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Items: 39


Chemical Biology Framework to Illuminate Proteostasis.

Sebastian RM, Shoulders MD.

Annu Rev Biochem. 2020 Feb 25. doi: 10.1146/annurev-biochem-013118-111552. [Epub ahead of print]


Genetic Engineering by DNA Recombineering.

Papa LJ 3rd, Shoulders MD.

Curr Protoc Chem Biol. 2019 Sep;11(3):e70. doi: 10.1002/cpch.70.


Targeting defective proteostasis in the collagenopathies.

Wong MY, Shoulders MD.

Curr Opin Chem Biol. 2019 Jun;50:80-88. doi: 10.1016/j.cbpa.2019.02.021. Epub 2019 Apr 24. Review.


Mass Spectrometry-Based Proteomics to Define Intracellular Collagen Interactomes.

Doan ND, DiChiara AS, Del Rosario AM, Schiavoni RP, Shoulders MD.

Methods Mol Biol. 2019;1944:95-114. doi: 10.1007/978-1-4939-9095-5_7.


SUMOylation and the HSF1-Regulated Chaperone Network Converge to Promote Proteostasis in Response to Heat Shock.

Liebelt F, Sebastian RM, Moore CL, Mulder MPC, Ovaa H, Shoulders MD, Vertegaal ACO.

Cell Rep. 2019 Jan 2;26(1):236-249.e4. doi: 10.1016/j.celrep.2018.12.027.


An Adaptable Platform for Directed Evolution in Human Cells.

Berman CM, Papa LJ 3rd, Hendel SJ, Moore CL, Suen PH, Weickhardt AF, Doan ND, Kumar CM, Uil TG, Butty VL, Hoeben RC, Shoulders MD.

J Am Chem Soc. 2018 Dec 26;140(51):18093-18103. doi: 10.1021/jacs.8b10937. Epub 2018 Dec 14.


A Sensitive, Nonradioactive Assay for Zn(II) Uptake into Metazoan Cells.

Richardson CER, Nolan EM, Shoulders MD, Lippard SJ.

Biochemistry. 2018 Dec 18;57(50):6807-6815. doi: 10.1021/acs.biochem.8b01043. Epub 2018 Dec 5.


A cysteine-based molecular code informs collagen C-propeptide assembly.

DiChiara AS, Li RC, Suen PH, Hosseini AS, Taylor RJ, Weickhardt AF, Malhotra D, McCaslin DR, Shoulders MD.

Nat Commun. 2018 Oct 11;9(1):4206. doi: 10.1038/s41467-018-06185-2.


XBP1s activation can globally remodel N-glycan structure distribution patterns.

Wong MY, Chen K, Antonopoulos A, Kasper BT, Dewal MB, Taylor RJ, Whittaker CA, Hein PP, Dell A, Genereux JC, Haslam SM, Mahal LK, Shoulders MD.

Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):E10089-E10098. doi: 10.1073/pnas.1805425115. Epub 2018 Oct 10.


Destabilized adaptive influenza variants critical for innate immune system escape are potentiated by host chaperones.

Phillips AM, Ponomarenko AI, Chen K, Ashenberg O, Miao J, McHugh SM, Butty VL, Whittaker CA, Moore CL, Bloom JD, Lin YS, Shoulders MD.

PLoS Biol. 2018 Sep 17;16(9):e3000008. doi: 10.1371/journal.pbio.3000008. eCollection 2018 Sep.


Enhanced ER proteostasis and temperature differentially impact the mutational tolerance of influenza hemagglutinin.

Phillips AM, Doud MB, Gonzalez LO, Butty VL, Lin YS, Bloom JD, Shoulders MD.

Elife. 2018 Sep 6;7. pii: e38795. doi: 10.7554/eLife.38795.


A Processive Protein Chimera Introduces Mutations across Defined DNA Regions In Vivo.

Moore CL, Papa LJ 3rd, Shoulders MD.

J Am Chem Soc. 2018 Sep 19;140(37):11560-11564. doi: 10.1021/jacs.8b04001. Epub 2018 Jul 18.


A High-Throughput Assay for Collagen Secretion Suggests an Unanticipated Role for Hsp90 in Collagen Production.

Wong MY, Doan ND, DiChiara AS, Papa LJ 3rd, Cheah JH, Soule CK, Watson N, Hulleman JD, Shoulders MD.

Biochemistry. 2018 May 15;57(19):2814-2827. doi: 10.1021/acs.biochem.8b00378. Epub 2018 May 3.


Characterization of an A-Site Selective Protein Disulfide Isomerase A1 Inhibitor.

Cole KS, Grandjean JMD, Chen K, Witt CH, O'Day J, Shoulders MD, Wiseman RL, Weerapana E.

Biochemistry. 2018 Apr 3;57(13):2035-2043. doi: 10.1021/acs.biochem.8b00178. Epub 2018 Mar 19.


A Method for Selective Depletion of Zn(II) Ions from Complex Biological Media and Evaluation of Cellular Consequences of Zn(II) Deficiency.

Richardson CER, Cunden LS, Butty VL, Nolan EM, Lippard SJ, Shoulders MD.

J Am Chem Soc. 2018 Feb 21;140(7):2413-2416. doi: 10.1021/jacs.7b12897. Epub 2018 Feb 12.


Host proteostasis modulates influenza evolution.

Phillips AM, Gonzalez LO, Nekongo EE, Ponomarenko AI, McHugh SM, Butty VL, Levine SS, Lin YS, Mirny LA, Shoulders MD.

Elife. 2017 Sep 26;6. pii: e28652. doi: 10.7554/eLife.28652.


Adapting Secretory Proteostasis and Function Through the Unfolded Protein Response.

Wong MY, DiChiara AS, Suen PH, Chen K, Doan ND, Shoulders MD.

Curr Top Microbiol Immunol. 2018;414:1-25. doi: 10.1007/82_2017_56. Review.


Multidimensional chemical control of CRISPR-Cas9.

Maji B, Moore CL, Zetsche B, Volz SE, Zhang F, Shoulders MD, Choudhary A.

Nat Chem Biol. 2017 Jan;13(1):9-11. doi: 10.1038/nchembio.2224. Epub 2016 Oct 31.


Mapping and Exploring the Collagen-I Proteostasis Network.

DiChiara AS, Taylor RJ, Wong MY, Doan ND, Rosario AM, Shoulders MD.

ACS Chem Biol. 2016 May 20;11(5):1408-21. doi: 10.1021/acschembio.5b01083. Epub 2016 Mar 9.


The Path of Least Resistance: Mechanisms to Reduce Influenza's Sensitivity to Oseltamivir.

Phillips AM, Shoulders MD.

J Mol Biol. 2016 Feb 13;428(3):533-537. doi: 10.1016/j.jmb.2015.12.019. Epub 2015 Dec 31. No abstract available.


Transportable, Chemical Genetic Methodology for the Small Molecule-Mediated Inhibition of Heat Shock Factor 1.

Moore CL, Dewal MB, Nekongo EE, Santiago S, Lu NB, Levine SS, Shoulders MD.

ACS Chem Biol. 2016 Jan 15;11(1):200-10. doi: 10.1021/acschembio.5b00740. Epub 2015 Nov 19.


XBP1s Links the Unfolded Protein Response to the Molecular Architecture of Mature N-Glycans.

Dewal MB, DiChiara AS, Antonopoulos A, Taylor RJ, Harmon CJ, Haslam SM, Dell A, Shoulders MD.

Chem Biol. 2015 Oct 22;22(10):1301-12. doi: 10.1016/j.chembiol.2015.09.006.


4-ketoproline: An electrophilic proline analog for bioconjugation.

Choudhary A, Kamer KJ, Shoulders MD, Raines RT.

Biopolymers. 2015 Mar;104(2):110-5. doi: 10.1002/bip.22620.


ATF6 activation reduces the secretion and extracellular aggregation of destabilized variants of an amyloidogenic protein.

Chen JJ, Genereux JC, Qu S, Hulleman JD, Shoulders MD, Wiseman RL.

Chem Biol. 2014 Nov 20;21(11):1564-74. doi: 10.1016/j.chembiol.2014.09.009. Epub 2014 Oct 23.


Unfolded protein response-induced ERdj3 secretion links ER stress to extracellular proteostasis.

Genereux JC, Qu S, Zhou M, Ryno LM, Wang S, Shoulders MD, Kaufman RJ, Lasmézas CI, Kelly JW, Wiseman RL.

EMBO J. 2015 Jan 2;34(1):4-19. doi: 10.15252/embj.201488896. Epub 2014 Oct 31.


Characterizing the altered cellular proteome induced by the stress-independent activation of heat shock factor 1.

Ryno LM, Genereux JC, Naito T, Morimoto RI, Powers ET, Shoulders MD, Wiseman RL.

ACS Chem Biol. 2014 Jun 20;9(6):1273-83. doi: 10.1021/cb500062n. Epub 2014 Apr 16.


Broadly applicable methodology for the rapid and dosable small molecule-mediated regulation of transcription factors in human cells.

Shoulders MD, Ryno LM, Cooley CB, Kelly JW, Wiseman RL.

J Am Chem Soc. 2013 Jun 5;135(22):8129-32. doi: 10.1021/ja402756p. Epub 2013 May 21.


Stress-independent activation of XBP1s and/or ATF6 reveals three functionally diverse ER proteostasis environments.

Shoulders MD, Ryno LM, Genereux JC, Moresco JJ, Tu PG, Wu C, Yates JR 3rd, Su AI, Kelly JW, Wiseman RL.

Cell Rep. 2013 Apr 25;3(4):1279-92. doi: 10.1016/j.celrep.2013.03.024. Epub 2013 Apr 11.


Synthesis of 5-fluoro- and 5-hydroxymethanoprolines via lithiation of N-BOC-methanopyrrolidines. Constrained Cγ-exo and Cγ-endo Flp and Hyp conformer mimics.

Krow GR, Shoulders MD, Edupuganti R, Gandla D, Yu F, Sonnet PE, Sender M, Choudhary A, DeBrosse C, Ross CW 3rd, Carroll P, Raines RT.

J Org Chem. 2012 Jun 15;77(12):5331-44. doi: 10.1021/jo300700a. Epub 2012 May 25.


Synthesis of conformationally constrained 5-fluoro- and 5-hydroxymethanopyrrolidines. Ring-puckered mimics of gauche- and anti-3-fluoro- and 3-hydroxypyrrolidines.

Krow GR, Edupuganti R, Gandla D, Yu F, Sender M, Sonnet PE, Zdilla MJ, DeBrosse C, Cannon KC, Ross CW 3rd, Choudhary A, Shoulders MD, Raines RT.

J Org Chem. 2011 May 20;76(10):3626-34. doi: 10.1021/jo200117p. Epub 2011 Apr 18.


Interstrand dipole-dipole interactions can stabilize the collagen triple helix.

Shoulders MD, Raines RT.

J Biol Chem. 2011 Jul 1;286(26):22905-12. doi: 10.1074/jbc.M110.199984. Epub 2011 Apr 10.


Oligomers of a 5-carboxy-methanopyrrolidine β-amino acid. A search for order.

Krow GR, Liu N, Sender M, Lin G, Centafont R, Sonnet PE, DeBrosse C, Ross CW 3rd, Carroll PJ, Shoulders MD, Raines RT.

Org Lett. 2010 Dec 3;12(23):5438-41. doi: 10.1021/ol1022917. Epub 2010 Nov 2.


The aberrance of the 4S diastereomer of 4-hydroxyproline.

Shoulders MD, Kotch FW, Choudhary A, Guzei IA, Raines RT.

J Am Chem Soc. 2010 Aug 11;132(31):10857-65. doi: 10.1021/ja103082y.


Stereoelectronic and steric effects in side chains preorganize a protein main chain.

Shoulders MD, Satyshur KA, Forest KT, Raines RT.

Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):559-64. doi: 10.1073/pnas.0909592107. Epub 2009 Dec 31.


Origin of the stability conferred upon collagen by fluorination.

Shoulders MD, Kamer KJ, Raines RT.

Bioorg Med Chem Lett. 2009 Jul 15;19(14):3859-62. doi: 10.1016/j.bmcl.2009.03.168. Epub 2009 Apr 21.


Modulating collagen triple-helix stability with 4-chloro, 4-fluoro, and 4-methylprolines.

Shoulders MD, Raines RT.

Adv Exp Med Biol. 2009;611:251-2. No abstract available.


Collagen structure and stability.

Shoulders MD, Raines RT.

Annu Rev Biochem. 2009;78:929-58. doi: 10.1146/annurev.biochem.77.032207.120833. Review.


4-chloroprolines: synthesis, conformational analysis, and effect on the collagen triple helix.

Shoulders MD, Guzei IA, Raines RT.

Biopolymers. 2008 May;89(5):443-54.


Reciprocity of steric and stereoelectronic effects in the collagen triple helix.

Shoulders MD, Hodges JA, Raines RT.

J Am Chem Soc. 2006 Jun 28;128(25):8112-3.

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