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Items: 1 to 50 of 99

1.

CP-481,715, a potent and selective CCR1 antagonist with potential therapeutic implications for inflammatory diseases.

Gladue RP, Tylaska LA, Brissette WH, Lira PD, Kath JC, Poss CS, Brown MF, Paradis TJ, Conklyn MJ, Ogborne KT, McGlynn MA, Lillie BM, DiRico AP, Mairs EN, McElroy EB, Martin WH, Stock IA, Shepard RM, Showell HJ, Neote K.

J Biol Chem. 2003 Oct 17;278(42):40473-80. Epub 2003 Aug 7.

2.

Leukotriene B4 receptor antagonism reduces monocytic foam cells in mice.

Aiello RJ, Bourassa PA, Lindsey S, Weng W, Freeman A, Showell HJ.

Arterioscler Thromb Vasc Biol. 2002 Mar 1;22(3):443-9.

PMID:
11884288
3.

Antagonizing leukotriene B4 receptors delays cardiac allograft rejection in mice.

Weringer EJ, Perry BD, Sawyer PS, Gilman SC, Showell HJ.

Transplantation. 1999 Mar 27;67(6):808-15.

PMID:
10199727
4.

trans-3-Benzyl-4-hydroxy-7-chromanylbenzoic acid derivatives as antagonists of the leukotriene B4 (LTB4) receptor.

Reiter LA, Koch K, Piscopio AD, Showell HJ, Alpert R, Biggers MS, Chambers RJ, Conklyn MJ, Cooper K, Cortina SR, Dibrino JN, Dominy BW, Farrell CA, Hingorani GP, Martinelli GJ, Ramchandani M, Wright KF.

Bioorg Med Chem Lett. 1998 Jul 21;8(14):1781-6.

PMID:
9873433
5.

Early eosinophil infiltration into the optic nerve of mice with experimental allergic encephalomyelitis.

Milici AJ, Carroll LA, Stukenbrok HA, Shay AK, Gladue RP, Showell HJ.

Lab Invest. 1998 Oct;78(10):1239-44.

PMID:
9800949
6.

The preclinical pharmacological profile of the potent and selective leukotriene B4 antagonist CP-195543.

Showell HJ, Conklyn MJ, Alpert R, Hingorani GP, Wright KF, Smith MA, Stam E, Salter ED, Scampoli DN, Meltzer S, Reiter LA, Koch K, Piscopio AD, Cortina SR, Lopez-Anaya A, Pettipher ER, Milici AJ, Griffiths RJ.

J Pharmacol Exp Ther. 1998 Jun;285(3):946-54.

PMID:
9618393
7.

Pharmacokinetics and pharmacodynamics of the leukotriene B4 receptor antagonist CP-105,696 in man following single oral administration.

Liston TE, Conklyn MJ, Houser J, Wilner KD, Johnson A, Apseloff G, Whitacre C, Showell HJ.

Br J Clin Pharmacol. 1998 Feb;45(2):115-21.

8.

The phosphodiesterase type 4 (PDE4) inhibitor CP-80,633 elevates plasma cyclic AMP levels and decreases tumor necrosis factor-alpha (TNFalpha) production in mice: effect of adrenalectomy.

Cheng JB, Watson JW, Pazoles CJ, Eskra JD, Griffiths RJ, Cohan VL, Turner CR, Showell HJ, Pettipher ER.

J Pharmacol Exp Ther. 1997 Feb;280(2):621-6.

PMID:
9023272
9.
11.

In vitro pharmacology of the novel phosphodiesterase type 4 inhibitor, CP-80633.

Cohan VL, Showell HJ, Fisher DA, Pazoles CJ, Watson JW, Turner CR, Cheng JB.

J Pharmacol Exp Ther. 1996 Sep;278(3):1356-61.

PMID:
8819523
12.

The in vivo pharmacology of CP-80, 633, a selective inhibitor of phosphodiesterase 4.

Turner CR, Cohan VL, Cheng JB, Showell HJ, Pazoles CJ, Watson JW.

J Pharmacol Exp Ther. 1996 Sep;278(3):1349-55.

PMID:
8819522
13.

Production and characterization of guinea pig IL-5 in baculovirus-infected insect cells.

Mansour M, Karmilowicz M, Hawrylik SJ, Nalcerio B, Angilly J, Conklyn MJ, Lilly CM, Drazen JM, Lee SE, Auperin DD, De Wet JR, Cohan VL, Showell HJ, Danley DE.

Am J Physiol. 1996 Jun;270(6 Pt 1):L1002-7.

PMID:
8764226
14.

Inhibition of leukotriene B4-receptor interaction suppresses eosinophil infiltration and disease pathology in a murine model of experimental allergic encephalomyelitis.

Gladue RP, Carroll LA, Milici AJ, Scampoli DN, Stukenbrok HA, Pettipher ER, Salter ED, Contillo L, Showell HJ.

J Exp Med. 1996 Apr 1;183(4):1893-8.

15.

Characterization of the pharmacological profile of the potent LTB4 antagonist CP-105,696 on murine LTB4 receptors in vitro.

Showell HJ, Breslow R, Conklyn MJ, Hingorani GP, Koch K.

Br J Pharmacol. 1996 Mar;117(6):1127-32.

16.

In vitro and in vivo effects of leukotriene B4 antagonism in a primate model of asthma.

Turner CR, Breslow R, Conklyn MJ, Andresen CJ, Patterson DK, Lopez-Anaya A, Owens B, Lee P, Watson JW, Showell HJ.

J Clin Invest. 1996 Jan 15;97(2):381-7.

17.

Expression and biologic characterization of the murine chemokine KC.

Bozic CR, Kolakowski LF Jr, Gerard NP, Garcia-Rodriguez C, von Uexkull-Guldenband C, Conklyn MJ, Breslow R, Showell HJ, Gerard C.

J Immunol. 1995 Jun 1;154(11):6048-57.

PMID:
7751647
18.

The in vitro and in vivo pharmacologic activity of the potent and selective leukotriene B4 receptor antagonist CP-105696.

Showell HJ, Pettipher ER, Cheng JB, Breslow R, Conklyn MJ, Farrell CA, Hingorani GP, Salter ED, Hackman BC, Wimberly DJ, et al.

J Pharmacol Exp Ther. 1995 Apr;273(1):176-84.

PMID:
7714764
19.

The Duffy antigen/receptor for chemokines (DARC) is expressed in endothelial cells of Duffy negative individuals who lack the erythrocyte receptor.

Peiper SC, Wang ZX, Neote K, Martin AW, Showell HJ, Conklyn MJ, Ogborne K, Hadley TJ, Lu ZH, Hesselgesser J, Horuk R.

J Exp Med. 1995 Apr 1;181(4):1311-7.

20.
21.

Prolonged microvascular vasodilation induced by leukotriene B4 in human skin is cyclooxygenase independent.

Larkin SW, Fraser L, Showell HJ, Williams TJ, Warren JB.

J Pharmacol Exp Ther. 1995 Jan;272(1):392-8.

PMID:
7815355
22.

The murine interleukin 8 type B receptor homologue and its ligands. Expression and biological characterization.

Bozic CR, Gerard NP, von Uexkull-Guldenband C, Kolakowski LF Jr, Conklyn MJ, Breslow R, Showell HJ, Gerard C.

J Biol Chem. 1994 Nov 25;269(47):29355-8.

23.

(+)-1-(3S,4R)-[3-(4-phenylbenzyl)-4-hydroxychroman-7-yl]cyclopentane carboxylic acid, a highly potent, selective leukotriene B4 antagonist with oral activity in the murine collagen-induced arthritis model.

Koch K, Melvin LS Jr, Reiter LA, Biggers MS, Showell HJ, Griffiths RJ, Pettipher ER, Cheng JB, Milici AJ, Breslow R, et al.

J Med Chem. 1994 Sep 30;37(20):3197-9. No abstract available.

PMID:
7932545
24.
25.

The role of individual Fc gamma receptors in aggregated IgG-stimulated protein tyrosine phosphorylation in the human neutrophil.

Richard S, Shaw AS, Showell HJ, Connelly PA.

Biochem Biophys Res Commun. 1994 Mar 15;199(2):653-61.

PMID:
7510959
26.

C5a as a model for chemotactic factor-stimulated tyrosine phosphorylation in the human neutrophil.

Richard S, Farrell CA, Shaw AS, Showell HJ, Connelly PA.

J Immunol. 1994 Mar 1;152(5):2479-87.

PMID:
8133059
27.

Structural and (patho)physiological diversity of PAF.

Pinckard RN, Woodard DS, Showell HJ, Conklyn MJ, Novak MJ, McManus LM.

Clin Rev Allergy. 1994 Winter;12(4):329-59. Review. No abstract available.

PMID:
7743461
28.
29.
30.

Tenidap: a novel inhibitor of calcium influx in a mast cell line.

Cleveland PL, Millard PJ, Showell HJ, Fewtrell CM.

Cell Calcium. 1993 Jan;14(1):1-16.

PMID:
8382561
31.
32.

Differential responsiveness of human neutrophils to the autocrine actions of 1-O-alkyl-homologs and 1-acyl analogs of platelet-activating factor.

Pinckard RN, Showell HJ, Castillo R, Lear C, Breslow R, McManus LM, Woodard DS, Ludwig JC.

J Immunol. 1992 Jun 1;148(11):3528-35.

PMID:
1316919
33.

A comparative study of the neutrophil stimulatory activity in vitro and pro-inflammatory properties in vivo of 72 amino acid and 77 amino acid IL-8.

Nourshargh S, Perkins JA, Showell HJ, Matsushima K, Williams TJ, Collins PD.

J Immunol. 1992 Jan 1;148(1):106-11.

PMID:
1727857
34.

Tyrosine phosphorylation is an early signaling event common to Fc receptor crosslinking in human neutrophils and rat basophilic leukemia cells (RBL-2H3).

Connelly PA, Farrell CA, Merenda JM, Conklyn MJ, Showell HJ.

Biochem Biophys Res Commun. 1991 May 31;177(1):192-201.

PMID:
1710446
35.

Human neutrophils exhibit disparate chemotactic factor gene expression.

Strieter RM, Kasahara K, Allen R, Showell HJ, Standiford TJ, Kunkel SL.

Biochem Biophys Res Commun. 1990 Dec 14;173(2):725-30.

36.

Evidence that peptidoleukotriene is a prerequisite for antigen-dependent thromboxane synthesis in IgG1-passively sensitized guinea pig lungs.

Cheng JB, Pillar JS, Conklyn MJ, Breslow R, Shirley JT, Showell HJ.

J Pharmacol Exp Ther. 1990 Nov;255(2):664-71.

PMID:
2243346
37.

IgG1-mediated acute pulmonary hypersensitivity response in the guinea pig. Involvement of specific lipid mediators.

Watson JW, Conklyn M, Showell HJ.

Am Rev Respir Dis. 1990 Nov;142(5):1093-8.

PMID:
2240832
38.

Disparate gene expression of chemotactic cytokines by human mononuclear phagocytes.

Strieter RM, Chensue SW, Standiford TJ, Basha MA, Showell HJ, Kunkel SL.

Biochem Biophys Res Commun. 1990 Jan 30;166(2):886-91.

39.
41.

Monocyte chemotactic protein gene expression by cytokine-treated human fibroblasts and endothelial cells.

Strieter RM, Wiggins R, Phan SH, Wharram BL, Showell HJ, Remick DG, Chensue SW, Kunkel SL.

Biochem Biophys Res Commun. 1989 Jul 31;162(2):694-700.

42.

Monokine-induced neutrophil chemotactic factor gene expression in human fibroblasts.

Strieter RM, Phan SH, Showell HJ, Remick DG, Lynch JP, Genord M, Raiford C, Eskandari M, Marks RM, Kunkel SL.

J Biol Chem. 1989 Jun 25;264(18):10621-6.

43.

Endothelial cell gene expression of a neutrophil chemotactic factor by TNF-alpha, LPS, and IL-1 beta.

Strieter RM, Kunkel SL, Showell HJ, Remick DG, Phan SH, Ward PA, Marks RM.

Science. 1989 Mar 17;243(4897):1467-9.

PMID:
2648570
44.

Involvement of peptidoleukotrienes in antigen-dependent thromboxane (TX) synthesis in IgG1-sensitized guinea pig lungs.

Cheng JB, Pillar J, Conklyn M, Breslow R, Shirley J, Showell HJ.

Adv Prostaglandin Thromboxane Leukot Res. 1989;19:187-90.

PMID:
2546382
45.

Monokine-induced gene expression of a human endothelial cell-derived neutrophil chemotactic factor.

Strieter RM, Kunkel SL, Showell HJ, Marks RM.

Biochem Biophys Res Commun. 1988 Nov 15;156(3):1340-5.

46.

Human C5a anaphylatoxin: gene synthesis, expression, and recovery of biologically active material from Escherichia coli.

Franke AE, Andrews GC, Stimler-Gerard NP, Gerard CJ, Showell HJ.

Methods Enzymol. 1988;162:653-68. No abstract available.

PMID:
3067055
47.

Ontogeny of the responsiveness to intravenous platelet-activating factor.

Angle MJ, Pinckard RN, Showell HJ, McManus LM.

Lab Invest. 1987 Sep;57(3):321-8.

PMID:
3626521
48.
49.

Effect of human serum and some of its components on neutrophil adherence and migration across an epithelium.

Cramer EB, Milks LC, Brontoli MJ, Ojakian GK, Wright SD, Showell HJ.

J Cell Biol. 1986 May;102(5):1868-77.

50.

Evidence for a role of the amino-terminal region in the biological activity of the classical anaphylatoxin, porcine C5a des-Arg-74.

Gerard C, Showell HJ, Hoeprich PD Jr, Hugli TE, Stimler NP.

J Biol Chem. 1985 Mar 10;260(5):2613-6.

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