoids Fill the Niche.

Shroyer NF.

Cell Stem Cell. 2016 Jun 2;18(6):686-7. doi: 10.1016/j.stem.2016.05.020.

16.

Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration.

Lindemans CA, Calafiore M, Mertelsmann AM, O'Connor MH, Dudakov JA, Jenq RR, Velardi E, Young LF, Smith OM, Lawrence G, Ivanov JA, Fu YY, Takashima S, Hua G, Martin ML, O'Rourke KP, Lo YH, Mokry M, Romera-Hernandez M, Cupedo T, Dow L, Nieuwenhuis EE, Shroyer NF, Liu C, Kolesnick R, van den Brink MRM, Hanash AM.

Nature. 2015 Dec 24;528(7583):560-564. doi: 10.1038/nature16460. Epub 2015 Dec 9.

17.

Characterization of stem/progenitor cell cycle using murine circumvallate papilla taste bud organoid.

Aihara E, Mahe MM, Schumacher MA, Matthis AL, Feng R, Ren W, Noah TK, Matsu-ura T, Moore SR, Hong CI, Zavros Y, Herness S, Shroyer NF, Iwatsuki K, Jiang P, Helmrath MA, Montrose MH.

Sci Rep. 2015 Nov 24;5:17185. doi: 10.1038/srep17185.

18.

Selenoprotein P influences colitis-induced tumorigenesis by mediating stemness and oxidative damage.

Barrett CW, Reddy VK, Short SP, Motley AK, Lintel MK, Bradley AM, Freeman T, Vallance J, Ning W, Parang B, Poindexter SV, Fingleton B, Chen X, Washington MK, Wilson KT, Shroyer NF, Hill KE, Burk RF, Williams CS.

J Clin Invest. 2015 Jul 1;125(7):2646-60. doi: 10.1172/JCI76099. Epub 2015 Jun 8.

19.

Transcriptome-wide Analysis Reveals Hallmarks of Human Intestine Development and Maturation In Vitro and In Vivo.

Finkbeiner SR, Hill DR, Altheim CH, Dedhia PH, Taylor MJ, Tsai YH, Chin AM, Mahe MM, Watson CL, Freeman JJ, Nattiv R, Thomson M, Klein OD, Shroyer NF, Helmrath MA, Teitelbaum DH, Dempsey PJ, Spence JR.

Stem Cell Reports. 2015 Jun 3. pii: S2213-6711(15)00122-8. doi: 10.1016/j.stemcr.2015.04.010. [Epub ahead of print]

20.

Natural compound methyl protodioscin protects against intestinal inflammation through modulation of intestinal immune responses.

Zhang R, Gilbert S, Yao X, Vallance J, Steinbrecher K, Moriggl R, Zhang D, Eluri M, Chen H, Cao H, Shroyer N, Denson L, Han X.

Pharmacol Res Perspect. 2015 Mar;3(2):e00118. doi: 10.1002/prp2.118. Epub 2015 Feb 10.

21.

Somatic stem cell heterogeneity: diversity in the blood, skin and intestinal stem cell compartments.

Goodell MA, Nguyen H, Shroyer N.

Nat Rev Mol Cell Biol. 2015 May;16(5):299-309. doi: 10.1038/nrm3980. Review.

22.

Establishment of human epithelial enteroids and colonoids from whole tissue and biopsy.

Mahe MM, Sundaram N, Watson CL, Shroyer NF, Helmrath MA.

J Vis Exp. 2015 Mar 6;(97). doi: 10.3791/52483.

23.

Glutamine and alanyl-glutamine promote crypt expansion and mTOR signaling in murine enteroids.

Moore SR, Guedes MM, Costa TB, Vallance J, Maier EA, Betz KJ, Aihara E, Mahe MM, Lima AA, Oriá RB, Shroyer NF.

Am J Physiol Gastrointest Liver Physiol. 2015 May 15;308(10):G831-9. doi: 10.1152/ajpgi.00422.2014. Epub 2015 Mar 19.

24.

The use of murine-derived fundic organoids in studies of gastric physiology.

Schumacher MA, Aihara E, Feng R, Engevik A, Shroyer NF, Ottemann KM, Worrell RT, Montrose MH, Shivdasani RA, Zavros Y.

J Physiol. 2015 Apr 15;593(8):1809-27. doi: 10.1113/jphysiol.2014.283028. Epub 2015 Feb 19.

25.

Activated STAT5 confers resistance to intestinal injury by increasing intestinal stem cell proliferation and regeneration.

Gilbert S, Nivarthi H, Mayhew CN, Lo YH, Noah TK, Vallance J, Rülicke T, Müller M, Jegga AG, Tang W, Zhang D, Helmrath M, Shroyer N, Moriggl R, Han X.

Stem Cell Reports. 2015 Feb 10;4(2):209-25. doi: 10.1016/j.stemcr.2014.12.004. Epub 2015 Jan 8.

26.

The transcriptional corepressor MTGR1 regulates intestinal secretory lineage allocation.

Parang B, Rosenblatt D, Williams AD, Washington MK, Revetta F, Short SP, Reddy VK, Hunt A, Shroyer NF, Engel ME, Hiebert SW, Williams CS.

FASEB J. 2015 Mar;29(3):786-95. doi: 10.1096/fj.14-254284. Epub 2014 Nov 14.

27.

An in vivo model of human small intestine using pluripotent stem cells.

Watson CL, Mahe MM, Múnera J, Howell JC, Sundaram N, Poling HM, Schweitzer JI, Vallance JE, Mayhew CN, Sun Y, Grabowski G, Finkbeiner SR, Spence JR, Shroyer NF, Wells JM, Helmrath MA.

Nat Med. 2014 Nov;20(11):1310-4. doi: 10.1038/nm.3737. Epub 2014 Oct 19.

28.

Helicobacter pylori targets cancer-associated apical-junctional constituents in gastroids and gastric epithelial cells.

Wroblewski LE, Piazuelo MB, Chaturvedi R, Schumacher M, Aihara E, Feng R, Noto JM, Delgado A, Israel DA, Zavros Y, Montrose MH, Shroyer N, Correa P, Wilson KT, Peek RM Jr.

Gut. 2015 May;64(5):720-30. doi: 10.1136/gutjnl-2014-307650. Epub 2014 Aug 14.

29.

Establishment of Gastrointestinal Epithelial Organoids.

Mahe MM, Aihara E, Schumacher MA, Zavros Y, Montrose MH, Helmrath MA, Sato T, Shroyer NF.

Curr Protoc Mouse Biol. 2013 Dec 19;3(4):217-40. doi: 10.1002/9780470942390.mo130179.

30.

Krüpple-like factor 5 is required for proper maintenance of adult intestinal crypt cellular proliferation.

Bell KN, Shroyer NF.

Dig Dis Sci. 2015 Jan;60(1):86-100. doi: 10.1007/s10620-014-3307-z. Epub 2014 Jul 29.

31.

Robust circadian rhythms in organoid cultures from PERIOD2::LUCIFERASE mouse small intestine.

Moore SR, Pruszka J, Vallance J, Aihara E, Matsuura T, Montrose MH, Shroyer NF, Hong CI.

Dis Model Mech. 2014 Sep;7(9):1123-30. doi: 10.1242/dmm.014399. Epub 2014 Jul 4.

32.

Indian Hedgehog mediates gastrin-induced proliferation in stomach of adult mice.

Feng R, Aihara E, Kenny S, Yang L, Li J, Varro A, Montrose MH, Shroyer NF, Wang TC, Shivdasani RA, Zavros Y.

Gastroenterology. 2014 Sep;147(3):655-666.e9. doi: 10.1053/j.gastro.2014.05.006. Epub 2014 May 20.

33.

Intestinal stem cells remain viable after prolonged tissue storage.

Fuller MK, Faulk DM, Sundaram N, Mahe MM, Stout KM, von Furstenberg RJ, Smith BJ, McNaughton KK, Shroyer NF, Helmrath MA, Henning SJ.

Cell Tissue Res. 2013 Nov;354(2):441-50. doi: 10.1007/s00441-013-1674-y. Epub 2013 Jul 3.

34.

Cdc42 coordinates proliferation, polarity, migration, and differentiation of small intestinal epithelial cells in mice.

Melendez J, Liu M, Sampson L, Akunuru S, Han X, Vallance J, Witte D, Shroyer N, Zheng Y.

Gastroenterology. 2013 Oct;145(4):808-19. doi: 10.1053/j.gastro.2013.06.021. Epub 2013 Jun 20.

35.

SPDEF functions as a colorectal tumor suppressor by inhibiting β-catenin activity.

Noah TK, Lo YH, Price A, Chen G, King E, Washington MK, Aronow BJ, Shroyer NF.

Gastroenterology. 2013 May;144(5):1012-1023.e6. doi: 10.1053/j.gastro.2013.01.043. Epub 2013 Feb 1.

36.

Kruppel-like factor 5 controls villus formation and initiation of cytodifferentiation in the embryonic intestinal epithelium.

Bell SM, Zhang L, Xu Y, Besnard V, Wert SE, Shroyer N, Whitsett JA.

Dev Biol. 2013 Mar 15;375(2):128-39. doi: 10.1016/j.ydbio.2012.12.010. Epub 2012 Dec 22.

37.

Notch in the intestine: regulation of homeostasis and pathogenesis.

Noah TK, Shroyer NF.

Annu Rev Physiol. 2013;75:263-88. doi: 10.1146/annurev-physiol-030212-183741. Epub 2012 Nov 26. Review.

PMID:
23190077
38.

Antenatal ureaplasma infection impairs development of the fetal ovine gut in an IL-1-dependent manner.

Wolfs TG, Kallapur SG, Knox CL, Thuijls G, Nitsos I, Polglase GR, Collins JJ, Kroon E, Spierings J, Shroyer NF, Newnham JP, Jobe AH, Kramer BW.

Mucosal Immunol. 2013 May;6(3):547-56. doi: 10.1038/mi.2012.97. Epub 2012 Oct 31.

PMID:
23149664
39.

Stem cell-derived human intestinal organoids as an infection model for rotaviruses.

Finkbeiner SR, Zeng XL, Utama B, Atmar RL, Shroyer NF, Estes MK.

MBio. 2012 Jul 3;3(4):e00159-12. doi: 10.1128/mBio.00159-12. Print 2012.

40.

Insulin concentration modulates hepatic lipid accumulation in mice in part via transcriptional regulation of fatty acid transport proteins.

Softic S, Kirby M, Berger NG, Shroyer NF, Woods SC, Kohli R.

PLoS One. 2012;7(6):e38952. doi: 10.1371/journal.pone.0038952. Epub 2012 Jun 20.

41.

Functional intestinal stem cells after Paneth cell ablation induced by the loss of transcription factor Math1 (Atoh1).

Durand A, Donahue B, Peignon G, Letourneur F, Cagnard N, Slomianny C, Perret C, Shroyer NF, Romagnolo B.

Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):8965-70. doi: 10.1073/pnas.1201652109. Epub 2012 May 14.

42.

Intestinal crypts reproducibly expand in culture.

Fuller MK, Faulk DM, Sundaram N, Shroyer NF, Henning SJ, Helmrath MA.

J Surg Res. 2012 Nov;178(1):48-54. doi: 10.1016/j.jss.2012.03.037. Epub 2012 Apr 10.

43.

Enterocyte STAT5 promotes mucosal wound healing via suppression of myosin light chain kinase-mediated loss of barrier function and inflammation.

Gilbert S, Zhang R, Denson L, Moriggl R, Steinbrecher K, Shroyer N, Lin J, Han X.

EMBO Mol Med. 2012 Feb;4(2):109-24. doi: 10.1002/emmm.201100192. Epub 2012 Jan 9.

44.

NOTCH Signaling and ATOH1 in Colorectal Cancers.

Kazanjian A, Shroyer NF.

Curr Colorectal Cancer Rep. 2011 Jun;7(2):121-127.

45.

Intestinal development and differentiation.

Noah TK, Donahue B, Shroyer NF.

Exp Cell Res. 2011 Nov 15;317(19):2702-10. doi: 10.1016/j.yexcr.2011.09.006. Epub 2011 Sep 24. Review.

46.

Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium.

Gerbe F, van Es JH, Makrini L, Brulin B, Mellitzer G, Robine S, Romagnolo B, Shroyer NF, Bourgaux JF, Pignodel C, Clevers H, Jay P.

J Cell Biol. 2011 Mar 7;192(5):767-80. doi: 10.1083/jcb.201010127.

47.

Interleukin-13 (IL-13)/IL-13 receptor alpha1 (IL-13Ralpha1) signaling regulates intestinal epithelial cystic fibrosis transmembrane conductance regulator channel-dependent Cl- secretion.

Wu D, Ahrens R, Osterfeld H, Noah TK, Groschwitz K, Foster PS, Steinbrecher KA, Rothenberg ME, Shroyer NF, Matthaei KI, Finkelman FD, Hogan SP.

J Biol Chem. 2011 Apr 15;286(15):13357-69. doi: 10.1074/jbc.M110.214965. Epub 2011 Feb 8.

48.

GATA factors regulate proliferation, differentiation, and gene expression in small intestine of mature mice.

Beuling E, Baffour-Awuah NY, Stapleton KA, Aronson BE, Noah TK, Shroyer NF, Duncan SA, Fleet JC, Krasinski SD.

Gastroenterology. 2011 Apr;140(4):1219-1229.e1-2. doi: 10.1053/j.gastro.2011.01.033. Epub 2011 Jan 21.

49.

Vertebrate intestinal endoderm development.

Spence JR, Lauf R, Shroyer NF.

Dev Dyn. 2011 Mar;240(3):501-20. doi: 10.1002/dvdy.22540. Epub 2011 Jan 18. Review.

50.

Complex interplay between β-catenin signalling and Notch effectors in intestinal tumorigenesis.

Peignon G, Durand A, Cacheux W, Ayrault O, Terris B, Laurent-Puig P, Shroyer NF, Van Seuningen I, Honjo T, Perret C, Romagnolo B.

Gut. 2011 Feb;60(2):166-76. doi: 10.1136/gut.2009.204719.

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