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Safety of direct oral anticoagulants in patients with hereditary hemorrhagic telangiectasia.

Shovlin CL, Millar CM, Droege F, Kjeldsen A, Manfredi G, Suppressa P, Ugolini S, Coote N, Fialla AD, Geisthoff U, Lenato GM, Mager HJ, Pagella F, Post MC, SabbĂ  C, Sure U, Torring PM, Dupuis-Girod S, Buscarini E; VASCERN-HHT.

Orphanet J Rare Dis. 2019 Aug 28;14(1):210. doi: 10.1186/s13023-019-1179-1.


Veterans Specific Activity Questionnaire (VSAQ): a new and efficient method of assessing exercise capacity in patients with pulmonary arteriovenous malformations.

Gawecki F, Myers J, Shovlin CL.

BMJ Open Respir Res. 2019 Mar 1;6(1):e000351. doi: 10.1136/bmjresp-2018-000351. eCollection 2019.


Patients with in-situ metallic coils and Amplatzer vascular plugs used to treat pulmonary arteriovenous malformations since 1984 can safely undergo magnetic resonance imaging.

Alsafi A, Jackson JE, Fatania G, Patel MC, Glover A, Shovlin CL.

Br J Radiol. 2019 Jun;92(1098):20180752. doi: 10.1259/bjr.20180752. Epub 2019 Apr 24.


Safety of thalidomide and bevacizumab in patients with hereditary hemorrhagic telangiectasia.

Buscarini E, Botella LM, Geisthoff U, Kjeldsen AD, Mager HJ, Pagella F, Suppressa P, Zarrabeitia R, Dupuis-Girod S, Shovlin CL; VASCERN-HHT.

Orphanet J Rare Dis. 2019 Feb 4;14(1):28. doi: 10.1186/s13023-018-0982-4.


Prevention of serious infections in hereditary hemorrhagic telangiectasia: roles for prophylactic antibiotics, the pulmonary capillaries-but not vaccination.

Shovlin C, Bamford K, SabbĂ  C, Mager HJ, Kjeldsen A, Droege F, Buscarini E, Dupuis-Girod S; VASCERN HHT.

Haematologica. 2019 Feb;104(2):e85-e86. doi: 10.3324/haematol.2018.209791. No abstract available.


Exercise capacity reflects airflow limitation rather than hypoxaemia in patients with pulmonary arteriovenous malformations.

Gawecki F, Strangeways T, Amin A, Perks J, McKernan H, Thurainatnam S, Rizvi A, Jackson JE, Santhirapala V, Myers J, Brown J, Howard LSGE, Tighe HC, Shovlin CL.

QJM. 2019 May 1;112(5):335-342. doi: 10.1093/qjmed/hcz023.


Uptake and radiological findings of screening cerebral magnetic resonance scans in patients with hereditary haemorrhagic telangiectasia.

Fatania G, Gilson C, Glover A, Alsafi A, Jackson JE, Patel MC, Shovlin CL.

Intractable Rare Dis Res. 2018 Nov;7(4):236-244. doi: 10.5582/irdr.2018.01103.


Low serum haptoglobin and blood films suggest intravascular hemolysis contributes to severe anemia in hereditary hemorrhagic telangiectasia.

Thielemans L, Layton DM, Shovlin CL.

Haematologica. 2019 Apr;104(4):e127-e130. doi: 10.3324/haematol.2018.205682. Epub 2018 Oct 18. No abstract available.


Acquired Transpleural Systemic Artery-to-Pulmonary Artery Communication Mimicking a Pulmonary Arteriovenous Malformation and Causing a False-Positive Diagnosis of a Pulmonary Embolus.

Alsafi A, Shovlin CL, Jackson JE.

J Vasc Interv Radiol. 2018 Sep;29(9):1313-1315. doi: 10.1016/j.jvir.2017.12.016. No abstract available.


European Reference Network For Rare Vascular Diseases (VASCERN) Outcome Measures For Hereditary Haemorrhagic Telangiectasia (HHT).

Shovlin CL, Buscarini E, Kjeldsen AD, Mager HJ, Sabba C, Droege F, Geisthoff U, Ugolini S, Dupuis-Girod S.

Orphanet J Rare Dis. 2018 Aug 15;13(1):136. doi: 10.1186/s13023-018-0850-2.


Executive summary of the 12th HHT international scientific conference.

Andrejecsk JW, Hosman AE, Botella LM, Shovlin CL, Arthur HM, Dupuis-Girod S, Buscarini E, Hughes CCW, Lebrin F, Mummery CL, Post MC, Mager JJ.

Angiogenesis. 2018 Feb;21(1):169-181. doi: 10.1007/s10456-017-9585-2.


British Thoracic Society Clinical Statement on Pulmonary Arteriovenous Malformations.

Shovlin CL, Condliffe R, Donaldson JW, Kiely DG, Wort SJ; British Thoracic Society.

Thorax. 2017 Dec;72(12):1154-1163. doi: 10.1136/thoraxjnl-2017-210764.


Pulmonary arteriovenous malformations emerge from the shadows.

Shovlin CL, Condliffe R, Donaldson JW, Kiely DG, Wort SJ.

Thorax. 2017 Dec;72(12):1071-1073. doi: 10.1136/thoraxjnl-2017-211072. No abstract available.


Long-term outcomes of patients with pulmonary arteriovenous malformations considered for lung transplantation, compared with similarly hypoxaemic cohorts.

Shovlin CL, Buscarini E, Hughes JMB, Allison DJ, Jackson JE.

BMJ Open Respir Res. 2017 Oct 13;4(1):e000198. doi: 10.1136/bmjresp-2017-000198. eCollection 2017.


The Lung in Hereditary Hemorrhagic Telangiectasia.

Dupuis-Girod S, Cottin V, Shovlin CL.

Respiration. 2017;94(4):315-330. doi: 10.1159/000479632. Epub 2017 Aug 30. Review.


Cerebral Abscess Associated With Odontogenic Bacteremias, Hypoxemia, and Iron Loading in Immunocompetent Patients With Right-to-Left Shunting Through Pulmonary Arteriovenous Malformations.

Boother EJ, Brownlow S, Tighe HC, Bamford KB, Jackson JE, Shovlin CL.

Clin Infect Dis. 2017 Aug 15;65(4):595-603. doi: 10.1093/cid/cix373.


Pulmonary arteriovenous malformations: evidence of physician under-education.

Shovlin CL, Gossage JR.

ERJ Open Res. 2017 Apr 12;3(2). pii: 00104-2016. doi: 10.1183/23120541.00104-2016. eCollection 2017 Apr.


7-day weighed food diaries suggest patients with hereditary hemorrhagic telangiectasia may spontaneously modify their diet to avoid nosebleed precipitants.

Finnamore H, Silva BM, Hickson BM, Whelan K, Shovlin CL.

Orphanet J Rare Dis. 2017 Mar 28;12(1):60. doi: 10.1186/s13023-017-0576-6.


Hemoglobin Is a Vital Determinant of Arterial Oxygen Content in Hypoxemic Patients with Pulmonary Arteriovenous Malformations.

Rizvi A, Macedo P, Babawale L, Tighe HC, Hughes JMB, Jackson JE, Shovlin CL.

Ann Am Thorac Soc. 2017 Jun;14(6):903-911. doi: 10.1513/AnnalsATS.201611-872OC.


Cancer and hereditary haemorrhagic telangiectasia.

Hosman AE, Shovlin CL.

J Cancer Res Clin Oncol. 2017 Feb;143(2):369-370. doi: 10.1007/s00432-016-2298-x. Epub 2016 Nov 11.


Can Iron Treatments Aggravate Epistaxis in Some Patients With Hereditary Hemorrhagic Telangiectasia?

Shovlin CL, Gilson C, Busbridge M, Patel D, Shi C, Dina R, Abdulla FN, Awan I.

Laryngoscope. 2016 Nov;126(11):2468-2474. doi: 10.1002/lary.25959. Epub 2016 Apr 23.


Embolisation of PAVMs reported to improve nosebleeds by a subgroup of patients with hereditary haemorrhagic telangiectasia.

Shovlin CL, Patel T, Jackson JE.

ERJ Open Res. 2016 Apr 29;2(2). pii: 00035-2016. eCollection 2016 Apr.


Dietary supplement use and nosebleeds in hereditary haemorrhagic telangiectasia - an observational study.

Chamali B, Finnamore H, Manning R, Laffan MA, Hickson M, Whelan K, Shovlin CL.

Intractable Rare Dis Res. 2016 May;5(2):109-13. doi: 10.5582/irdr.2016.01019.


Reported cardiac phenotypes in hereditary hemorrhagic telangiectasia emphasize burdens from arrhythmias, anemia and its treatments, but suggest reduced rates of myocardial infarction.

Shovlin CL, Awan I, Cahilog Z, Abdulla FN, Guttmacher AE.

Int J Cardiol. 2016 Jul 15;215:179-85. doi: 10.1016/j.ijcard.2016.04.006. Epub 2016 Apr 7.


Low Dose Iron Treatments Induce a DNA Damage Response in Human Endothelial Cells within Minutes.

Mollet IG, Patel D, Govani FS, Giess A, Paschalaki K, Periyasamy M, Lidington EC, Mason JC, Jones MD, Game L, Ali S, Shovlin CL.

PLoS One. 2016 Feb 11;11(2):e0147990. doi: 10.1371/journal.pone.0147990. eCollection 2016.


Circulatory contributors to the phenotype in hereditary hemorrhagic telangiectasia.

Shovlin CL.

Front Genet. 2015 Apr 9;6:101. doi: 10.3389/fgene.2015.00101. eCollection 2015.


Hypoxaemia, sport and polycythaemia: a case from Imperial College London.

Yasuda W, Jackson JE, Layton DM, Shovlin CL.

Thorax. 2015 Jun;70(6):601-3. doi: 10.1136/thoraxjnl-2014-206381. Epub 2015 Apr 8. No abstract available.


Pulmonary arteriovenous malformations and their mimics.

Gill SS, Roddie ME, Shovlin CL, Jackson JE.

Clin Radiol. 2015 Jan;70(1):96-110. doi: 10.1016/j.crad.2014.09.003. Epub 2014 Nov 17. Review.


Pulmonary arteriovenous malformations.

Shovlin CL.

Am J Respir Crit Care Med. 2014 Dec 1;190(11):1217-28. doi: 10.1164/rccm.201407-1254CI. Review.


Orthodeoxia and postural orthostatic tachycardia in patients with pulmonary arteriovenous malformations: a prospective 8-year series.

Santhirapala V, Chamali B, McKernan H, Tighe HC, Williams LC, Springett JT, Bellenberg HR, Whitaker AJ, Shovlin CL.

Thorax. 2014 Nov;69(11):1046-7. doi: 10.1136/thoraxjnl-2014-205289. Epub 2014 Apr 8.


Top dietary iron sources in the UK.

Finnamore HE, Whelan K, Hickson M, Shovlin CL.

Br J Gen Pract. 2014 Apr;64(621):172-3. doi: 10.3399/bjgp14X677761. No abstract available.


Cardiopulmonary exercise testing demonstrates maintenance of exercise capacity in patients with hypoxemia and pulmonary arteriovenous malformations.

Howard LSGE, Santhirapala V, Murphy K, Mukherjee B, Busbridge M, Tighe HC, Jackson JE, Hughes JMB, Shovlin CL.

Chest. 2014 Sep;146(3):709-718. doi: 10.1378/chest.13-2988.


Ischaemic strokes in patients with pulmonary arteriovenous malformations and hereditary hemorrhagic telangiectasia: associations with iron deficiency and platelets.

Shovlin CL, Chamali B, Santhirapala V, Livesey JA, Angus G, Manning R, Laffan MA, Meek J, Tighe HC, Jackson JE.

PLoS One. 2014 Feb 19;9(2):e88812. doi: 10.1371/journal.pone.0088812. eCollection 2014.


Relationships between epistaxis, migraines, and triggers in hereditary hemorrhagic telangiectasia.

Elphick A, Shovlin CL.

Laryngoscope. 2014 Jul;124(7):1521-8. doi: 10.1002/lary.24526. Epub 2014 Jan 23.


Specific cancer rates may differ in patients with hereditary haemorrhagic telangiectasia compared to controls.

Hosman AE, Devlin HL, Silva BM, Shovlin CL.

Orphanet J Rare Dis. 2013 Dec 20;8:195. doi: 10.1186/1750-1172-8-195.


Hemorrhage-adjusted iron requirements, hematinics and hepcidin define hereditary hemorrhagic telangiectasia as a model of hemorrhagic iron deficiency.

Finnamore H, Le Couteur J, Hickson M, Busbridge M, Whelan K, Shovlin CL.

PLoS One. 2013 Oct 16;8(10):e76516. doi: 10.1371/journal.pone.0076516. eCollection 2013.


Directional next-generation RNA sequencing and examination of premature termination codon mutations in endoglin/hereditary haemorrhagic telangiectasia.

Govani FS, Giess A, Mollet IG, Begbie ME, Jones MD, Game L, Shovlin CL.

Mol Syndromol. 2013 Apr;4(4):184-96. doi: 10.1159/000350208. Epub 2013 Apr 11.


Antiplatelet and anticoagulant agents in hereditary hemorrhagic telangiectasia.

Devlin HL, Hosman AE, Shovlin CL.

N Engl J Med. 2013 Feb 28;368(9):876-8. doi: 10.1056/NEJMc1213554. No abstract available.


Lifestyle and dietary influences on nosebleed severity in hereditary hemorrhagic telangiectasia.

Silva BM, Hosman AE, Devlin HL, Shovlin CL.

Laryngoscope. 2013 May;123(5):1092-9. doi: 10.1002/lary.23893. Epub 2013 Feb 12.


Low serum iron levels are associated with elevated plasma levels of coagulation factor VIII and pulmonary emboli/deep venous thromboses in replicate cohorts of patients with hereditary haemorrhagic telangiectasia.

Livesey JA, Manning RA, Meek JH, Jackson JE, Kulinskaya E, Laffan MA, Shovlin CL.

Thorax. 2012 Apr;67(4):328-33. doi: 10.1136/thoraxjnl-2011-201076. Epub 2011 Dec 14.


Managing passengers with stable respiratory disease planning air travel: British Thoracic Society recommendations.

Ahmedzai S, Balfour-Lynn IM, Bewick T, Buchdahl R, Coker RK, Cummin AR, Gradwell DP, Howard L, Innes JA, Johnson AO, Lim E, Lim WS, McKinlay KP, Partridge MR, Popplestone M, Pozniak A, Robson A, Shovlin CL, Shrikrishna D, Simonds A, Tait P, Thomas M; British Thoracic Society Standards of Care Committee.

Thorax. 2011 Sep;66 Suppl 1:i1-30. doi: 10.1136/thoraxjnl-2011-200295. No abstract available.


Pulmonary thromboemboli modifying the natural history of pulmonary arteriovenous malformations.

Roked F, Jackson JE, Fuld J, Basheer FT, Chilvers ER, Beattie S, Shovlin CL.

Am J Respir Crit Care Med. 2011 Mar 15;183(6):828-9. No abstract available.


Hereditary haemorrhagic telangiectasia: pathophysiology, diagnosis and treatment.

Shovlin CL.

Blood Rev. 2010 Nov;24(6):203-19. doi: 10.1016/j.blre.2010.07.001. Epub 2010 Sep 25. Review.


Vascular haemostasis.

Key NS, DE Paepe A, Malfait F, Shovlin CL.

Haemophilia. 2010 Jul;16 Suppl 5:146-51. doi: 10.1111/j.1365-2516.2010.02313.x.


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